Article
Plant Sciences
Almuthanna K. Alkaraki, Maisam A. Aldmoor, Jamil N. Lahham, Mohammed Awad
Summary: The study aimed to develop a DNA barcoding method to identify and characterize Daphne mucronata Royle and Thymelaea hirsuta plant species. The research found that DNA barcoding successfully identified the two plant species using chloroplast genes.
Article
Integrative & Complementary Medicine
Ammar Bader, Valentina Santoro, Valentina Parisi, Nicola Malafronte, Iyad Al-Sheikh, Anna Cacciola, Maria Paola Germano, Valeria D'Angelo
Summary: This study evaluated the antiangiogenic and antioxidant activities of the Middle-Eastern medicinal plant Daphne mucronata subsp. Linearifolia. The research found that root extracts and isolated compounds from the plant exhibited antiangiogenic effects and strong antioxidant activity. These findings suggest the potential beneficial role of Daphne mucronata in managing oxidative stress-related diseases.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Zhuo-Ya Tang, Run-Zhu Fan, Ai-Ping Yin, Di-Kai Tang, Abrar Ahmed, Jin Cao, Sheng Yin, Rong Pu, Gui-Hua Tang
Summary: The stem and root barks of Daphne giraldii Nitsche, also known as Zushima, contain 26 flavonoids, including some new flavonoids, which have shown significant anti-inflammatory properties. This traditional Chinese medicine has great potential for treating various diseases and could be a promising candidate for drug development.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Anatomy & Morphology
Ghulam Dastagir, Imran Ahmad, Noor Ul Uza
Summary: The study aimed to establish micromorphological standards of Daphne mucronata Royle and Myrtus communis, which showed distinct organoleptic features and anatomical structures. Anatomical study facilitates the detection of adulteration with inferior commercial varieties, exhausted drugs, cheaper natural substances, and chemicals. This can aid in the preparation of taxonomic key for the identification of these species.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Environmental Sciences
Farajollah Tarnian, Sunil Kumar, Hossein Azarnivand, Mohammad Ali Zare Chahouki, Amir Mirzaei Mossivand
Summary: Using Maxent model, the current and future potential distribution of D. mucronata in Iran was predicted, indicating that climate change may lead to a decrease in its distribution range.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2021)
Article
Plant Sciences
Lingjian Tan, Kouharu Otsuki, Mi Zhang, Takashi Kikuchi, Misaki Okayasu, Isao Azumaya, Di Zhou, Ning Li, Li Huang, Chin-Ho Chen, Wei Li
Summary: Twelve macrocyclic daphnane diterpenoids, including six new compounds, were isolated from the whole plant of Daphne pedunculata. Their structures were determined using various methods, and their anti-HIV activity was evaluated. The compounds showed significant activity against HIV, providing further insights into the structure-activity relationships of macrocyclic daphnane diterpenoids.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Perveen Bano, Kanwal Iftikhar, Kinza Rafi, Bina Shaheen Siddiqui, Shabana Usman Simjee, Sabira Begum
Summary: The pro-neurogenic activity of the petroleum ether soluble and insoluble fractions of the methanol extract of Daphne mucronata stem extract and a pure compound, daphnin, obtained from the more active petroleum ether insoluble fraction, was evaluated on primary cell cultures prepared from the neonatal mice brain cortex and hippocampus. It showed significant proliferation of the cells as assessed by MTT assay.
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
(2023)
Article
Biology
Nausheen Nazir, Jebran Muhammad, Rukhsana Ghaffar, Mohammad Nisar, Muhammad Zahoor, Faheem Uddin, Riaz Ullah, Amal Alotaibi
Summary: The methanolic extract of Daphne mucronata leaves exhibited strong antioxidant activity and protective effects against liver and kidney injuries induced by paracetamol, possibly due to its high content of phenolic and flavonoid compounds.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rui Guo, Zhi-Kang Duan, Qian Li, Guo-Dong Yao, Shao-Jiang Song, Xiao-Xiao Huang
Summary: Using liquid chromatography with tandem mass spectrometry guided molecular networking, researchers obtained and characterized 12 undescribed guaiane-type sesquiterpenoids, named tanguticatins A-L, 19 known analogs, and a previously undescribed tri-terpene tanguticatin M from Daphne tangutica Maxim. These compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells, and tanguticatin E and K showed more potent effects than the positive control minocycline.
Article
Chemistry, Multidisciplinary
Muhammad Imran, Ahmad Irfan, Sajjad Hussain, Mohammed A. Assiri, Jalal Uddin, Ajaz Hussain, Noreen Khalid, Abdullah G. Al-Sehemi
Summary: Ten coumarin class of compounds, including a new fused coumarinolignoid mucronin-C, were isolated from Daphne mucronata Royle. The structures and antioxidant properties of these compounds were determined through various chemical and spectroscopic methods. Experimental data showed that compounds with smaller ionization potential values exhibited better antioxidant activity.
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Shu-Hui Dong, Mei-Ya Lian, Jin-Ling Han, Yun-Fei Ai, Xiao-Fang Zhou, Ming Bai, Xiao-Xiao Huang, Shao-Jiang Song
Summary: Fractionation based on biological activity screening and NMR characteristic signals analysis resulted in the isolation of seventeen diarylpentanoids from the whole plant of Daphne bholua Buch.-Ham. ex D. Don, including nine previously undescribed compounds. Their structures and stereochemistry were determined through comprehensive spectroscopic data, J-based configurational analysis, and quantum chemical calculations. The inhibitory potentials of all isolates against acetylcholinesterase were evaluated both in vitro and in silico.
Article
Biochemistry & Molecular Biology
Leila Ghorbani, Pooran Golkar, Reza Jafary, Mohsen Ahmadi, Alireza Allafchian
Summary: This study evaluated the secondary metabolites, essential oils (EOs) compositions, and antioxidant activity in medicinal plants from Isfahan rangelands. The study found that these plants are rich in natural antioxidants and bioactive compounds, which can be used in ethno pharmacological fields, food, and industrial applications.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Medicinal
Ying Liu, Pinyi Gao, Xiao Liang, Yangyang Zhang, Xiaoqi Yu, Xiaobian Xue, Lara Kockaya, Pankaj Pandey, Robert J. Doerksen, Xiaojuan Wang, Guodong Yao, Wanchun Chu, Xin Chen, Shaojiang Song, Mark T. Hamann, Lingzhi Li
Summary: We discovered 23 new prenyl-flavonoids and 13 known molecules from Daphne giraldii Nitsche, some of which have significant bioactivity against hepatoma carcinoma. By combining mass spectrometry, nuclear magnetic resonance, and computational approaches, we identified a polyprenyl-flavonoid called Daphnegiratriprenylone A with a triprenyl substitution. This new approach of using computational tools for the assignment of natural product structures was found to be reliable compared to conventional techniques. Several compounds showed potent and selective activity against Hep3B cells, and polyprenyl-flavonoids were found to inhibit FGFR1, a potential target for these compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Forestry
Ghobad Babaei, Seyyed Alireza Esmaeilzadeh-Hosseini, Hamzeh Ali Shirmardi, Assunta Bertaccini
Summary: A phyllody disease was observed in Daphne mucronata plants in western Iran, with PCR and sequencing analysis confirming the presence of 16SrIX-B phytoplasma. This is the first report of this phytoplasma in a non-Prunus species, highlighting the possible reservoir role of D. mucronata for the phytoplasma affecting stone fruits in the Middle East.
Article
Chemistry, Medicinal
Lingjian Tan, Kouharu Otsuki, Mi Zhang, Takashi Kikuchi, Di Zhou, Ning Li, Li Huang, Chin-Ho Chen, Wei Li
Summary: Daphnepedunins G and H with an unusual macrocyclic structure were isolated from Daphne pedunculata. Their structures were determined and their methyl esters showed potent anti-HIV activity.
JOURNAL OF NATURAL MEDICINES
(2023)
