Review
Endocrinology & Metabolism
Stephen Halada, Victoria Casado-Medrano, Julia A. Baran, Joshua Lee, Poojita Chinmay, Andrew J. Bauer, Aime T. Franco
Summary: Differentiated thyroid cancer and breast cancer, predominantly affecting women, share hormonal connections. The breast is responsive to thyroid hormone signaling and the thyroid is responsive to estrogen, leading to cancer progression. Obesity-related adipocyte alterations and environmental toxicants also contribute to hormonal changes in both breast and thyroid tissues. Further research on hormonal crosstalk is necessary to understand and develop potential therapeutic options for these cancers.
Review
Medicine, General & Internal
Ioannis A. Voutsadakis
Summary: Breast cancer is influenced by nuclear receptors, including estrogen receptor, progesterone receptor, and androgen receptor. Non-steroid nuclear receptors, such as vitamin D receptor and thyroid receptors, also play a role in breast cancer pathophysiology. Thyroid hormones can affect breast cancer risk and cell survival through canonical receptors and additional membrane receptors. Understanding the implications of the thyroid axis in breast cancer is important for prognosis and treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Carole Ann Spencer
Summary: This review highlights the development of laboratory thyroid tests over the past seven decades, from manual isotopically labeled iodine procedures to automated nonisotopic tests. The introduction of radioimmunoassay techniques and monoclonal antibody technology has played a crucial role in the evolution of thyroid testing. Despite improvements, current tests still face limitations in terms of numerical differences and interferences from reagents and autoantibodies.
Article
Chemistry, Analytical
Sylwia Baluta, Marta Romaniec, Kinga Halicka-Stepien, Michalina Alicka, Aleksandra Piela, Katarzyna Pala, Joanna Cabaj
Summary: This article presents a novel and selective electrochemical bioassay for the determination of free thyroid hormone using antibody and laccase. The biosensor was based on a glassy carbon electrode modified with a Fe3O4@graphene nanocomposite, an antibody with high affinity for the hormone, and laccase. The biosensor exhibited sensitivity, selectivity, and stability towards the hormone, and showed excellent recovery results in synthetic serum samples.
Review
Radiology, Nuclear Medicine & Medical Imaging
Petra Petranovic Ovcaricek, Frederik A. Verburg, Martha Hoffmann, Ioannis Iakovou, Jasna Mihailovic, Alexis Vrachimis, Markus Luster, Luca Giovanella
Summary: Numerous studies suggest a stimulating effect of triiodothyronine and thyroxin on cancer. The majority of evidence indicates an association between hyperthyroidism and the risk of developing cancer, as well as a poorer cancer prognosis. The rapid establishment of euthyroidism through radioiodine therapy is crucial in the management of hyperthyroidism in cancer patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Health Care Sciences & Services
Enke Baldini, Augusto Lauro, Domenico Tripodi, Daniele Pironi, Maria Ida Amabile, Iulia Catalina Ferent, Eleonora Lori, Federica Gagliardi, Maria Irene Bellini, Flavio Forte, Patrizia Pacini, Vito Cantisani, Vito D'Andrea, Salvatore Sorrenti, Salvatore Ulisse
Summary: Epidemiological studies have shown an association between thyroid diseases and extra-thyroidal malignancies, particularly breast cancer. Patients with autoimmune thyroiditis have an increased risk of breast cancer, although the risk is lower for those who are thyroid autoantibody-positive. The molecular links between thyroid autoimmunity and breast cancer remain uncertain.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Richard J. Robbins, Trisha D. Cubb, Maleeha Zahid, Jiaqiong Xu
Summary: In this study, researchers found that elevated serum antithyroglobulin antibody (TgAb) levels may be a predictive marker for persistent or recurrent thyroid cancer. The results showed that patients with high TgAb levels were more likely to have positive lymph nodes and a higher incidence of cancer recurrence. Therefore, patients with elevated TgAb levels should be closely monitored for possible thyroid cancer recurrence.
ENDOCRINE PRACTICE
(2023)
Article
Environmental Sciences
Kei Nomiyama, Yasuo Yamamoto, Akifumi Eguchi, Hiroyuki Nishikawa, Hazuki Mizukawa, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Shouta M. M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka
Summary: This study investigated the potential health effects of organohalogen compounds (OHCs) on pet cats. The results showed that exposure to harmful substances leads to a decrease in serum thyroid hormone levels and chronic oxidative stress in pet cats. Parent compounds and phenolic compounds exhibit different mechanisms of action and biological effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Agnieszka Adamska, Andrzej Raczkowski, Zofia Stachurska, Marcin Kondraciuk, Adam Jacek Kretowski, Marcin Adamski, Irina Kowalska, Karol Adam Kaminski
Summary: This study investigated the relationships between thyroid hormones and body composition, as well as the distribution of fat in different regions. The results showed that in men, TSH was associated with visceral adipose tissue, while fT3 was positively correlated with total fat mass, android fat mass, and gynoid fat mass. These associations were not observed in women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Feng Wang, Guro F. F. Giskeodegard, Sissel Skarra, Monica J. J. Engstrom, Lars Hagen, Jurgen Geisler, Tomi S. S. Mikkola, Matti J. J. Tikkanen, Julia Debik, Randi J. J. Reidunsdatter, Tone F. F. Bathen
Summary: Metabolic reprogramming in breast cancer involves changes in steroid hormone synthesis and metabolism, which may influence carcinogenesis, breast cancer growth, and response to therapy. This study aimed to examine whether serum steroid hormone concentrations could predict the risk of recurrence and treatment-related fatigue in patients with breast cancer. It was found that serum steroid hormone concentrations differed between relapse and relapse-free patients, and baseline cortisol levels were lower in patients who relapsed.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Amichay Meirovitz, Benjamin Nisman, Tanir M. Allweis, Einat Carmon, Luna Kadouri, Bella Maly, Ofra Maimon, Tamar Peretz
Summary: This study evaluated the association between serum thyroid hormone levels and morphological presentations and prognosis of breast cancer. The results showed a significant positive association between serum FT3 level and pathological features, as well as poor prognosis. There was no significant association between serum TSH level and breast cancer parameters.
ANTICANCER RESEARCH
(2022)
Review
Medicine, General & Internal
Armando Patrizio, Silvia Martina Ferrari, Giulio Stoppini, Elena Palmisano, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Eugenia Balestri, Valeria Mazzi, Chiara Botrini, Agnese Proietti, Fausto Fama, Salvatore Benvenga, Alessandro Antonelli, Poupak Fallahi
Summary: Breast cancer often metastasizes to sites such as the bone, lungs, brain, and liver, but rarely involves the thyroid gland. We investigated thyroid metastasis (TM) from breast cancer and found it to be a rare occurrence. However, it significantly impacts the prognosis of patients, emphasizing the importance of considering secondary thyroid malignancies in follow-up care. Thyroid surgery can help control the local disease burden.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marcela Valko-Rokytovska, Peter Ocenas, Aneta Salayova, Zuzana Kostecka
Summary: Metabolomics is a promising analytical method for the diagnosis and prognosis of breast cancer, offering a comprehensive non-invasive approach. Targeted metabolomics of steroid hormones play a crucial role in the classification and development of breast cancer, with high potential for effective diagnosis and monitoring of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Aleck Hercbergs, Hung-Yun Lin, Shaker A. Mousa, Paul J. Davis
Summary: Thyroid hormone acts on cancer cells through its receptor on the cell surface to promote cell proliferation. It can promote the growth of estrogen receptor-positive breast cancer cells in the absence of estrogen. Additionally, it may contribute to aggressive breast cancer behavior by stimulating immune checkpoint inhibitor gene expression and anti-apoptosis mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hongtao Wang, Shiwen Li, Jinyuan Shi, Chuyao Feng, Yanan Wang, Fan Zhang
Summary: This study explores the potential causal relationship between breast cancer and thyroid cancer using large-sample genome-wide association studies (GWAS) data. The results suggest that gene-driven thyroid cancer does not cause estrogen receptor-positive breast cancer and is actually a protective factor, while gene-driven estrogen receptor-positive breast cancer can lead to the development of thyroid cancer.