Article
Plant Sciences
Shivani, Mitali Mahajan, Babit Kumar Thakur, Probir Kumar Pal
Summary: The productivity and quality of rose oil from old plantations can be improved through ground-level pruning, especially when performed in October.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Construction & Building Technology
Sirong Qu, Zhiliang Wang, Weiwei Liu
Summary: This study established an outdoor clothing model for Changsha based on climate characteristics through two consecutive years of field experiments, verifying the assumption that clothing adjustment is influenced by temperature.
BUILDING AND ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
John R. Lamb, Lori L. Jennings, Valborg Gudmundsdottir, Vilmundur Gudnason, Valur Emilsson
Summary: Recent advances in protein profiling technology have revealed the organization of proteins in circulation, their genetic control, and their close association with various diseases. Unlike networks in solid tissues, serum protein networks consist of members synthesized across different tissues, with genetic analysis showing their role in systemic homeostasis and individual disease states.
TRENDS IN MOLECULAR MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
Mark A. Pallansch
Summary: The United States and the United Kingdom are facing outbreaks of imported poliovirus due to undervaccination.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Virology
Gustavo Saint-Pierre Contreras, Daniel Conei Valencia, Luis Lizama, Daniela Vargas Zuniga, Luis Fidel Avendano Carvajal, Sandra Ampuero Llanos
Summary: Human adenoviruses (HAdV) are important pathogens causing acute respiratory diseases in pediatrics and immunocompromised patients. They have a wide range of types and can cause various symptoms, including respiratory and gastrointestinal disorders. HAdV has strong stability and resistance to detergents. Diagnosis can be made through immunochromatography or polymerase chain reaction. This review highlights the variability and pandemic potential of HAdV, emphasizing the use of recombinant AdV vaccines to control future pandemics.
Review
Endocrinology & Metabolism
Agata Berlinska, Renata Swiatkowska-Stodulska, Krzysztof Sworczak
Summary: In the era of COVID-19, Endocrinology had to adapt by simplifying diagnostic and treatment approaches to meet the challenges posed by the pandemic. International expert statements offered guidance with a focus on hypercortisolemic patients and iatrogenic hypercortisolemia due to glucocorticoid use.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Samuel M. Lockhart, Stephen O'Rahilly
Summary: Colchicine, an anti-inflammatory agent commonly used to treat gout, exerts its effects in mice by inducing the hormone GDF-15 in the liver, as demonstrated by Weng et al. in the latest issue of Nature Metabolism.
Article
Medicine, General & Internal
Massimo Torreggiani, Antoine Chatrenet, Antioco Fois, Maria Rita Moio, Beatrice Maze, Jean Philippe Coindre, Romain Crochette, Mickael Sigogne, Samuel Wacrenier, Lena Lecointre, Conrad Breuer, Hafedh Fessi, Giorgina Barbara Piccoli
Summary: The study investigated the referral pattern of CKD patients in a large nephrology unit, finding that CKD staging increases with age and comparing the impact of different formulas on estimating kidney function. The results showed that regardless of the equation used, the current referral pattern does not affect the need for CKD care in elderly patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Kyusik Ahn, Seung-Jae Lee, Inhee Mook-Jung
Summary: This article assesses the current state of knowledge on brain aging, with a focus on the roles of white matter and microglia, and suggests potential approaches for rejuvenating the aged brain.
AGEING RESEARCH REVIEWS
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sai Shao, Qinjian Sun
Summary: TOF MRA is crucial for evaluating cerebrovascular stenosis, and a novel evaluation system can enhance its accuracy by considering the changes in hemodynamics and resulting different imaging presentations.
EUROPEAN RADIOLOGY
(2022)
Article
Cell Biology
Jennifer L. Uhrlaub, Mladen Jergovic, Christine M. Bradshaw, Sandip Sonar, Christopher P. Coplen, Jarrod Dudakov, Kristy O. Murray, Marion C. Lanteri, Michael P. Busch, Marcel R. M. van den Brink, Janko Nikolich-Zugich
Summary: Older humans and animals exhibit reduced immune responses to infection and vaccination, which is correlated to the numbers and frequency of naive T cells. Increasing the number of CD8 T cells can improve clinical outcomes of West Nile virus. However, IL-7C treatment does not improve immune defense against the virus in older animals.
Review
Chemistry, Applied
Peipei Wang, Lianli Chi, Zhenqing Zhang, Hongmei Zhao, Fuming Zhang, Robert J. Linhardt
Summary: Heparin, an old but first-line anticoagulant, has various pharmacological functions such as anticoagulant, anti-viral, anti-tumor, and anti-inflammatory activities. Recent studies have also shown that heparin can decrease mortality in COVID-19 patients through its non-anticoagulant properties.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Cristina Miralpeix, Ana Cristina Reguera, Anna Fosch, Sebastian Zagmutt, Nuria Casals, Daniela Cota, Rosalia Rodriguez-Rodriguez
Summary: The hypothalamus plays a crucial role in the pathogenesis of obesity, with disrupted endocannabinoid system considered a landmark indicator. Recent research has expanded knowledge of the complex endocannabinoid system, focusing on CB receptors, ligands, non-CB receptors, and metabolizing enzymes, particularly in the hypothalamus. The insights gained have provided promising targets for tackling obesity and related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
T. Jake Liang
Summary: New strategies utilizing nucleic acid technologies are being explored for the treatment of chronic hepatitis B, with a pilot clinical study of antisense oligonucleotide treatment demonstrating the potential promise of this approach.
Review
Biochemistry & Molecular Biology
Evgenii Gusev, Yulia Zhuravleva
Summary: Pro-inflammatory stress is inherent in damaged or threatened cells and is defined by various components. The microvascular inflammatory response plays a key role in the development of classical inflammatory foci, which can also lead to systemic inflammation. The division of inflammation into different variants has evolutionary roots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Xanthie Volckmar, Marcus Vallejo, Michael J. Bertoldo, Quynh-Nhu Nguyen, David J. Handelsman, Orin Chisholm, Antoinette Anazodo
Summary: A review of reproductive studies on 32 newly approved oncology drugs showed limited human research and some impact on animal fertility. Only 4 drugs provided recommendations on potential human fertility risks, highlighting the need for more data on the reproductive effects of novel oncology drugs.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Carl Jenkinson, Reena Desai, Malcolm D. McLeod, Jonathan Wolf Mueller, Martin Hewison, David J. Handelsman
Summary: This study analyzed the contribution of sulfate and glucuronide vitamin D metabolites relative to unconjugated levels in human serum. The results showed that sulfate conjugates formed a higher proportion of circulating vitamin D metabolites compared to glucuronide conjugates. The findings suggest that a combination of both conjugated and unconjugated measurements may provide a more accurate assessment of vitamin D status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Arpita Das, Robert Cumming, Vasikaran Naganathan, Fiona Blyth, David G. Le Couteur, David J. Handelsman, Louise M. Waite, Rosilene V. R. Ribeiro, Stephen J. Simpson, Vasant Hirani
Summary: The study found that moderate intake of total dietary protein was associated with lower all-cause and cancer mortality. Animal protein intake was positively associated with mortality risk, while plant protein intake was inversely associated with mortality.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Review
Endocrinology & Metabolism
David J. Handelsman
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
David J. Handelsman
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemical Research Methods
David J. Handelsman, Feyrous Bacha, Marsha DeBono, Sue Sleiman, Margaret R. Janu
Summary: The high sensitivity of antidoping detection tests can lead to inadvertent doping by athletes unknowingly ingesting contaminated environmental sources. Athletes have recently claimed that positive antidoping tests were a result of exchanging bodily fluids with nonathlete partners who used prohibited substances. The measurement of drugs in semen is limited, and an emerging issue is the presence of residual urine in semen samples. This study employed concurrent creatinine measurements to determine the urine content in semen samples.
DRUG TESTING AND ANALYSIS
(2022)
Article
Endocrinology & Metabolism
David J. Handelsman, Reena Desai, Ann J. Conway, Nandini Shankara-Narayana, Bronwyn G. A. Stuckey, Warrick J. Inder, Mathis Grossmann, Bu Beng Yeap, David Jesudason, Lam P. Ly, Karen Bracken, Gary Allen Wittert
Summary: The recovery of reproductive hormones after stopping injectable testosterone undecanoate (TU) treatment is slow and may take longer than 12 months to be complete. The persistent reduction in serum sex hormone-binding globulin (SHBG) and testosterone reflects the lasting effects of exogenous testosterone on hepatic SHBG secretion.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Matti L. Gild, Mark Stuart, Roderick J. Clifton-Bligh, Audrey Kinahan, David J. Handelsman
Summary: Abuse of hormones is common in elite sports, with androgens and erythropoietin being the most prohibited substances. The prohibition of thyroid hormone (TH) use remains controversial, but based on present data, it is neither justified nor feasible to prohibit TH in elite sports.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Chris S. Coyle, Melanie Prescott, David J. Handelsman, Kirsty A. Walters, Rebecca E. Campbell
Summary: Polycystic ovary syndrome (PCOS) is associated with androgen excess and abnormal luteinizing hormone (LH) secretion. Chronic exposure to androgens in mice leads to reproductive and metabolic impairments, but does not affect GABAergic input to GnRH neurons. These findings suggest that centrally driven mechanisms in hyperandrogen-mediated PCOS pathophysiology may vary depending on the developmental stage of androgen excess.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Kim M. Kiely, Saman Khalatbari-Soltani, Fiona M. Blyth, Vasikaran Naganathan, David J. Handelsman, Louise M. Waite, David G. Le Couteur, Moyra E. Mortby, Robert G. Cumming, Kaarin J. Anstey
Summary: This study aimed to assess the association between self-reported hearing difficulties and future risk of falling among older adults. The findings from the two Australian cohorts showed mixed results, suggesting that self-reported hearing difficulties may be predictive of falls in some cases but not in others.
Article
Obstetrics & Gynecology
Z. N. Azene, S. R. Davis, J. J. McNeil, A. M. Tonkin, D. J. Handelsman, R. M. Islam
Summary: This study investigated the association between estrone and sex hormone binding globulin (SHBG) concentrations with lipid concentrations in older postmenopausal women. The results showed that estrone and SHBG are associated with lipid concentrations in older women, with SHBG providing additional clinical predictive utility for the assessment of cardiometabolic disease risk.
Article
Endocrinology & Metabolism
Anne R. Cappola, Richard J. Auchus, Ghada El-Hajj Fuleihan, David J. Handelsman, Rita R. Kalyani, Michael McClung, Cynthia A. Stuenkel, Michael O. Thorner, Joseph G. Verbalis
Summary: Multiple changes occur in various endocrine systems as individuals age. The understanding of age-related changes and their clinical management is developing. This statement reviews the current research in different endocrine axes and conditions specific to older individuals, including available therapies, clinical trials, key points, and scientific gaps. The goal is to inform future research to improve prevention and treatment strategies for age-associated endocrine conditions in older individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
David J. Handelsman, Matti Gild, Roderick Clifton-Bligh, Naomi Speers, Dorothy Kouzios, Melissa C. McMartin, Reena Desai
Summary: This study investigated the prevalence of thyroid hormone (TH) abuse among Australian athletes undergoing antidoping tests for WADA-compliant sports. The results showed that only 4 per 1000 athletes had biochemical thyrotoxicosis, and the prevalence of TH usage based on the doping control forms was also 4 per 1000 athletes. These estimates were consistent with international competition data and lower than the estimated T4 prescription rates in the age-matched Australian population.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Andrology
David J. Handelsman, Amanda Idan, Sue Sleiman, Fey Bacha, Georgina V. Long, Alexander M. Menzies, Tejnei Vaishnav, Noosha Litkouhi, Xanthie Volckmar, William Ledger, Antoinette Anazodo
Summary: The effects of non-cytotoxic and immunotherapy drugs on human testicular function in cancer patients have not been systematically studied. This study aimed to investigate the effects of these drugs in cancer patients who had not undergone gonadotoxic treatment. The results showed that non-cytotoxic and immunotherapy drugs moderately affected testicular exocrine function (sperm production) and its hormonal correlates (follicle-stimulating hormone, inhibin B), but had minimal impact on testicular endocrine function (testosterone, luteinizing hormone).
