Article
Health Care Sciences & Services
Jing Xu, Jiarui Ou, Chen Li, Zheng Zhu, Jian Li, Hailun Zhang, Junchen Chen, Bin Yi, Wu Zhu, Weiru Zhang, Guanxiong Zhang, Qian Gao, Yehong Kuang, Jiangning Song, Xiang Chen, Hong Liu
Summary: A machine learning model was developed to diagnose Psoriatic arthritis (PsA) and analyze its progression risk using 3961 patients' clinical records. General additive models (GAMs) and the Kaplan-Meier method were applied to analyze the efficacy of various drugs on psoriasis treatment and inhibiting PsA progression. The results showed accurate prediction of PsA and its progression and analysis of drug efficacy.
NPJ DIGITAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ruijie Cao, Zhongqiang Yao, Zhuohua Lin, Pengqing Jiao, Ligang Cui
Summary: This study compared the performance of the 2022 ACR/EULAR classification criteria for Takayasu's arteritis (TAK) with the 1990 ACR criteria in a Chinese population. The 2022 criteria showed superior sensitivity, positive predictive value, negative predictive value, accuracy, and AUC compared to the 1990 criteria. Adding new imaging modalities to the 1990 criteria improved its performance, but it still lagged behind the 2022 criteria.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Rheumatology
Angela Mc Ardle, Anna Kwasnik, Agnes Szentpetery, Belinda Hernandez, Andrew Parnell, Wilco Jager, Sytze Roock, Oliver FitzGerald, Stephen R. Pennington
Summary: Analysis of serum proteins using different technical platforms can differentiate patients with early inflammatory arthritis with psoriatic arthritis from those with rheumatoid arthritis. Subsequent validation studies confirmed a subset of proteins measured by multiple reaction monitoring can effectively differentiate PsA and RA patients.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Immunology
Martin Aringer, Karen Costenbader, Thomas Doerner, Sindhu R. Johnson
Summary: This article reviews the evolution of classification criteria for systemic lupus erythematosus (SLE) and discusses the current gold standard criteria developed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). The article explores the implications of these criteria on the definition and management of SLE.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Medicine, General & Internal
Oliver FitzGerald, Alexis Ogdie, Vinod Chandran, Laura C. Coates, Arthur Kavanaugh, William Tillett, Ying Ying Leung, Maarten deWit, Jose U. Scher, Philip J. Mease
Summary: Psoriatic arthritis (PsA) is a complex inflammatory disease related to psoriasis, presenting challenges in diagnosis and treatment. There are no diagnostic criteria or tests available, and disease heterogeneity may be explained by differences in genotype. New targeted therapies have shown promise in improving outcomes for PsA patients.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Review
Medicine, General & Internal
Tania Gudu, Beverly Ng, Hannah Jethwa, Catherine Graham, Veda Kudva, Jashmitha Rammanohar, Chen Zhang, Mark Sapsford, Deepak R. Jadon
Summary: This review evaluated the role of ultrasound (US) in the early diagnosis of psoriatic arthritis (PsA). The study found that PsA patients had a higher frequency of US abnormalities, particularly enthesis and Power Doppler (PD) signal. US-detected entheseal abnormalities were more frequent in PsA patients compared to other conditions.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Ruben Queiro, Pablo Coto-Segura, Ignacio Brana, Marina Pino, Stefanie Burger
Summary: This study analyzed the potential connections between human leukocyte antigen-C*06 (HLA-C*06) and the cardiometabolic profile of psoriatic disease patients. The results showed that patients carrying HLA-C*06 had an earlier age of onset, more severe skin disease, but after adjusting for age, sex, and disease duration, they demonstrated a lower prevalence of hypertension, smaller waist circumference, and lower BMI.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Bastiaan T. van Dijk, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Summary: ITI is commonly found in patients with early RA and other arthritides, particularly in hand joints. It is associated with clinical symptoms such as hand arthritis and increased acute-phase reactants. In RA, ITI is related to local MCP joint synovitis, tenosynovitis, and osteitis, as well as joint tenderness and swelling.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Medicine, General & Internal
Tomoyuki Hioki, Mayumi Komine, Mamitaro Ohtsuki
Summary: Psoriatic arthritis is a chronic inflammatory disorder that can cause deformities and joint damage, impacting quality of life. Early diagnosis and intervention are important to prevent permanent disability, but the clinical features overlap with other diseases, making early detection and intervention challenging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Antonio Wong, Justine Y. Ye, Richard J. Cook, Dafna D. Gladman, Vinod Chandran
Summary: This study found that symptoms of anxiety/depression reduce the probability of achieving sustained MDA in PsA patients. Comprehensive management of PsA should include measures to address these comorbidities.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Immunology
Javier Narvaez, Paula Estrada, Paola Vidal-Montal, Joan Miquel Nolla
Summary: This study confirms that the new classification criteria for GCA are more sensitive than the old ACR criteria in real-life clinical settings, across all clinical phenotypes.
AUTOIMMUNITY REVIEWS
(2023)
Article
Rheumatology
Sara Nysom Christiansen, Mikkel Ostergaard, Ole Slot, Viktoria Fana, Lene Terslev
Summary: Ultrasound, specifically for double contour and tophus, shows high specificity, positive predictive values, and accuracies in diagnosing gout. However, lower specificities were found for aggregates and erosions. Ultrasound examination of MTP joints for double contour or tophus was sufficient to identify all MSU-positive patients with gout signs.
Article
Rheumatology
Michele Maria Luchetti Gentiloni, Valentino Paci, Ilaria Cimaroli, Alice Agostinelli, Melania Giannoni, Anna Campanati, Federico Diotallevi, Marina Carotti, Francesco Sessa, Raffaella Sordillo, Cristina Macchini, Federico Fiorini, Leonardo Massaccesi, Monia Ciferri, Marco Gigli, Valentina Marconi, Lucia Perini, Andrea Marani, Andrea Giovagnoni, Gabriele Polonara, Anna Maria Offidani, Devis Benfaremo, Fabian Proft, Denis Poddubnyy, Gianluca Moroncini
Summary: A dermatology-based screening strategy proved to be valuable in detecting and characterizing patients with axial PsA in a cohort of psoriasis patients. It also helped identify a substantial number of undiagnosed peripheral PsA patients.
Article
Rheumatology
Asami Ohara, Naomi Iwata, Shiro Sugiura, Naoki Abe, Haruna Nakaseko, Shinji Kawabe
Summary: This study compared the sensitivity and specificity of the EULAR/ACR-2019 criteria with prior classification schemes for cSLE patients. The EULAR/ACR-2019 criteria had high sensitivity but low specificity, while the original criteria reported earlier in 2019 may offer higher specificity and be more appropriate for classifying SLE in a pediatric population.
CLINICAL RHEUMATOLOGY
(2022)
Article
Surgery
N. J. Preston, G. A. McHugh, E. M. A. Hensor, A. J. Grainger, P. J. O'Connor, P. G. Conaghan, M. H. Stone, S. R. Kingsbury
Summary: This study evaluated the feasibility and acceptability of a standardized virtual clinic (VC) approach for the follow-up of hip and knee total joint arthroplasty (TJA) patients. The results suggest that a standardized VC is a feasible alternative for TJA patients and is acceptable to key stakeholders.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2023)
Article
Orthopedics
Alan Brett, Michael A. Bowes, Philip G. Conaghan
Summary: This study aimed to compare CT and MRI assessments of 3D imaging biomarkers. The results showed a strong correlation between CT and MRI measurements of B-scores, but there were some biases in area measurements. Additionally, there were different biases in 3D joint space width between the lateral and medial compartments.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn, Antonella Delmestri, Lindsay K. K. Smith, Andrew Judge, Sarah R. R. Kingsbury, Martin H. H. Stone, Philip G. G. Conaghan
Summary: Follow-up visits after primary hip or knee replacement surgery have been recommended, but their benefits have not been specifically examined. This study found that patients attending follow-up visits had a higher risk of revision surgery.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Editorial Material
Orthopedics
Tonia L. Vincent, Philip G. Conaghan
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Xuanxiao Xie, Gina M. Doody, Farag Shuweihdi, Philip G. Conaghan, Frederique Ponchel
Summary: B cells in patients with OA show altered proliferation and differentiation capabilities, but are still able to produce antibodies, especially in the synovium.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Jean-Yves Reginster, Nasser M. Al-Daghri, Jotheeswaran A. Thiyagarajan, Charlotte Beaudart, Olivier Bruyere, Nansa Burlet, Manju Chandran, Mario Coelho da Silva, Philip G. Conaghan, Willard H. Dere, Adolfo Diez-Perez, Peyman Hadji, Philippe Halbout, Mickael Hiligsmann, John A. Kanis, Eugene V. McCloskey, Sif Ormarsdottir, Daniel Prieto-Alhambra, Regis P. Radermecker, Rene Rizzoli, Yousef Al-Saleh, Stuart L. Silverman, Lee S. Simon, Friederike Thomasius, Tjeerd van Staa, Andrea Laslop, Cyrus Cooper, Nicholas C. Harvey
Summary: This narrative review summarises the recommendations of a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO) for real-world evidence studies in osteoporosis research. The review emphasizes the importance of conducting research using real-world data to the highest standards and ensuring transparency throughout the study process.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Rheumatology
Gurjit S. Kaeley, Georg Schett, Philip G. Conaghan, Dennis McGonagle, Frank Behrens, Philippe Goupille, Corine Gaillez, Bhumik Parikh, Catherine Bakewell
Summary: This study evaluated the treatment response of enthesitis in PsA patients treated with secukinumab or adalimumab for 52 weeks. The results showed that both drugs had similar efficacy in resolving enthesitis, including time to resolution. The authors concluded that inhibition of IL-17 with secukinumab reduced clinical enthesitis similarly to TNF-alpha inhibition with adalimumab.
Article
Rheumatology
Kaleb Michaud, Philip G. Conaghan, Sang Hee Park, Karissa Lozenski, Mirko Fillbrunn, Vadim Khaychuk, Elyse Swallow, John Vaile, Henry Lane, Ha Nguyen, Janet Pope
Summary: The efficacy of abatacept is enhanced in anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF)-positive patients with rheumatoid arthritis (RA). Analysis of four early RA abatacept trials revealed that abatacept had a differential impact on SPEAR and non-SPEAR patients.
RHEUMATOLOGY AND THERAPY
(2023)
Review
Rheumatology
Agata Burska, Javier Rodriguez-Carrio, Robert Biesen, Willem A. Dik, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, P. G. Conaghan, Marjan Versnel, Ed Vital
Summary: This study systematically reviewed the literature on assay methods for evaluating type I interferon (IFN-I) pathway activation and aimed to harmonize related terminology. Data from 276 papers on 412 methods were extracted and summarized. Consensus terminology was developed to define different aspects of IFN-I research and practice.
Review
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, P. G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Ed Vital, Marjan Versnel
Summary: This article provides a systematic review of assays measuring IFN-I pathway activation and summarizes the potential clinical utility in various rheumatic and musculoskeletal diseases. The results show that IFN-I pathway activation is associated with disease diagnosis, disease activity assessment, prognosis, response to treatment, and assay responsiveness. However, the heterogeneity in techniques and technical conditions are major limitations.
Article
Rheumatology
Anna Dossing, Marius Henriksen, Karen Ellegaard, Sabrina Mai Nielsen, Lisa K. Stamp, Felix C. Mueller, Margreet Kloppenburg, Ida K. Haugen, Geraldine M. McCarthy, Philip G. Conaghan, Louise Ulff-Moller Dahl, Lene Terslev, Roy D. Altman, Fabio Becce, Elisabeth Ginnerup-Nielsen, Lene Jensen, Mikael Boesen, Robin Christensen, Ulla Dal, Henning Bliddal
Summary: This study aimed to investigate the efficacy and safety of colchicine compared to placebo in the treatment of hand osteoarthritis. The results showed that treatment with colchicine did not effectively relieve finger pain and was associated with more adverse events.
LANCET RHEUMATOLOGY
(2023)
Article
Orthopedics
John A. Carrino, Timothy E. McAlindon, Tom J. Schnitzer, Ali Guermazi, Marc C. Hochberg, Philip G. Conaghan, Mark T. Brown, Aimee Burr, Robert J. Fountaine, Glenn C. Pixton, Lars Viktrup, Kenneth M. Verburg, Christine R. West
Summary: This study monitored patients with osteoarthritis who were treated with tanezumab and found that higher doses were associated with increased risk of RPOA, TJR, and CJSE. Patients with more severe symptoms of osteoarthritis were also at higher risk of RPOA. Patients with KL grade 4 joints at baseline had the highest risk of RPOA2 or TJR.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
T. Schnitzer, M. Pueyo, H. Deckx, E. van der Aar, K. Bernard, S. Hatch, M. van der Stoep, S. Grankov, D. Phung, O. Imbert, D. Chimits, K. Muller, M. C. Hochberg, H. Bliddal, W. Wirth, F. Eckstein, P. G. Conaghan
Summary: This study aimed to evaluate the efficacy and safety of the anti-catabolic ADAMTS-5 inhibitor S201086/GLPG1972 for the treatment of symptomatic knee osteoarthritis. The results showed that S201086/GLPG1972 did not significantly reduce rates of cartilage loss or modify symptoms in adults with knee osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Letter
Rheumatology
Anna Dossing, Philip G. Conaghan, Lisa K. Stamp, Geraldine M. McCarthy, Marius Henriksen, Robin Christensen, Lene Terslev, Karen Ellegaard, Niels Henrik Soe, Lars Juul, Philip Hansen, Dimitar Ivanov Radev, Janus Damm Nybing, Mikael Boesen, Henning Bliddal
Article
Rheumatology
Dawn Groves-Williams, Elizabeth C. Lavender, Christine Comer, Mark Conner, Rachel K. Nelligan, Kim L. Bennell, Sarah R. Kingsbury, Philip G. Conaghan, Gretl A. McHugh
MUSCULOSKELETAL CARE
(2023)