Article
Pharmacology & Pharmacy
Jian Li, Li Deng, Lijuan Tian, Shiqi Du, Bo Li, J. Zhou
Summary: In this study, a method for extraction and separation of tamsulosin hydrochloride and its related substances from core-shell structure pellets capsules was established. The method was validated and proved to be effective and accurate through forced degradation experiments. This method has potential applications in the evaluation of related substances, routine quality control, and extraction of other core-shell structure pellets capsules.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Madiha Melha Yahoum, Selma Toumi, Hichem Tahraoui, Sonia Lefnaoui, Mohammed Kebir, Abdeltif Amrane, Aymen Amin Assadi, Jie Zhang, Lotfi Mouni
Summary: This study aimed to prepare xanthan gum microspheres using ionotropic gelation for the encapsulation of metformin hydrochloride. The obtained microspheres, based on different fractions of xanthan gum, showed an average size ranging from 110.96 μm to 208.27 μm. The encapsulation efficiency reached 93.11% at a 1.25% biopolymer concentration. The swelling study demonstrated significant swelling in the gastric and intestinal environments, with release profiles showing sustained release kinetics.
Article
Pharmacology & Pharmacy
Hussein Allaboun, Khouloud A. Alkhamis, Suhair S. Al-Nimry
Summary: The study aimed to investigate the interaction between cation exchange resins and verapamil hydrochloride. Uptake studies showed that the resin with the lowest cross-linking had the highest uptake capacity. XRD, SEM, and particle size analysis confirmed the amorphous nature of the drug-resin complexes. Release studies demonstrated that conventional dissolution testing did not maintain sink conditions and that increasing the volume of samples withdrawn and fresh dissolution medium added significantly increased the drug release. The diffusion of exchanging cations through the liquid film was determined to be the rate-limiting step.
Article
Veterinary Sciences
Sihem Bouriche, Angela Alonso-Garcia, Carlos M. Carceles-Rodriguez, Farouk Rezgui, Emilio Fernandez-Varon
Summary: Metformin-loaded PLA microparticles showed promising characteristics in terms of physicochemical properties and potential therapeutic benefits in rabbits, with improved pharmacokinetic profiles observed. However, the impact on bioavailability should be carefully considered for future dose and formulation design, especially before testing in other animal species in veterinary medicine.
BMC VETERINARY RESEARCH
(2021)
Article
Polymer Science
Xin Jin, Chengxiong Wei, Chengwei Wu, Wei Zhang
Summary: A core-shell hydrogel assembly is proposed as a gastroretentive carrier for sustained release of metformin hydrochloride. The assembly can release the drug for 72 hours in vitro and maintain stable blood drug concentration for nearly 80 hours in vivo.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Electrochemistry
Maha Mahmoud Ibrahim, Khadiga Mohamed Kelani, Nesreen Khamis Ramadan, Eman Saad Elzanfaly, Shimaa Abdel-Atty
Summary: A simple electrochemical method was developed for the determination of Loperamide hydrochloride (LOP). The method showed high sensitivity and good analytical performance. It was successfully applied to determine LOP in its pure form, pharmaceutical formulation, in the presence of co-administered drugs and in human plasma. The newly fabricated carbon paste electrode modified with silver sulfadiazine and zinc oxide exhibited excellent electrochemical properties. The proposed method was validated and found to be environmentally friendly.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Pharmacology & Pharmacy
Taha Umair Wani, Abdul Aala Fazli, Syed Naiem Raza, Nisar Ahmad Khan, Faheem A. Sheikh
Summary: This study developed a novel expandable film based on hydroxypropyl methylcellulose K4M/ethyl cellulose for prolonged retention of losartan potassium in the stomach. The film significantly altered the pharmacokinetic parameters of the drug and its active metabolite, as demonstrated by in vivo and in vitro experiments.
Article
Pharmacology & Pharmacy
Hossein Kamali, Malihe Karimi, Mohammadreza Abbaspour, Azadeh Nadim, Farzin Hadizadeh, Elham Khodaverdi, Farhad Eisvand
Summary: This study aimed to develop a method for obtaining a sustained-release formulation of naltrexone using a lipid liquid crystal-based approach. The results showed that the new method using sorbitan monooleate was effective in sustaining the release of naltrexone and had better uniformity compared to existing formulations. The study also confirmed the biocompatibility of the new delivery system.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Hye-Ryeong Park, Su Hyun Seok, Kyu-Mok Hwang, Ju-Young Kim, Chun-Woong Park, Eun-Seok Park
Summary: This study developed sustained-release orodispersible films (ODFs) of donepezil hydrochloride (DPH) to improve medication compliance in patients with Alzheimer's disease.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Article
Biochemical Research Methods
Li Peng, Xinyu Wang, Hongwan Dang
Summary: An efficient and reliable LC-MS/MS method for simultaneous quantification of meropenem and imipenem in rat plasma was established and validated. This method was successfully applied to investigate the pharmacokinetics of intravenous injection of meropenem and imipenem in rats.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Chemistry, Medicinal
Hongfei Liu, Xiaoya Xie, Chao Chen, Caleb Kesse Firempong, Yingshu Feng, Limin Zhao, Xuezhi Yin
Summary: The study aimed to prepare a clonidine hydrochloride sustained-release suspension. The results showed that the suspension had a delayed Tmax, reduced Cmax, and a gentler concentration-time curve compared to ordinary tablets. The relative bioavailability of the suspension was 111.65% compared to the tablets.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Medicine, Research & Experimental
Haofan Liu, Bingwen Zhang, Yanna Chen, Zhe Cui, Liandong Hu
Summary: The objective of this study was to explore an innovative sustained release technology and design a new microporous resin-based polymer device (RPD) for controlled release of glipizide (GZ). The results showed that the resin layer prepared by photocurable resin can effectively control the release of GZ and exhibit excellent in vitro release and in vivo pharmacokinetic properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Yun Bae Ji, Soyeon Lee, Hyeon Jin Ju, Hee Eun Kim, Jung Hyun Noh, Sangdun Choi, Kinam Park, Hai Bang Lee, Moon Suk Kim
Summary: In this study, donepezil-loaded PLGA and PLA microspheres were prepared and wrapped in a polyethylene glycol-b-polycaprolactone hydrogel to reduce the dosing frequency of injections for Alzheimer's disease treatment. The Dp-PLA-M/PC formulation showed good injectability and sustained release pattern, making it a promising choice for reducing the dosing frequency of Dp injections.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Medicinal
Duanduan Cong, Wenyuan Qi, Xiaohui Liu, Xiaoyu Xu, Lingyun Dong, Wei Xue, Kexin Li
Summary: This study aimed to compare the pharmacokinetic characteristics of enteric-coated sustained-release (EcSr) aspirin tablets with enteric-coated (Ec) aspirin tablets in healthy Chinese participants. The results showed that EcSr aspirin tablets had less inter-individual variation in release and absorption, and meals had no significant effect on their pharmacokinetics.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka
Summary: This study aimed to develop a sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique. By rational screening of hydrophobic carriers, the release profile of DH was successfully modified, and a preferable release pattern was obtained by optimizing the ratio of carriers and pore-forming agents as well as the extrusion temperature profile.
