Article
Immunology
Dianjiang Yu, Yufeng Zhai, Peimin He, Rui Jia
Summary: This study applied transcriptomic and metabolomic analysis to investigate the effects of WSSV challenge on L. vannamei hepatopancreas. The results showed that WSSV disrupts the immune system and causes metabolic disorder in L. vannamei.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Xing-Chao Ren, Xiao-Yuan Wan, Qing-Hui Liu
Summary: Ribosomes are crucial in the antiviral immune response of Litopenaeus vannamei, with LvRPL4-L and LvRPS16 showing increased expression after WSSV infection. Silencing of LvRPL4-L or LvRPS16 led to significantly higher viral copy numbers and mortality rates. This study provides insight into the role of LvRPL4-L and LvRPS16 in the immune response of L. vannamei against WSSV.
AQUACULTURE REPORTS
(2021)
Article
Fisheries
Yi-Lun Chen, Ramya Kumar, Chun-Hung Liu, Han-Ching Wang
Summary: Peritrophins play essential roles in the porosity and strength of the peritrophic membrane in the shrimp midgut and have a crucial role in determining the colonization and tissue distribution of AHPND-causing bacteria. The binding of LvPeritrophin to WSSV and AHPND-causing bacteria was confirmed, and silencing of LvPeritrophin inhibited WSSV gene expression but increased bacterial colonization. The findings contribute to our understanding of host-pathogen interactions and can be applied in developing strategies for shrimp aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Sheng Wang, Haoyang Li, Peng Zhu, Qihui Fu, Bin Yin, Qinyao Li, Rongjian Chen, Xiewu Jiang, Shaoping Weng, Jianguo He, Chaozheng Li
Summary: LvMAPKKK15, a homolog of MAPKKK15 in shrimp, is abundantly expressed in early development stages and in eyestalk, nerve, and hemocytes. It responds to challenges of Poly (I: C) and WSSV, and its knockdown leads to decreased sensitivity to WSSV infection in shrimp. LvMAPKKK15 can up-regulate WSSV immediate early genes and suppress anti-viral factors LvVago1-5, indicating its role in WSSV pathogenesis.
Article
Fisheries
Yiwen Jian, Lingwei Ruan, Wenyang Lin, Jie Ran, Yalin Yang, Hong Shi
Summary: TEAD family transcription factors play a vital regulatory role in cell proliferation, apoptosis, tumor formation, and antiviral immunity. In this study, a novel homolog of the TEAD family, LvScalloped, was cloned and characterized from Litopenaeus vannamei. LvScalloped was found to be up-regulated in response to WSSV infection, and knockdown of LvScalloped reduced viral gene transcription and mortality in L. vannamei. Further investigation showed that LvScalloped can activate the immediate-early viral gene promoter and interact with LvYorkie to regulate cell viability. This study provides insights into the virus-host interactions and the functional mechanism of the Hippo signaling pathway in shrimp.
Article
Fisheries
Jie Ren, Wenyang Lin, Hong Shi, Yiwen Jian, Lingwei Ruan
Summary: The Hippo signaling pathway, including its core molecule Yorkie, plays important roles in organ size control, development, tumorigenesis, and immunity. In this study, a Yorkie homolog named LvYKI was cloned and characterized from Litopenaeus vannamei. LvYKI showed different regulatory mechanisms in different tissues and was involved in white spot syndrome virus (WSSV) infection. Knocking down of LvYKI inhibited the transcription of WSSV genes and delayed shrimp mortality, while increasing hemocyte apoptosis. Moreover, LvYKI was found to interact with Lv beta-catenin, linking the Wnt and Hippo signaling pathways in innate immunity. This study provides insights into the role of LvYKI in the interaction between shrimp and virus, enhancing our understanding of the molecular mechanism in innate immunity.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Qiang Fu, Kun Sun, Juan Sui, Xupeng Li, Jiawang Cao, Jian Tan, Baolong Chen, Kun Luo, Sheng Luan, Jie Kong, Xianhong Meng
Summary: This study investigated the performance differences among offspring obtained by intra- and inter-strain crosses using two shrimp strains, A and B, with outstanding WSSV resistance and growth, respectively. The results showed that crossbreeding can complement the advantages of different strains, with the cross of strain BA performing the best in terms of WSSV resistance and growth. The heritability estimates of body length and weight were medium, and there were significant genetic and phenotypic correlations among growth-related traits. The study provides important reference data for breeding disease-resistant and fast-growing shrimp strains.
AQUACULTURE REPORTS
(2023)
Article
Virology
Xu Zhang, Li-Peng Shan, Qi Zhao, Lei Liu, Xu OuYang, Yang Hu, Chen-Jie Fei, Jiong Chen
Summary: This study evaluated and screened active molecules from Chinese herbs against WSSV and found that taxifolin had the highest inhibition rate. Taxifolin treatment decreased the infectivity and genome copy number of WSSV, reduced shrimp mortality, and blocked horizontal transmission of the virus. Additionally, taxifolin enhanced the innate immunity of shrimp and improved their resistance to WSSV. These results suggest that taxifolin has the potential to block WSSV outbreak and reduce shrimp culture loss.
Article
Fisheries
Zhifei Chen, Depeng Fan, Luqing Pan, Chen Su, Yanjun Ding, Mingxiang Lu
Summary: This study found that dietary quercetin improved the growth performance of Litopenaeus vannamei shrimp, enhanced antioxidant capability and immune response, regulated the composition and structure of intestinal microbiota, and reduced cumulative mortality after white spot syndrome virus challenge.
Article
Zoology
Rui-Feng Zou, Xing-Chao Ren, Qing-Hui Liu
Summary: The study cloned the full-length cDNA sequence of LvSPARC-L from shrimp, and indicated that LvSPARC-L might play an antiviral role by regulating apoptosis.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2021)
Article
Fisheries
Zi-ang Wang, Jiefu Zheng, Linwei Yang, Hongliang Zuo, Shengwen Niu, Shaoping Weng, Jianguo He, Xiaopeng Xu
Summary: Research on the Pacific white shrimp LvWnt11 gene show that it plays different roles in immune responses against Vibrio parahaemolyticus and white spot syndrome virus infections. LvWnt11 regulates expression of various immune-related factors and may help to uncover immune mechanisms in crustaceans.
Article
Fisheries
Haoyang Li, Qinyao Li, Sheng Wang, Jianguo He, Chaozheng Li
Summary: In this study, a MIP-T3 homolog from shrimp Litopenaeus vannamei was cloned and identified. The LvMIP-T3 played a positive role in the TRAF6/NF-kappa B/AMPs axis-mediated defense response and facilitated the expression of antimicrobial peptides to oppose infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Monica Janeth Cabrera-Stevens, Arturo Sanchez-Paz, Fernando Mendoza-Cano, Cristina Escobedo-Fregoso, Trinidad Encinas-Garcia, Regina Elizondo-Gonzalez, Alberto Pena-Rodiguez
Summary: After evaluating the effects of functional feeds on gene expression and WSSV resistance in Litopenaeus vannamei shrimp, it was found that shrimp fed with turmeric and maca meal, as well as algae extract, showed higher survival rates against WSSV infection compared to those fed with reference feed, vitamin C, and beta-glucan. The transcriptomic response of shrimp fed with turmeric and maca meal and algae extract feeds indicated differentially expressed genes potentially related to WSSV resistance.
Article
Fisheries
Yang Hu, Lei Liu, Li-Peng Shan, Jiong Chen
Summary: Paeoniflorin, a natural compound, shows significant anti-WSSV activity in shrimp aquaculture, providing protection against WSSV infection, increasing the expression of antimicrobial peptides in shrimp, and potentially inhibiting horizontal transmission of the virus.
JOURNAL OF FISH DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
Po-Tsang Lee, Jing Huang, Chin-Yi Huang, Zi-Xuan Liu, Han-Yang Yeh, Huai-Ting Huang, Li-Li Chen, Fan-Hua Nan, Meng-Chou Lee
Summary: The study demonstrates that phycoerythrin from Colaconema sp. can act as an immunomodulator in whiteleg shrimp, enhancing immune gene expression and innate immune parameters to increase survival rates when challenged with viruses or bacteria.
Article
Cardiac & Cardiovascular Systems
A. Separham, L. Pourafkari, B. Kazemi, Y. Haghizadeh, F. Akbarzadeh, M. Toufan, H. Sate, N. D. Nader
Article
Engineering, Biomedical
Zohreh Karimi, Ehsan Seyedjafari, Fatemeh Sadat Mahdavi, Seyed Mahmoud Hashemi, Arash Khojasteh, Bahram Kazemi, Samira Mohammadi-Yeganeh
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Cell Biology
Leila Beikmohammadi, Mojgan Bandehpour, Seyed Mahmoud Hashemi, Bahram Kazemi
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Parasitology
Bahman Rahimi Esboei, Bahram Kazemi, Mohammad Zarei, Mehdi Mohebali, Hossein Keshavarz Valian, Saeedeh Shojaee, Fatemeh Zahedipour, Shirzad Fallahi, Parisa Mousavi, Raziyeh Mahmoudzadeh, Mirataollah Salabati
ACTA PARASITOLOGICA
(2019)
Article
Biochemistry & Molecular Biology
Armina Alagheband Bahrami, Mojgan Bandehpour, Bahman Khalesi, Bahram Kazemi
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Amin Barkhordari, Abbas Behzad-Behbahani, Vahid Jajarmi, Mojgan Bandehpour, Gholamreza Rafiei-Dehbidi, Fatemeh Safari, Fereydoun Mahboudi, Bahram Kazemi
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Akram Jalali, Mojgan Bandehpour, Rouzbeh Chegeni, Hossein Ghanbarian, Yasaman Mardani-Dashti, Sayyed Hamid Zarkesh-Esfahani, Bahram Kazemi
Summary: Using Leishmania tarentolae as an expression system for producing therapeutic recombinant proteins is cost-effective, efficient, and requires less labor.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Reyhaneh Hoseinpoor, Bahram Kazemi, Masoumeh Rajabibazl, Azam Rahimpour
JOURNAL OF BIOTECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Nasrin Mohammadi, Mojgan Bandehpour, Fattah Sotoodehnejadnematalahi, Bahram Kazemi
Summary: The study successfully designed and expressed the Ecarin metalloproteinase, and verified its enzyme activity through experiments. Combining the predictive results from the I-TASSER server, it helped to better understand the relationship between the structure and function of the Ecarin metalloproteinase.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2022)
Article
Pharmacology & Pharmacy
Aref Shiralipour, Babak Khorsand, Leila Jafari, Mohammad Salehi, Mahsa Kazemi, Javad Zahiri, Vahid Jajarmi, Bahram Kazemi
Summary: This study analyzed the problem of drug resistance in breast cancer using computational and systems biology approaches. Six key lysosome-related genes were identified as potential therapeutic targets for drug-resistant breast cancer.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Plant Sciences
Elnaz Bafandeh, Farnaz Kheirandish, Zeinab Hosseini, Saeed Veiskarami, Marzieh Rashidipour, Bahram Kazemi, Atiyeh Darbandi, Shirzad Fallahi, Arian Karimi Rouzbahani
Summary: Olive leaf extract (OLE) can significantly reduce the expression of DHFR gene and have a slight effect on the expression of PTR1 gene in Leishmania major parasite.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Infectious Diseases
Farideh Tohidi, Zahra Babaei, Bahram Kazemi, Mojgan Bandehpour, Iraj Sharifi, Mohammad Reza Rabiei, Ebrahim Saedi Dezaki
JOURNAL OF VECTOR BORNE DISEASES
(2019)
Article
Biochemistry & Molecular Biology
H. Sobati, A. Dalimi, B. Kazemi, F. Ghaffarifar
MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY
(2019)
Article
Multidisciplinary Sciences
Seyed Sajad Shahrokhi, Mahnaz Kesmati, Bahram Kazemi
Article
Biotechnology & Applied Microbiology
Shahla Korani, Bahram Kazemi, Adel Haghighi, Amin Reza Nikpoor, Mojgan Bandehpour
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2019)