期刊
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
卷 13, 期 8, 页码 4093-4095出版社
ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
DOI: 10.7314/APJCP.2012.13.8.4093
关键词
Pituitary adenoma; proteomic fingerprint; diagnostic model
类别
资金
- Zhejiang medical and health science and technology plan [2009A226]
- Taizhou city science and Technology Bureau [091KY06, 051KY48]
- Taizhou College [08ND33]
- Jiaojiang District Science and Technology Bureau [31067]
Objective: To determine whether pituitary adenomas can be diagnosed by identifying protein biomarkers in the serum. Methods: We compared serum proteins from 65 pituitary adenoma patients and 90 healthy donors using proteomic fingerprint technology combining magnetic beads with matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). Results: A total of 42 M/Z peaks were identified as related to pituitary adenoma (P<0.01). A diagnostic model established based on three biomarkers (3382.0, 4601.9, 9191.2) showed that the sensitivity of diagnosing pituitary adenoma was 90.0% and the specificity was 88.3%. The model was further tested by blind analysis showing that the sensitivity was 88.0% and the specificity was 83.3%. Conclusions: These results suggest that proteomic fingerprint technology can be used to identify pituitary adenoma biomarkers and the model based on three biomarkers (3382.0, 4601.9, 9191.2) provides a powerful and reliable method for diagnosing pituitary adenoma.
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