Article
Rheumatology
Seema Sharma, Darren Plant, John Bowes, Alex Macgregor, Suzanne Verstappen, Anne Barton, Sebastien Viatte
Summary: HLA-DRB1 haplotypes associated with susceptibility to RA are also associated with increased risk of cardiovascular mortality in IP, independent of known CV risk factors. This suggests that genetic factors will play a significant role in predicting cardiovascular mortality risk beyond serological markers in the future.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Rheumatology
Nilasha Ghosh, Pankti Reid, Carlos Andres Aude, Jessica Kirschman, Susan Goodman, Vivian P. Bykerk, Amit Lakhanpal, Diviya Rajesh, Karmela K. Chan, William H. Robinson, Anne R. Bass
Summary: In this study, the expansion of ACPA epitopes in CCP+ICI-IA was compared with patients with RA. It was found that patients with ICI-IA had lower ACPA titres and targeted fewer ACPA epitopes compared to longstanding RA patients, and there were no significant differences in the presence of the shared epitope between ICI-IA patients and ICI controls. This suggests that ICI-IA may represent an accelerated model of RA pathogenesis.
Article
Immunology
Adil Ahmed Ali, Khalid Eltahir Khalid, Somaya Elhaj Mohammed, Mohammed Salman Akhtar, Osman Khalafalla Saeed
Summary: The aim of this study was to determine the frequency of HLA class II alleles and haplotypes in Sudanese patients with Rheumatoid Arthritis (RA). The study found that HLA-DRB1*04 and *10 alleles were more common in RA patients, while HLA-DRB1*07 allele was significantly less common. HLA-DQB1*03 allele was strongly associated with RA risk, whereas HLA-DQB1*02 and *06 showed protective effects against RA. Several specific HLA haplotypes were also found to be significantly associated with RA risk or protection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Guillaume Larid, Mikael Pancarte, Geraldine Offer, Cyril Clavel, Marielle Martin, Vincent Pradel, Isabelle Auger, Pierre Lafforgue, Jean Roudier, Guy Serre, Nathalie Balandraud
Summary: In this study of 184 ACPA-positive RA patients, it was found that anti-alpha 505-515cit antibodies were associated with HLA-DRB1*04:01, and high levels of these antibodies were associated with rheumatoid nodules. This suggests that immune complexes containing these antibodies may play a role in the development of rheumatoid nodules, offering a new therapeutic opportunity for patients with this condition.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Jean-Marie Berthelot, Christelle Darrieutort-Laffite, Benoit Le Goff
Summary: This narrative review gathers current evidence for the contribution of RA HLA-DRB1, PTPN22, and CTLA4 polymorphisms to gut dysbiosis in RA, especially at its onset. The study found that the selection of gut microbiota during the first months/year is critical, and imperfect tolerization may increase the risk of RA. The overall microbial composition of stools was strongly associated with HLA-DRB1 RA risk allele, and Prevotella copri was partly heritable.
Article
Immunology
Laura Massarenti, Christian Enevold, Dres Damgaard, Niels Odum, Peter Garred, Morten Frisch, Miriam A. Shelef, Soren Jacobsen, Claus Henrik Nielsen
Summary: This study found an association between PADI4 gene polymorphisms and ACPA-positive RA, particularly in HLA-DRB1*04-positive individuals, and independently with ACPA-negative RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Paola V. Ferrero, Luisina I. Onofrio, Cristina del Valle Acosta, Estefania R. Zacca, Nicolas E. Ponce, Eduardo Mussano, Laura B. Onetti, Ignacio I. Cadile, Alicia B. Costantino, Marina L. Werner, Luciana A. Mas, Teresita Alvarellos, Carolina L. Montes, Eva V. Acosta Rodriguez, Adriana Gruppi
Summary: The subsets of Tfh and Tfr cells in rheumatoid arthritis (RA) show altered dynamics after treatment and are associated with HLA class-II variants and disease activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemical Research Methods
Birga A. Mengesha, Lin Ning, Jian Huang
Summary: This review study investigated the association between Human Leukocyte Antigen (HLA) HLA-DRB1 alleles and the risk of Rheumatoid Arthritis (RA). The results demonstrated that certain HLA-DRB1 alleles were significantly associated with an increased risk of RA, while others were potentially protective against the disease. This study provides important insights into the relationship between HLA-DRB1 and the risk of RA in different ethnic groups.
CURRENT BIOINFORMATICS
(2022)
Review
Biology
Anastasia-Vasiliki Madenidou, Sophie Mavrogeni, Elena Nikiphorou
Summary: Cardiovascular morbidity and mortality are higher in inflammatory arthritis (IA) compared to the general population. The European League Against Rheumatism (EULAR) published guidelines in 2016 on cardiovascular disease (CVD) risk management in IA and plans to update them based on emerging evidence. Evidence shows that both traditional CVD factors and inflammation contribute to the higher CVD burden in IA. Prompt screening and management of CVD and related risk factors are necessary, and non-invasive cardiovascular imaging plays an important role in accurately detecting cardiovascular lesions in IA patients.
Review
Immunology
Nuria Barbarroja, Miriam Ruiz-Ponce, Laura Cuesta-Lopez, Carlos Perez-Sanchez, Chary Lopez-Pedrera, Ivan Arias-de La Rosa, Eduardo Collantes-Estevez
Summary: Liver disease is a significant cause of increased morbidity and mortality worldwide. Inflammation and the accumulation of fat in the liver can lead to hepatic damage, progressing to fibrosis and eventually cirrhosis, which are closely associated with cardiovascular disease. Patients with inflammatory conditions like rheumatoid arthritis and psoriatic arthritis have a higher risk of liver disease compared to the general population, possibly due to chronic inflammation, autoimmunity, treatments, and metabolic deregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xiaohui Xu, Tingwei Zhang, Xuyun Xia, Yuanyuan Yin, Sihan Yang, Dongqing Ai, Han Qin, Mengjiao Zhou, Jinlin Song
Summary: Periodontitis is a highly prevalent condition globally that not only leads to tooth loss but also exacerbates systemic diseases. Understanding the molecular mechanisms underlying periodontitis and its association with other cell death pathways can contribute to the development of new therapeutic strategies. This review discusses the role of pyroptosis in periodontitis progression, its interaction with apoptosis, necroptosis, and NETosis, and its connection to systemic diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Manuel Silverio-Antonio, Federica Parlato, Patricia Martins, Nikita Khmelinskii, Sandra Braz, Joao Eurico Fonseca, Joaquim Polido-Pereira
Summary: The article describes a unique presentation of paraneoplastic arthritis (PA) and highlights the importance of considering underlying cancer in elderly male patients with polyarthritis and systemic symptoms.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Ami Schattner
Summary: Mortality is increased in rheumatoid arthritis, primarily due to cardiovascular diseases. The pathogenesis involves accelerated atherosclerosis and chronic inflammation. The best cardiovascular protection is achieved by early suppression of inflammation and disease activity, as well as addressing traditional risk factors.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Marta Rojas-Gimenez, Clementina Lopez-Medina, Maria Lourdes Ladehesa-Pineda, Maria angeles Puche-Larrubia, Ignacio Gomez-Garcia, Jerusalem Calvo-Gutierrez, Pedro Segui-Azpilcueta, Maria del Carmen Abalos-Aguilera, Desiree Ruiz-Vilchez, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez
Summary: The study compared the inflammation's effect on subclinical atherosclerosis in patients with RA and SpA using carotid ultrasound. Results showed that when diseases were well controlled, subclinical atherosclerosis in both groups was similar, but in moderate-high disease activity, cIMT was greater in RA patients compared to SpA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Marta Gonzalez-Sierra, Adrian Quevedo-Rodriguez, Alejandro Romo-Cordero, Gael Gonzalez-Chretien, Juan Carlos Quevedo-Abeledo, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Candelaria Martin-Gonzalez, Miguel Angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIRI) have been identified as potential blood-derived inflammatory biomarkers. In this study, these composite blood scores were analyzed in relation to cardiovascular risk factors and subclinical atherosclerosis in patients with rheumatoid arthritis (RA).
Article
Rheumatology
Mrinalini Dey, Sizheng S. Zhao, Robert J. Moots, Sytske Anne Bergstra, Robert B. Landewe, Nicola J. Goodson
Summary: This study aimed to explore the association between increased BMI and the response to conventional synthetic DMARDs in patients with rheumatoid arthritis (RA). The study found that in patients with established RA, obese individuals were less likely to achieve a good treatment response and were more likely to be treated with combination therapy. Additionally, overweight and obese patients were exposed to higher doses of MTX medication.
Review
Economics
Gemma E. Shields, Elizabeth Camacho, Tracey Farragher, Paul Clarkson, Arpana Verma, Linda M. Davies
Summary: This review evaluates existing economic evaluations of interventions in schizophrenia and found that patient heterogeneity is frequently mentioned but rarely thoroughly investigated. Understanding and acknowledging patient heterogeneity may alter the conclusions of cost-effectiveness evaluations, and further research is encouraged in this area.
Article
Economics
Gemma E. Shields, Mark Wilberforce, Paul Clarkson, Tracey Farragher, Arpana Verma, Linda M. Davies
Summary: The use of population averages in cost-effectiveness analysis may hide important differences across subgroups. Many challenges may limit the robust inclusion of subgroup analysis in cost-effectiveness analysis, including difficulties with prespecifying and justifying subgroup analysis, identifying implementable subgroups, resource and data requirements, and statistical and ethical concerns. Greater transparency of subgroup reporting is recommended to address these challenges in future research.
Article
Rheumatology
Sizheng Steven Zhao, Eftychia Bellou, Suzanne M. M. Verstappen, Michael J. Cook, Jamie C. Sergeant, Richard B. Warren, Anne Barton, John Bowes
Summary: Observational and genetic evidence suggest that BMI and glycemic control are associated with increased risk of psoriatic disease, while psoriatic disease is associated with increased risk of coronary artery disease.
Review
Genetics & Heredity
Philippa D. K. Curry, Andrew P. Morris, Anne Barton, James Bluett
Summary: Psoriatic arthritis is a chronic musculoskeletal disease that affects a significant proportion of psoriasis patients. The response to targeted therapies, such as TNF inhibitors, varies among patients. Researchers have been investigating potential genetic biomarkers for predicting drug response. Although several genetic variants have been reported to correlate with TNF inhibitor response, further validation and implementation into clinical practice are needed.
PHARMACOGENOMICS JOURNAL
(2023)
Article
Rheumatology
Ryan M. Hum, Pauline Ho, Nisha Nair, Meghna Jani, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Darren Plant, Anne Barton
Summary: This study suggests that higher levels of TNF-a inhibitor serum drug levels (SDLs) are associated with good treatment response in fully adherent patients. Interventions to improve SDLs, such as encouraging adherence, may improve treatment response. The identified SDL cut-offs for adalimumab and certolizumab may be useful in clinical practice.
Review
Biochemistry & Molecular Biology
Robert Gurke, Annika Bendes, John Bowes, Michaela Koehm, Richard M. Twyman, Anne Barton, Dirk Elewaut, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Rik J. Lories, Eduard Resch, Stefan Rueping, Klaus Scholich, Jochen M. Schwenk, James C. Waddington, Phil Whitfield, Gerd Geisslinger, Oliver FitzGerald, Frank Behrens, Stephen R. Pennington
Summary: The definitive diagnosis and early treatment of immune-mediated inflammatory diseases (IMIDs) are challenging due to variable clinical manifestations. Psoriatic arthritis (PsA) is an example of such a disease. The detection of molecular biomarkers offers hope for the early diagnosis and treatment of PsA, but specific biomarkers are not yet available. By analyzing multi-omics data and integrating them with clinical assessment, it is possible to develop molecular profiles that improve the diagnosis and treatment outcomes of PsA patients.
Letter
Rheumatology
Sizheng Steven Zhao, Anne Barton, John Bowes
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemical Research Methods
Elena Vigorito, Anne Barton, Costantino Pitzalis, Myles J. Lewis, Chris Wallace
Summary: In this study, a Bayesian beta-binomial mixture model (BBmix) is proposed for calling genotypes using RNA-Seq data, which can model specific biases in RNA-Seq. The benchmarking results show that BBmix generally outperforms competitors in genotype calling, with an increase of up to 1.4% in the accuracy of heterozygous calls. BBmix can be easily incorporated into standard genotype calling pipelines and the model parameters are generally transferable within datasets, making it possible to call genotypes in a large number of samples with less than 1 hour of learning.
Letter
Rheumatology
Philippa D. K. Curry, Hector Chinoy, Meghna Jani, Darren Plant, Kimmie L. Hyrich, Ann W. Morgan, A. G. Wilson, John D. Isaacs, Andrew P. Morris, Anne Barton, James Bluett
JOURNAL OF RHEUMATOLOGY
(2023)
Letter
Rheumatology
Chuan Fu Yap, Nisha Nair, Annick de Vries, Floris C. Loeff, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Stephanie F. Ling, Chuan Fu Yap, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant
Summary: This study aimed to identify proteomic biomarkers associated with clinical outcome measures in patients with rheumatoid arthritis (RA) starting biologic disease-modifying antirheumatic drugs (bDMARDs). Through SWATH-MS analysis of serum samples from RA patients before and after 3 months of treatment, ten proteins were found to be significantly associated with clinical outcome measures, and one of them was validated in an independent cohort.
Article
Medicine, General & Internal
Kate McLintock, Robbie Foy, Krysia Canvin, Sue Bellass, Philippa Hearty, Nat Wright, Marie Cunningham, Nicola Seanor, Laura Sheard, Tracey Farragher
Summary: The study reveals significant room for improvement in the quality of primary care for prisoners, with marked variations that remain even after adjusting for prison and prisoner characteristics.
Article
Rheumatology
Katriona Goldmann, Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Nisha Nair, Cankut Cubuk, Paul McKeigue, Michael R. Barnes, Anne Barton, Costantino Pitzalis, Myles J. Lewis
Summary: This study conducted expression quantitative trait locus (eQTL) analysis using RNA-Sequencing to explore the link between genetic variants and gene expression in rheumatoid arthritis (RA) patients. The analysis identified 898 eQTL genes in synovium and blood, with 232 genes in common. A specific eQTL at HLA-DPB2 was found to be associated with clinical severity and the lympho-myeloid pathotype.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Criminology & Penology
Sue Bellass, Krysia Canvin, Kate McLintock, Nat Wright, Tracey Farragher, Robbie Foy, Laura Sheard
Summary: This review provides an overview of research undertaken to develop quality indicators suitable for prison healthcare. The study found inconsistencies in the selection processes of quality indicators for prison healthcare, with limited patient involvement. The selected indicators predominantly measured healthcare processes rather than health outcomes or healthcare structure. Developing performance measures for prison healthcare is challenging due to resource constraints, data system functionality, and comparability issues with the non-incarcerated population.