Review
Medicine, General & Internal
Lorena Alexandra Lisencu, Eduard-Alexandru Bonci, Alexandru Irimie, Ovidiu Balacescu, Cosmin Lisencu
Summary: This review discusses the role of circulating tumor cells (CTCs) in chemoresistance in metastatic breast cancer patients. It highlights that CTCs with stem cell and mesenchymal features are aggressive subtypes that can survive chemotherapy, leading to chemoresistance and disease progression. Hemodynamic shear stress and dynamic changes among CTCs are also important factors in disease progression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Ami N. Shah, Kristen J. Carroll, Lorenzo Gerratana, Chenyu Lin, Andrew A. Davis, Qiang Zhang, Saya Jacob, Brian Finkelman, Youbin Zhang, Wenen Qiang, Paolo D'Amico, Carolina Reduzzi, William J. Gradishar, Amir Behdad, Massimo Cristofanilli
Summary: Data shows that premenopausal women diagnosed with metastatic breast cancer have unique clinical, pathological, and molecular features compared to their postmenopausal counterparts, potentially impacting treatment options.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Florian Reinhardt, Luisa Coen, Mahdi Rivandi, Andre Franken, Eunike Sawitning Ayu Setyono, Tobias Lindenberg, Jens Eberhardt, Tanja Fehm, Dieter Niederacher, Franziska Knopf, Hans Neubauer
Summary: DanioCTC is a novel workflow that injects patient-derived CTCs into zebrafish, enabling studies on the metastatic potential of these rare tumor cells.
Article
Medical Laboratory Technology
Jingya Zhang, Qian Wei, Dong Dong, Li Ren
Summary: This study investigated the application value of tumor markers in monitoring distant metastasis of breast cancer, revealing that combined detection of multiple markers is more valuable than using a single tumor marker.
CLINICA CHIMICA ACTA
(2021)
Article
Oncology
Alexia Lopresti, Claire Acquaviva, Laurys Boudin, Pascal Finetti, Severine Garnier, Anais Aulas, Maria Lucia Liberatoscioli, Olivier Cabaud, Arnaud Guille, Alexandre de Nonneville, Quentin Da Costa, Emilie Denicolai, Jihane Pakradouni, Anthony Goncalves, Daniel Birnbaum, Francois Bertucci, Emilie Mamessier
Summary: In this study, atypical cells in the blood of metastatic breast cancer patients were isolated and analyzed using a micro-filtration technic. Three subsets of circulating tumor cells were identified, each with different prognostic values. Moreover, a subset of CTCs was found to be a potential stratification tool for selecting patients for early clinical trials. This study highlights the heterogeneity of CTCs and their potential as a non-invasive tool for precision medicine.
Article
Engineering, Biomedical
Chun Liu, Miao Li, Zhao-Xia Dong, Dong Jiang, Xiaojing Li, Shuibin Lin, Demeng Chen, Xuenong Zou, Xing-Ding Zhang, Gary D. Luker
Summary: The study showed that breast cancer cells behave differently in environments with different stiffness: cells tend to proliferate in soft environments and migrate in stiff environments. Breast cancer cells switch metabolic pathways and gene expression in response to varying environmental stiffness.
ACTA BIOMATERIALIA
(2021)
Article
Oncology
Cvetka Grasic Kuhar, Jernej Silvester, Marina Mencinger, Tanja Ovcaricek, Maja Cemazar, Simona Miceska, Ziva Modic, Anamarija Kuhar, Tanja Jesenko, Veronika Kloboves Prevodnik
Summary: In this study, we analyzed liquid biopsy samples from metastatic breast cancer patients to study different biomarkers. We found that a higher number of circulating tumor cells was correlated with a greater likelihood of detecting clusters and megakaryocytes among the patients. The presence of megakaryocytes in the peripheral blood of cancer patients was also confirmed, which is a rare finding. Furthermore, a higher pan-inflammatory value was associated with lower overall survival, providing insight into the depth of the metastatic process. Liquid biopsy is an important source of new biomarkers for the treatment of metastatic cancer patients.
Article
Oncology
Dorothea Sonja Schott, Monika Pizon, Ulrich Pachmann, Katharina Pachmann, Rainer Schobert, Andrea Wittig, Matthias Maeurer
Summary: This study investigated changes in CETC and cCSC numbers in breast cancer patients before and after radiotherapy, finding that CETC numbers correlated with tumor aggressiveness and cCSCs could be successfully monitored during treatment. Patients treated with neoadjuvant chemotherapy had higher CETC and tumorsphere numbers compared to those treated with adjuvant chemotherapy.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Giacomo Da Col, Fabio Del Ben, Michela Bulfoni, Matteo Turetta, Lorenzo Gerratana, Serena Bertozzi, Antonio Paolo Beltrami, Daniela Cesselli
Summary: Quantitative image analysis of circulating cells can be used to predict bone metastasis and overall survival in metastatic breast cancer. Circularity and diameter are the most significant predictive features, and machine learning models can improve prediction accuracy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Analytical
Qiuyue Wu, Lin Zhu, Xinyu Wei, Mingxia Zhang, Chi Zhang, Zhenlong You, Suhui Zhang, Yanling Song, Dan Liu, Chaoyong Yang
Summary: Circulating tumor cell (CTC)-based liquid biopsy has great potential as a diagnostic approach, but its clinical application has been limited due to a lack of systematic research. In this study, a mouse model of breast cancer recurrence was used to evaluate a microfluidic-based CTC detection method. The results showed that CTCs could be detected earlier using an EpCAM antibody-functionalized chip compared to other imaging technologies. Monitoring of CTCs after tumor resection indicated their gradual clearance from the blood. These findings provide a basis for CTC detection in monitoring tumorigenesis and metastasis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Pharmacology & Pharmacy
Ramya Dhandapani, Swaminathan Sethuraman, Uma Maheswari Krishnan, Anuradha Subramanian
Summary: By developing a smart nanotheranostic system, circulating tumor clusters (CTCs) can be tracked and eliminated, reducing metastatic progression and increasing the survival rate of breast cancer patients.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Oncology
Evan N. Cohen, Gitanjali Jayachandran, Hui Gao, Phillip Peabody, Heather B. McBride, Franklin D. Alvarez, Megumi Kai, Juhee Song, Yu Shen, Jie S. Willey, Bora Lim, Vicente Valero, Naoto T. Ueno, James M. Reuben
Summary: Circulating tumor cells (CTCs) are valuable indicators for managing metastatic breast cancer (MBC). Enrichment of CTCs based on size and deformability can capture a wider range of tumor cells, providing a complementary approach to tissue biopsy. A longitudinal study using a microcavity array showed that the shift from epithelial CTCs to those with a mesenchymal expression pattern is associated with worse clinical outcomes.
Review
Oncology
Caterina Gianni, Michela Palleschi, Giuseppe Schepisi, Chiara Casadei, Sara Bleve, Filippo Merloni, Marianna Sirico, Samanta Sarti, Lorenzo Cecconetto, Giandomenico Di Menna, Francesco Schettini, Ugo De Giorgi
Summary: Lymphocytic indexes may be associated with prognosis and treatment outcomes in breast cancer, and immune system targeted therapies show promise.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yauheni A. Shliakhtunou, Valery M. Siamionau, Vyacheslau V. Pobyarzhin
Summary: This study demonstrates the impact of transcription phenotype of circulating tumor cells on prognosis in non-metastatic breast cancer, which can contribute to improving the treatment efficacy of breast cancer.
Article
Oncology
Pei-Hung Chang, Chun-Hui Lee, Tyler Min-Hsien Wu, Kun-Yun Yeh, Hung-Ming Wang, Wen-Kuan Huang, Sheng-Chieh Chan, Wen-Chi Chou, Feng-Che Kuan, Hsuan-Chih Kuo, Yung-Chia Kuo, Ching-Chih Hu, Jason Chia-Hsun Hsieh
Summary: This study explores the role of circulating tumor cells (CTCs) and circulating cancer stem-like cells (cCSCs) in predicting the outcomes of patients with metastatic breast cancer after one cycle of chemotherapy. The results show that a decline in CTCs and cCSCs is associated with improved chemotherapy response, longer progression-free survival (PFS), and longer overall survival (OS).
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Ozgur Aslan, Metin Demir, Mehmet Koseoglu
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2016)
Article
Rheumatology
Mustafa Ozmen, Esin Oktay, Emine F. Tarhan, Ozgur Aslan, Utku Oflazoglu, Mehmet H. Koseoglu
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2016)
Article
Cardiac & Cardiovascular Systems
Ersin Cagri Simsek, Selcen Yakar Tuluce, Kamil Tuluce, Sadik Volkan Emren, Serap Cuhadar, Cem Nazli
CONGENITAL HEART DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Muammer Yucel, Alperen Ihtiyar, Mehmet Koseoglu
Summary: The study found that erythrocyte sedimentation rate (ESR) is not affected by fasting-satiety status or diurnal variation at different time points, suggesting that blood sampling for ESR can be done during the day if necessary.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2021)
Article
Medical Laboratory Technology
Serap Cuhadar, Hayat Ozkanay Yoruk, Mehmet Koseoglu, Kaan Katircioglu
Summary: Blood gas analysis is an essential test for critically ill patients, but the instability of blood gases is a problem. This study evaluated the effects of time and temperature on blood gas stability. The results showed that blood gas analysis results can be reliable under certain time and temperature conditions.
Article
Health Care Sciences & Services
Alperen Halil Ihtiyar, Mehmet Hicri Koseoglu, Fatma Demet Arslan
Summary: This study investigated diurnal variations in routine biochemical parameters in blood samples and found no significant changes in several parameters throughout the day, but clinically significant changes in glucose, cholesterol, triglyceride, bilirubin, albumin, urea nitrogen, uric acid, sodium, potassium, chloride, and amylase levels. Clinicians should consider the timing of blood sampling and the diurnal variations in these parameters for accurate diagnosis and treatment follow-up.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2023)
Meeting Abstract
Respiratory System
Muzaffer Onur Turan, Nurhan Sarioglu, Pakize Ayse Turan, Ozer Ozdemir, Nevin Fazlioglu, Mehmet Koseoglu, Hayat Ozkanay, Ozgur Guney, Arzu Mirici
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Medicine, General & Internal
Zeynep Ozturk, Serap Cuhadar
Article
Medicine, General & Internal
Fatma Demet Arslan, Mehmet Koseoglu, Aysenur Atay, Yavuz Yigit, Yasemin Akcay, Eser Sozmen
JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
Fatma Demet Ince, Aysenur Atay, Mehmet Hicri Koseoglu, Hamit Yasar Ellidag, Murat Yesil, Erdal Deveci
INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL
(2016)
Article
Medical Laboratory Technology
Serap Cuhadar, Mehmet Koseoglu, Yasemin Cinpolat, Guler Bugdayci, Murat Usta, Tuna Semerci
Article
Biochemistry & Molecular Biology
Yavuz Yigit, Fatma Demet Arslan Ince, Mehmet Hicri Koseoglu, Aysenur Atay, Hamit Yasar Ellidag
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2015)
Article
Medicine, Research & Experimental
Metin Canbal, Haydar Kaya, Aksel Kocoglu, Can D. Telli, Erkan Kaya, Mehmet Koseoglu, Yasin Akgoz, Nurcan Gokgoz, Senol Dane
CLINICAL AND INVESTIGATIVE MEDICINE
(2015)