Article
Biochemistry & Molecular Biology
Abdulhakeem Alsughayer, Abdel-Zaher A. Elassar, Abdulaziz A. Hasan, Fakhreia Al Sagheer
Summary: The main goal of this article is to develop new derivatives of commercial antibiotics and test their activities against different microorganisms. Various novel antibiotic derivatives were synthesized using different organic reagents and tested for their structural confirmation and bioactivities against gram-positive and gram-negative bacteria, showing high to moderate antibacterial activity. Additionally, these novel compounds demonstrated good effects against ciprofloxacin-resistant bacteria.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Zawadzka, Aleksandra Felczak, Iwona E. Glowacka, Dorota G. Piotrowska, Katarzyna Lisowska
Summary: The newly synthesised, functionalised carbazole derivative 2 showed strong inhibitory effects on Gram-positive bacterial strains and limited the growth of Pseudomonas aeruginosa and Aspergillus flavus. It increased the permeability of cellular membrane and exhibited strong effects on human fibroblasts. Further modification of this compound may lead to effective drugs, especially against drug-resistant staphylococci.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Qidi Kong, Yushe Yang
Summary: Antimicrobial resistance poses a global challenge as the effectiveness of old antibiotics diminishes. Discovery and development of antibacterial agents have been accelerated to replenish the limited and shrinking arsenal of antibiotics. Significant advances have been made in recent years in the antibacterial field, including new compounds of known classes and new compounds with new mechanisms.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Metallurgy & Metallurgical Engineering
Arash Fattah-alhosseini, Maryam Molaei, Meisam Nouri, Kazem Babaei
Summary: Mg and its alloys are suitable choices for implant materials due to their biodegradability and biocompatibility features. However, the high electrochemical activity of these materials results in fast degradation and severe corrosion. The use of plasma electrolytic oxidation (PEO) surface modification technique can enhance the antibacterial activity of Mg and its alloys while maintaining their corrosion protection properties.
JOURNAL OF MAGNESIUM AND ALLOYS
(2022)
Article
Multidisciplinary Sciences
Irfan Ahmad, Mohammad Y. Alshahrani, Shadma Wahab, Alhanouf I. Al-Harbi, Nazima Nisar, Yasser Alraey, Abdulaziz Alqahtani, Mushtaq Ahmad Mir, Safia Irfan, Mohd Saeed
Summary: The study reveals that zinc oxide nanoparticles exhibit significant antibacterial efficacy, making them potential substitutes for antibacterial agents, particularly against Gram-positive bacterial isolates.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Yuanhao Liu, Yunlong Lu, Zhongren Xu, Xiaoyan Ma, Xiuli Chen, Wukun Liu
Summary: Multidrug resistance is a significant issue in antibiotic clinical application, leading researchers to explore the potential of auranofin and other gold complexes as antibacterial agents. These advances offer a new perspective on the treatment of bacterial infections.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemical Research Methods
Martina Traykovska, Robert Penchovsky
Summary: In recent decades, antibiotic drug resistance has become a significant challenge in modern medicine due to the emergence of bacteria strains resistant to known antibiotics. Riboswitches have emerged as novel targets for antibacterial drug discovery. This study describes the design and applications of antisense oligonucleotides as antibacterial agents targeting riboswitches, demonstrating their suitability for drug development.
ACS SYNTHETIC BIOLOGY
(2022)
Review
Engineering, Biomedical
Wenlong Huang, Lingxi Meng, Yuan Chen, Zaiquan Dong, Qiang Peng
Summary: Antibiotic therapy is important, but its improper use and emergence of drug resistance have reduced its effectiveness. Therefore, developing more potent antimicrobial therapies is crucial. Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria have been used as active agents, drug carriers, and vaccine adjuvants, showing great potential.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Kefurong Deng, Yachao Li, Xiaoyu Liang, Cheng Shen, Zenan Zeng, Xianghui Xu
Summary: This study developed virus-inspired nanodrugs for high-efficiency antibiotic delivery and enhanced antibacterial effects, demonstrating their potential application in antibacterial treatment.
CHINESE CHEMICAL LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Megan A. Laune, Syed Ahad Zahidi, Jared T. Wiemann, Yan Yu
Summary: Nanosized liposomes can enhance the potency of antibiotics by fusing with bacterial membranes, but the interaction mechanisms are poorly understood. The fusion interactions between cationic liposomes and Escherichia coli were found to be heterogeneous, resulting in different antibacterial outcomes.
ACS APPLIED NANO MATERIALS
(2022)
Article
Food Science & Technology
Yuecheng Meng, Li Lou, Zhipeng Shao, Jie Chen, Yanhua Li, Tianqi Zhang
Summary: This study investigated the antimicrobial activity and mechanism of whey protein-epsilon-PL complexes against Gram-positive bacteria. The complexes effectively inhibited the growth of Staphylococcus aureus and Bacillus subtilis, with a strong bactericidal effect on Bacillus subtilis. The complexes were found to disrupt the cell membrane structure in Bacillus subtilis, forming holes on the surface. Molecular dynamics simulation showed that the complexes captured phospholipid molecules of the bacterial membrane through electrostatic interaction, leading to the formation of holes on the bacterial surface.
Review
Infectious Diseases
Dayse Pereira Dias Silva, Macley Silva Cardoso, Alexandre Jose Macedo
Summary: Bacterial resistance is a major driving force in the worldwide search for new antibacterial agents. Endophytic microorganisms are a promising alternative for drug discovery, as they produce a vast number of metabolites with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites against medically important bacteria, particularly gram-negative species. The findings presented in this review provide 166 molecules with characterized chemical structures and antibacterial activities. Additionally, the low cost, ease of maintenance, and optimization-controlled fermentation conditions support reproducibility at a commercial scale.
Article
Plant Sciences
Yangseon Kim, Da Jung Lim, Jeong-Sup Song, Jung-Ae Kim, Byoung-Hee Lee, Youn Kyoung Son
Summary: This study investigated the chemical composition and antimicrobial activity of Dryopteris sp. extracts in Korea. Flavonoids were identified in both D. lacera and D. bissetiana extracts, and the extracts exhibited antibacterial activity against Gram-positive pathogens. These plants can be further explored as Gram-positive selective antibiotics.
Article
Biochemistry & Molecular Biology
Florin Aonofriesei
Summary: The combination of two compounds can effectively limit antibiotic resistance in specific pathogens, with surfactants enhancing the antibacterial effect by modifying the permeability of bacterial cells. This research highlights the possibility of using non-toxic surfactants to control microbial resistance and offers practical applications in the field of antimicrobials.
Article
Chemistry, Multidisciplinary
Venkatachalam Rajagopal, Nivedhitha Jothi Narayanan, Murugavel Kathiresan, Deepak Kumar Pattanayak, Vembu Suryanarayanan
Summary: A new covalent organic polymer comprising triazine and o-tolidine was synthesized by solvothermal method and its antibacterial activity was evaluated. The results have significant implications for the design of new porous polymers for antibacterial applications.
MATERIALS TODAY CHEMISTRY
(2021)
