The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing

Homozygous Deletions and Recurrent Amplifications Implicate New Genes Involved in Prostate Cancer

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Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort

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Cancer statistics, 2012

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Copy number alterations of c-MYC and PTEN are prognostic factors for relapse after prostate cancer radiotherapy

(2012) Gaetano Zafarana et al.   CANCER

Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines

(2012) Y. Li et al.   CANCER RESEARCH

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

Poly-gene fusion transcripts and chromothripsis in prostate cancer

(2012) Chunxiao Wu et al.   GENES CHROMOSOMES & CANCER

nFuse: Discovery of complex genomic rearrangements in cancer using high-throughput sequencing

(2012) A. McPherson et al.   GENOME RESEARCH

RNA editing in the human ENCODE RNA-seq data

(2012) E. Park et al.   GENOME RESEARCH

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

(2012) J. Liu et al.   GENOME RESEARCH

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

(2012) Y. Drier et al.   GENOME RESEARCH

Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes

(2012) T.-M. Kim et al.   GENOME RESEARCH

The transcriptional landscape and mutational profile of lung adenocarcinoma

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Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer

(2012) Chunxiao Wu et al.   JOURNAL OF PATHOLOGY

From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer

(2012) Anna V Lapuk et al.   JOURNAL OF PATHOLOGY

Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer

(2012) Alison H M Reid et al.   MODERN PATHOLOGY

Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase, an Exploitable Tumor Target

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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

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Subgroup-specific structural variation across 1,000 medulloblastoma genomes

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The mutational landscape of lethal castration-resistant prostate cancer

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Multipotent and unipotent progenitors contribute to prostate postnatal development

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Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

(2012) Matthieu Le Gallo et al.   NATURE GENETICS

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Traversing the genomic landscape of prostate cancer from diagnosis to death

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Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements

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Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

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The complexity of prostate cancer: genomic alterations and heterogeneity

(2012) Lara K. Boyd et al.   Nature Reviews Urology

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

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AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

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Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients

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Detection of recurrent rearrangement breakpoints from copy number data

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Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

(2011) Qi Cao et al.   CANCER CELL

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

(2011) J. Chad Brenner et al.   CANCER CELL

Common Structural and Epigenetic Changes in the Genome of Castration-Resistant Prostate Cancer

(2011) T. W. Friedlander et al.   CANCER RESEARCH

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Copy number alterations in prostate tumors and disease aggressiveness

(2011) Iona Cheng et al.   GENES CHROMOSOMES & CANCER

Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer

(2011) J. H. Kim et al.   GENOME RESEARCH

Common Gene Rearrangements in Prostate Cancer

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Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study

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ERG–TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin

(2011) Sean R Williamson et al.   MODERN PATHOLOGY

The genomic complexity of primary human prostate cancer

(2011) Michael F. Berger et al.   NATURE

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

(2011) John R Prensner et al.   NATURE BIOTECHNOLOGY

How does DNA break during chromosomal translocations?

(2011) M. Nambiar et al.   NUCLEIC ACIDS RESEARCH

Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers

(2011) A. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular classification of prostate cancer using curated expression signatures

(2011) E. K. Markert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Urine TMPRSS2:ERG Fusion Transcript Stratifies Prostate Cancer Risk in Men with Elevated Serum PSA

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OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer

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Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

(2011) H. Beltran et al.   Cancer Discovery

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

(2010) A H M Reid et al.   BRITISH JOURNAL OF CANCER

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors

(2010) C. M. Robbins et al.   GENOME RESEARCH

Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing

(2010) D. Pflueger et al.   GENOME RESEARCH

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

(2010) Nallasivam Palanisamy et al.   NATURE MEDICINE

Identification of a Cell of Origin for Human Prostate Cancer

(2010) A. S. Goldstein et al.   SCIENCE

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

Steroid Hormone Receptors in Prostate Cancer: A Hard Habit to Break?

(2009) Gerhardt Attard et al.   CANCER CELL

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

(2009) Chunru Lin et al.   CELL

A Group of Genome-Based Biomarkers That Add to a Kattan Nomogram for Predicting Progression in Men with High-Risk Prostate Cancer

(2009) P. L. Paris et al.   CLINICAL CANCER RESEARCH

Distinct genomic aberrations associated withERGrearranged prostate cancer

(2009) Francesca Demichelis et al.   GENES CHROMOSOMES & CANCER

Pathway Biomarker Profiling of Localized and Metastatic Human Prostate Cancer Reveal Metastatic and Prognostic Signatures†

(2009) Robert L. Grubb et al.   JOURNAL OF PROTEOME RESEARCH

An Update of the Gleason Grading System

(2009) Jonathan I. Epstein   JOURNAL OF UROLOGY

A luminal epithelial stem cell that is a cell of origin for prostate cancer

(2009) Xi Wang et al.   NATURE

ETS gene fusions in prostate cancer

(2009) Jeremy P. Clark et al.   Nature Reviews Urology

Induced Chromosomal Proximity and Gene Fusions in Prostate Cancer

(2009) R.-S. Mani et al.   SCIENCE