Article
Biochemistry & Molecular Biology
Peifang Qin, Jianguo Yan, Haitao Huang, Qi Wang, Mao Li, Yuting Zhang, Jiahui Wang, Tingting Jiang, Xiaoling Zhang, Yali Zhou
Summary: Equilibrative nucleoside transporter 3 (ENT3), a member of the solute carrier family 29, plays an important role in hepatocellular carcinoma (HCC). It is upregulated in HCC and associated with poor prognosis and clinical features. Knockdown of ENT3 inhibits cell proliferation, migration, and invasion, and promotes apoptosis through inhibition of the AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Xiang-Peng Tan, Ben-Han Xiong, Yuan-Xu Zhang, Shen-Li Wang, Qian Zuo, Jing Li
Summary: This study discovered the highly expressed FXYD5 in sorafenib-resistant HCC cells and its higher expression level in HCC tissues compared to par-acancerous tissues. The downregulation of FXYD5 reversed the resistance of Huh7/sora cells to sorafenib, while overexpression of FXYD5 reduced the sensitivity of HCC cells to sorafenib. Additionally, abnormal activation of the Akt/mTOR signaling pathway was found in Huh7/sora cells, and MK2206, an Akt inhibitor, increased the sensitivity of HCC cells to sorafenib. The expression level of p-Akt was positively correlated with the expression of FXYD5 in HCC tissues.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Kim
Summary: The study found that kahweol induces apoptosis in hepatocellular carcinoma cells by inhibiting the phosphorylation of specific signaling pathways, suggesting it as a potential inhibitor of HCC cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Shu-xian Li, Chao Li, Xin-ru Pang, Juan Zhang, Gong-chang Yu, Abrey J. Yeo, Martin F. Lavin, Hua Shao, Qiang Jia, Cheng Peng
Summary: Long-term exposure to crystalline silica particles leads to silicosis, for which there is currently no specific treatment. The study found that metformin can alleviate inflammation and fibrosis in the lungs of silicosis patients by activating autophagy through the AMPK-mTOR pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guangjie Zhan, Tiantian Wei, Huichen Xie, Xiaoming Xie, Jun Hu, Hao Tang, Yating Cheng, Huaifeng Liu, Shujing Li, Guohua Yang
Summary: Apoptosis and autophagy can act cooperatively or antagonistically in self-elimination process. This study aims to investigate the function and molecular mechanism of trillin on autophagy in hepatocellular carcinoma (HCC) cells. The results demonstrated that trillin could inhibit autophagy in HCC cells and enhance apoptosis by activating the mTOR/STAT3 signaling pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Reproductive Biology
Jiao Jiao Zhang, Ya Qi Li, Yu Sha Wang, Liang Chen, Xian Zhong Wang
Summary: Metformin inhibits Sertoli cell proliferation, while 17β-estradiol weakens its inhibitory effects. The regulation is possibly mediated by the AMPK/TSC2/mTOR signaling pathway.
Article
Oncology
Chunsen Li, Zhenzhen Li, Lingxie Song, Lian Meng, Guixuan Xu, Haijun Zhang, Jianming Hu, Feng Li, Chunxia Liu
Summary: The GEFT-Rac1/Cdc42-mTOR pathway plays a crucial role in inhibiting autophagy and apoptosis in RMS, with high expression levels of Rac1 and Beclin1 protein being closely associated with the clinical stage and tumor diameter of RMS patients respectively.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jun Huang, Zhuang Li, Yunwei Hu, Guanyu Chen, Zuoyi Li, Yanyan Xie, Haixiang Huang, Wenru Su, Xiaoqing Chen, Dan Liang
Summary: Azithromycin alleviates experimental autoimmune uveitis (EAU) in mice by regulating the balance between T effector cells (Teff) and T regulatory cells (Treg) through the mTOR signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Environmental Sciences
Mingfei Wu, Yan Cong, Kailu Wang, Haiyang Yu, Xuan Zhang, Mingyue Ma, Zhiwen Duan, Xiucong Pei
Summary: This study investigates the effects of BPA on macrophages and its mechanism of action. The results show that BPA decreases cell viability and disrupts macrophage function by inhibiting autophagy and inducing apoptosis. Activation of autophagy and inhibition of apoptosis can ameliorate the damage caused by BPA on macrophages.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Haibo Zhang, Lei Ma, Eungyung Kim, Junkoo Yi, Hai Huang, Hyeonjin Kim, Muhammad Atif Raza, Sijun Park, Soyoung Jang, Kirim Kim, Sung-Hyun Kim, Youngkyun Lee, Eunkyong Kim, Zae Young Ryoo, Myoung Ok Kim
Summary: This study aimed to investigate the potential anticancer activity and underlying mechanisms of rhein, a natural compound extracted from rhubarb, on oral cancer cells. The results showed that rhein significantly inhibited oral cancer cell growth by inducing apoptosis and S-phase cell cycle arrest. It also inhibited migration and invasion of oral cancer cells through the regulation of epithelial-mesenchymal transition-related proteins. Rhein exerted its anticancer activity by inducing oral cancer cell apoptosis and ROS accumulation via the AKT/mTOR signaling pathway in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Jun Cai, Lu-Chen Zhang, Ren-Jie Zhao, Li-Min Pu, Ke-Yuan Chen, Ali Adnan Nasim, Elaine Lai-Han Leung, Xing-Xing Fan
Summary: This study demonstrates that chelerythrine (CLT) effectively inhibits migration and proliferation of rheumatoid arthritis cells and induces cell death. The effects of CLT are mediated through the activation of the AMPK/mTOR/ULK-1 signaling pathway, leading to increased levels of intracellular reactive oxygen species (ROS) and apoptosis. In addition, CLT shows promising results in ameliorating arthritis and protecting against inflammation and bone damage in an in vivo model.
Article
Pharmacology & Pharmacy
Min Yeong Kim, Hyesook Lee, Seon Yeong Ji, So Young Kim, Hyun Hwangbo, Shin-Hyung Park, Gi-Young Kim, Cheol Park, Sun-Hee Leem, Su Hyun Hong, Yung Hyun Choi
Summary: The study demonstrated that IALT exhibited anti-cancer activity in HCC Hep3B cells by inducing ROS-dependent activation of the JNK signaling pathway. IALT-induced growth inhibition and apoptosis were associated with the activation of death-receptor-related proteins, caspases, and Bid truncation. In addition, IALT contributed to mitochondrial integrity disruption, cytochrome c release, and increased Bax/Bcl-2 expression ratio, leading to caspase-dependent apoptosis.
Article
Chemistry, Medicinal
Ai-Yuan Xiu, Qian Ding, Zhen Li, Chun-Qing Zhang
Summary: Doxazosin inhibits autophagy by activating the PI3K/Akt/mTOR signaling pathway, attenuating liver fibrosis. It also blocks HSC proliferation and migration, inducing cell apoptosis in a concentration-dependent manner. Additionally, doxazosin activates the PI3K/Akt/mTOR pathway which regulates fibrosis, autophagy, and apoptosis in HSCs.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Plant Sciences
Yi Zuo, Chao-zheng Zhang, Qing Ren, Yao Chen, Xiao Li, Ji-rui Yang, Hong-xiang Li, Wen-tao Tang, Hing-Man Ho, Chen Sun, Mei-mei Li, Bo Ren, Yun Deng, Mao-lin Wang, Jun Lu
Summary: This study investigated the anti-cancer effects of VOA on breast cancer cells and elucidated the underlying mechanisms, including activation of mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway. Additionally, VOA significantly reduced tumor size without causing apparent toxicity.
Review
Clinical Neurology
Xichen Wang, Yuke Fu, Benson O. A. Botchway, Yufeng Zhang, Yong Zhang, Tian Jin, Xuehong Liu
Summary: The pathogenesis of spinal cord injury (SCI) is complex, and there is no effective treatment currently available. Quercetin, as a potential interventional agent, has therapeutic effects in SCI by modulating the mTOR signaling pathway to improve pathological alterations.
FRONTIERS IN NEUROLOGY
(2022)