Review
Biochemistry & Molecular Biology
Sofie Eline Tollefsen, Ole Solheim, Patricia Mjones, Sverre Helge Torp
Summary: Meningioma is a common brain tumor without approved specific drugs. This study aims to compile the current insights of somatostatin analogs for treating patients with meningioma. A systematic search was conducted, and 17 eligible studies were evaluated. Although the efficacy of somatostatin analogs remains unclear, some studies suggest that they may be a last-option treatment for severely ill-patients. However, a controlled study or randomized clinical trial is needed to establish their efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Laura Streit, Sophie Moog, Sylvain Hugel, Marion Rame, Emeline Tanguy, Virginie Andry, Herbert A. Schmid, Laurent Brunaud, Florence Bihain, Claire Nomine-Criqui, Yannick Goumon, Stephanie Lacomme, Sandra Lomazzi, Michel Vix, Didier Mutter, Nicolas Vitale, Stephane Ory, Stephane Gasman
Summary: NETs like pheochromocytoma can cause severe symptoms and life-threatening conditions. Treatment with somatostatin analogues may help inhibit the secretion of catecholamines. The study found that SOM230 could effectively inhibit catecholamine secretion and be considered a potential anti-secretory treatment for patients with pheochromocytoma.
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonella Giampietro, Federica Mirra, Federico Donfrancesco, Tommaso Tartaglione, Pier Paolo Mattogno, Flavia Angelini, Lauretti Liverana, Marco Gessi, Anile Carmelo, Guido Rindi, Andrea Giustina, Maria Fleseriu, Alfredo Pontecorvi, Laura De Marinis, Antonio Bianchi
Summary: The study investigated predictors of response to Pegvisomant and Pasireotide LAR in acromegaly patients, finding that factors such as tumor extension, Ki67-Li levels, and IGF-I levels may impact treatment efficacy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Oncology
Jessica Amaru, Federica Barbieri, Marica Arvigo, Agnese Solari, Adriana Bajetto, Federica Nista, Claudia Campana, Gabriele Gaggero, Alessandro Prior, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Tullio Florio, Federico Gatto
Summary: The first-generation somatostatin receptor ligands (fg-SRLs), like octreotide, and the second-generation ligand, pasireotide, act mainly through SST2 in somatotroph tumor cells, and their combination does not show any additional benefits.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Han Chung Low, Young Soon Tay, Simon Yew Kuang Ong, Wei Ying Tham, Sean Xuexian Yan
Summary: This case report presents a 68-year-old man with metastatic small bowel neuroendocrine tumor who underwent peptide receptor radionuclide therapy. Despite a miscommunication in scheduling, the tumoral uptake was not reduced after the fourth cycle of therapy, suggesting that stopping somatostatin analogs before the therapy may not be necessary.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Sebastian Gulde, Tobias Wiedemann, Mathias Schillmaier, Isabel Valenca, Amelie Lupp, Katja Steiger, Hsi-Yu Yen, Stephen Baeuerle, Johannes Notni, Raul Luque, Herbert Schmid, Stefan Schulz, Donna P. Ankerst, Franz Schilling, Natalia S. Pellegata
Summary: There is currently a lack of effective medical therapy for residual/recurrent nonfunctioning pituitary tumors (NFPTs). Pasireotide may be an effective treatment, especially for female NFPTs patients. Female NFPTs patients have higher levels of Sstr3 expression, which may also be present in human NFPTs patients.
Article
Endocrinology & Metabolism
Leonidas Nikolaos Diamantopoulos, Faidon-Marios Laskaratos, Markos Kalligeros, Ruchir Shah, Shaunak Navalkissoor, Gopinath Gnanasegaran, Jamie Banks, Jack Smith, Benjamin Jacobs, Michail Galanopoulos, Dalvinder Mandair, Martyn Caplin, Christos Toumpanakis
Summary: In this study, above-label doses of somatostatin analogs showed promising antiproliferative effects in patients with inoperable/metastatic gastroenteropancreatic neuroendocrine tumors. Symptomatic improvement and disease control were observed in some patients after 3-weekly administration, with certain factors associated with inferior or better progression-free survival. Higher doses of SSAs may be beneficial as a bridge to other treatments, particularly for patients with specific tumor characteristics.
NEUROENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Shanshan Qin, Yuanyou Yang, Jiajia Zhang, Yuzhen Yin, Weihao Liu, Han Zhang, Xin Fan, Mengdie Yang, Fei Yu
Summary: Intravenously administered [At-211]SAB-Oct showed significant efficacy against SSTR2-positive SCLC tumors, suppressing tumor growth and enhancing the efficacy of immunotherapy by up-regulating specific proteins on tumor cell membrane surface.
MOLECULAR PHARMACEUTICS
(2023)
Article
Endocrinology & Metabolism
Artak Labadzhyan, L. B. Nachtigall, M. Fleseriu, M. B. Gordon, M. Molitch, L. Kennedy, S. L. Samson, Y. Greenman, N. Biermasz, M. Bolanowski, A. Haviv, W. Ludlam, G. Patou, C. J. Strasburger
Summary: Results from trials investigating oral octreotide capsules as an alternative treatment for acromegaly showed consistent biochemical response, durability of response, and patient preference for oral treatment, despite differences in trial design.
Article
Multidisciplinary Sciences
Joan Gil, Montserrat Marques-Pamies, Miguel Sampedro, Susan M. Webb, Guillermo Serra, Isabel Salinas, Alberto Blanco, Elena Valassi, Cristina Carrato, Antonio Pico, Araceli Garcia-Martinez, Luciana Martel-Duguech, Teresa Sardon, Andreu Simo-Servat, Betina Biagetti, Carles Villabona, Rosa Camara, Carmen Fajardo-Montanana, Cristina Alvarez-Escola, Cristina Lamas, Clara V. Alvarez, Ignacio Bernabeu, Monica Marazuela, Mireia Jorda, Manel Puig-Domingo
Summary: This study aimed to predict the response of acromegaly patients to somatostatin receptor ligands (SRL) using mathematical modeling and clinical information. Accuracy of patient stratification was significantly improved when the cohort was fragmented based on relevant clinical characteristics. The proposed stratification method based on tumor characteristics, sex, age, and multiple biomarkers achieved accuracies ranging from 71% to 95%. The use of data mining offers a promising approach for personalized medicine in acromegaly.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Winson Y. Cheung, Callahan LaForty, Anna Liovas, Heather McKechnie, Jonathan M. Loree
Summary: This real-world observational study provides valuable insights into the use of somatostatin analogs in clinical settings and may help guide treatment selection.
Review
Endocrinology & Metabolism
A. Faggiano
Summary: This review summarizes the relevant data on long-acting SSAs in NET patients, showing that long-acting SSAs are an effective and safe initial therapy for well differentiated NET, providing long-term tumor growth and symptom control in selected patients.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Philippe Bonnin, Tania Vitalis, Leslie Schwendimann, Alexandre Boutigny, Nassim Mohamedi, Valerie C. Besson, Christiane Charriaut-Marlangue
Summary: PJ34 treatment in neonatal mice after hypoxic brain injury showed reduced BBB permeability, decreased astrocyte demise, and tissue loss. These results suggest a protective effect of PJ34 on hypoxic brain injury.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hendrik Ungefroren, Axel Kuenstner, Hauke Busch, Soren Franzenburg, Kim Luley, Fabrice Viol, Joerg Schrader, Bjoern Konukiewitz, Ulrich F. Wellner, Sebastian M. Meyhoefer, Tobias Keck, Jens-Uwe Marquardt, Hendrik Lehnert
Summary: The study shows that SST and SSA can regulate the expression of neuroendocrine genes in multiple panNET cell lines, suggesting that crosstalk between SST and TGF-β signaling is a general feature of panNETs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Rong-zhi Huang, Jie Zheng, Feng-ling Liu, Qing-ling Li, Wen-hui Huang, Dan-meng Zhang, Qiang-chu Wu
Summary: This study aimed to understand the differences in pathogenesis of RA and OA through in-depth studies of autophagy, revealing differences in autophagy levels between the two diseases. A novel autophagy related index (ARI) constructed from CXCR4 and SERPINA showed high disease identification potential and was verified in an independent cohort, indicating great promise for clinical applications.
FRONTIERS IN GENETICS
(2021)
Article
Ophthalmology
Bastian Grundel, Marc-Antoine Bernardeau, Holger Langner, Christoph Schmidt, Daniel Boehringer, Marc Ritter, Paul Rosenthal, Andrea Grandjean, Stefan Schulz, Philipp Daumke, Andreas Stahl
Summary: This study utilized text mining to extract information from clinical texts and found that the extraction performance was good for certain data such as visual acuity, intraocular pressure, and accompanying diagnoses, showing potential for future applications. However, manual adjustments are still necessary to improve accuracy.
Article
Health Care Sciences & Services
Stefanie Jauk, Diether Kramer, Alexander Avian, Andrea Berghold, Werner Leodolter, Stefan Schulz
Summary: This study evaluated the user acceptance of a machine learning-based application supporting delirium management in hospitals. Results showed that healthcare professionals found the application useful, easy to understand, and appreciated the additional information provided. However, actual system use was still low during the pilot study.
JOURNAL OF MEDICAL SYSTEMS
(2021)
Correction
Health Care Sciences & Services
Stefanie Jauk, Diether Kramer, Alexander Avian, Andrea Berghold, Werner Leodolter, Stefan Schulz
JOURNAL OF MEDICAL SYSTEMS
(2021)
Article
Medical Informatics
Pilar Lopez-Ubeda, Alexandra Pomares-Quimbaya, Manuel Carlos Diaz-Galiano, Stefan Schulz
Summary: This paper proposes a method to automatically extract and classify Spanish medical terms weighted per sub-domain from MEDLINE titles and abstracts, aiming to reduce the ambiguity and improve NLP tasks in specific clinical specialties. The results demonstrate that the specialized term set SCOVACLIS helps to enhance text classification problems and achieves improvements in F-measure by 6 percentage points compared to a baseline. This study supports the hypothesis that specific term sets can reduce ambiguity compared to a general vocabulary, and highlights the importance of domain-specific resources in biomedical NLP tasks.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Article
Biochemistry & Molecular Biology
Rainer K. Reinscheid, Fabrizio Mafessoni, Annika Luettjohann, Kay Juengling, Hans-Christian Pape, Stefan Schulz
Summary: The study of the NPS peptide system reveals functional attenuation mutations in human genes, potentially for adaptation to environmental conditions. Ancestral alleles of NPSR1 are found in Neandertal and Denisovan genomes, while derived alleles are present in ancient anatomically modern human genomes, suggesting they arose in modern Homo sapiens. World genotype frequencies for NPSR1 SNPs show regional homogeneity but also support an out-of-Africa scenario, with potential weak or balancing selection indicated by high-frequency polymorphisms. The presence of a hypomorphic mutation in NPS precursor in Eurasian Neandertal genomes suggests introgression into the human gene pool through interbreeding, particularly in Southern Europe.
Article
Biochemistry & Molecular Biology
Belen Juanes Cortes, Jose Antonio Vera-Ramos, Ruth C. Lovering, Pascale Gaudet, Astrid Laegreid, Colin Logie, Stefan Schulz, Maria del Mar Roldan-Garcia, Martin Kuiper, Jesualdo Tomas Fernandez-Breis
Summary: Gene regulation computational research involves handling heterogeneous data by generating knowledge models from gene regulation cartoons using ontologies and semantic tools. These models support data annotation by extracting entities, reusing content from existing ontologies, and implementing the knowledge models. The method was applied to two gene regulation scenarios to illustrate its use in supporting data annotation from research articles.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Article
Biochemistry & Molecular Biology
Martin Kuiper, Joseph Bonello, Jesualdo T. Fernandez-Breis, Philipp Bucher, Matthias E. Futschik, Pascale Gaudet, Ivan V. Kulakovskiy, Luana Licata, Colin Logie, Ruth C. Lovering, Vsevolod J. Makeev, Sandra Orchard, Simona Panni, Livia Perfetto, David Sant, Stefan Schulz, Steven Vercruysse, Daniel R. Zerbino, Astrid Laegreid
Summary: Following nine workshops organized by GREEKC, experts from around the world worked to improve the Gene Regulation Knowledge Commons (GRKC) by standardizing and updating workflows, as well as involving end-users in the design process, leading to significant achievements in enhancing the GRKC.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Biochemistry & Molecular Biology
David W. Sant, Michael Sinclair, Christopher J. Mungall, Stefan Schulz, Daniel Zerbino, Ruth C. Lovering, Colin Logie, Karen Eilbeck
Summary: The Sequence Ontology (SO) is a structured, controlled vocabulary for genomic annotation. The GREEKC initiative aims to curate information on how gene expression is regulated at the molecular level. Recent updates to the SO include more accurate, human-readable terms, new definitions, and relationships related to gene expression.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Article
Biochemistry & Molecular Biology
Amelie Lupp, Blanca Ehms, Ralf Stumm, Johannes Goeckeritz, Christian Mawrin, Stefan Schulz
Summary: The researchers investigated the localization of SST4 in normal and neoplastic human tissues using a knockin mouse model expressing SST4-eGFP fusion protein and a novel rabbit monoclonal anti-human SST4 antibody. They demonstrated that SST4 is prominently expressed in certain cells in the cortex and trigeminal ganglion, and the specificity of the antibody was confirmed through immunoblot and preadsorption experiments. The antibody was also found to be valuable for identifying SST4-expressing tumors in adrenal cortex, exocrine pancreas, and other tissues during routine histopathological examinations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Pooja Dasgupta, Thomas Gunther, Stefan Schulz
Summary: Veldoreotide is a full agonist of SSTR2, SSTR4, and SSTR5, showing high potency and efficacy in HEK293 and BON-1 cells.
Article
Biochemistry & Molecular Biology
Maria Bubb, Anna-Sophia Lieselott Beyer, Pooja Dasgupta, Daniel Kaemmerer, Joerg Saenger, Katja Evert, Ralph M. Wirtz, Stefan Schulz, Amelie Lupp
Summary: GPER is widely expressed in human non-neoplastic and neoplastic tissues and a novel antibody has been developed to detect GPER-expressing tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Benjamin Wende, Anna-Sophia Liselott Beyer, Niklas Ruhnke, Daniel Kaemmerer, Joerg Saenger, Stefan Schulz, Amelie Lupp
Summary: A rabbit monoclonal antibody, 8H9L8, was developed for studying the protein expression of CALCRL. The antibody was confirmed to be specific and used for immunohistochemical analyses of normal and neoplastic tissues. CALCRL was found to be expressed in various tissues and showed strong expression in certain tumors, potentially serving as a useful target for future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Markus Kreuzthaler, Mathias Brochhausen, Cilia Zayas, Bernd Blobel, Stefan Schulz
Summary: This paper provides an overview of the linguistic and ontological challenges in transforming health ecosystems for precision medicine. It discusses the need for standardization and interoperability in clinical and research data representation, as well as smart support for content comprehension by humans and machines. The paper explores the current use of natural language processing in extracting information from healthcare texts and highlights the importance of biomedical ontologies in integrating heterogeneous data sources. It also addresses misconceptions and shortcomings in the field and suggests future steps for data interoperability.
FRONTIERS IN MEDICINE
(2023)
Article
Biology
Sebastian Fritzwanker, Falko Nagel, Andrea Kliewer, Viviane Stammer, Stefan Schulz
Summary: Phosphorylation of receptors is unstable during routine immunohistochemical procedures, requiring the use of phosphatase inhibitors for specific GPCR antibodies. We showed that phosphorylation of receptors is highly unstable during routine immunohistochemical procedures, and the use of phosphatase inhibitors is necessary for specific GPCR antibodies. Our findings were confirmed using phosphorylation state-specific MOP and CB1 antibodies.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Behavioral Sciences
Masao Miyazaki, Jana Caspers, Tamako Miyazaki, Reiko Uenoyama, Shota Ichizawa, Stefan Schulz