Article
Food Science & Technology
Maria Julia Martinez, Adriana Balbina Andreu, Luciana Barbini
Summary: Hepatocellular carcinoma (HCC) is a common and deadly tumor. Late diagnosis and treatment delay contribute to poor prognosis. Polyphenols from potatoes have antioxidant properties and cytotoxic effects on HCC cells, making them a potential treatment option.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mona Bahremani, Nadereh Rashtchizadeh, Mehdi Sabzichi, Amir Mansour Vatankhah, Sepideh Danaiyan, Haniyeh Poursistany, Jamal Mohammadian, Amir Ghorbanihaghjo
Summary: The study found that new methods with lesser toxicity are needed to mitigate the dose-dependent adverse effects of anticancer agents. The objective of the research was to evaluate the efficacy of GLUT1 inhibitor in augmenting the efficiency of docetaxel in cancer cells. The results showed that co-administration of docetaxel and GLUT1 inhibitor significantly increased apoptosis and decreased the expression of certain genes involved in the apoptosis pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Engineering, Biomedical
Reza Mahmoudi, Fatemeh Hassandokht, Maryam Tajali Ardakani, Bahman Karimi, Abazar Roustazadeh, Shabnam Tarvirdipour, Mehzad Jafari Barmak, Mohsen Nikseresht, Marzieh Baneshi, Ali Mousavizadeh, Mohsen Saghebray Shirazi, Mohsen Alipour, Hassan Bardania
Summary: The co-delivery system of Curcumin and Cisplatin liposomes demonstrated a synergistic effect in inducing apoptosis in breast cancer cells, with optimized concentrations and entrapment efficiencies. The system showed significant reduction in breast cancer cell viability and higher apoptotic effects compared to free and liposomal Cis, indicating its potential for encapsulating and releasing both hydrophobic and hydrophilic drugs with reduced cytotoxic effects and increased potency.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Food Science & Technology
Martin Samuel Hernandez-Zazueta, Joel Said Garcia-Romo, Luis Noguera-Artiaga, Ivan Luzardo-Ocampo, Angel Antonio Carbonell-Barrachina, Pablo Taboada-Antelo, Rocio Campos-Vega, Ema Carina Rosas-Burgos, Maria Guadalupe Burboa-Zazueta, Josafat Marina Ezquerra-Brauer, Juan Manuel Martinez-Soto, Hisila del Carmen Santacruz-Ortega, Armando Burgos-Hernandez
Summary: O. vulgaris ink, particularly the dichloromethane extract, demonstrates potential health benefits such as antimutagenic, cytoprotective, and antiproliferative effects on human cancer cell lines. The discovery of a novel compound in the purified fractions highlights the promising bioactivity of understudied marine natural products like OI, which may have implications for cancer prevention and treatment. Further research is needed to explore the mechanisms and health benefits of OI at different levels of investigation.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Daniel Augustynowicz, Marta Kinga Lemieszek, Jakub Wladyslaw Strawa, Adrian Wiater, Michal Tomczyk
Summary: Cinquefoils have been widely used in folk medicine for managing gastrointestinal diseases, cancer, thyroid disorders, and wound healing. In this study, extracts from different Potentilla species were analyzed for their cytotoxic and antiproliferative effects on colon cancer cells. The results showed that these extracts had stronger effects on cancer cells compared to normal cells, suggesting their potential as anti-colorectal cancer agents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Slindelo Mposula, Daniel G. Amoako, Anou M. Somboro, Isaiah Arhin, Hezekiel M. Kumalo, Rene B. Khan
Summary: The study investigated the toxic effects of Terminalia phanerophlebia on human renal cells, revealing that its extract led to apoptosis and necrosis in Hek293 cells mainly through upregulation of p53, Bax, NF-kappa B, and downregulation of caspase activity.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Environmental Sciences
Ali Alamer, Daoud Ali, Saud Alarifi, Abdullah Alkahtane, Mohammed AL-Zharani, Mohamed M. Abdel-Daim, Gadah Albasher, Rafa Almeer, Nouf K. Al-Sultan, Abdulaziz Almalik, Ali H. Alhasan, Christos Stournaras, Saquib Hasnain, Saad Alkahtani
Summary: The experiment conducted on Bi(2)O(3)NPs revealed their ability to induce oxidative stress and increase apoptosis in human breast cancer cells, leading to dysfunction of mitochondrial membrane potential and chromosome condensation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biology
Mariam Abdulaziz Alkhateeb, Wedad Refaiea Al-Otaibi, Qwait AlGabbani, Amena Ali Alsakran, Alaa Ahmed Alnafjan, Amani Mohammed Alotaibi, Wedad Saeed Al-Qahtani
Summary: This study demonstrated the impact of aqueous extract of basil blossoms on human breast cancer cells, showing high levels of flavonoids and phenolic compounds with anticancer and antioxidant activities.
BIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Fuad Fares, Soliman Khatib, Jacob Vaya, Lital Sharvit, Einav Eizenberg, Solomon Wasser
Summary: This study identified the active compounds in Cyathus stratus with anti-pancreatic cancer activity. The compounds were purified using RP-18 preparative chromatography and further separated using various chromatographic techniques. The purified compound, striatal C, showed significant anti-cancer activity and induced apoptosis in human pancreatic cancer cells.
Article
Food Science & Technology
Zhou Chen, Dan Hong, Siting Li, Yingmin Jia
Summary: Brevilaterins, produced by Brevibacillus laterosporus, have excellent antimicrobial properties and potential as anticancer agents. In this study, the cytotoxic effects of Brevilaterin B/C (BB/BC) on gastric cancer cells were investigated. BB and BC significantly inhibited cell proliferation and migration, induced LDH release, and increased apoptotic rate. Moreover, BB/BC-induced ROS production and changes in mitochondrial membrane potential were observed, suggesting a close association between apoptosis and ROS elevation.
Article
Biochemistry & Molecular Biology
Aleksandra Brankiewicz, Sara Trzos, Magdalena Mrozek, Malgorzata Opydo, Elzbieta Szostak, Michal Dziurka, Monika Tuleja, Agnieszka Loboda, Ewa Pochec
Summary: Oxidative stress and hypoxic microenvironment play crucial roles in the progression of aggressive human melanoma. This study aimed to assess the effects of different Hypericum perforatum extracts and hyperforin salt on melanoma cells under normoxic and hypoxic conditions. We found that the cytotoxic, pro-apoptotic, and antioxidant effects of the extracts varied depending on their composition, melanoma stage, and oxygen level. Importantly, the composition of extracts from different origins, including in vitro cultured plants, may be significant in therapeutic applications.
Article
Nutrition & Dietetics
Ming-Chang Tsai, Ching-Chun Chen, Tsui-Hwa Tseng, Yun-Ching Chang, Yi-Jie Lin, I-Ning Tsai, Chi-Chih Wang, Chau-Jong Wang
Summary: Anthocyanins from Hibiscus sabdariffa can induce apoptosis in colorectal cancer cells through the activation of AMPK signaling pathways. This study elucidates the regulatory role of HAs in apoptosis-related proteins in colorectal cancer cells.
Article
Plant Sciences
Armelle T. Mbaveng, Cedric G. T. Noulala, Anne R. M. Samba, Simplice B. Tankeo, Ghislain W. Fotso, Emmanuel N. Happi, Bonaventure T. Ngadjui, Veronique P. Beng, Victor Kuete, Thomas Efferth
Summary: This study investigated the phytochemical constituents of Araliopsis soyauxii and found that extracts and compound 12 showed cytotoxicity against various cancer cell lines. The mechanisms of inducing apoptosis varied between ASB and compound 12, indicating their potential as sources of cytotoxic phytochemicals for further exploration in developing anticancer drugs.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ganesh Kumar Raut, Genji Sukumar, Moumita Chakrabarti, Jolly Janette Mendonza, Srihari Pabbaraja, B. Jagan Mohan Reddy, Ramakrishna Sistla, Sai Balaji Andugulapati, Manika Pal Bhadra
Summary: Polyphenols are natural compounds with anti-tumorigenic effects. This study designed and synthesized a compound that interferes with the cell cycle progression in aggressive prostate cancer. Further experiments showed that the compound inhibits the viability of prostate cancer cells and induces apoptosis through oxidative stress. In a mouse model, the compound showed no toxicity and reduced the tumor burden.
Article
Biochemistry & Molecular Biology
Guo-Kai Wang, Yun-Peng Sun, Wen-Fang Jin, Yang Yu, Jian-Yong Zhu, Jin-Song Liu
Summary: Sixteen new limonoids and 18 known limonoids were isolated from Swietenia macrophylla, and their structures were determined. Limonoid 19 exhibited significant cytotoxic effects against A375 cells and induced apoptosis.
BIOORGANIC CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Wannaluk Thaworn, Surat Hongsibsong, Marninphan Thongkham, Supamit Mekchay, Wiwat Pattanawong, Korawan Sringarm
Summary: This study successfully produced a single-chain antibody against bull Y-bearing sperm, which is significant for techniques involving sexed bull semen.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kraikrit Utama, Nopawit Khamto, Puttinan Meepowpan, Paitoon Aobchey, Jiraporn Kantapan, Korawan Sringarm, Sittiruk Roytrakul, Padchanee Sangthong
Summary: This study investigated the inhibitory effects of the natural product 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) derived from Syzygium nervosum A. Cunn. ex DC. on various cancer cell lines, particularly cervical cancer. DMC displayed significant antiproliferative activity in different cervical cancer cell lines and induced DNA damage, cell cycle arrest, and apoptosis. The findings suggest that DMC has the potential to be developed as a therapeutic agent for antiproliferative cervical cancer treatment.
Article
Engineering, Chemical
Sukanya Haituk, Patchareeya Withee, Jiraporn Sangta, Chanokned Senwanna, Pattarapol Khamsaw, Anuruddha Karunarathna, Surat Hongsibsong, Korawan Sringarm, Shashanka K. Prasad, Sarana Rose Sommano, Ratchadawan Cheewangkoon
Summary: This study identifies the diversity of sooty molds in Thailand using morphology and phylogenetic analysis. The secondary metabolites produced by the sooty molds were analyzed, and their antifungal and antioxidant activities were tested. The preliminary screening suggests that the sooty molds have the potential to produce novel compounds and contribute to sustainable agriculture.
Article
Agriculture, Dairy & Animal Science
Punnawut Yama, Chayanon Yadmak, Molarat Sangkate, Jakree Jitjumnong, Warittha U-krit, Nalinthip Promsao, Napatsorn Montha, Paiwan Sudwan, Raktham Mektrirat, Julakorn Panatuk, Wilasinee Inyawilert, Korawan Sringarm, Chompunut Lumsangkul, Wanaporn Tapingkae, Hien Van Doan, Pin-Chi Tang, Tossapol Moonmanee
Summary: The study showed that follicular and uterine arterial indices from color Doppler ultrasonography could be helpful in predicting the resumption of ovarian activity after hormonal stimulation in inactive ovary cows, providing important clinical implications.
Article
Biology
Supamit Mekchay, Nanthana Pothakam, Worrarak Norseeda, Pantaporn Supakankul, Tawatchai Teltathum, Guisheng Liu, Watcharapong Naraballobh, Trisadee Khamlor, Korawan Sringarm, Patcharin Krutmuang
Summary: The polymorphisms of porcine IFNA16 and TNFRSF19 genes were found to be associated with intramuscular fat content and fatty acid composition, suggesting their potential role in lipid deposition and fatty acid deposition in the muscle tissue of pigs.
Article
Biology
Marvin Bryan Segundo Salinas, Teepakorn Lertwichaikul, Chakorn Khunkaew, Sukolrat Boonyayatra, Korawan Sringarm, Phongsakorn Chuammitri, Anucha Sathanawongs
Summary: This study aims to clarify the freezability phenomena in swamp buffalo epididymal spermatozoa (ES). The results showed variations in motility, motion and kinematics, oxidative stress status, and specific sperm proteins between high and low freezability groups.
Article
Food Science & Technology
Korawan Sringarm, Niraporn Chaiwang, Watcharapong Wattanakul, Prapas Mahinchai, Apinya Satsook, Rakkiat Norkeaw, Mintra Seel-audom, Tossapol Moonmanee, Supamit Mekchay, Sarana Rose Sommano, Warintorn Ruksiriwanich, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Chaiwat Arjin
Summary: This study aimed to investigate the effects of perilla cake supplementation in a low-lysine diet on the meat quality of late-phase pigs. The results showed that adding perilla cake significantly increased intramuscular fat and marbling score, while reducing boiling loss and shear force value. However, it was found that perilla cake supplementation led to a significant increase in malondialdehyde levels in meat compared to the basal diet. Additionally, perilla cake supplementation significantly increased the level of alpha-linolenic acid in backfat and longissimus thoracis et lumborum muscle.
Article
Plant Sciences
Warintorn Ruksiriwanich, Chiranan Khantham, Anurak Muangsanguan, Chuda Chittasupho, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Sarana Rose Sommano, Korawan Sringarm, Emilia Ferrer, Francisco J. Barba
Summary: In this study, the bioactive compounds in shallot extract were evaluated for their hair growth-promoting activities. The results showed that phenolic compounds were the major constituents of the extract and exhibited anti-inflammatory effects. The extract also regulated the expression of genes related to hair growth pathways. These findings suggest that shallot extract has potential in promoting hair growth.
Article
Biology
Korawan Sringarm, Marninphan Thongkham, Supamit Mekchay, Chompunut Lumsangkul, Wannaluk Thaworn, Wiwat Pattanawong, Ekaphot Rangabpit, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Anucha Sathanawongs, Surat Hongsibsong
Summary: This study evaluates the efficiency of bovine sperm sexing using magnetic-activated cell sorting (MACS) by scFv antibody against Y-chromosome-bearing sperm (Y-scFv) coupled to magnetic microbeads and its effects on kinematic variables, sperm quality, and X/Y-sperm ratio. The results show that PY-microbeads are highly effective in separating Y-sperm from X-sperm with no negative impact on the quality of X-sperm. The technique produces high percentages of X-sperm and Y-sperm, making it a feasible method for bovine sperm sexing.
Article
Agronomy
Chiranan Khantham, Warintorn Ruksiriwanich, Korawan Sringarm, Chanakan Prom-u-thai, Sansanee Jamjod, Chaiwat Arjin, Anurak Muangsanguan, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Francisco J. Barba, Sarana Rose Sommano, Romchat Chutoprapat, Korawinwich Boonpisuttinant
Summary: The aim of this study was to investigate the effects of KDML105 bran extract on gene expression involved in the hair cycle, as well as its antioxidant and anti-inflammatory activities. The extract contained compounds such as tocopherols, gamma-oryzanol, phytic acid, and phenolic compounds, which contributed to its antioxidant capacities. Treatment with the extract reduced nitric oxide production and downregulated SRD5A2 and TGFB1 expressions in HFDPCs, while upregulating CTNNB1 and VEGF genes. The findings suggest that KDML105 bran extract may play a role in promoting hair growth and angiogenesis, making it a promising source of anti-hair loss substances.
Article
Plant Sciences
Warintorn Ruksiriwanich, Pichchapa Linsaenkart, Chiranan Khantham, Anurak Muangsanguan, Korawan Sringarm, Pensak Jantrawut, Chanakan Prom-u-thai, Sansanee Jamjod, Supapohn Yamuangmorn, Chaiwat Arjin, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Francisco J. Barba, Sarana Rose Sommano, Romchat Chutoprapat, Korawinwich Boonpisuttinant
Summary: Alopecia and gray hair are common hair abnormalities with psychological impacts, and chemical treatments have distressing side effects. This study focused on the waste of rice cultivars from Thailand and evaluated their potential for hair revitalization. The BB4CMU rice bran oil (RBO) showed comparable melanin production induction to the standard drug theophylline, and it also exhibited inhibitory effects on steroid 5 alpha-reductase genes. Thus, BB4CMU-RBO could be a promising candidate for hair revitalization from natural resources.
Article
Food Science & Technology
Nuha Binte Iesa, Supakit Chaipoot, Rewat Phongphisutthinant, Pairote Wiriyacharee, Bee Gim Lim, Korawan Sringarm, Michael Burgett, Bajaree Chuttong
Summary: This study investigated the physical characteristics and antioxidant activity of freeze-dried dewaxed cerumen of Tetragonula laevicpes encapsulated with different carrier matrices. The results showed that all carrier matrices exhibited good powder characteristics and high antioxidant activity.
Article
Plant Sciences
Warintorn Ruksiriwanich, Pichchapa Linsaenkart, Anurak Muangsanguan, Korawan Sringarm, Pensak Jantrawut, Chaiwat Arjin, Sarana Rose Sommano, Yuthana Phimolsiripol, Francisco J. Barba
Summary: Datura metel L. (thorn apple) was extracted using supercritical carbon dioxide technique and its biological activities were evaluated through various assays. The extract exhibited significant wound healing and inhibitory effects on MMP-2 expression, as well as upregulation of genes involved in the sonic hedgehog pathway. The results suggest that supercritical carbon dioxide extraction could be a potential method for Datura metel extraction and wound closure.
Article
Food Science & Technology
Anurak Muangsanguan, Pichchapa Linsaenkart, Tanakarn Chaitep, Jiraporn Sangta, Sarana Rose Sommano, Korawan Sringarm, Chaiwat Arjin, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Juan M. Castagnini, Warintorn Ruksiriwanich
Summary: This study utilized supercritical fluid extraction to obtain six coffee pulp extracts, with the SFE-4 extract showing the highest phenolic, flavonoid, and caffeine contents. This extract enhanced migration and cell proliferation in human hair follicle dermal papilla cells, and also exhibited scavenging effects on radicals and stimulation on certain genes, potentially aiding in hair loss prevention and promoting hair growth pathways.
Review
Horticulture
Pattarapol Khamsaw, Jiraporn Sangta, Pirawan Chaiwan, Pornchai Rachtanapun, Sasithorn Sirilun, Korawan Sringarm, Sarinthip Thanakkasaranee, Sarana Rose Sommano
Summary: The Sustainable Development Goals are crucial for improving production and consumption systems and eliminating hunger and poverty. Citrus fruits, being a major fruit crop, experience significant biomass loss due to biotic stresses. Therefore, adopting a bio-circular approach in citrus fruit production can reduce agricultural by-products and promote green economy.
