Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis-like Phenotype in Mice

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis

(2012) Carol G. Chen et al.   ARTHRITIS AND RHEUMATISM

Contribution of Proteoglycan Osmotic Swelling Pressure to the Compressive Properties of Articular Cartilage

(2011) EunHee Han et al.   BIOPHYSICAL JOURNAL

Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

(2011) Ingrid M B H van de Laar et al.   JOURNAL OF MEDICAL GENETICS

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

(2009) Daniel R. McCulloch et al.   GENE EXPRESSION PATTERNS

PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation

(2009) M. Zhang et al.   JOURNAL OF CELL SCIENCE

Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade

(2009) Marcela Hernández Ríos et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis

(2009) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transforming Growth Factor-β1 Stimulates Chondrogenic Differentiation of Posterofrontal Suture–Derived Mesenchymal Cells In Vitro

(2008) Yue Xu et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreERT2 transgenic mice

(2007) M. Zhu et al.   OSTEOARTHRITIS AND CARTILAGE