Article
Andrology
Yan-fen Zhou, Yu-yang Hou, Qian Ban, Meng-ling Zhang, Tao Huang, Bo Ma, Liang Shi, Qi Zhang
Summary: This study investigates the metabolites in seminal plasma of healthy men, obese men, and men with obesity-induced asthenozoospermia. It is found that obesity affects the metabolite composition in seminal plasma and abnormal energy metabolism is closely related to obesity-induced asthenozoospermia.
Article
Medical Laboratory Technology
Yuyang Hou, Yuanping He, Jingjie Wang, Yanfen Zhou, Bo Ma, Xin Li, Liang Shi, Qi Zhang
Summary: By analyzing the metabolic profiles of four different types of asthenozoospermia, this study revealed abnormal changes in metabolites and metabolic pathways associated with the disease. The findings provide new clues and evidence for the etiology, diagnosis, and treatment of asthenozoospermia.
CLINICA CHIMICA ACTA
(2023)
Article
Reproductive Biology
Gemma Gaitskell-Phillips, Francisco E. Martin-Cano, Jose M. Ortiz-Rodriguez, Eva Da Silva-Alvarez, Javier Masot, Eloy Redondo, Maria C. Gil, Cristina Ortega-Ferrusola, Fernando J. Pena
Summary: Seminal plasma proteins play crucial roles in sperm functionality, and their abundance in samples correlates with the quality of ejaculates from different stallions. Identifying specific proteins in seminal plasma could potentially help improve the quality of stallion ejaculates and enhance breeding strategies.
Article
Biochemical Research Methods
J. Willforss, J. M. Morrell, S. Resjo, T. Hallap, P. Padrik, V Siino, D. J. de Koning, E. Andreasson, F. Levander, P. Humblot
Summary: The study utilized liquid chromatography mass spectrometry to analyze proteins in the seminal plasma of bulls, identifying specific proteins consistently correlated with fertility across multiple seasons. By combining these proteins, a molecular signature predictive of fertility was created. These findings enhance understanding of the bull seminal plasma proteome and potentially offer valuable markers for predicting fertility in individual bulls.
JOURNAL OF PROTEOMICS
(2021)
Article
Medicine, Research & Experimental
Ling He, Xingwu Wu, Rongye Wu, Ping Guo, Wenfeng He, Wanlei Sun, He Chen
Summary: This study revealed the expression changes of piRNAs in asthenozoospermia, providing clues for understanding the pathogenesis of this condition. Through bioinformatics analysis and experimental validation, differentially expressed piRNAs were found to be mainly associated with functions such as transcription, signal transduction, and cell differentiation. Four selected piRNAs were proven to have good diagnostic capability, and their combination further improved the diagnostic efficacy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Andrology
Manesh Kumar Panner Selvam, Ashok Agarwal
Summary: This study compared the seminal plasma proteome of healthy fertile men with varicocele patients, identifying differentially expressed proteins associated with processes such as acrosome binding, protein folding, and oxidative stress. Validation confirmed abnormal expression levels of key proteins in varicocele patients. These findings suggest that aberrant seminal plasma protein expression could serve as an indicator of sperm pathology in varicocele patients.
WORLD JOURNAL OF MENS HEALTH
(2021)
Editorial Material
Cell Biology
Xiaojing Jia, Shuangyuan Wang, Jieli Lu
Summary: Nakayasu et al.'s investigation on children from the TEDDY study showed that plasma protein biomarkers have strong predictive value in identifying the emergence of persistent autoantibodies and type 1 diabetes. Interestingly, this predictive accuracy was observed six months prior to the onset of autoimmunity.
CELL REPORTS MEDICINE
(2023)
Article
Biochemical Research Methods
A. Ashwitha, Kerekoppa P. Ramesha, Poornima Ramesh, Chinmaya Narayana Kootimole, M. Joel Devadasan, Shruthi Ammankallu, Sakthivel Jeyakumar, Arumugam Kumaresan, Vedamurthy Gowdar Veerappa, D. N. Das, Thottethodi Subrahmanya Keshava Prasad
Summary: This study investigated the differential regulation of spermatozoal and seminal plasma proteins between low and high ERR bulls. Proteins associated with sperm motility were found to be differentially regulated. This research holds promise for the development of markers related to semen quality, aiding in the selection of bulls.
JOURNAL OF PROTEOMICS
(2023)
Article
Biochemistry & Molecular Biology
Naouel Gharbi, Dagne Roise, Jorunn-Elise Forre, Amanda J. Edson, Helena A. Hushagen, Valentina Tronci, Ann-Kristin Froyset, Kari E. Fladmark
Summary: The redox-sensitive protein DJ-1 is essential in protecting the retina from oxidative stress, with its absence leading to age-dependent degenerative changes. Restoration of DJ-1 expression in Muller cells inhibits the degenerative phenotype, highlighting the key role of Muller cell DJ-1 in protecting the retina from oxidative stress associated with aging.
Review
Biochemistry & Molecular Biology
Heriberto Rodriguez-Martinez, Emilio A. Martinez, Juan J. Calvete, Fernando J. Pena Vega, Jordi Roca
Summary: Seminal plasma, a non-cellular component of semen, plays a crucial role in sperm function and interactions with the female reproductive tract. It participates in diverse pre-fertilization events and triggers gene function changes to prepare for successful pregnancy. Despite the fertility of SP-free spermatozoa, its components have diagnostic biomarker potential and can be used as additives to improve reproductive strategies in livestock and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Dandan Wang, Kadiliya Jueraitetibaike, Ting Tang, Yanbo Wang, Jun Jing, Tongmin Xue, Jinzhao Ma, Siyuan Cao, Ying Lin, Xiaoyan Li, Rujun Ma, Xi Chen, Bing Yao
Summary: The study showed that implantation rates were lower in female mice treated with seminal plasma from reproductively older males compared to those treated with seminal plasma from younger males. RNA-sequencing analysis revealed altered levels of dendritic cell-related cytokines and chemokines in the uteri of the former group. In vivo and in vitro experiments demonstrated a weaker inhibitory effect of aged seminal plasma on dendritic cell maturation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Ursula Kern, Klemens Froehlich, Johanna Bedacht, Nico Schmidt, Martin L. Biniossek, Nicole Gensch, Katja Baerenfaller, Oliver Schilling
Summary: DJ-1 is a crucial component of cellular proteomes, with its C-terminal helix 8 playing a key role in deglycation activity. The presence or absence of helix 8 in DJ-1 significantly impacts mitochondrial and lysosomal biology. The pleiotropic nature of DJ-1 is further demonstrated by its indirect modulation of lysosomal protease activity.
Article
Biotechnology & Applied Microbiology
Kai Yu, Kai Xiao, Qin-qiang Sun, Run-feng Liu, Liang-feng Huang, Peng-fei Zhang, Hui-yan Xu, Yang-qing Lu, Qiang Fu
Summary: This study compared the protein correlation between spermatozoa, seminal plasma, and seminal plasma exosomes (SPEs) in buffalo and analyzed the protein differences between high-motility and low-motility SPEs. The protein composition of SPEs was mostly derived from spermatozoa and seminal plasma, and a functional network of reproductive process-related proteins was identified. The study also found differential protein expression between high-motility and low-motility SPEs. These findings provide valuable information for identifying biomarkers associated with male infertility.
Article
Agriculture, Dairy & Animal Science
Bincheng Tang, Guangjuan Xie, Xinyue Hu, Xin Zhang, Shenqiang Hu, Jiwei Hu, Bo Hu, Liang Li, Jiwen Wang
Summary: Semen quality is crucial in evaluating the reproductive ability of drakes. This study identified seminal plasma proteins associated with semen quality by comparing the proteomic profiles of high-quality and low-quality semen in drakes. The differentially expressed proteins were found to be enriched in various biological pathways, and several candidate proteins were identified as potentially important for semen quality regulation.
Article
Biochemistry & Molecular Biology
Joao C. Ribeiro, Rita Nogueira-Ferreira, Francisco Amado, Marco G. Alves, Rita Ferreira, Pedro F. Oliveira
Summary: Infertility, particularly in males, is linked to an imbalance between ROS production and antioxidants, leading to oxidative stress. Proteomic studies using mass spectrometry are helping to uncover the molecular mechanisms associated with male oxidative stress infertility. The identification of antioxidant proteins is crucial for understanding male infertility and developing new treatment options.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Multidisciplinary Sciences
Waqas Azeem, Margrete Reime Hellem, Jan Roger Olsen, Yaping Hua, Kristo Marvyin, Yi Qu, Biaoyang Lin, Xisong Ke, Anne Margrete Oyan, Karl-Henning Kalland
Article
Cardiac & Cardiovascular Systems
Xingfu Huang, Yanjia Chen, Junhui Xiao, Hongxin Zhao, Yizhen Chen, Shenrong Liu, Liwei He, Zheng Huang, Haobin Zhou, Dingli Xu, Jian Peng
CLINICAL CARDIOLOGY
(2018)
Article
Multidisciplinary Sciences
Qian Chen, Chaoying Hu, Yanmei Liu, Rong Song, Wenjing Zhu, Hongxin Zhao, Antonio Nino, Fan Zhang, Yun Liu
Article
Biophysics
Liang Ma, Bin Zhang, Changchun Zhou, Yuting Li, Binjie Li, Mengfei Yu, Yichen Luo, Lei Gao, Duo Zhang, Qian Xue, Qingchong Qiu, Biaoyang Lin, Jun Zou, Huayong Yang
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Multidisciplinary Sciences
Qing-Chong Qiu, Lin Wang, Shan-Shan Jin, Guan-Feng Liu, Jie Liu, Liang Ma, Rui-Fang Mao, Ying-Ying Ma, Na Zhao, Ming Chen, Biao-Yang Lin
SCIENTIFIC REPORTS
(2018)
Review
Medicine, Research & Experimental
Hongxin Zhao, Yi Ning, James Cooper, Rodrigo Refoios Camejo, Xiajun Ni, Bingming Yi, Daniel Parks
ADVANCES IN THERAPY
(2019)
Article
Cardiac & Cardiovascular Systems
Xing Wang, Yan He, Tao Wang, Chunming Li, Zihui Ma, Heng Zhang, Handong Ma, Hongxin Zhao
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Cardiac & Cardiovascular Systems
Xingfu Huang, Yanjia Chen, Yuli Huang, Hongxin Zhao, Liwei He, Zhenni Tan, Dingli Xu, Jian Peng
CLINICAL CARDIOLOGY
(2020)
Article
Endocrinology & Metabolism
Xing Wang, Chunming Li, Yan He, Tao Wang, Heng Zhang, Zihui Ma, Handong Ma, Hongxin Zhao
ARCHIVES OF OSTEOPOROSIS
(2020)
Article
Medicine, General & Internal
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Amy Hai Yan Chan, Manju Chandran, Ching-Lung Cheung, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff Lange, E. Michael Lewiecki, Jiannong Liu, Kenneth K. C. Man, Mirhelen Mendes de Abreu, Nicolas Moore, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Daniel Prieto-Alhambra, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Hongxin Zhao, Ian C. K. Wong
Summary: This study aims to investigate global secular trends in hip fracture incidence, mortality, and use of postfracture pharmacological treatment across different geographical regions using a unified methodology.
Review
Biotechnology & Applied Microbiology
Biaoyang Lin, Yingying Ma, ShengJun Wu
Summary: Chronic liver disease (CLD) is a global health burden, and there is a need for improved biomarkers, diagnostic methods, and the integration of multi-omics data with the help of artificial intelligence. This review summarizes the emerging frontiers and challenges in multi-omics data integration in liver pathology research, as well as the impact of digital transformation in this field.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Biaoyang Lin, Shengjun Wu
Summary: Digital transformation is revolutionizing personalized medicine and systems science by enabling real-time patient feedback and in-depth phenotypic analysis with advanced technologies like artificial intelligence and the Internet of Medical Things.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Biaoyang Lin, Yingying Ma, Shengjun Wu, Yunhua Liu, Longgen Liu, Lihua Wu
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Jie Liu, Ruifang Mao, Guoping Ren, Xiaoyan Liu, Yanling Zhang, Jili Wang, Yan Wang, Meiling Li, Qingchong Qiu, Lin Wang, Guanfeng Liu, Shanshan Jin, Liang Ma, Yingying Ma, Na Zhao, Jiajun Yan, Hongwei Zhang, Biaoyang Lin
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2019)
Letter
Biotechnology & Applied Microbiology
Biaoyang Lin
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2019)