Article
Anesthesiology
Anthony Lembo, John M. Kelley, Judy Nee, Sarah Ballou, Johanna Iturrino, Vivian Cheng, Vikram Rangan, Jesse Katon, William Hirsch, Irving Kirsch, Kathryn Hall, Roger B. Davis, Ted J. Kaptchuk
Summary: In the study on irritable bowel syndrome, open-label placebo (OLP) treatment was found to be superior to no-pill control (NPC) and had similar efficacy to double-blind placebo (DBP).
Article
Nutrition & Dietetics
Welma Stonehouse, Bianca Benassi-Evans, Jana Bednarz, Andrew D. Vincent, Stephen Hall, Catherine L. Hill
Summary: This study showed that a commercially available krill oil supplement can improve knee pain, stiffness, and physical function in adults with mild to moderate knee osteoarthritis. The supplement is safe to consume.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Obstetrics & Gynecology
Emily R. Aldrich, Tiffanie Y. Tam, Leah M. Saylor, Catrina C. Crisp, Jennifer Yeung, Rachel N. Pauls
Summary: This study aimed to evaluate the effect of diazepam rectal suppositories on early postoperative pain after hysterectomy and vaginal reconstruction for pelvic organ prolapse.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Orthopedics
Janne K. Hofstad, Jomar Klaksvik, Tina S. Wik
Summary: This study aimed to investigate whether adding local infiltration analgesia (LIA) to the postoperative analgesic regimen could reduce postoperative pain or have an opioid-reducing effect in hip fracture patients. The results showed similar pain scores in both the LIA and placebo groups postoperatively, but significantly reduced opioid consumption was found in patients receiving LIA.
Article
Gastroenterology & Hepatology
Isabelle Mack, Juliane Schwille-Kiuntke, Nazar Mazurak, Beate Niesler, Kurt Zimmermann, Hubert Moennikes, Paul Enck
Summary: This study investigated the effectiveness of a nonviable probiotic lysate (BL) in the treatment of IBS and found that BL was not effective for all IBS subtypes, but may offer a treatment option for IBS-D which needs further verification through adequately powered drug trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Food Science & Technology
Samuel A. Goldlust, Mojgan Kavoosi, Jennifer Nezzer, Mehran Kavoosi, Walter Korz, Kenneth Deck
Summary: The study found that tetrodotoxin (TTX) may have potential efficacy in treating chemotherapy-induced neuropathic pain (CINP). Although there was no significant difference in average Numeric Pain Rating Scale (NPRS) scores, the 30 μg twice daily TTX cohort showed significant differences from the placebo group in some secondary quality of life (QOL) indicators. Adverse events were mostly mild to moderate, with oral paresthesia and hypoesthesia being the most common.
Article
Oncology
Sarah Prinsloo, Ted J. Kaptchuk, Dirk De Ridder, Randall Lyle, Eduardo Bruera, Diane Novy, Carlos H. Barcenas, Lorenzo G. Cohen
Summary: This study used a closed-loop brain-computer interface (BCI) to treat chemotherapy-induced peripheral neuropathy (CIPN). The results showed significant symptom reduction and improvements in the BCI and placebo control (PLC) groups, with the BCI group having larger effect size differences from the waitlist control group. These findings suggest that BCI is a promising treatment for CIPN and may have longer lasting effects.
Article
Anesthesiology
Peter E. Amato, John R. Coleman, Tomasz P. Dobrzanski, Donald A. Elmer, Frank W. Gwathmey, April E. Slee, Neil A. Hanson
Summary: This study demonstrates that a preoperative PENG block does not improve analgesia following arthroscopic hip surgery.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Yutaka Osuga, Yoshifumi Seki, Masataka Tanimoto, Takeru Kusumoto, Kentarou Kudou, Naoki Terakawa
Summary: This study evaluated the efficacy and safety of relugolix in treating endometriosis-associated pain, showing that oral administration of relugolix alleviated pain in a dose-response manner and was generally well tolerated. Relugolix demonstrated efficacy and safety comparable to leuprorelin, another treatment option.
FERTILITY AND STERILITY
(2021)
Article
Nutrition & Dietetics
Akifumi Toguchi, Naoto Noguchi, Toshihiro Kanno, Akira Yamada
Summary: This study found that oral consumption of MSM improved knee joint pain and overall health conditions in healthy participants, based on a randomized, double-blind, placebo-controlled trial.
Article
Anesthesiology
Jonathan Vela, Lene Dreyer, Kristian Kjaer Petersen, Lars Arendt-Nielsen, Kirsten Skjaerbaek Duch, Salome Kristensen
Summary: This study aimed to investigate the use of CBD as an adjuvant analgesic therapy in patients with hand osteoarthritis or psoriatic arthritis. The results showed no significant effects of CBD on pain intensity, sleep quality, depression, anxiety, or pain catastrophizing scores compared to placebo.
Article
Gastroenterology & Hepatology
B. D. Wilkie, R. Chandra, J. Chua, D. C. S. Lam, E. D. Paratz, V An, J. O. Keck
Summary: The study found that oral metronidazole did not significantly reduce posthaemorrhoidectomy pain, suggesting it should not be routinely used as an adjunct to analgesia.
COLORECTAL DISEASE
(2021)
Article
Oncology
Jason A. Chesney, Antoni Ribas, Georgina Long, John M. Kirkwood, Reinhard Dummer, Igor Puzanov, Christoph Hoeller, Thomas F. Gajewski, Ralf Gutzmer, Piotr Rutkowski, Lev Demidov, Petr Arenberger, Sang Joon Shin, Pier Francesco Ferrucci, Andrew Haydon, John Hyngstrom, Johannes van Thienen, Sebastian Haferkamp, Josep Malvehy Guilera, Bernardo Leon Rapoport, Ari VanderWalde, Scott J. Diede, James R. Anderson, Sheryl Treichel, Edward L. Chan, Sumita Bhatta, Jennifer Gansert, Frank Stephen Hodi, Helen Gogas
Summary: In this phase III study, the combination of T-VEC and pembrolizumab did not significantly improve progression-free survival or overall survival in patients with advanced melanoma. These findings indicate that this combination therapy is not effective in this patient population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Lucio Marinelli, Luca Puce, Laura Mori, Massimo Leandri, Gian Marco Rosa, Antonio Curra, Francesco Fattapposta, Carlo Trompetto
Summary: This study suggests that the use of nabiximols is likely safe in stroke patients, but no significant improvement in spasticity was observed. This may be due to the low pain levels in the recruited patients or different spasticity mechanisms between post-stroke and multiple sclerosis patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Anesthesiology
Milly Rambhia, An Chen, Amanda H. Kumar, W. Michael Bullock, Michael Bolognesi, Jeffrey Gadsden
Summary: Genicular nerve blockade is associated with a reduction in opioid consumption at 24 hours in patients undergoing primary total knee arthroplasty.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2021)
Article
Orthopedics
M. A. Karsdal, K. M. Verburg, C. R. West, A. C. Bay-Jensen, D. S. Keller, R. H. G. P. Arends
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Clinical Neurology
Leslie Tive, Alfonso E. Bello, David Raclin, Thomas J. Schnitzer, Ha Nguyen, Mark T. Brown, Christine R. West
JOURNAL OF PAIN RESEARCH
(2019)
Article
Medicine, General & Internal
Thomas J. Schnitzer, Richard Easton, Shirley Pang, Dennis J. Levinson, Glenn Pixton, Lars Viktrup, Isabelle Davignon, Mark T. Brown, Christine R. West, Kenneth M. Verburg
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2019)
Letter
Rheumatology
Francis Berenbaum, Francisco J. Blanco, Ali Guermazi, Kenji Miki, Takaharu Yamabe, Lars Viktrup, Rod Junor, William Carey, Mark T. Brown, Christine R. West, Kenneth M. Verburg
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Anesthesiology
John D. Markman, Robert B. Bolash, Timothy E. McAlindon, Alan J. Kivitz, Manuel Pombo-Suarez, Seiji Ohtori, Frank W. Roemer, David J. Li, Lars Viktrup, Candace Bramson, Christine R. West, Kenneth M. Verburg
Article
Rheumatology
Thomas J. Schnitzer, Arifulla Khan, Louis Bessette, Isabelle Davignon, Mark T. Brown, Glenn Pixton, William R. Prucka, Leslie Tive, Lars Viktrup, Christine R. West
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2020)
Correction
Clinical Neurology
L. Tive, A. E. Bello, D. Radin
JOURNAL OF PAIN RESEARCH
(2020)
Article
Rheumatology
Marc C. Hochberg, John A. Carrino, Thomas J. Schnitzer, Ali Guermazi, David A. Walsh, Alexander White, Satoru Nakajo, Robert J. Fountaine, Anne Hickman, Glenn Pixton, Lars Viktrup, Mark T. Brown, Christine R. West, Kenneth M. Verburg
Summary: In patients with stable NSAID therapy, subcutaneous tanezumab resulted in more joint safety events than continued NSAIDs, with differences dependent on dosage. Tanezumab 5 mg significantly improved pain and physical function at 16 weeks compared to NSAIDs.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Anesthesiology
Francis Berenbaum, Richard Langford, Serge Perrot, Kenji Miki, Francisco J. Blanco, Takaharu Yamabe, Naoki Isogawa, Rod Junor, William Carey, Lars Viktrup, Christine R. West, Mark T. Brown, Kenneth M. Verburg
Summary: Subcutaneous tanezumab reduced pain within the first week and improvements in pain and function were sustained over 24 weeks compared with placebo.
EUROPEAN JOURNAL OF PAIN
(2021)
Article
Rheumatology
Thomas J. Schnitzer, Francis Berenbaum, Philip G. Conaghan, Robert H. Dworkin, Davide Gatti, Ruoyong Yang, Lars Viktrup, Isabelle Davignon, Christine R. West, Kenneth M. Verburg
Summary: In this study, it was found that patients who showed improvement of 30% or more in pain and function domains were mostly responders on the pain/function composite endpoint. The separation of tanezumab from placebo was consistent across different endpoints, with better effects observed in patients with knee index joints compared to hip.
RHEUMATOLOGY AND THERAPY
(2021)
Article
Clinical Neurology
Shin-Ichi Konno, Takuya Nikaido, John D. Markman, Makoto Ohta, Toshiya Machida, Naoki Isogawa, Hiroki Yoshimatsu, Lars Viktrup, Mark T. Brown, Christine R. West, Kenneth M. Verburg
Summary: This study examined the long-term use of tanezumab in Japanese patients with chronic low back pain and found that tanezumab was well tolerated with improvements in symptoms.
Article
Surgery
Michael A. Mont, Takaharu Yamabe, John A. Carrino, Lars Viktrup, Mary Anne Nemeth, Mark T. Brown, Aimee Burr, Christine R. West, Kenneth M. Verburg
Summary: This study evaluated the postoperative outcomes of patients who had undergone total joint replacement while participating in tanezumab randomized phase 3 OA studies, showing infrequent procedural difficulties, complications, and corrective procedures, which were more common in patients adjudicated as normal progression of OA.
SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH
(2021)
Article
Rheumatology
Francis Berenbaum, Francisco J. Blanco, Ali Guermazi, Kenji Miki, Takaharu Yamabe, Lars Viktrup, Rod Junor, William Carey, Mark T. Brown, Christine R. West, Kenneth M. Verburg
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Review
Toxicology
Patrice Belanger, Christine R. West, Mark T. Browne
JOURNAL OF TOXICOLOGICAL SCIENCES
(2018)
Article
Neurosciences
Patricia A. Walicke, Franz Hefti, Roxanne Bales, Shiao-Ping Lu, Jon L. Ruckle, Mark T. Brown, Christine R. West, David L. Shelton