Article
Biochemistry & Molecular Biology
Wook-Young Baek, Yang-Seon Choi, Sang-Won Lee, In-Ok Son, Ki-Woong Jeon, Sang-Dun Choi, Chang-Hee Suh
Summary: Toll-like receptors (TLRs) play a crucial role in the innate immune system, with studies showing their regulatory effects on immune and inflammatory diseases. A TLR inhibitor peptide (TIP1) was found to suppress downstream signaling mediated by TIR domain-containing adapters, suggesting its potential as a candidate for treating systemic lupus erythematosus (SLE).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Wenqian Wang, Chenran Yue, Sheng Gao, Shuting Li, Jianan Zhou, Jiaqing Chen, Jiahong Fu, Weijian Sun, Chunyan Hua
Summary: Exosomal miRNAs show potential as biomarkers in SLE/LN patients for renal injury diagnosis. Exosomes are considered optimal delivery vehicles due to their high stability, minimal toxicity, low immunogenicity, and specific target effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zhou She, Cuifang Li, Feifeng Wu, Jueyi Mao, Min Xie, Marady Hun, Amin Sheikh Abdirahman, Senlin Luo, Wuqing Wan, Jidong Tian, Chuan Wen
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by multisystemic and multi-organ involvement. The role of B1 cells in SLE remains unclear, but understanding their mechanism can provide new insights into the pathogenesis and treatment of SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ryo Hisada, Tatsuya Atsumi
Summary: Despite advances in treatment, thrombosis remains the leading cause of death in SLE. aPL are the main triggers of thrombosis in SLE patients, with a frequency of approximately 30-40%. Lupus anticoagulant, anticardiolipin, anti-beta 2-glycoprotein I antibodies, and non-criteria aPL are risk factors for thrombosis in SLE. Multiple positivity for aPL and calculated scores can predict the risk of thrombosis. Treatment with anticoagulants and/or low-dose aspirin may be appropriate for aPL-positive SLE patients.
Article
Pharmacology & Pharmacy
Yi Zhang, FengQi Zhang, YiNi Gao, MeiJiao Wang, Yan Gao, HaiChang Li, Jing Sun, ChengPing Wen, ZhiJun Xie
Summary: Through experimental evidence, it has been found that triptolide (TP) exerts therapeutic effects on SLE by regulating miR-146a expression, inhibiting the TLR7/NF-kappa B signaling pathway, and affecting B cell activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Claus-Juergen Bauer, Pantelis Karakostas, Nadine Weber, Charlotte Behning, Birgit Stoffel-Wagner, Peter Brossart, Ramona Dolscheid-Pommerich, Valentin Sebastian Schaefer
Summary: This study is the first to prospectively investigate the performance of two of today's most commonly applied anti-dsDNA testing methods head-to-head under real-world conditions, as well as their correlation with other clinical and serological disease parameters in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Akinori Okada, Yuji Nozaki, Shinya Rai, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura
Summary: This case study presents a 35-year-old male patient with both HIV infection and concomitant SLE, highlighting the challenges in choosing treatment strategies for these two conditions that involve conflicting immunological responses. Rheumatologists in Japan should consider the possibility of HIV infection when diagnosing autoimmune diseases, especially given the relatively low prevalence of HIV in the country.
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Linyu Geng, Wenqiang Qu, Jun Liang, Wei Kong, Xue Xu, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Huayong Zhang, Xuebing Feng, Jiaqi Chen, Lingyun Sun
Summary: This study developed survival analysis models using data mining techniques to predict the survival outcomes and status of hospitalized systemic lupus erythematosus patients in Jiangsu province. Cox proportional hazards model and neural network models were used for analysis and prediction, and semi-supervised learning and cost-sensitivity were employed to address data imbalance and pseudo label credibility. The study identified the impact of cardiopulmonary and neuropsychiatric involvement, abnormal blood urea nitrogen levels, and alanine aminotransferase level on patient survival time, and developed a graphical user interface to assist physicians in diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xingyun Zhao, Shifen Wang, Shengjun Wang, Jue Xie, Dawei Cui
Summary: This review systematically summarizes the role of the mTOR signaling pathway in the pathogenesis of systemic lupus erythematosus (SLE), regulatory T cell dysfunction, and the treatment of SLE.
CLINICAL IMMUNOLOGY
(2022)
Article
Dermatology
Haruka Koizumi, Yoshinao Muro, Yuta Yamashita, Takuya Takeichi, Marvin J. Fritzler, Masashi Akiyama
Summary: Studies have shown that the prevalence of anti-KIF20B antibodies is higher in patients with systemic lupus erythematosus (SLE) compared to healthy controls. SLE patients with anti-KIF20B antibodies tend to have higher SLE Disease Activity Index-2000 (SLEDAI-2K) scores, indicating a potential clinical significance of these antibodies in SLE.
JOURNAL OF DERMATOLOGY
(2023)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Article
Medicine, Research & Experimental
Yen-Po Tsao, Fang-Yu Tseng, Chih-Wei Chao, Ming-Han Chen, Yi-Chen Yeh, Babamale Olarewaju Abdulkareem, Se-Yi Chen, Wen-Ting Chuang, Pei-Ching Chang, I-Chun Chen, Pin-Hsuan Wang, Chien-Sheng Wu, Chang-Youh Tsai, Szu-Ting Chen
Summary: Signaling driven by nucleic acid sensors contributes to interferonopathy-mediated autoimmune diseases. NLRP12, a pyrin-containing NLR protein, acts as a negative regulator of innate immune activation and type I interferon (IFN-I) production. In patients with systemic lupus erythematosus (SLE), reduced levels of NLRP12 were observed in peripheral blood mononuclear cells (PBMCs) and were inversely correlated with IFNA expression and high disease activity. NLRP12 expression was suppressed by epigenetic regulation under IFN-I treatment, leading to a feedback loop between low NLRP12 expression and increased IFN-I production.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Gastroenterology & Hepatology
Elisa Biliotti, Donatella Palazzo, Francesca Tinti, Maria Domenica D'Alessandro, Rozenn Esvan, Raffaella Labriola, Andrea Cappoli, Ilaria Umbro, Lorenzo Volpicelli, Alessandra Bachetoni, Erica Villa, Anna Paola Mitterhofer, Paola Rucci, Gloria Taliani
Summary: The study found that tubular dysfunction is an unrecognized feature of HCV-related kidney disease in cirrhotic patients and its presence should be primarily investigated in subjects with glomerular damage, diabetes, and hypertension. Tubular dysfunction resolves in the majority of cases after HCV clearance.
LIVER INTERNATIONAL
(2021)
Review
Biology
Francesca Tinti, Silvia Lai, Annalisa Noce, Silverio Rotondi, Giulia Marrone, Sandro Mazzaferro, Nicola Di Daniele, Anna Paola Mitterhofer
Summary: Chronic kidney disease (CKD) is characterized by systemic manifestations and symptoms, with traditional risk factors such as arterial hypertension, diabetes mellitus, and dyslipidemia. Acute kidney injury (AKI) is considered an additional risk factor for worsening CKD. Inflammation and oxidative stress play important roles in the pathogenesis of CKD.
Article
Rheumatology
Laura Gragnani, Serena Lorini, Lorenzo Martini, Cristina Stasi, Marcella Visentini, Luisa Petraccia, Niccolo Marello, Monica Monti, Silvia Marri, Francesco Madia, Valdo Ricca, Anna Linda Zignego
Summary: HCV frequently causes neuropsychiatric disorders, with cryoglobulinemic vasculitis patients experiencing more severe symptoms. Direct acting antivirals (DAAs) have shown significant benefits in improving depression and anxiety in HCV patients, particularly in those with cryoglobulinemic vasculitis.
CLINICAL RHEUMATOLOGY
(2022)
Letter
Rheumatology
Marcella Visentini, Laura Gragnani, Stefano Angelo Santini, Teresa Urraro, Annalisa Villa, Monica Monti, Andrea Palladino, Luisa Petraccia, Francesca La Gualana, Serena Lorini, Silvia Marri, Francesco Madia, Lucia Stefanini, Stefania Basili, Massimo Fiorilli, Clodoveo Ferri, Anna Linda Zignego, Milvia Casato
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Chemistry, Medicinal
Giulia Siciliano, Veronica Di Paolo, Dante Rotili, Rossella Migale, Francesca Pedini, Marialuisa Casella, Serena Camerini, Daniele Dalzoppo, Rob Henderson, Tonnie Huijs, Koen J. Dechering, Antonello Mai, Anna Maria Caccuri, Marco Lalle, Luigi Quintieri, Pietro Alano
Summary: This work investigates the activity of NBDHEX and its carboxylic acid metabolite on the human malaria parasite Plasmodium falciparum. NBDHEX shows strong activity against all blood stages of the parasite, with a higher potency against the gametocytes. Covalent modifications of gametocyte proteins are found to be associated with the antiparasitic effect of NBDHEX. Both NBDHEX and its metabolite have limited cytotoxicity in vitro, making them potential starting points for the development of new drugs to block malaria transmission.
Review
Environmental Sciences
Michele Basilicata, Manuela Di Lauro, Vincenzo Campolattano, Giulia Marrone, Roberto Celotto, Anna Paola Mitterhofer, Patrizio Bollero, Nicola Di Daniele, Annalisa Noce
Summary: Chronic kidney disease (CKD) is a global public health problem and recent studies have shown a causal relationship between CKD and oral diseases. Oral diseases are common in CKD patients, including chronic periodontitis, bone lesions, oral infections, and oral cancer. Standardized therapy for oral diseases is currently lacking, however, natural bioactive compounds (NBCs) could serve as a new possible adjuvant therapy for managing these conditions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Alessandro Camponeschi, Kathrin Klasener, Timothy Sundell, Christina Lundqvist, Paul T. Manna, Negar Ayoubzadeh, Martina Sundqvist, Katrin Thorarinsdottir, Mariele Gatto, Marcella Visentini, Karin Onnheim, Alaitz Aranburu, Huamei Forsman, Olov Ekwall, Linda Fogelstrand, Inger Gjertsson, Michael Reth, Inga-Lill Martensson
Summary: A recent study revealed that CD38 is a novel member of the IgM-BCR coreceptor, associating with CD19 in resting B cells and with CD19 and IgM after BCR stimulation. Targeting CD38 with an antibody impairs B cell proliferation and survival, as well as the formation of IgM:CD19 synapses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biology
Giacomo Paonessa, Giulia Siciliano, Rita Graziani, Cristiana Lalli, Ottavia Cecchetti, Cristina Alli, Roberto La Valle, Alessia Petrocchi, Alessio Sferrazza, Monica Bisbocci, Mario Falchi, Carlo Toniatti, Alberto Bresciani, Pietro Alano
Summary: High-throughput screening and validation assays have identified potential antimalarial drugs that can kill both sexual and asexual blood stages of Plasmodium falciparum, thus blocking parasite transmission through mosquitoes.
COMMUNICATIONS BIOLOGY
(2022)
Article
Nutrition & Dietetics
Silverio Rotondi, Lida Tartaglione, Marzia Pasquali, Maria Jose Ceravolo, Anna Paola Mitterhofer, Annalisa Noce, Monica Tavilla, Silvia Lai, Francesca Tinti, Maria Luisa Muci, Alessio Farcomeni, Sandro Mazzaferro
Summary: This study evaluated the association between cognitive impairment (evaluated using MoCA scores) and nutritional status (evaluated using MIS scores) in hemodialysis patients. The results showed that both cognitive impairment and malnutrition were prevalent in hemodialysis patients, and malnutrition was identified as a risk factor for cognitive impairment.
Article
Immunology
Laura Gragnani, Marcella Visentini, Serena Lorini, Stefano Angelo Santini, Gianfranco Lauletta, Cesare Mazzaro, Teresa Urraro, Luca Quartuccio, Fabio Cacciapaglia, Piero Ruscitti, Antonio Tavoni, Silvia Marri, Giuseppina Cusano, Luisa Petraccia, Caterina Naclerio, Elena Treppo, Giulia del Frate, Ilenia Di Cola, Vincenzo Raimondo, Daniela Scorpiniti, Monica Monti, Lorenzo Puccetti, Giusy Elia, Poupak Fallahi, Stefania Basili, Salvatore Scarpato, Florenzo Iannone, Milvia Casato, Alessandro Antonelli, Anna Linda Zignego, Clodoveo Ferri
Summary: This study investigated the prevalence and outcome of COVID-19 in a large series of MCs patients, as well as the safety and immunogenicity of COVID-19 vaccines. The results showed a significantly higher prevalence of COVID-19 in MCs patients compared to the general population, and the use of immunomodulators was associated with an increased risk of infection. Additionally, MCs patients with COVID-19 had a higher mortality rate, and older age was correlated with worse COVID-19 outcomes. The vaccination immunogenicity was impaired in MCs patients, and certain immunomodulators hindered the vaccine-induced immune response.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Samantha Donsante, Giulia Siciliano, Mariagrazia Ciardo, Biagio Palmisano, Valeria Messina, Valeria de Turris, Giorgia Farinacci, Marta Serafini, Francesco Silvestrini, Alessandro Corsi, Mara Riminucci, Pietro Alano
Summary: Recent evidence suggests that the bone marrow (BM) plays a key role in the diffusion of P. falciparum malaria by providing a niche for the maturation of the parasite gametocytes, responsible for human-to-mosquito transmission. Suitable humanized in vivo models to study the mechanisms of the interplay between the parasite and the human BM components are still missing. We report a novel experimental system based on the infusion of immature P. falciparum gametocytes into immunocompromised mice carrying chimeric ectopic ossicles whose stromal and bone compartments derive from human osteoprogenitor cells. Our model represents a powerful tool to study BM function and the interplay essential for parasite transmission in P. falciparum malaria and can be extended to study other infections in which the human BM plays a role.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Adolfo Marco Perrotta, Antonietta Gigante, Silverio Rotondi, Paolo Mene, Adriano Notturni, Stefano Schiavetto, Gaetano Tanzilli, Chiara Pellicano, Giuseppe Guaglianone, Francesca Tinti, Paolo Palange, Sandro Mazzaferro, Rosario Cianci, Silvia Lai
Summary: This study aimed to evaluate the possible association between renal resistive index (RRI) and the development of contrast-induced acute kidney injury (CIAKI), as well as its association with subclinical markers of atherosclerosis and cardiovascular risk factors. The results showed that patients with CIAKI had significantly higher RRI, IMT, CRP, and SUA values compared to those who did not develop CIAKI.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Hematology
Marcella Visentini, Andrea Pica, Giancarlo D'Ippolito, Eleonora Sculco, Francesca La Gualana, Laura Gragnani, Marzia Miglionico, Cesare Mazzaro, Massimo Fiorilli, Stefania Basili, Maurizio Martelli, Alice Di Rocco, Milvia Casato, Giuseppe Gentile, Alessandro Pulsoni
Summary: Studies suggest that both active and past hepatitis B virus (HBV) infection may increase the risk of developing diffuse large B-cell lymphoma (DLBCL) in low endemic areas. This conclusion is based on a retrospective review of clinical records in Italy, involving 253 DLBCL patients and 694 patients with different types of indolent B-cell non-Hodgkin's lymphoma (NHL). The study found that DLBCL patients had a higher prevalence of both active HBV infection and past infection compared to indolent NHL patients. These findings highlight the importance of further research in areas with different rates of HBV infection.
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Cesare Mazzaro, Marcella Visentini, Laura Gragnani, Filippo Vit, Erika Tissino, Federico Pozzo, Robel Papotti, Milvia Casato, Anna Linda Zignego, Tamara Bittolo, Antonella Zucchetto, Massimo Degan, Riccardo Bomben, Valter Gattei
Summary: We examined 23 hepatitis C virus (HCV)-infected patients with lymphoproliferative diseases or monoclonal B lymphocytosis who were treated with direct agent antiviral (DAAs) per clinical practice. DAA therapy resulted in undetectable HCV-RNA and complete remission of cryoglobulinemia vasculitis, but did not effectively eliminate pathological B-cell clones.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)