Review
Dermatology
Kevin Syam, Shaheer A. Joiya, Sumayyah Khan, P. Nithin Unnikrishnan
Summary: The analysis of existing randomized controlled trials on maggot debridement therapy (MDT) indicates its effectiveness in diabetic foot ulcers, but its efficacy in chronic peripheral vascular disease ulcers remains inconclusive. Further studies are recommended to evaluate the cost-effectiveness and patient experience.
ADVANCES IN SKIN & WOUND CARE
(2021)
Article
Dermatology
Xin-Juan Sun, Jin-An Chen, Gai Li, Lei Wang, Tian-Yuan Wang, Ai-Ping Wang
Summary: The impact of maggot debridement therapy (MDT) on macrophages during the healing process of diabetic foot ulcers (DFU) was determined in this study. The activation phenotype and markers associated with macrophage activation were evaluated. M2 macrophages were over-expressed while M1 macrophages were under-expressed in the healing process following MDT. The activation markers of macrophages exhibited a correlation with Th1/Th2 cytokines.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Microbiology
Daniel Morris, Micah Flores, Llinos Harris, John Gammon, Yamni Nigam
Summary: Chronic wounds pose a significant healthcare challenge globally, primarily due to bacterial biofilms hindering healing. This systematic review examines the interaction between larval therapy and chronic wound biofilms. The findings highlight that larval therapy, involving the controlled application of blowfly larvae, acts on chronic wound bacteria biofilms through the secretion and excretion of biologically active substances. However, further research is needed to standardize the methodology and bridge knowledge gaps in this area.
Article
Engineering, Biomedical
Tengfei Ma, Xinyun Zhai, Yongkang Huang, Mengzhen Zhang, Xiaoli Zhao, Yaping Du, Chunhua Yan
Summary: The MoS2-CeO2 nanocomposite combines antibacterial and antioxidant properties, demonstrating excellent PTT antibacterial capability through 808 nm laser treatment, reducing the risk of infection in chronic wounds, especially diabetic ulcer wounds.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Dermatology
Yukie Kataoka, Mao Kunimitsu, Gojiro Nakagami, Sofoklis Koudounas, Carolina D. Weller, Hiromi Sanada
Summary: Chronic wounds are difficult to heal wounds caused by disrupted wound healing mechanisms, which have a high risk of infection and biofilm formation. Ultrasonic debridement has been introduced as a new method to decrease infection and promote healing of chronic wounds. Studies indicate that both non-contact and direct contact ultrasonic debridement devices have positive effects on wound healing by reducing biofilm formation or bacterial load. Further research on ultrasonic debridement in chronic wounds is needed to establish optimal settings and improve outcomes.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Yujie Dong, Qi Yang, Xiaojie Sun
Summary: Cell therapy has shown efficacy in reducing ulcer size, improving wound closure rate, and decreasing major amputations compared to standard therapy. However, for patients with cutaneous ulcers caused by peripheral artery disease-related critical limb ischemia, cell therapy did not significantly alleviate pain symptoms.
HUMAN GENE THERAPY
(2021)
Review
Medicine, General & Internal
Gisele Abreu Coelho, Philippe-Henri Secretan, Lionel Tortolano, Loic Charvet, Najet Yagoubi
Summary: This review aims to identify and discuss the different stages of chronic wound progression, focusing on the changes in the biochemical composition of the wound microenvironment, particularly in venous leg ulcers (VLUs). It provides detailed information about the pathophysiology of venous ulcers and reviews the known changes in the VLU microenvironment as the VLU evolves. Additionally, it discusses simulating conditions for VLU and highlights potentially relevant simulating media to assess the biological safety of medical devices intended to be in contact with these wounds.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Youn Hwan Kim, Hyung Sup Shim, Jihye Lee, Sang Wha Kim
Summary: The study compared the wound size reduction rate between patients receiving paste-type ADM and standard wound care over a 12-week period, showing significantly greater reduction rates in the ADM group, with most wounds achieving healing successfully.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Mingzhi Song, Junwei Zong, Linxuan Zou, Zhuodong Fu, Jing Liu, Shouyu Wang
Summary: Chronic wounds have become a global epidemic disease with poor prognosis and difficulties in treatment. This study proposes a new combination therapy consisting of biological debridement and stem cell therapy, which has the potential to become a therapeutic method with extensive source, biological intelligence, safety, and high efficiency.
MEDICAL HYPOTHESES
(2022)
Article
Dermatology
Kyoichi Matsuzaki, Akira Miyamoto
Summary: A large diabetic heel ulcer with peripheral arterial disease can increase the risk of limb loss, and multimodal therapy, including partial calcanectomy, is a treatment option. Maggot therapy can be considered as an additional treatment option after reducing the wound size through negative-pressure wound therapy.
ADVANCES IN SKIN & WOUND CARE
(2022)
Article
Environmental Sciences
Dariusz Bazalinski, Joanna Przybek Mita, Lucyna Scislo, Pawel Wiech
Summary: This study aimed to assess the readiness of a group of qualified nurses to implement Maggot Debridement Therapy (MDT). The findings revealed that the nurses' perception and readiness to implement the method were at an average level, and the sight of maggots in wounds caused negative emotions among medical personnel. Moreover, the higher the nurses' knowledge of the MDT method, the more motivated they are to implement it in practice.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Jie Zhang, Jin'an Chen, Chunchen Gao, Xinjuan Sun, Lei Wang, Zhiwei Hu, Gai Li, Jing Wang, Aiping Wang
Summary: In this study, the researchers investigated the potential healing effects of maggot treatment on diabetic foot ulcers (DFUs) by studying regulatory T cells (Tregs). They found that maggot debridement therapy (MDT) significantly increased the expression of Treg markers and genes related to Treg function in DFU patients. In vitro experiments using mouse spleen cells also confirmed these findings. The results suggest that MDT and its secretions can enhance Treg levels and may have therapeutic implications for DFU healing.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
C. H. McKenna, D. Asgari, T. L. Crippen, L. Zheng, R. A. Sherman, J. K. Tomberlin, R. P. Meisel, A. M. Tarone
Summary: The study found differential expression of immunity-related genes when exposed to pathogens, with a stronger response to Pseudomonas aeruginosa which increased over time, while few genes responded to Acinetobacter baumannii and expression was not time-dependent. The response to feeding on pathogens indicates common responses and features distinct to each pathogen, which can be useful in improving wound debridement therapy and developing biomimetic alternatives.
INSECT MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mazlan Zawani, Mh Busra Fauzi
Summary: This paper reviews the use of injectable hydrogel as a polymer-based solution for diabetic foot ulcers, focusing on factors such as the socioeconomic burden of chronic wounds, biomaterials recommended by government, commercial hydrogel products, mechanism of injectable hydrogel, current research progress on novel injectable hydrogel, and future perspectives in DFU management.
Review
Emergency Medicine
Xuerong Wei, Minxiong Li, Zijun Zheng, Jun Ma, Yanbin Gao, Lianglong Chen, Yujie Peng, Shengxiang Yu, Lei Yang
Summary: Cellular senescence plays a crucial role in chronic wounds, and novel strategies targeting senescence can be applied for their treatment.
Article
Medicine, General & Internal
Hong L. E. Tan, Alexis Hure, Roseanne Peel, Stephen Hancock, John Attia
Summary: Hypertriglyceridaemia has a high prevalence in the community, and clinical predictors can help manage cardiovascular risk.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Obstetrics & Gynecology
Ha T. Nguyen, Montarat Thavorncharoensap, Toi L. Phung, Thunyarat Anothaisintawee, Usa Chaikledkaew, Abhasnee Sobhonslidsuk, Pattarawalai Talungchit, Nathorn Chaiyakunapruk, John Attia, Gareth J. McKay, Ammarin Thakkinstian
Summary: A combination of hepatitis B vaccination and immunoglobulin significantly reduces the risk of vertical transmission of hepatitis B virus. Maternal tenofovir further reduces the transmission risk for mothers positive for both hepatitis B surface and envelope antigens. However, no additional agents provide further benefit for infants of mothers with mixed, unknown, or negative hepatitis B envelope antigen status compared to hepatitis B vaccination alone.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Urology & Nephrology
Tunlanut Sapankaew, Kunlawat Thadanipon, Narisa Ruenroengbun, Kamolpat Chaiyakittisopon, Atiporn Ingsathit, Pawin Numthavaj, Nathorn Chaiyakunapruk, Gareth McKay, John Attia, Ammarin Thakkinstian
Summary: The results of the study suggest that allopurinol and febuxostat are the preferred ULTs for reducing composite renal events and improving renal function.
Article
Geriatrics & Gerontology
Mary Revelas, Anbupalam Thalamuthu, Anna Zettergren, Christopher Oldmeadow, Jenna Najar, Nazib M. Seidu, Nicola J. Armstrong, Carlos Riveros, John B. Kwok, Peter R. Schofield, Julian N. Trollor, Margda Waern, Margaret J. Wright, Henrik Zetterberg, David Ames, Kaj Belnnow, Henry Brodaty, Rodney J. Scott, Ingmar Skoog, John R. Attia, Perminder S. Sachdev, Karen A. Mather
Summary: This study found that individuals with a high polygenic risk for exceptional longevity have a lower prevalence of metabolic syndrome, suggesting that high-risk individuals have a healthy metabolic profile that promotes longevity.
Article
Oncology
Songporn Oranratnachai, Sasivimol Rattanasiri, Ekaphop Sirachainan, Amarit Tansawet, Nilubol Raunroadroong, Gareth J. McKay, John Attia, Ammarin Thakkinstian
Summary: This study compares the clinical effectiveness of FOLFOX and Sorafenib as first-line treatments for advanced hepatocellular carcinoma (aHCC). Despite shorter overall survival and progression-free survival, FOLFOX still extended the survival time of patients.
Article
Neurosciences
Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Sungmin Hong, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Stefan Ropele, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ramin Zand, Patrick F. McArdle, Bradford B. Worrall, Christina Jern, Arne G. Lindgren, Jane Maguire, Ona Wu, Natalia S. Rost
Summary: This study aimed to investigate the influence of stroke lesions in rich-club brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex. The analysis showed that rich-club regions had substantial relevance in explaining unfavorable functional outcome and the effect was more pronounced in women.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Jacob Opio, Katie Wynne, John Attia, Stephen Hancock, Christopher Oldmeadow, Brian Kelly, Kerry Inder, Mark McEvoy
Summary: This study used Bayesian survival analysis to estimate the risk of cardiovascular disease in older adults with overweight or obesity without metabolic risk factors. The results showed that there was an increased risk of cardiovascular disease in this population, even in the absence of any metabolic abnormalities.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Nursing
Emma Doherty, John Wiggers, Luke Wolfenden, Belinda Tully, Christophe Lecathelinais, John Attia, Elizabeth J. Elliott, Adrian Dunlop, Ian Symonds, Chris Rissel, Tracey W. Tsang, Melanie Kingsland
Summary: This study investigated the differential effectiveness of a practice change intervention based on subgroups of pregnant women and types and location of maternity services. The results showed that the intervention may have had similar effects between different subgroups and service types and locations, except for non-Aboriginal women and women who had not consumed alcohol in pregnancy for whom the intervention was potentially more effective.
Article
Endocrinology & Metabolism
Sukanya Siriyotha, Thitiya Lukkunaprasit, Teeranan Angkananard, Panu Looareesuwan, Gareth J. McKay, John Attia, Ammarin Thakkinstian
Summary: This study aimed to compare the cardiovascular benefits of different antihyperglycemic drugs as add-on therapies to metformin. The results showed significant advantages of SGLT2i and TZD in reducing CVE in patients with type 2 diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Psychology, Multidisciplinary
Suparee Boonmanunt, Oraluck Pattanaprateep, Boonsong Ongphiphadhanakul, Gareth McKay, John Attia, Ivo Vlaev, Ammarin Thakkinstian
Summary: This study examined the effectiveness of standard and behavioral incentivization programs for promoting healthy diet, weight control, and physical activity. Through a systematic review and meta-analysis of 35 randomized controlled trials, the study found that deposit and lottery-based incentives were the most effective in motivating individuals to engage in healthy behaviors. Post-intervention, deposit and standard financial incentives were found to be the most effective for promoting physical activity. The study highlights the importance of behavioral insights in improving the effectiveness of incentivization programs. However, the short-term benefits of lottery-based approaches for physical activity were noted.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Ronald C. Plotnikoff, Anna K. Jansson, Mitch J. Duncan, Jordan J. Smith, Adrian Bauman, John Attia, David R. Lubans
Summary: The aim of this study was to assess the impact of an innovative mHealth intervention called ecofit on muscular fitness, cardiorespiratory fitness, physical activity, and social-cognitive mediators among community-dwelling adults. The study utilized a cluster randomized controlled trial design and recruited 245 participants. The results showed that the intervention led to significant improvements in muscular fitness, physical activity behavior, and related cognitions.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Rebecca L. Haslam, Jennifer N. Baldwin, Kristine Pezdirc, Helen Truby, John Attia, Melinda J. Hutchesson, Tracy Burrows, Robin Callister, Leanne Hides, Billie Bonevski, Deborah A. Kerr, Sharon Kirkpatrick, Megan E. Rollo, Tracy A. McCaffrey, Clare E. Collins
Summary: This study investigated the impact of personalised web-based dietary feedback on young adults' diet quality and found that recruiting and retaining young adults in web-based dietary interventions are challenging.
PUBLIC HEALTH NUTRITION
(2023)
Editorial Material
Respiratory System
John Attia
Article
Public, Environmental & Occupational Health
Amarit Tansawet, Boonying Siribumrungwong, Suphakarn Techapongsatorn, Pawin Numthavaj, Napaphat Poprom, Gareth J. McKay, John Attia, Ammarin Thakkinstian
Summary: This study aimed to evaluate the risk of surgical site infection (SSI) in individual patients undergoing complicated appendectomy with delayed primary closure (DPC) compared to primary closure (PC), considering individual risk factors. The findings showed that most patients benefited from early PC compared to DPC. These results can inform SSI prevention strategies for patients with complicated appendicitis.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Meeting Abstract
Respiratory System
V Murphy, M. Jensen, E. Holliday, W. Giles, H. Barrett, L. Callaway, A. Bisits, M. Peek, S. Seeho, A. Abbott, A. Robijn, P. Colditz, A. Searles, J. Attia, K. McCaffery, M. Hensley, J. Mattes, P. Gibson