Article
Multidisciplinary Sciences
Tae-Hwan Kim, Seo Young Park, Ji Hui Shin, Seunghun Lee, Kyung Bin Joo, Bon San Koo
Summary: This retrospective study found a significant correlation between serum alkaline phosphatase (ALP) levels and radiographic changes in patients with ankylosing spondylitis (AS). The study suggests that serum ALP levels measured approximately 5 years before may serve as a surrogate marker for predicting spinal radiographic changes in AS patients.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Desiree van der Heijde, Mikkel Ostergaard, John D. Reveille, Xenofon Baraliakos, Andris Kronbergs, David M. Sandoval, Xiaoqi Li, Hilde Carlier, David H. Adams, Walter P. Maksymowych
Summary: This study evaluates the long-term effect of IXE on radiographic changes in the spine in patients with r-axSpA and identifies potential predictors of progression. The majority of patients had no radiographic progression in the spine through 2 years of treatment.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
John Charles Snow, Kyle Simpson, Proton Rahman, Samuel Howarth, Diana De Carvalho
Summary: The study evaluated the criterion-concurrent validity for a clinically feasible measurement method of measuring spine mobility using tri-axial accelerometers in patients with radiographic Spondyloarthritis. Results showed that the accelerometer method had stronger correlation to radiographic measures in forward bending, while tape measures performed better in lateral bending. The Lateral Spinal Flexion Test and Domjan Test showed the best criterion-concurrent validity among all tests examined in the study.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Rheumatology
Alexandre Sepriano, Sofia Ramiro, Stephanie Wichuk, Praveena Chiowchanwisawakit, Joel Paschke, Desiree van der Heijde, Robert Landewe, Walter P. Maksymowych
Summary: The study found that TNFi can slow down spinal radiographic progression in patients with radiographic axial SpA, which may be partially related to their effects on inflammation as measured by the ASDAS.
ARTHRITIS & RHEUMATOLOGY
(2021)
Review
Medicine, General & Internal
Angelos Kaspiris, Argyris C. C. Hadjimichael, Ioanna Lianou, Ilias D. D. Iliopoulos, Dimitrios Ntourantonis, Dimitra Melissaridou, Olga D. D. Savvidou, Evangelia Papadimitriou, Efstathios Chronopoulos
Summary: Osteoarthritis is a degenerative joint disease that primarily affects weight-bearing joints in middle-aged and elderly patients, leading to dysfunction and pain. This study aimed to explore the pathophysiology of subchondral bone cysts (SBCs) in osteoarthritis, as well as their association with disease progression, clinical symptoms, postoperative outcomes, and potential complications. A literature review on PubMed articles revealed theories involving MMPs secretion, angiogenesis, and enhanced bone turnover as responses to abnormal mechanical loads in the development of SBCs. Additionally, novel therapies such as celecoxib-coated microspheres and local administration of IGF-1 and activated chondrocytes showed promise in hindering SBC expansion and preventing osteoarthritis progression if untreated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Runsheng Wang, Walter P. Maksymowych
Summary: The IL-23/IL-17 pathway plays a crucial role in the pathogenesis of axial spondyloarthritis, with clinical trials showing that monoclonal antibodies targeting IL-17A can improve symptoms and MRI inflammation in patients. Treatment with a bispecific antibody targeting both IL-17A and IL-17F also showed effectiveness in reducing spinal ankylosis development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Shengyuan Zheng, Senbo An, Yan Luo, Djandan Tadum Arthur Vithran, Shaoqu Yang, Bangbao Lu, Zhenhan Deng, Yusheng Li
Summary: HYBID is a new enzyme that degrades hyaluronan and is present in various cells of the human body. Recent research has found that HYBID is over-expressed in chondrocytes and synoviocytes associated with osteoarthritis. High levels of HYBID are significantly correlated with cartilage degeneration and hyaluronic acid degradation in the joints. Additionally, HYBID can contribute to inflammatory responses and tissue fibrosis in the joints, exacerbating osteoarthritis. Understanding the role of HYBID in osteoarthritis could provide new insights for treatment strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Kyung-Ann Lee, So Yun Lee, Se Hee Kim, Hyun-Sook Kim, Hae-Rim Kim, Sang-Hoon Lee
Summary: Pregnancy and delivery do not affect the radiographic progression of the spine and sacroiliac joints in women with radiographic axial spondyloarthritis.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Berthold Hoppe, Christian Schwedler, Hildrun Haibel, Maryna Verba, Fabian Proft, Mikhail Protopopov, Hans-Gert Heuft, Valeria Rios Rodriguez, Anke Edelmann, Martin Rudwaleit, Joachim Sieper, Denis Poddubnyy
Summary: This study found that in patients with axial spondyloarthritis, there is an association between C-reactive protein levels related to radiographic spinal progression and specific coagulation-related genotypes, especially in individuals predisposed to loose fibrin clots susceptible to fibrinolysis.
Review
Immunology
Su Liu, Guoqing Li, Huihui Xu, Qichang Wang, Yihao Wei, Qi Yang, Ao Xiong, Fei Yu, Jian Weng, Hui Zeng
Summary: This systematic review summarizes the literature on the correlation between gut microbiome (GMB) and osteoarthritis (OA) and explores the underlying mechanisms. The findings suggest that dysbiosis of GMB can worsen OA and alterations in GMB composition can affect intestinal permeability and levels of inflammatory factors. However, there is a lack of high-quality studies evaluating the effects of GMB on OA, and future research should focus on prospective, cohort studies combined with multi-omics to clarify the correlation further.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Caroline D. Hoemann, Javier Rodriguez Gonzalez, Jessica Guzman-Morales, Gaoping Chen, Ebrahim Jalali Dil, Basil D. Favis
Summary: This study found that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold, and were compatible with trabecular bone integration. Compared to drill-only defects, the 83-99-PCL scaffold induced angiogenesis and slight bone resorption, with the smallest change in bone volume fraction.
BIOACTIVE MATERIALS
(2022)
Article
Rheumatology
Walter P. Maksymowych, Rebecca Bolce, Gaia Gallo, Emily Seem, Vladimir J. Geneus, David M. Sandoval, Mikkel Ostergaard, Kurisu Tada, Xenofon Baraliakos, Atul Deodhar, Lianne S. Gensler
Summary: This study evaluated the efficacy of ixekizumab in the treatment of patients with radiographic axial SpA, regardless of elevated CRP levels or evidence of spinal inflammation on MRI. Ixekizumab demonstrated significant efficacy in improving symptoms in these patients.
Article
Multidisciplinary Sciences
Dong Woo Han, Yong Seok Choi, Hye Won Kim, Seunghwan Shin, You-Jung Ha, Eun Ha Kang, Jun Won Park, Jin Kyun Park, Kichul Shin, Yeong Wook Song, Yun Jong Lee
Summary: Extracellular PKM2 levels are increased in rheumatoid arthritis (RA) patients and correlated with disease activity and radiographic progression. exPKM2 may regulate RA-related joint damage by affecting osteoclastogenesis.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Tongyu Chen, Wei Wei, Jin Yu, Shuangxiang Xu, Jianjian Zhang, Xiang Li, Jincao Chen
Summary: This review provides an overview of the current advances in the pathophysiology of Moyamoya disease (MMD) and discusses the genetic, angiogenic, and inflammatory factors related to disease progression. Understanding the pathophysiology of MMD may lead to the development of non-surgical approaches to slow or halt the progression of this disease.
Article
Rheumatology
Katharina Ziegeler, Sevtap Tugce Ulas, Denis Poddubnyy, Fabian Proft, Valeria Rios Rodriguez, Judith Rademacher, Kay Geert A. Hermann, Torsten Diekhoff
Summary: Joint shape variations are associated with inflammatory lesions on SI joint MRIs in axSpA patients. This should be taken into consideration in future research on the interplay of mechanical strain and inflammation in axSpA.
Article
Rheumatology
Mikhail Protopopov, Fabian Proft, Stephanie Wichuk, Pedro M. Machado, Robert G. Lambert, Ulrich Weber, Susanne Juhl Pedersen, Mikkel Ostergaard, Joachim Sieper, Martin Rudwaleit, Xenofon Baraliakos, Walter P. Maksymowych, Denis Poddubnyy
Summary: This study compares the ability of MRI and conventional radiography to detect structural lesions indicative of axSpA.
Review
Rheumatology
Ying-Ying Leung, Tatiana V. Korotaeva, Liliana Candia, Susanne Juhl Pedersen, Wilson Bautista Molano, Eric M. Ruderman, Radjesh Bisoendial, Rodolfo Perez-Alamino, Wendy Olsder, Burkhard Moeller, Simeon Grazio, Tania Gudu, Girish M. Mody, Carlos Pineda, Helena Raffayova, Sherry Rohekar, Claudia Goldenstein-Schainberg, Sergio R. Gutierrez Urena, Julio Cesar Casasola Vargas, Bhowmik Meghnathi, Roopa Prasad, Pascal Richette, Jose Roberto S. Miranda, Nikolas Malliotis, Ulla Lindqvist, David Simon, Amara Ezeonyeli, Enrique R. Soriano, Oliver FitzGerald
Summary: The objective of this study was to provide evidence for the efficacy and safety of therapeutic options for the peripheral arthritis domain of PsA for the revised 2021 GRAPPA treatment recommendations. Evidence was derived from new RCTs and recommendations were made for different patient groups based on their treatment history and response. Different classes of therapeutic options were strongly recommended for different patient groups.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Iris Eshed, Torsten Diekhoff, Kay Geert A. Hermann
Summary: Pelvic radiography is recommended as the initial imaging modality for suspected axSpA, but CT and MRI are superior for diagnosing sacroiliitis. Recent findings suggest that low-dose CT of the sacroiliac joints and MRI with sequences sensitive to cortical bone are more accurate and reliable than radiographs.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Correction
Rheumatology
Lykke M. Ornbjerg, Louise Linde, Stylianos Georgiadis, Simon H. Rasmussen, Ulf Lindstrom, Johan Askling, Brigitte Michelsen, Daniela Di Giuseppe, Johan K. Wallman, Karel Pavelka, Jakub Zavada, Michael J. Nissen, Gareth T. Jones, Heikki Relas, Laura Pirila, Matija Tomsic, Ziga Rotar, Arni Jon Geirsson, Bjorn Gudbjornsson, Eirik K. Kristianslund, Irene van der Horst-Bruinsma, Anne Gitte Loft, Karin Laas, Florenzo Iannone, Addolorata Corrado, Adrian Ciurea, Maria J. Santos, Helena Santos, Catalin Codreanu, Nurullah Akkoc, Ozgul S. Gunduz, Bente Glintborg, Mikkel Ostergaard, Merete Lund Hetland
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Rosa Marie Kiil, Ulrich Weber, Anne Gitte Loft, Rikke Damkjaer Maimburg, Anne Grethe Jurik
Summary: This study investigated the prevalence, evolution, and topography of sacroiliac joint MRI lesions in pregnant and postpartum women. The results showed that 41% of women met the current sacroiliitis definition at 12 months postpartum, which may result in false-positive diagnoses of axial spondyloarthritis in postpartum women. The lesions were mainly clustered in the anterior middle joint portions and there were virtually no erosions at 12 months postpartum.
ARTHRITIS & RHEUMATOLOGY
(2023)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Keno K. Bressem, Lisa C. Adams, Fabian Proft, Kay Geert A. Hermann, Torsten Diekhoff, Laura Spiller, Stefan M. Niehues, Marcus R. Makowski, Bernd Hamm, Mikhail Protopopov, Valeria Rios Rodriguez, Hildurn Haibel, Judith Rademacher, Murat Torgutalp, Robert G. Lambert, Xenofon Baraliakos, Walter P. Maksymowych, Janis L. Vahldiek, Denis Poddubny
Article
Rheumatology
Torsten Diekhoff, Denis Poddubnyy, Fabian Proft, Katharina Ziegeler, Dominik Deppe, Christoph Niedermeier, Kay Geert A. Hermann
Summary: By comparing CT and MRI scans of patients with axial SpA, it was found that joint space lesions show increased density and may contain calcified matrix, suggesting new bone formation. The proportion of calcified matrix gradually increases in type C lesions.
Article
Medicine, General & Internal
Dominik Deppe, Katharina Ziegeler, Kay Geert A. Hermann, Fabian Proft, Denis Poddubnyy, Felix Radny, Marcus R. R. Makowski, Maximilian Muhle, Torsten Diekhoff
Summary: This study aimed to evaluate the ability of low-dose dual-energy computed tomography (ld-DECT) virtual non-calcium (VNCa) images to detect bone marrow pathologies in patients with axial spondyloarthritis (axSpA). Sixty-eight patients underwent both ld-DECT and MRI for assessment. The accuracy of ld-DECT in detecting osteitis and fatty bone marrow deposition was evaluated, and correlations with MRI were calculated. The results showed that ld-DECT had limited sensitivity and specificity in detecting these pathologies, and higher radiation might be needed for more accurate analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jakob M. Moller, Lars Boesen, Adam Espe Hansen, Karen Kettles, Vibeke Logager
Summary: The purpose of this study was to quantify the variability of ADC and investigate if there were significant differences in ADC between MRI systems and sequences. A phantom model with fixed ADC values was tested in six MRI systems using different sequences. Statistical analysis revealed significant differences in ADC measurements between vendors, while the variation of ADC between MRI systems and sequences was deemed clinically irrelevant.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Health Care Sciences & Services
Brigitte Michelsen, Mikkel Ostergaard, Michael John Nissen, Adrian Ciurea, Burkhard Moeller, Lykke Midtboll Ornbjerg, Jakub Zavada, Bente Glintborg, Alan Macdonald, Karin Laas, Dan Nordstroem, Bjorn Gudbjornsson, Florenzo Iannone, Pasoon Hellmand, Tore Kristian Kvien, Ana Maria Rodrigues, Catalin Codreanu, Ziga Rotar, Isabel Castrejon Fernandez, Johan Karlsson Wallman, Jiri Vencovsky, Anne Gitte Loft, Maureen Heddle, Sigrid Vorobjov, Anna-Mari Hokkanen, Gerdur Groendal, Marco Sebastiani, Marleen van de Sande, Eirik Klami Kristianslund, Maria Jose Santos, Corina Mogosan, Matija Tomsic, Federico Diaz-Gonzalez, Daniela Di Giuseppe, Merete Lund Hetland
Summary: This is the first report to compare EULAR and national treatment recommendations for PsA patients across Europe, and the first this decade to compare ASAS-EULAR and national treatment recommendations in axSpA patients. An electronic survey was conducted with rheumatologists in 15 European countries from October 2021 to April 2022. The study found variations in adherence to EULAR/ASAS-EULAR recommendations and the use of different medications across countries, highlighting the need for updates and alignment with international recommendations.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Rheumatology
Helena Port, Signe Holm Nielsen, Peder Frederiksen, Sofie Falkenlove Madsen, Anne-Christine Bay-Jensen, Inge Juul Sorensen, Bente Jensen, Anne Gitte Loft, Ole Rintek Madsen, Mikkel Ostergaard, Susanne Juhl Pedersen
Summary: This study investigated whether extracellular matrix (ECM) blood-based biomarkers reflect the pharmacodynamic effect and response to TNF-a inhibitor therapy in patients with axial spondyloarthritis (axSpA). The results showed that ECM metabolites exhibited a pharmacodynamic effect and were associated with ASDAS response.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Walter P. Maksymowych, Jacob L. Jaremko, Susanne J. Pedersen, Iris Eshed, Ulrich Weber, Andrew McReynolds, Paul Bird, Stephanie Wichuk, Robert G. Lambert
Summary: This study compared the performance of two new web-based MRI scoring systems (KIMRISS and MOAKS) in quantification of bone marrow lesions (BML) and synovitis-effusion (S-E). The results showed that KIMRISS had higher reliability and usability in evaluating BML and synovitis. Both methods should be further compared in clinical trials of new therapies for OA.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Rheumatology
Louise Linde, Lykke M. Ornbjerg, Simon H. Rasmussen, Thorvardur Jon Love, Anne Gitte Loft, Jakub Zavada, Jiri Vencovsky, Karin Laas, Dan Nordstrom, Tuulikki Sokka-Isler, Bjorn Gudbjornsson, Gerdur Grondal, Florenzo Iannone, Roberta Ramonda, Pasoon Hellamand, Eirik K. Kristianslund, Tore K. Kvien, Ana M. Rodrigues, Maria J. Santos, Catalin Codreanu, Ziga Rotar, Matija Tomsic, Isabel Castrejon, Federico Diaz-Gonzales, Daniela Di Giuseppe, Lotta Ljung, Michael J. Nissen, Adrian Ciurea, Gary J. Macfarlane, Maureen Heddle, Bente Glintborg, Mikkel Ostergaard, Merete L. Hetland
Summary: This study investigates the differences and commonalities in the set-up, data collection, and patient-reported outcome measures (PROMs) in European clinical registries for axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). The study finds significant heterogeneity in registry design and data collection, but an increase in data completeness of PROMs in recent years. These findings may impact the results of collaborative research in the future.
ARTHRITIS RESEARCH & THERAPY
(2023)