Review
Immunology
Zi-Yi Song, Duo Yuan, Sheng-Xiao Zhang
Summary: Ankylosing spondylitis is a chronic condition that affects the spine and sacroiliac joints, with multifactorial etiology and pathogenesis that remain elusive. Gut microbiota as an environmental factor plays a critical role in the pathogenesis of AS through various mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi
Summary: HLA-B27 positive patients with axial spondyloarthritis (AxSpA) tend to have lower disease activity compared to HLA-B27 negative patients, as indicated by higher BASDAI scores. HLA-B27 positive patients with mild back pain are more likely to be diagnosed with AxSpA, suggesting a cognitive bias introduced by the HLA-B27 test.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Zena Chen, Xuqi Zheng, Xinyu Wu, Jialing Wu, Xiaomin Li, Qiujing Wei, Xi Zhang, Linkai Fang, Ou Jin, Jieruo Gu
Summary: The study found that the gut microbiome was significantly restored in AS patients after adalimumab therapy, with a higher abundance of Comamonas in non-responders compared to responders, although no statistical difference was observed. These results suggest the potential of gut microbiome as biomarkers for therapeutic evaluation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Javier Fernandez-Torres, Yessica Zamudio-Cuevas, Nathalie Montano-Armendariz, Ivan Alejandro Lujan-Juarez, Roberto Sanchez-Sanchez, Karina Martinez-Flores
Summary: The study found that variants of the ERAP1 gene may interact with smoking to increase the risk of AS in patients, especially those carrying the B27 allele.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Immunology
Denis Wakefield, Daniel Clarke, Peter McCluskey
Summary: Over the past 5 years, there has been steady progress in understanding the pathogenesis, clinical features, and treatment of acute anterior uveitis (AU). Large gene wide association studies have confirmed AU as a polygenic disease with overlaps with other conditions. Recent research has shown the importance of the microbiome in AU, with evidence suggesting that HLA B27 may influence gut microbiome composition. Clinical investigations have confirmed the typical features of AU and the value of immunosuppressive treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
Chin-Man Wang, Ming-Kun Liu, Yeong-Jian Jan Wu, Jing-Chi Lin, Jian-Wen Zheng, Jianming Wu, Ji-Yih Chen
Summary: The study examined the impact of ERAP1 allelic variants and their interaction with HLA-B27 on ankylosing spondylitis susceptibility. It discovered multiple ERAP1 SNVs and allelic variants in Taiwanese individuals, and found that ERAP1 variants significantly contribute to the development of AS in a HLA-B27-dependent manner.
Review
Clinical Neurology
Naiwen Hu, Dongxia Liu, Na Zhao, Xia Wang, Yanyan Bai, Hongsheng Sun
Summary: The study found significant associations between TNF-238, -308, -857, -1031, and -863 minor alleles and AS susceptibility in the HLA-B27 positive population. However, no association was found between TNF polymorphisms and AS in the HLA-B27-positive patients group and the HLA-B27-positive healthy controls group. Other gene SNPs may play a role in AS susceptibility in the HLA-B27-positive population.
EUROPEAN SPINE JOURNAL
(2021)
Article
Rheumatology
Rodrigo Garcia-Salinas, Santiago Ruta, Jessica Torres Chichande, Sebastian Magri
Summary: This study aimed to evaluate the frequency of HLA-B27 in Argentinean patients with axial spondyloarthritis and analyze its performance as a diagnostic biomarker. The results showed that HLA-B27-positive patients had an earlier age of onset, higher BASFI, and more extra-articular SpA features. However, HLA-B27 had low sensitivity but good specificity for the diagnosis of SpA.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinbo Yang, Lee I. I. Garner, Ivan V. V. Zvyagin, Michael A. A. Paley, Ekaterina A. A. Komech, Kevin M. M. Jude, Xiang Zhao, Ricardo A. A. Fernandes, Lynn M. M. Hassman, Grace L. L. Paley, Christina S. S. Savvides, Simon Brackenridge, Max N. N. Quastel, M. M. Chudakov, Paul Bowness, Wayne M. M. Yokoyama, Andrew J. J. McMichael, Geraldine M. M. Gillespie, K. Christopher Garcia
Summary: The human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis and the eye. The mechanism by which HLA-B*27 facilitates disease remains unknown, but it may involve the presentation of pathogenic peptides to CD8(+) T cells. In this study, orphan T cell receptors (TCRs) expressing a disease-associated public beta-chain variable region-complementary-determining region 3 beta (BV9-CDR3 beta) motif were isolated from blood and synovial fluid T cells from individuals with ankylosing spondylitis (AS) and from the eye in individuals with acute anterior uveitis (AAU). These TCRs showed consistent alpha-chain variable region (AV21) chain pairing and were clonally expanded in the joint and eye. Using peptide libraries, self-peptides and microbial peptides that activated the AS- and AAU-derived TCRs were identified. Structural analysis revealed that TCR cross-reactivity for peptide-MHC was rooted in a shared binding motif present in both self-antigens and microbial antigens that engages the BV9-CDR3 beta TCRs. These findings suggest that both microbial antigens and self-antigens could play a pathogenic role in HLA-B*27-associated disease.
Article
Rheumatology
Adelmo Segota, Tea Schnurrer-Luke-Vrbanic, Viviana Avancini-Dobrovic, Filip Miric
Summary: The aim of this study was to compare four forms of axial spondyloarthritis (axSpA): non-radiographic axial spondyloarthritis (nr-axSpA), ankylosing spondylitis (AS), non-radiographic axial psoriatic arthritis (nr-axPsA) and radiographic axial psoriatic arthritis (r-axPsA). The study analyzed gender differences, human leukocyte antigen (HLA) typing, laboratory values, radiographic and magnetic resonance scans of 137 patients. The key findings included newly detected HLA typing beyond HLA-27 positivity, which could serve as possible biomarkers for early detection of axSpA.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Magali Berland, Victoria Meslier, Samar Berreira Ibraim, Emmanuelle Le Chatelier, Nicolas Pons, Nicolas Maziers, Florence Thirion, Franck Gauthier, Florian Plaza Onate, Jean-Pierre Furet, Ariane Leboime, Roula Said-Nahal, Florence Levenez, Nathalie Galleron, Benoit Quinquis, Philippe Langella, Stanislav Dusko Ehrlich, Maxime Breban
Summary: This study further characterized the gut microbiota in patients with SpA and found dysbiosis compared to healthy controls. Disease activity and genetic background were shown to influence the composition of the gut microbiota in SpA patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Rheumatology
Lei Wang, Yiwen Wang, Pei Zhang, Chuan Song, Fei Pan, Gang Li, Lihua Peng, Yunsheng Yang, Zhimin Wei, Feng Huang
Summary: This study conducted a systematic review on the characteristics of gut microbiota in patients with Spondyloarthritis (SpA) compared to healthy controls, and found significant differences. Specific taxa-level differences were identified in different subtypes of SpA. The findings lay the groundwork for evidence-based microbial treatment.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Immunology
Fataneh Tavasolian, Robert D. Inman
Summary: Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disability with a complex etiology involving genetic susceptibility, epigenetic modifications, and environmental factors. MicroRNAs and the gut microbiome play critical roles in the immunopathogenesis of AS, suggesting a co-evolutionary symbiotic link between host immunity and the gut microbiome. Significant advances have been made in understanding the immunological mechanisms underlying AS.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
Nan Sheng, Yingying Gao, Hui Li, Wenwen Wang, Linyu Geng, Bo Zhang, Qiang Huang, Xueqin Wang, Lingyun Sun
Summary: This study explored the associations between several single nucleotide polymorphisms (SNPs) in the coding gene of tumor necrosis factor alpha (TNFa) and ankylosing spondylitis (AS) risk. The results showed that the T allele of rs1799724 was associated with increased AS risk, while the A allele of rs361525 was associated with decreased AS risk. Moreover, the contributions of rs1799724 and rs361525 to AS risk were dependent on HLA-B27 status.
FRONTIERS IN IMMUNOLOGY
(2022)
