期刊
ASIAN JOURNAL OF ANDROLOGY
卷 16, 期 4, 页码 572-580出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1008-682X.125401
关键词
blood-testis barrier; genetically-modified mouse; seminiferous tubule; sertoli cells; spermatogenesis
资金
- National Basic Research Program of China (973) [2013CB947900, 2013CB945502, 2014CB943101]
- National Natural Science Foundation of China [31371519]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-R-07]
The blood-testis barrier (BTB) is found between adjacent Sertoli cells in the testis where it creates a unique microenvironment for the development and maturation of meiotic and postmeiotic germ cells in seminiferous tubes. It is a compound proteinous structure, composed of several types of cell junctions including tight junctions (TJs), adhesion junctions and gap junctions (GJs). Some of the junctional proteins function as structural proteins of BTB and some have regulatory roles. The deletion or functional silencing of genes encoding these proteins may disrupt the BTB, which may cause immunological or other damages to meiotic and postmeiotic cells and ultimately lead to spermatogenic arrest and infertility. In this review, we will summarize the findings on the BTB structure and function from genetically-modified mouse models and discuss the future perspectives.
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