Article
Cell Biology
Hsiao-Hsuan Wang, Wei-Yu Chen, Yi-Hsun Huang, Sheng-Min Hsu, Yeou-Ping Tsao, Yu-Hsiang Hsu, Ming-Shi Chang
Summary: Dry eye disease (DED) is a common ophthalmic disease affecting millions of people worldwide. Recent studies have shown that inflammation plays a central role in DED, and IL-20 is a proinflammatory cytokine involved in various inflammatory diseases. This study demonstrated the role of IL-20 in DED and presented a potential therapeutic option using the anti-IL-20 monoclonal antibody (mAb) 7E.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Borde Cvjetinovic, Drina Jankovic, Zorana Milanovic, Marija Mirkovic, Jelena Petrovic, Zeljko Prijovic, Emiliya Poghosyan, Sanja Vranjes-Buric
Summary: Micro-sized multivesicular liposomes labeled with Lu-177 were prepared and tested in vitro and in vivo for potential use in radiosynoviorthesis therapy. The results demonstrated high stability and retention of Lu-177-micro liposomes in synovial fluid for up to 30 days, suggesting their possible application in RSO therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Obstetrics & Gynecology
Ruriko Nakae, Shinya Matsuzaki, Satoshi Serada, Koji Matsuo, Mayu Shiomi, Kazuaki Sato, Yoshikazu Nagase, Satoko Matsuzaki, Satoshi Nakagawa, Kosuke Hiramatsu, Akiko Okazawa, Toshihiro Kimura, Tomomi Egawa-Takata, Eiji Kobayashi, Yutaka Ueda, Kiyoshi Yoshino, Tetsuji Naka, Tadashi Kimura
Summary: Uterine leiomyosarcoma highly expresses CD70, and treatment with CD70-antibody-drug conjugate demonstrates significant antitumor effects in CD70-positive tumors, suggesting a potential therapeutic implication for the treatment of uterine leiomyosarcoma.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Immunology
Xiaolei Liu, Li Li, Qian Wang, Fengchao Jiang, Pei Zhang, Fei Guo, Hongjun Liu, Jian Huang
Summary: A new humanized anti-IL-6 mAb HZ-0408b with potent binding and neutralizing activity to human IL-6 has been developed. It showed a high species specificity and lower cross-reactivity compared to other anti-IL-6 mAbs. HZ-0408b exhibited a stronger inhibitory effect on IL-6 signaling and effectively reduced joint swelling and plasma CRP levels in a monkey CIA model.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Susmita Srivastava, Mahaboobkhan Rasool
Summary: IL-6 plays a significant role in inflammation and rheumatoid arthritis (RA), and excessive IL-6 negatively affects immune cells. Therapeutic strategies targeting IL-6 include antibodies and JAK inhibitors, but side effects are a concern.
Review
Chemistry, Medicinal
Tsz-Ying Lau, Hiu-Yee Kwan
Summary: Breast cancer, a common and deadly cancer, can be effectively inhibited and prevented by fucoxanthin and its metabolites. Fucoxanthin also possesses anti-obesity effects and overcomes drug resistance. This review summarizes the anti-cancer mechanisms of fucoxanthin and provides novel strategies for its development as an anti-cancer therapeutic agent.
Article
Multidisciplinary Sciences
Katy Diallo, Numa Simons, Souraya Sayegh, Michel Baron, Yannick Degboe, Jean-Frederic Boyer, Andrey Kruglov, Sergei Nedospasov, Julien Novarino, Meryem Aloulou, Nicolas Fazilleau, Arnaud Constantin, Alain Cantagrel, Jean-Luc Davignon, Benjamin Rauwel
Summary: The study shows that the binding of anti-TNF biologics to tmTNF can reduce the severity of arthritis by increasing the expression of anti-inflammatory markers and decreasing inflammation. This suggests a complementary explanation for the effects of anti-TNF biologics in treating inflammatory diseases and opens the door to studies on new arginase-1-dependent therapeutic targets.
Article
Chemistry, Multidisciplinary
Fan Lee, Ki Hyun Bae, Shengyong Ng, Atsushi Yamashita, Motoichi Kurisawa
Summary: The study found that hyaluronic acid-EGCG conjugates have the potential as an anti-arthritic agent, targeting fibroblast-like synoviocytes, and exhibiting superior anti-proliferative and anti-inflammatory activities.
Article
Cell Biology
Tamara T. Lah, Metka Novak, Milagros A. Pena Almidon, Oliviero Marinelli, Barbara Zvar Baskovic, Bernarda Majc, Mateja Mlinar, Roman Bosnjak, Barbara Breznik, Roby Zomer, Massimo Nabissi
Summary: Among primary brain tumors, glioblastoma is the most aggressive and modern therapies have not significantly improved patient survival rates. Recent studies have shown that cannabigerol (CBG) may be a promising alternative to THC for treating glioblastoma, as it has similar anti-tumor effects without the psychoactive side effects. CBG has been found to effectively impair the progression of glioblastoma and destroy therapy-resistant cancer stem cells, suggesting it may have potential as a new adjuvant treatment strategy for this lethal cancer.
Review
Pharmacology & Pharmacy
Satoshi Saito, Masashi Tanaka, Noriko Satoh-Asahara, Roxana Octavia Carare, Masafumi Ihara
Summary: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of beta-amyloid (A beta) in cerebral vessels, leading to complications such as intracerebral hemorrhage. Studies indicate a common pathogenic mechanism between CAA and Alzheimer's disease, with Taxifolin potentially serving as an effective therapy for CAA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Wenyan Fu, Renfei Cai, Zetong Ma, Tian Li, Changhai Lei, Jian Zhao, Shi Hu
Summary: The study showed that TIGIT-Fc fusion protein can increase immune tolerance, induce specific cell types in fetal immune cells, and help successful pregnancies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
In Kang, Yumin Kim, Heung Kyu Lee
Summary: Gamma delta T cells play important roles in tumor immunity and have potential applications in GBM treatment. However, limitations still exist and further research is needed. This review summarizes the effector functions of gamma delta T cells, current advances and limitations, and suggests future research directions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Chao-Yi Wu, Huang-Yu Yang, Jenn-Haung Lai
Summary: Synovial inflammation and destruction of articular cartilage and bone are key characteristics of autoimmune arthritis. Current treatments targeting proinflammatory cytokines and Janus kinases have shown promise, but many patients still lack adequate disease control. Recent advances in understanding the imbalance of immune cells and bone cells in autoimmune arthritis have highlighted new therapeutic targets, particularly focused on synovial fibroblasts. This commentary comprehensively reviews the interactions between synovial fibroblasts, bone cells, and immune cells and their contributions to the immunopathogenesis of autoimmune arthritis, providing insights into novel treatment approaches.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohamad Hossein Pourhanifeh, Kazem Abbaszadeh-Goudarzi, Mohammad Goodarzi, Sara G. M. Piccirillo, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Zatollah Asemi, Hamed Mirzaei
Summary: Melanoma, the most life-threatening skin malignancy, has steadily increasing incidence. Resveratrol, a polyphenol found in grapes, exhibits anti-cancer properties but requires more clinical trials for efficacy validation.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Nilakshi Barua, Alak Kumar Buragohain
Summary: Curcumin, derived from the plant Curcuma longa, has been extensively studied for its biological and chemical properties, displaying a range of pharmacological activities such as antimicrobial, anti-inflammatory, antioxidant, and antitumor effects. Its potential in improving tuberculosis outcomes has been identified, but there is a scarcity of reviews on its antitubercular activity. Further preclinical and clinical investigations are crucial before recommending curcumin formulations for public health use against tuberculosis.