Article
Andrology
Jun Ho Lee, Hyuk-Dal Jung, Jae Duck Choi, Jung Yoon Kang, Tag Keun Yoo, Yeon Won Park
Summary: This study aimed to investigate the association between testosterone levels and LDL levels. The results indicated an inverse association between testosterone and triglyceride levels, a positive association with high-density lipoprotein cholesterol levels, and an inverted U-shaped association with LDL levels. Further research is needed to understand the relationship between very low or very high LDL concentrations and circulating testosterone in men.
Article
Public, Environmental & Occupational Health
Jorg G. Morland, Per Magnus, Stein Emil Vollset, David A. Leon, Randi Selmer, Aage Tverdal
Summary: The benefits of elevated high-density lipoprotein cholesterol (HDL-C) levels are challenged by U-shaped relations with all-cause mortality. The association with cause-specific mortality is less studied. Higher HDL-C levels were associated with increased mortality risk for several diseases, which have also been associated with heavy drinking.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Kei Nakajima, Manami Igata, Ryoko Higuchi, Kotone Tanaka, Kaori Mizusawa, Teiji Nakamura
Summary: Both low and extremely high HDL-C concentrations are associated with high blood pressure. The former association might be dependent on excess fat mass concomitant with low HDL-C, whereas the latter association may be largely dependent on frequent alcohol consumption.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Food Science & Technology
Seyedeh-Masomeh Derakhshandeh-Rishehri, Saeed Ghobadi, Masoumeh Akhlaghi, Shiva Faghih
Summary: Calcium supplement intake is associated with a significant reduction in low density lipoprotein cholesterol level, especially in individuals without dyslipidemia, higher calcium intakes, and longer period of consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Hayato Tada, Hirofumi Okada, Atsushi Nohara, Ryuji Toh, Amane Harada, Katsuhiro Murakami, Takuya Iino, Manabu Nagao, Tatsuro Ishida, Ken-ichi Hirata, Masayuki Takamura, Masa-aki Kawashiri
Summary: The function of high-density lipoprotein (HDL) is more important than the HDL cholesterol (HDL-C) level in predicting the risk of coronary artery disease (CAD). A study on patients with familial hypercholesterolemia (FH) found that serum cholesterol uptake capacity (CUC) levels were significantly lower in patients with CAD compared to those without CAD. The study also showed that CUC levels were negatively correlated with the carotid plaque score and were independently associated with CAD, while HDL-C was not.
CIRCULATION JOURNAL
(2023)
Article
Medicine, General & Internal
Siwen Zang, Yanlei Chen, Haike Guo, Min Zhang, Guanrong Zhang, Lixin Zhang, Liang Zhang, Qingyang Liu, Jin Zeng, Chun-Han Lo, Ying Cui, Qianli Meng
Summary: This study investigated the relationship between serum lipids and pterygium in a large-scale rural population in Southern China aged 40 years or older. The study found that increased levels of high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were positively associated with the risk of pterygium. This association was stronger in participants aged 40-49 years and those with a normal body mass index (BMI).
Article
Endocrinology & Metabolism
Yuxiu Wang, Jiaoyue Zhang, Huiqing Li, Wen Kong, Juan Zheng, Yan Li, Qi Wei, Qin Li, Li Yang, Ying Xu, Li Li, Hanyu Wang, Hui Sun, Wenfang Xia, Geng Liu, Xueyu Zhong, Kangli Qiu, Han Wang, Hua Liu, Xiaoli Song, Si Xiong, Yumei Liu, Zhenhai Cui, Lulu Chen, Tianshu Zeng
Summary: Novel hematological parameters derived from high-density lipoprotein-cholesterol (HDL-C) were rarely studied as indicators for the risk of poor outcomes in patients with severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. Lower HDL-C concentrations and higher neutrophil to HDL-C ratio (NHR) at admission were significantly associated with a poor prognosis in COVID-19 patients and diabetes subgroup.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Andreina Arias, Alonso Quiroz, Nicolas Santander, Eugenia Morselli, Dolores Busso
Summary: Cholesterol plays a crucial role in maintaining the proper functioning of animal cells. Abnormal metabolism of high-density lipoproteins (HDL) may affect female fertility. HDL in follicular fluid (FF) can uptake excess unesterified cholesterol (UC) from cumulus cells, and the accumulation of UC may impair the developmental capacity of the egg. Cholesterol accumulation can affect cell viability and the activity of membrane proteins, potentially through the activation of calcium channels and dysregulation of cell death/survival signaling pathways. Evaluating cholesterol and lipid levels is important for the diagnosis and treatment of infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medical Laboratory Technology
Yang Geng, Yan Liu, Yan Chen, Zhenwen Zhang, Liping Wang, Xiaobo Li, Binlan Xia, Bin Song, Hengzhong Zhang
Summary: In the Chinese population with a high risk of stroke, a higher LDLc/HDLc ratio was significantly associated with the presence of carotid plaques.
CLINICAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Hee-Won Noh, Yena Jeon, Ji-Hye Kim, Ga-Young Lee, Soo-Jee Jeon, Kyu-Yeun Kim, Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Summary: This study found that the serum total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) is associated with mortality in peritoneal dialysis patients. Patients with higher TC/HDL-C had higher body mass index, diabetes prevalence, and serum albumin level. However, individual levels of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were not associated with mortality.
Review
Environmental Sciences
Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim
Summary: This systematic review examines the associations between perfluoroalkyl substances (PFAS) and lipid concentrations in human populations. The results suggest that PFAS exposure is associated with higher levels of LDL, HDL, and TC, while the association with TG tends to be negative. Additionally, the study indicates a positive relationship between PFAS concentrations and cholesterol-related health outcomes. Further research is needed to investigate the effects of less-studied PFAS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Gabriele Mazzuferi, Tiziana Bacchetti, Md Obaidul Islam, Gianna Ferretti
Summary: Breast cancer is a major cause of female mortality, with recent studies focusing on the role of lipoproteins, cholesterol metabolism alterations, and oxidative stress in the molecular mechanism of the disease. Low levels of HDL-C have been suggested as a risk factor for breast cancer, but conflicting results have been reported. Alterations in enzyme activity associated with HDL and higher levels of lipid peroxidation markers in breast cancer patients suggest dysfunctional HDL may play a role in the disease.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yuan Kong, Yong-Jia Yi, Xiao-Qing Liu, Pan Yu, Lin-Guo Zhao, Dong-Dong Li
Summary: In this study, a series of berberine analogs were synthesized and evaluated for their lipid-lowering activities. Compound 1m was found to exhibit potent cholesterol inhibitory activity and had significant effects on LDLC and HDLC levels. The results suggest that 1m has the potential to be a new lipid-lowering agent.
BIOORGANIC CHEMISTRY
(2022)
Article
Medicine, General & Internal
Rahul Aggarwal, Deepak L. Bhatt, Fatima Rodriguez, Robert W. Yeh, Rishi K. Wadhera
Summary: Lipid concentrations improved among US adults over the past decade, while rates of lipid control did not significantly change among adults receiving statin therapy. There were improvements in lipid control among certain racial and ethnic groups, but disparities remained between genders and races.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
