Article
Immunology
Xin Jin, Jia Chen, Jian Wu, Ying Lu, Baohua Li, Wenning Fu, Wei Wang, Dawei Cui
Summary: This study found significant differences in the frequency of cTfh cell subsets and associated B cell subsets between active and inactive SLE patients, with elevated levels of cytokines associated with cTfh cells in active SLE patients. Additionally, Tfh cell subsets and plasmablasts may have important roles in the pathogenesis of SLE and could be potential targets for therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Daeun Choi, Jimin Kim, Jae Won Yang, Ji Hong Kim, Seoyeon Park, Jae Il Shin
Summary: Systemic lupus erythematosus is a chronic autoimmune disease with heterogeneous clinical presentation. Epigenetic factors, particularly microRNAs, have therapeutic potential in SLE pathogenesis. This review summarizes the current understanding of lupus pathogenesis, focusing on dysregulation of microRNAs in patients compared to healthy controls, as well as their potential pathogenic roles. Controversial microRNAs and future research directions are also discussed. Additionally, the importance of considering the specimen used to assess microRNA dysregulation in studies is emphasized.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell & Tissue Engineering
Mingchao Zhang, Takerra K. Johnson-Stephenson, Weiran Wang, Yang Wang, Jing Li, Limin Li, Ke Zen, Xi Chen, Dihan Zhu
Summary: Exosomes from bone marrow-derived mesenchymal stem cells promote the anti-inflammatory polarization of macrophages and alleviate lupus nephritis by consuming apoptotic debris and inducing the recruitment of regulatory T cells.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Fanny Urbain, Maharajah Ponnaiah, Farid Ichou, Marie Lhomme, Clement Materne, Sophie Galier, Julien Haroche, Eric Frisdal, Alexis Mathian, Herve Durand, Micheline Pha, Miguel Hie, Anatol Kontush, Philippe Cluzel, Philippe Lesnik, Zahir Amoura, Maryse Guerin, Fleur Cohen Aubart, Wilfried Le Goff
Summary: This study uncovers the contribution of disturbed metabolism to the presence of coronary artery calcium and the associated risk of coronary heart disease in patients with systemic lupus erythematosus (SLE). Identification of novel lipid and metabolite biomarkers may help stratifying patients for reducing cardiovascular disease morbidity and mortality in SLE.
Review
Immunology
Tomohiro Koga, Kunihiro Ichinose, Atsushi Kawakami, George C. Tsokos
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease with IL-17-producing cells playing a key role in its pathogenesis, making them a therapeutic target. Targeting IL-17 for treatment shows promising potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wenqian Wang, Chenran Yue, Sheng Gao, Shuting Li, Jianan Zhou, Jiaqing Chen, Jiahong Fu, Weijian Sun, Chunyan Hua
Summary: Exosomal miRNAs show potential as biomarkers in SLE/LN patients for renal injury diagnosis. Exosomes are considered optimal delivery vehicles due to their high stability, minimal toxicity, low immunogenicity, and specific target effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ruben Osuna-Gomez, Ivan Castellvi, Maria Mulet, Ma Angels Ortiz, Douglas E. Brough, Helen Sabzevari, Roshanak T. Semnani, Silvia Vidal
Summary: This study investigated the role of IL-35 in systemic sclerosis (SSc) patients, focusing on CD4+ T cell response and immunomodulatory cytokine production. The study found significantly lower plasma IL-35 concentrations in SSc patients, and the levels of IL-35 showed a negative correlation with TGF-beta and IL-17. Flow cytometry analysis revealed higher levels of IL-35 receptor expression on monocytes and lower levels on CD8+ T cells in SSc patients. The addition of recombinant IL-35 reduced the percentage of IL-17+CD4+ T cells and increased the percentage of IL-35+CD4+ T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Yi-Giien Tsai, Pei-Fen Liao, Kai-Hung Hsiao, Hung-Ming Wu, Ching-Yuang Lin, Kuender D. Yang
Summary: Systemic lupus erythematosus (SLE) is a heterogeneous multisystem inflammatory disease. Immune regulatory cells, particularly Treg subsets, and low-dose IL-2 therapy play important roles in the pathogenesis and treatment of SLE.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Swayanka Biswas, Katja Bieber, Rudolf Armin Manz
Summary: IL-10 is a cytokine that has pleiotropic effects on immune cells, including both suppressive and activating functions. It plays a dual role in Systemic lupus Erythematosus (SLE), inhibiting pro-inflammatory effector functions while also promoting extrafollicular antibody response. IL-10 is produced by B cells, myeloid cells, and certain T cell subsets, and it drives B cell responses, proliferation, class switching, and plasma cell formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
M. Constanza Baroni Pietto, Paola R. Lev, Ana C. Glembotsky, Cecilia P. Marin Oyarzun, Graciela Gomez, Victoria Collado, Cecilia Pisoni, Ramiro A. Gomez, Matias Grodzielski, Jacqueline Gonzalez, Karina Marino, Paula G. Heller, Nora P. Goette, Rosana F. Marta
Summary: The study found that systemic lupus erythematosus (SLE) patients with thrombocytopenia have abnormalities in platelet clearance and production, mainly due to apoptosis and desialylation leading to low platelet count. These abnormalities are more frequently observed in patients with thrombocytopenia and active disease.
Article
Multidisciplinary Sciences
Mengmeng Xiang, Yang Feng, Yilun Wang, Jie Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This meta-analysis revealed that the circulating level of interleukin-18 is significantly higher in systemic lupus erythematosus (SLE) patients compared to healthy controls. Patients with higher SLEDAI scores, Asian, White, Arab, or mixed ethnicity tend to have elevated levels of IL-18, indicating the potential role of IL-18 in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Izumi Kurata, Natsuko Mikami, Ayako Ohyama, Atsumu Osada, Yuya Kondo, Hiroto Tsuboi, Takayuki Sumida, Isao Matsumoto
Summary: The study found that SLE-TFR cells have functional defects in suppressing TFH cells, leading to decreased ability to inhibit them, and their PD-1 expression is correlated with disease activity and antibody levels. However, low-dose IL-2 therapy may be helpful in restoring this inhibitory function.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Liseth Carmona-Perez, Mauricio Rojas, Carlos Munoz-Vahos, Adiana Vanegas-Garcia, Gloria Vasquez
Summary: In patients with active SLE, there is an increase in plasma MPs concentration that correlates positively with the SLEDAI score. CD14+ MPs are significantly more abundant in patients with SLE compared to healthy controls. SLE MPs have decreased levels of miR-146a, but increased levels of miR-126 in aSLE MPs, which correlates positively with the SLEDAI score.
Article
Immunology
Jijuan Yang, Chun Li, Shuhong Chi, Hongliang Wei, Wenqing Du, Qikuan Hu
Summary: This study identified the upregulation of miRNA miR-762 in both SLE and NPSLE samples, which can suppress the expression of GIPC3 and may be involved in the development of SLE and NPSLE.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Rheumatology
Xiang Guo, Brandon W. Higgs, Anne-Christine Bay-Jensen, Yuling Wu, Morten A. Karsdal, Michael Kuziora, Alex Godwood, David Close, Patricia C. Ryan, Lorin K. Roskos, Wendy I. White
Article
Gastroenterology & Hepatology
Jian Xin Zheng, Yuan Jia Tang, Tai Hua Yang, Tian Qin, Jin Chuan Liu, Xiang Qian Gu, Feng Xue, Qiang Xia
JOURNAL OF DIGESTIVE DISEASES
(2019)
Article
Cell Biology
Yonggang Zhou, Binqing Fu, Xiuxiu Xu, Jinghe Zhang, Xianhong Tong, Yanshi Wang, Zhongjun Dong, Xiaoren Zhang, Nan Shen, Yiwen Zhai, Xiangdong Kong, Rui Sun, Zhigang Tian, Haiming Wei
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Rheumatology
Jun Li, Huihua Ding, Yao Meng, Guanhua Li, Qiong Fu, Qiang Guo, Zhihua Yin, Zhizhong Ye, Haibo Zhou, Nan Shen
ARTHRITIS & RHEUMATOLOGY
(2020)
Biographical-Item
Rheumatology
Nan Shen, Peter E. Lipsky
Article
Rheumatology
Yan Ye, Xueliang Zhang, Teng Li, Jiaqiang Ma, Ran Wang, Chunmei Wu, Runci Wang, Chunde Bao, Shuang Ye, Nan Shen, Qiang Guo, Qiong Fu, Xiaoming Zhang
Summary: The aim of this study was to identify immunologic features and biomarkers predicting prognosis in patients with ADM-ILD. The results showed that patients with ADM-ILD can be stratified based on immune cell subsets, which can predict disease activity and clinical outcomes, and immunophenotype is an independent risk factor associated with prognosis.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Engineering, Biomedical
Jiali Zhang, Qianqian Guo, Dai Dai, Jian Yu, Liting Wang, Zhihua Wu, Huihua Ding, Nan Shen, Yourong Duan
Summary: Excessive CD4(+ )T helper (Th)-B-cell interactions and loss of Treg homeostasis are crucial to the pathogenesis of systemic lupus erythematosus (SLE). In this study, RAP-encapsulated ICOS/CD40L bispecific nanoparticles were designed to selectively target SLE Th cells and inhibit Th-B-cell reciprocal activation, with the sustained release of RAP further promoting the expansion of Treg cells and alleviating SLE progression without obvious toxicity.
Article
Medicine, General & Internal
J. J. Shin, W. Fanr, J. Par-Youngs, M. Piecychna, L. Leng, K. Israni-Winger, H. Qing, J. Gu, H. Zhao, W. L. Schulz, S. Unlu, J. Kuster, G. Young, J. Liu, A. Ko, A. Baeza Garcia, M. Sauler, A. Wisnewski, L. Young, A. Orduna, A. Wang, K. Ocskay, A. Garcia-Blesa, P. Hegyi, M. E. Armstrong, P. D. Mitchell, D. Bernardo, A. Garami, I Kang, R. Bucala
Summary: This study found that the high-expression MIF CATT(7) allele was less frequent in COVID-19 patients compared to healthy controls, but more frequent in hospitalized patients compared to outpatients. In addition, hospitalized COVID-19 patients had higher serum MIF levels compared to outpatients and uninfected healthy controls. Experimental mice with a high-expression MIF allele showed more severe disease than those with a low-expression MIF allele. Therefore, the polymorphism of the MIF gene is associated with susceptibility to COVID-19 and disease severity.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Rheumatology
Wei Fan, Jennefer Par-Young, Kaiyan Li, Yi Zhang, Pingping Xiao, Li Hua, Lin Leng, Xuyan Chen, Richard Bucala
Summary: This retrospective study aimed to describe the clinical profiles and high-risk indicators of primary Sjogren's syndrome (pSS) patients with central nervous system (CNS) involvement (pSS-CNS). The study found that the prevalence of CNS involvement in pSS patients was 10.2%, with neurological manifestations as the initial symptom in 31.3% of the cases. Hemiparesis, paraparesis, dysphonia, blurred vision, and dysfunctional proprioception were common manifestations in pSS-CNS patients. Cerebral infarction, demyelination, myelitis, and angiostenosis were commonly found on imaging in these patients. Lung involvement, positive anti-SSA antibody test, and reduced C3 levels were identified as potential risk factors for CNS involvement in pSS. High-dose glucocorticoids and immunosuppressive therapy were effective in improving the condition in 60% of pSS-CNS patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Immunology
Zhaorui Cheng, Guojun Hou, Nan Shen
Summary: Autoimmune diseases (ADs) are characterized by autoreactive immune cells and inflammation. Non-coding RNAs (ncRNAs) have been found to play a significant role in ADs and immune responses. Dysregulation of ncRNAs in immune cells disrupts immune homeostasis and is implicated in various ADs. ncRNAs could be potential biomarkers for AD diagnosis and therapeutic targets. This review focuses on recent studies on the involvement of ncRNAs in autoimmunity and ADs.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Danting Zhang, Fangfang Sun, Jie Chen, Huihua Ding, Xiaodong Wang, Nan Shen, Ting Li, Shuang Ye
Summary: Four trajectories of 24-hour urine protein in lupus nephritis were identified and user-friendly nomograms were developed to predict treatment response. These findings have important implications for guiding the management of lupus nephritis and designing clinical trials.
Article
Rheumatology
Huihua Ding, Cheng Lin, Jingyi Cai, Qiang Guo, Min Dai, Chandra Mohan, Nan Shen
ARTHRITIS RESEARCH & THERAPY
(2020)
Article
Rheumatology
Jing Zeng, Xinyu Meng, Ping Zhou, Zhihua Yin, Qinglian Xie, Hong Zou, Nan Shen, Zhizhong Ye, Yuanjia Tang
ARTHRITIS RESEARCH & THERAPY
(2019)
Article
Immunology
Jiayi Zheng, Ruru Guo, Yuanjia Tang, Qiong Fu, Jie Chen, Lingling Wu, Lin Leng, Richard Bucala, Yang Song, Liangjing Lu
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Oncology
Rajiv Raja, Michael Kuziora, Philip Z. Brohawn, Brandon W. Higgs, Ashok Gupta, Phillip A. Dennis, Koustubh Ranade
CLINICAL CANCER RESEARCH
(2018)