Article
Biochemistry & Molecular Biology
Samuel S. Valenca, Brittany E. Dong, Elizabeth M. Gordon, Ramon C. Sun, Christopher M. Waters
Summary: This study reveals the crucial role of ASK1 in bleomycin-induced pulmonary fibrosis in mice, mediated through the p38 and ERK1/2 signaling pathways. Inhibition of ASK1 can attenuate the progression of fibrosis and improve relevant indicators and histological parameters.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yani Wang, Siqi Hu, Lisha Shen, Song Liu, Linyan Wan, Shuhui Yang, Mengjie Hou, Xinlun Tian, Hongbing Zhang, Kai-Feng Xu
Summary: In this study, it was found that there was no critical role of autophagy in the development of pulmonary fibrosis post-bleomycin in a mouse model at different stages. The continually up- or downregulated profiles, including gene profiles, and the corresponding functions and pathways may provide insights into IPF therapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Pharmacology & Pharmacy
Zhiwei Xu, Xianli Yuan, Qiaoyan Gao, Yan Li, Mingcai Li
Summary: The overexpression of IL-38 in mice with bleomycin-induced pulmonary fibrosis reduced body weight loss and inflammation, while increasing the release of anti-inflammatory cytokines, suggesting that IL-38 may be a new strategy for the treatment of pulmonary fibrosis by regulating the balance of inflammatory cytokines.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wanhai Qin, Bruno Crestani, C. Arnold Spek, Brendon P. Scicluna, Tom van der Poll, JanWillem Duitman
Summary: This study found that TET2 expression is decreased in IPF patients and AEC2 cells, but AEC2-specific TET2 deficiency does not affect bleomycin-induced pulmonary fibrosis.
Article
Food Science & Technology
Bei Liu, Jinyu Yang, Jiatong Hao, Haifeng Xie, Kuniyoshi Shimizu, Renshi Li, Chaofeng Zhang
Summary: Mogrol from Siratia grosvenorii demonstrated anti-fibrotic effects by suppressing TGF-beta 1 pathway, restoring NOX4 expression, and promoting AMPK phosphorylation. The protective effect against lung fibrosis may be attributed to the activation of AMPK and amelioration of TGF-beta 1 signalling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Monica L. Brown Lobbins, Imara-Safi O. Scott, Andrzej T. Slominski, Karen A. Hasty, Sicheng Zhang, Duane D. Miller, Wei Li, Tae-Kang Kim, Zorica Janjetovic, Tejesh S. Patel, Linda K. Myers, Arnold E. Postlethwaite
Summary: The study shows that the noncalcemic vitamin D analog, 17,20S(OH)(2)pD, can suppress total collagen production, dermal thickness, and total collagen content in a fibrosis model, while also increasing MMP-13 expression and decreasing expression of other related factors, as well as suppressing certain cytokines in the serum. This antifibrotic property offers new therapeutic approaches for fibrotic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yunzhang Wu, Yongchao Qi, Zhibing Qiu, Wen Chen
Summary: The study demonstrates that CARMA3 plays a crucial role in the pathogenesis of bleomycin-induced pulmonary fibrosis, potentially offering a target for therapeutic intervention by mitigating inflammation, collagen deposition, and alveolar epithelial cell damage.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Yuanyuan Han, Mao Jiang, Rongling He, Xin Lv, Xiaohua Liao, Yijun He, Fan Zhang, Lingzhi Long, Guoliang Jiang, Zhangzhe Peng, Lijian Tao, Gaoyun Hu, Jie Meng
Summary: The study found that the newly synthesized drug MFD can alleviate lung fibrosis by suppressing TGF-beta/Smad2 and MAPK pathways, reducing cell apoptosis and EMT in the fibrotic process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Habtamu B. Derseh, Kopiyawaththage U. E. Perera, Sasika N. Vithana Dewage, Andrew Stent, Emmanuel Koumoundouros, Louise Organ, Charles N. Pagel, Ken J. Snibson
Summary: Idiopathic pulmonary fibrosis is a chronic lung disease characterized by excessive ECM deposition. Lowering serum copper levels with tetrathiomolybdate may be beneficial for treating pulmonary fibrosis, as it attenuates angiogenesis and fibrosis development while improving lung function. Additionally, tetrathiomolybdate treatment downregulates VEGF expression and suppresses inflammatory cell accumulation, suggesting it as a potential therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuhua Liu, Shaofang Wang, Xueqi Gong, Yingshuo Wang, Tonghui Xu
Summary: Research indicates that B7, a B chain of recombinant human relaxin, effectively inhibits bleomycin-induced pulmonary inflammation, improving damaged alveolar structure, reducing collagen deposition, and suppressing primary pathological features of idiopathic pulmonary fibrosis.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yunyun Quan, Zhujun Yin, Shilong Chen, Jirui Lang, Liyang Han, Jing Yi, Lu Zhang, Qianhua Yue, Weiwei Tian, Ping Chen, Shenglin Du, Jianbo Wang, Ying Dai, Hua Hua, Jin Zeng, Li Li, Junning Zhao
Summary: The main objective of this study was to investigate the alterations in the gut microbiota (GM) of pulmonary fibrosis (PF) mice induced by bleomycin (BLM) with its underlying mechanisms. It was found that BLM induced significant apoptosis of pulmonary cells and increased expression levels of pro-apoptotic genes and pro-fibrotic targets. Additionally, the GM balance was disrupted, with changes in the relative abundance of specific bacterial strains.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xiaoyu Wan, Yongtao Xiao, Xinbei Tian, Ying Lu, Haiqing Chu
Summary: The aim of this study is to investigate the roles of CD11b+ monocytes/macrophages in the progression of pulmonary fibrosis. The expression levels of CD11B gene and inflammatory genes in IPF patients are evaluated. CD11b cells are conditionally depleted in CD11b-DTR mice and pulmonary fibrosis is induced using bleomycin. The results show that CD11b+ monocytes/macrophages contribute to pulmonary fibrosis and represent a potential therapeutic target for IPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jingxuan Cui, Chengyu Zhang, Hongliang Liu, Lijun Yang, Xiao Liu, Jingjing Zhang, Ying Zhou, Junhua Zhang, Xiaohui Yan
Summary: In this study, mannose-modified hierarchically porous UiO-66 nanoparticles were used to encapsulate recombinant human bleomycin hydrolase and transported into epithelial cells to prevent pulmonary fibrosis during BLM-based chemotherapies. The encapsulation of rhBLMH in the MHP-UiO-66 NPs protected the enzyme and enhanced cellular uptake, providing more efficient lung protection against BLMs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Faisal Fakhouri, Matthew Joseph, Megan Ballinger, Vasudha Shukla, David Weimar, Caymen Novak, Samir Ghadiali, Arunark Kolipaka
Summary: This study used magnetic resonance elastography (MRE), histology, and bronchoalveolar lavage (BAL) to study changes in the mechanical and structural properties of the lungs after bleomycin-induced pulmonary fibrosis in pigs. The results demonstrated that MRE can be used to detect changes in lung stiffness in pigs after bleomycin challenge.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Medicine, General & Internal
Heayon Lee, In Kyoung Kim, Jeonghyeon Im, Bae Suk Jin, Hwan Hee Kim, Sei Won Kim, Chang Dong Yeo, Sang Haak Lee
Summary: This study evaluated the effects of intermittent hypoxia on lung fibrosis in an elderly mouse model and found that obstructive sleep apnea may have harmful impacts on lung fibrosis. Older patients with idiopathic pulmonary fibrosis and obstructive sleep apnea may deserve more attention.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Dermatology
Akimasa Saito, Yuki Ichimura, Noriko Kubota, Ryota Tanaka, Yoshiyuki Nakamura, Yasuhiro Fujisawa, Rei Watanabe, Yosuke Ishitsuka, Manabu Fujimoto, Naoko Okiyama
Summary: In patients with GVHD, KCs in skin lesions of chronic GVHD show marked production of TGF beta 1, while IFN-gamma-deficient CD8 T-cell recipients have lower expression of TGF beta 1 in the epidermis. IFN-gamma promotes TGF beta 1 production by apoptotic KCs, mediating the development of widespread sclerodermatous changes in KC-targeting GVHD.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Editorial Material
Dermatology
Yuri Shimizu, Yorihisa Kotobuki, Noriko Arase, Hisashi Arase, Ichiro Katayama, Manabu Fujimoto
ANNALS OF DERMATOLOGY
(2022)
Letter
Dermatology
Emi Kaneda, Kyoko Tonomura, Yorihisa Kotobuki, Ikuko Ueda-Hayakawa, Kanako Tasaka, Manabu Fujimoto
JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Dermatology
Tatsuya Ogawa, Yosuke Ishitsuka, Yoshiyuki Nakamura, Rei Watanabe, Naoko Okiyama, Yasuhiro Fujisawa, Manabu Fujimoto, Dennis R. Roop, Toshifumi Nomura
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Ryota Tanaka, Yuki Ichimura, Noriko Kubota, Risa Konishi, Yoshiyuki Nakamura, Seiya Mizuno, Satoru Takahashi, Manabu Fujimoto, Toshifumi Nomura, Naoko Okiyama
Summary: This study aimed to elucidate the regulatory role of LCs through the PD-1/PD-L1 axis and found that LCs disrupt the exacerbation of psoriasis through PD-L1.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Letter
Dermatology
Hanako Koguchi-Yoshioka, Hajime Nakano, Eijiro Akasaka, Atsushi Tanemura, Ichiro Katayama, Daisuke Sawamura, Manabu Fujimoto, Mari Wataya-Kaneda
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Kazunori Yokoi, Noriko Arase, Takashi Shimbo, Manabu Fujimoto, Atsushi Tanemura
ACTA DERMATO-VENEREOLOGICA
(2023)
Letter
Dermatology
Yutaka Matsumura, Rei Watanabe, Hanako Koguchi-Yoshioka, Yuumi Nakamura, Aki Saito, Miki Kume, Shuichi Nakai, Yosuke Ishitsuka, Junichi Furuta, Manabu Fujimoto
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Yasushi Kikuchi, Tomoki Tamakoshi, Ryuichi Ishida, Ryosuke Kobayashi, Shiho Mori, Akemi Ishida-Yamamoto, Manabu Fujimoto, Yasufumi Kaneda, Katsuto Tamai
Summary: In this study, researchers developed an ex vivo gene therapy for recessive dystrophic epidermolysis bullosa (RDEB) using autologous mesenchymal stromal cells (MSCs). The gene-modified MSCs were injected into mice with type VII collagen deficiency, leading to continuous and widespread expression of type VII collagen. The therapy showed successful application in both early blistering skin and advanced ulcerative lesions in the RDEB mouse model.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Oncology
Kazunori Yokoi, Yoshiaki Yasumizu, Naganari Ohkura, Koei Shinzawa, Daisuke Okuzaki, Nene Shimoda, Hideya Ando, Nanako Yamada, Manabu Fujimoto, Atsushi Tanemura
Summary: In this study, it was found that the skin tightness of hypopigmented lesions in vitiligo patients was more evident compared to uninvolved perilesional skin. Collagen homeostasis in vitiligo lesions appeared to be maintained despite the excessive oxidative stress associated with the disease. The expression of collagen-related genes and anti-oxidative enzymes was upregulated, collagen degeneration was attenuated, and the NRF2 signaling pathway was activated in vitiligo dermis.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Editorial Material
Rheumatology
Manabu Fujimoto
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Dermatology
Mari Wataya-Kaneda, Shinichirou Maeda, Ayumi Nakamura, Misa Hayashi, Manabu Fujimoto
Summary: A pilot study was conducted to evaluate the safety and efficacy of 0.2% sirolimus gel for venous and capillary malformations, and to compare its efficacy with systemic sirolimus treatment. The results showed that the gel was as clinically effective as systemic treatment and more effective for early active lesions, even systemic venous malformations.
JOURNAL OF DERMATOLOGY
(2023)
Review
Immunology
Yutaka Matsumura, Rei Watanabe, Manabu Fujimoto
Summary: B cells, including regulatory B cells (Bregs), regulate inflammation through an inhibitory mechanism mediated by interleukin 10 (IL-10). Bregs have been reported in various disease models and play a role in autoimmune diseases, infectious diseases, cancer, and organ-transplant rejection. In addition to IL-10, other cytokines and membrane-binding molecules are also involved in the suppressive functions of Bregs. The identification and classification of Breg fractions remains challenging due to the variations in their activity and differentiation stages in different disease models.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Allergy
Yutaka Matsumura, Rei Watanabe, Yasuko Niijima, Haruka Kawakita, Junichi Furuta, Yoshiyuki Nakamura, Yosuke Ishitsuka, Naoko Okiyama, Yasuhiro Fujisawa, Manabu Fujimoto
Summary: The study tracked the serum levels of IL-6, IL-10, BAFF, and APRIL in three DIHS patients, showing that IL-6 and IL-10 tended to be elevated during disease activity while BAFF and APRIL increased during the improved phase. The results suggest that continuous B cell activation may be involved in the prolonged disease activity of DIHS and the development of autoimmune disorders.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2021)
Article
Rheumatology
Nhung Thi My Ly, Ikuko Ueda-Hayakawa, Chuyen Thi Hong Nguyen, Trang Nguyen Mai Huynh, Izumi Kishimoto, Manabu Fujimoto, Hiroyuki Okamoto
Summary: The study found an imbalance of cT(FH) towards T-FH 1 in SSc patients, which may induce B cell alteration through IL-21 and IL-6 pathways, promoting inflammation and contributing to the pathogenesis of SSc disease.