Article
Immunology
Pureun Won, Youngkyun Kim, Hyerin Jung, Yeri Alice Rim, Dong Hyun Sohn, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju
Summary: The study demonstrated that monoclonal antibody 12G1 can directly detect citrullinated proteins in rheumatoid arthritis (RA) target tissue and sera, indicating its potential in arthritis induction. 12G1 may be useful for diagnosing RA, including seronegative RA, and could help to understand the pathophysiological role of citrullination in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Kenia Chavez Ramos, Maria del Pilar Canizares Macias
Summary: Anti-cyclic citrullinated peptide IgG antibodies are specific biomarkers for rheumatoid arthritis, with the ability to be detected in early stages and being faster and more sensitive than commercial ELISA kits.
Article
Immunology
Tan Wan Jiun, Haslina Taib, Wan Majdiah Wan Mohamad, Suharni Mohamad, Wan Syamimee Wan Ghazali
Summary: This study found no significant association between the bacterial load of Porphyromonas gingivalis (P. gingivalis), a primary periodontal pathogen, and the levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) and periodontitis. Despite the prevalence of periodontitis among RA patients, the bacterial load does not have an impact on the production of anti-CCP antibodies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Daniela Sieghart, Christian Konrad, Sascha Swiniarski, Helmuth Haslacher, Daniel Aletaha, Guenter Steiner
Summary: This study aimed to investigate the diagnostic performance of anti-CCP2 and anti-CCP3 IgG and IgA assays in patients with early RA, with a focus on the prognostic value of IgA ACPA. The results showed that the anti-CCP2 IgG and IgA assays had high specificity but low sensitivity. The anti-CCP3.1 assay had slightly higher sensitivity but lower specificity compared to the anti-CCP2 IgG assay.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang
Summary: ACPAs are autoantibodies commonly found in patients with RA, with most of the mechanisms of formation and bone destruction well-understood. Despite advances in clinical applications and targeted therapies related to ACPAs, the presence of different subtypes poses a limitation.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Xuan Tang, Zehao Liu, Zhihua Yang, Shengmei Xu, Maojie Wang, Xiumin Chen, Zehuai Wen, Runyue Huang
Summary: The use of Chinese medicine compound therapy in treating rheumatoid arthritis has been shown to effectively reduce serum levels of RF and anti-CCP, with potentially better clinical outcomes compared to Western medicine monotherapy. Active components in the Chinese medicine compound therapy may be responsible for its efficacy, warranting further investigation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Summary: Limited data are available on test utilization and intraindividual changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (anti-CCP) in Korean patients that visit local clinics and hospitals. This study retrospectively reviewed longitudinally measured RF and anti-CCP data in Korean patients and found qualitative changes in test results during follow-up in some patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Marie F. Hemon, Nathalie C. Lambert, Fanny Arnoux, Jean Roudier, Isabelle Auger
Summary: The critical immunological event in rheumatoid arthritis is the production of antibodies to citrullinated proteins. A peptide array method was used to analyze the fine specificity of anti-citrullinated peptide antibodies and the results showed that different mouse strains have different IgG responses to citrullinated peptides.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luigi Caputi, Giorgio B. Boncoraglio, Gaetano Bernardi, Emilio Ciusani, Marcello Dantes, Federica de Liso, Alessandra Erbetta, Gianluca Marucci, Caterina Matinato, Elena Corsini
Summary: A new laboratory marker, measuring the synthesis of specific antibodies in cerebrospinal fluid and serum, improves the accuracy of diagnosis for rheumatoid meningitis (RM).
Article
Immunology
Lisha Ma, Wensheng Wang, Lisha Li, Ying Chen, Binxuan Chen, Miaoli Shao, Yongjun Cheng, Renfang Zhou
Summary: This study evaluated a novel fully automated immunoturbidimetric assay for the detection of anti-CCP antibodies and compared it with the conventional ELISA method. The results showed that the four anti-CCP assays provided similar diagnostic information for rheumatoid arthritis (RA), with Qiangsheng's method being potentially more useful for large scale clinical screening due to its shorter testing time.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Chia Chen, Chung-Ming Huang, Ting-Yuan Liu, Ning Wu, Chia-Jung Chan, Peng-Yu Shih, Hsin-Han Chen, Shih-Yin Chen, Fuu-Jen Tsai
Summary: Rheumatoid arthritis is a systemic disease that causes non-infectious inflammation of the joints and surrounding tissues. It can lead to severe health problems, impact daily life, and even result in death. Diagnosis of RA is often based on the presence of blood serological markers, but about 20% of patients have negative results for these markers, making diagnosis difficult and delaying treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
James J. Son, Mariko Ishimori, James Mirocha, Michael H. Weisman, Lindsy J. Forbess
Summary: The study found a lower than expected positive predictive value of CCP 3.1 level in diagnosing rheumatoid arthritis (RA), but the likelihood of having an RA diagnosis increased with higher CCP levels.
Article
Chemistry, Analytical
Sathish Panneer Selvam, Somasekhar R. Chinnadayyala, Sungbo Cho
Summary: The study successfully developed an electrochemical aCCP immunosensor using SWV, demonstrating early detection of aCCP antibodies. The sensor showed high selectivity, stability, and good linear relationship within different concentration ranges.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Multidisciplinary Sciences
Yibo He, Changrong Ge, Alex Moreno-Giro, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lonnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmstrom, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, Rene E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev, Rikard Holmdahl
Summary: Although anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), their in vivo functions remain unclear. In this study, monoclonal ACPAs derived from RA patients were expressed in mice and their functions were analyzed. One of the antibodies, clone E4, showed a protective effect against antibody-induced arthritis in mice, suggesting therapeutic potential for ACPAs in RA.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyan Chen, Guangsheng Du, Shuting Bai, Liu Dijia, Chenglong Li, Yingying Hou, Yuandong Zhang, Zhirong Zhang, Tao Gong, Yao Fu, Massimo Bottini, Xun Sun
Summary: The study aimed at exploring the therapeutic effects and tolerogenic mechanism of a novel tolerogenic polypeptide vaccine, showing synergistic effects on regulatory T cells, promotion of IL-10 secretion, reduction of pro-inflammatory cytokines, and antibodies in experimental arthritis. This work could shed light on the development of tolerogenic therapeutics as novel immunotherapies for rheumatoid arthritis.
Letter
Rheumatology
Veerle F. A. M. Derksen, Diane van der Woude
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Quirine A. Dumoulin, Xanthe M. E. Matthijssen, Fenne Wouters, Doortje Krijbolder, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
L. van Ouwerkerk, D. van der Woude, T. Rispens, C. F. Allaart, T. W. J. Huizinga
Summary: This study evaluated the relationship between reported COVID-19-like symptoms and the presence of SARS-CoV-2 antibodies in patients with immune-mediated inflammatory disorders or post-solid organ transplantation. The results showed that the seroprevalence of SARS-CoV-2 antibodies after reported COVID-19-like symptoms was similar in patients with and without immunosuppressive medication compared to controls.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Lotte van Ouwerkerk, Maarten Boers, Paul Emery, Pascal H. P. de Jong, Robert B. M. Landewe, Willem Lems, Josef S. Smolen, Patrick Verschueren, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: This study investigated whether patients with rheumatoid arthritis (RA) can discontinue glucocorticoids (GC) after GC 'bridging' in the initial treatment step and identified factors that may affect this. The probability of using GC decreased over time after bridging therapy ended, while the probability of continuous GC use increased. In oral GC bridging studies, the probabilities of later and continuous GC use and the cumulative GC doses were higher compared to studies that included parenteral GC bridging.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Kevin L. Winthrop, John D. Isaacs, Philip J. Mease, Dimitrios T. Boumpas, Xenofon Baraliakos, Jacques-Eric Gottenberg, Stefan Siebert, Marta Mosca, Neil Basu, Dana Orange, R. Lories, Daniel Aletaha, Iain B. McInnes, Tom W. J. Huizinga, Reinhard E. Voll, Ellen M. Gravallese, Ferry C. Breedveld, Josef S. Smolen
Summary: This article summarizes the unmet clinical and scientific needs in the field of rheumatology. It highlights the importance of clinical trial design innovation and the need to better understand the natural history of rheumatic diseases. The article also identifies the specific unmet needs in different rheumatological disease-specific groups and emphasizes the importance of developing therapies and therapeutic strategies for treatment-refractory disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Bernardo D'Onofrio, Annette van der Helm-van Mil, Tom W. J. Huizinga, Elise van Mulligen
Summary: Drug-free remission is the desired outcome for RA patients, linked to symptom resolution and restoration of normal functioning. Early initiation of DMARD, strict monitoring, and drug adjustments are crucial for achieving DFR, and ACPA-negative patients are more likely to maintain remission.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Mami Tamai, Vincent Grundeken, Kazuhiko Arima, Robin ten Brinck, Annette H. M. van der Helm-van Mil, Nozomi Ohki, Masataka Uetani, Atsushi Kawakami
Summary: Using bilateral MRI, we found that symmetrical tenosynovitis at the MCP joint is predictive of RA development in UA patients.
Article
Rheumatology
Sarah J. H. Khidir, Maaike Boonstra, Sytske Anne Bergstra, Gerry W. M. Boerrigter, Elles M. Voog-van der Harst, Maarten K. Ninaber, Nina Ajmone Marsan, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil, Jeska K. de Vries-Bouwstra
Summary: This study aimed to investigate the course of maximal mouth opening in systemic sclerosis patients and determine the factors associated with smaller maximal mouth opening over time. The results showed that a majority of patients had stable maximal mouth opening, but those with more severe organ involvement had a smaller maximal mouth opening over time. Smaller maximal mouth opening was also associated with more mouth handicap.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Letter
Rheumatology
Jacopo Ciaffi, Sophie I. E. Liem, Nina M. van Leeuwen, Cornelia F. Allaart, Tom W. J. Huizinga, Jeska K. de Vries-Bouwstra
Article
Medicine, Research & Experimental
P. N. d'Ailly, C. Deugd, N. W. L. Schep, T. M. Kuijper, M. R. Kok, A. Willemze, J. H. Coert, P. H. P. de Jong, W. K. Lam-Tse, A. H. M. van der Helm-van Mil, I. Tchetverikov, A. E. A. M. Weel-Koenders, R. J. Bisoendial
Summary: This study aims to evaluate the effect of arthroscopic synovectomy and intra-articular corticosteroid injections (IACSI) on wrist function in patients with therapy-resistant rheumatoid arthritis (RA) and psoriatic arthritis (PsA). A prospective randomized controlled trial will be conducted, recruiting 80 eligible patients who will be randomly assigned to two different treatment groups. The primary outcome measure is the improvement of wrist function.
Article
Rheumatology
Doortje I. Krijbolder, Xanthe M. E. Matthijssen, Bastiaan T. van Dijk, Hanna W. van Steenbergen, Debbie M. Boeters, Annemiek Willemze, Anne A. Schouffoer, Annette H. M. van der Helm-van Mil
Summary: The progression of subclinical inflammation in different joint tissues was studied in patients with clinically suspect arthralgia (CSA) who develop rheumatoid arthritis (RA) and in patients with spontaneous resolution of pain. It was found that in RA progressors, synovitis, tenosynovitis, and osteitis increased simultaneously, with osteitis increasing just before RA development. In patients with pain resolution, simultaneous decreases in synovitis, tenosynovitis, and osteitis occurred, with tenosynovitis decreasing first.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Nikolet K. den Hollander, Annette H. M. van der Helm-van Mil, Hanna W. van Steenbergen
Summary: Obesity is associated with a higher risk of developing RA, but paradoxically, it is also linked to less radiographic progression after RA diagnosis. This study used MRI to investigate the relationship between obesity and MRI-detected osteitis, synovitis, and erosive progression in early arthritis patients. The results showed that higher BMI was associated with less osteitis in ACPA-positive RA, ACPA-negative RA, and other arthritides. Overweight and obesity were also found to be associated with less MRI-detected erosive progression.
Article
Rheumatology
N. K. den Hollander, M. Verstappen, B. T. van Dijk, A. H. M. van der Helm-van Mil, H. W. van Steenbergen
Summary: Using clinical features, this study identified five subgroups within undifferentiated arthritis (UA) and investigated their relationship with outcomes such as spontaneous resolution of arthritis and development of rheumatoid arthritis (RA). It was found that patients with persistent disease were nearly absent in the monoarthritis subgroups, while patients who developed RA were infrequent in these subgroups.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Emma C. de Moel, Leendert A. Trouw, Chikashi Terao, Nimmisha Govind, Mohammed Tikly, Hani El-Gabalawy, Irene Smolik, Holger Bang, Tom W. J. Huizinga, Rene E. M. Toes, Diane van der Woude
Summary: Rheumatoid arthritis (RA) occurs in different ethnic populations worldwide. This study revealed that anti-modified protein antibodies (AMPA) can be detected in RA patients across different continents and ethnicities, suggesting a common pathway involved in AMPA development. However, differences in AMPA levels and associated factors were observed among the different populations.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Michelle D. van den Beukel, Tineke J. van Wesemael, Anna Titia W. Hoogslag, Nicole Borggreven, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil, Rene E. M. Toes, Diane van der Woude, Leendert A. Trouw
Summary: It has been found that the presence of anti-malondialdehyde-acetaldehyde adducts and anti-advanced glycation end-products autoantibodies is common in rheumatoid arthritis patients. These autoantibodies are associated with HLA genes, inflammation, and clinical outcomes.