Article
Medicine, General & Internal
Chia-Wen Hsu, Bao-Bao Hsu, Malcolm Koo, Ming-Chi Lu
Summary: This study investigated the association of demographic factors, clinical manifestations, and disease activity of SLE with intimate relationships in female patients. The results showed that younger age, higher education level, employment, better self-reported health status, and lower SLE-DAS score were associated with better intimate relationships. In addition, intimate relationships were significantly associated with physical health, fatigue, and burden to others.
Article
Rheumatology
Ji-Hyoun Kang, Min-Ho Shin, Sung-Eun Choi, Haimuzi Xu, Dong-Jin Park, Shin-Seok Lee
Summary: This study investigated the performance of three definitions of low-level disease activity in SLE patients, finding that the lupus low disease activity state (LLDAS) was significantly associated with less organ damage, reduced flare, and improved quality of life during follow-up, while minimal disease activity (MDA) and low disease activity (LDA) showed no associations with these variables.
Review
Medicine, General & Internal
Lou Kawka, Aurelien Schlencker, Philippe Mertz, Thierry Martin, Laurent Arnaud
Summary: Fatigue is a common symptom in patients with SLE, affecting 67% to 90% of patients. It can impair health-related quality of life and lead to employment disability. Management should include targeted interventions such as pharmacological treatments and non-pharmacological therapies like psychological interventions and lifestyle changes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Francesco Natalucci, Fulvia Ceccarelli, Enrica Cipriano, Carlo Perricone, Giulio Olivieri, Carmelo Pirone, Giuseppe Mettola, Simona Truglia, Francesca Romana Spinelli, Cristiano Alessandri, Fabrizio Conti
Summary: This study found that joint involvement significantly influences disease-specific quality of life in SLE patients, with the musculoskeletal activity index DAS28 better correlating with LupusQoL domains, highlighting the need for specific musculoskeletal activity indices.
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Qing Wang, Junfeng Jia, Kui Zhang, Zhaohui Zheng, Huilin Liu
Summary: The aim of this study was to provide targeted psychological support and effective nursing for systemic lupus erythematosus (SLE) patients. The study found that anxiety among SLE patients is closely related to health-related quality of life, and disease activity and quality of life of SLE patients also affect their anxiety. Therefore, providing targeted psychological support and effective nursing is crucial for improving patients' self-awareness, mental health, and quality of life.
Article
Medicine, General & Internal
Lina Wirestam, Birgitta Gullstrand, Andreas Jern, Andreas Jonsen, Petrus Linge, Helena Tyden, Robin Kahn, Anders A. Bengtsson
Summary: Platelets play important roles in SLE as immune modulators, with smaller MPV values in SLE patients compared to controls. Individual MPV variation was low, and fluctuations in disease activity did not significantly impact MPV over time. Further studies are needed to evaluate MPV as a biomarker in SLE and to determine underlying mechanisms affecting platelet size.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Julia Mercader-Salvans, Maria Garcia-Gonzalez, Juan C. Quevedo-Abeledo, Adrian Quevedo-Rodriguez, Alejandro Romo-Cordero, Soledad Ojeda-Bruno, Fuensanta Gomez-Bernal, Raquel Lopez-Mejias, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: Ratios derived from complete blood count can be used as inflammatory biomarkers in systemic lupus erythematosus (SLE) patients. Despite lower cell counts, NLR, MLR, and PLR are higher in SLE patients. However, the relationship between these scores and disease characteristics is limited, with the complement system being the most consistent.
Article
Rheumatology
Nina M. van Leeuwen, Jacopo Ciaffi, Sophie I. E. Liem, Tom W. J. Huizinga, Jeska K. de Vries-Bouwstra
Summary: The study revealed that digital ulcers, Raynaud phenomenon, and gastrointestinal involvement are key factors contributing to the worsening of HRQoL over time in SSc patients. Additionally, PAH is a significant burden in prevalent cases.
Review
Medicine, General & Internal
Ioannis Parodis, Paul Studenic
Summary: Systemic lupus erythematosus is a chronic autoimmune disorder with detrimental effects on patient's quality of life. Its management requires interdisciplinary care and emphasis on patient-reported outcome measures to improve patient participation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yue Shi, Dandan Bi, Yanhong Wang, Ruofan Li, Lijun Wu, Cheng Zhao, Zhenbiao Wu, Xinwang Duan, Jian Xu, Feng Zhan, Min Yang, Shengyun Liu, Qin Li, Shuo Zhang, Lingshan Liu, Jiuliang Zhao, Xinping Tian, Xinying Li, Qian Wang, Xiaofeng Zeng
Summary: This study investigates the subjective well-being (SWB) of patients with systemic lupus erythematosus (SLE) and the impact of clinical characteristics, emotional variables, and related positive factors on SWB. The results show that SLE patients have lower life satisfaction compared to the general population. Active skin involvement and cumulative organ damage are negatively associated with life satisfaction, while age at enrollment is positively associated with life satisfaction.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Marcella Prete, Nicola Susca, Patrizia Leone, Andrea De Giacomo, Antonella Bray, Giuliano Brunori, Elvira Favoino, Federico Perosa, Vito Racanelli
Summary: Belimumab treatment improves the quality of life in SLE patients, reduces disease activity and corticosteroid dosage, and enhances health-related quality of life.
Article
Rheumatology
Serap Ozer, Hulya Kankaya, Rabiye Gun, Necla Yeler, Ozge Marangoz, Hilal Bozca
Summary: The study revealed that the sleep quality of patients with SLE is generally poor, influenced by both disease and sleep-related variables. Comprehensive sleep evaluation is necessary for the planning of treatment and care, in order to implement initiatives to improve sleep patterns in these patients.
Article
Rheumatology
Yudai Takase, Takeshi Iwasaki, Hiroshi Doi, Hideaki Tsuji, Motomu Hashimoto, Kentaro Ueno, Ryuta Inaba, Tomohiro Kozuki, Masashi Taniguchi, Yuya Tabuchi, Ryu Watanabe, Koji Kitagori, Shuji Akizuki, Kosaku Murakami, Ran Nakashima, Hajime Yoshifuji, Takahiro Itaya, Wataru Yamamoto, Ryuji Uozumi, Masao Tanaka, Koichiro Ohmura, Akio Morinobu
Summary: The study revealed a negative correlation between the quality of life of patients with systemic lupus erythematosus and irreversible organ damage, with musculoskeletal damage having a significant impact on health-related quality of life. The findings have important implications for understanding the impact of quality of life on irreversible organ damage in patients with SLE.
Article
Rheumatology
Amanda Hempel Zinglersen, Katrine Kjaer Iversen, Henrik Christian Bidstrup Leffers, Esben Laugesen, Jesper Fleischer, Soren Jacobsen
Summary: In a study of 111 SLE patients, it was found that about 24.1% of patients had definitive cardiovascular autonomic neuropathy (CAN), while the prevalence of any CAN was 53.7%. SLE patients with definitive CAN showed signs of mixed sympathetic-parasympathetic dysfunction, which was associated with a lower physical health-related quality of life component score.
LUPUS SCIENCE & MEDICINE
(2021)