Article
Rheumatology
Sofie A. M. Gernaat, Julia F. Simard, Anna-Karin Wikstrom, Elisabet Svenungsson, Elizabeth V. Arkema
Summary: The study found a risk association between systemic lupus erythematosus (SLE) and gestational diabetes mellitus (GDM), with women with SLE being more likely to develop GDM during pregnancy compared to general population controls.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Abir Mokbel, Doaa H. S. Attia, Hania S. Zayed, Nahlaa Eesa Naeem, Geilan Mahmoud, Rafat Riad, Soumaya Abou Elewa, Mohamed Youssef, Hisham Haggag, Sally S. Mohamed
Summary: This study aims to describe the pregnancy outcomes of SLE patients and identify predictors of adverse maternal and fetal outcomes. The study included 201 singleton pregnancies of 123 women with SLE. The study found that pregnancy planning, disease flares, and secondary antiphospholipid syndrome were predictors of adverse pregnancy outcomes.
Article
Rheumatology
Karel Venne, Susan Scott, Sasha Bernatsky, Evelyne Vinet
Summary: The study found that the rate of induced abortions in women with SLE is similar to that of the general population. Through multivariable analysis, it was observed that women exposed to teratogenic immunosuppressives or using corticosteroids did not have higher rates of induced abortions.
Article
Endocrinology & Metabolism
Yu Deng, Yiran Zhou, Jiangcheng Shi, Junting Yang, Hong Huang, Muqiu Zhang, Shuxian Wang, Qian Ma, Yingnan Liu, Boya Li, Jie Yan, Huixia Yang
Summary: Through gene expression data analysis and machine learning methods, this study identified SEZ6, NRAD1, and LPAR4 as potentially useful genetic biomarkers for predicting APO risk during early and mid-pregnancy in women with SLE.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Hui-hui Li, Lin-tao Sai, Shan Tian, Yuan Liu, Colman I. Freel, Kai Wang, Chi Zhou, Jing Zheng, Qiang Shu, Ying-jie Zhao
Summary: This study investigated the transcriptomic profiles of female and male placentas from women with SLE using RNA-seq. The results suggest that the SLE-dysregulated protein-coding genes in placentas may contribute to the pathophysiological progress of SLE pregnancies in a fetal sex-specific manner, leading to adverse pregnancy outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Anika Lucas, Amanda M. Eudy, Dafna Gladman, Michelle Petri, Murray Urowitz, Christina M. Wyatt, Megan E. B. Clowse
Summary: This study analyzed cohorts of pregnant women with SLE and found that LN was associated with fetal loss and preeclampsia. Active nephritis was associated with poor pregnancy outcome and fetal loss.
Article
Immunology
Nefeli Giannopoulou, Latika Gupta, Laura Andreoli, Daniele Lini, Elena Nikiphorou, Rohit Aggarwal, Vikas Agarwal, Ioannis Parodis
Summary: The study found that COVID-19 vaccination in pregnant SLE patients was safe and did not exacerbate their autoimmune disease. Minor vaccine-related adverse events were reported but did not affect daily functioning and resolved within a few days. No adverse pregnancy outcomes were reported. Overall, the risk/benefit ratio of COVID-19 vaccination in SLE patients and high-risk pregnancies is favorable.
AUTOIMMUNITY REVIEWS
(2023)
Article
Rheumatology
Sarah H. Chung, Kimiko Oshima, Michael Singleton, Jenna Thomason, Cara Currier, Stephen McCartney, Namrata Singh
Summary: Women with SLE are at high risk for cervical dysplasia, and this study investigated the prevalence of cervical cancer screening according to ASCCP guidelines in this population. The study found that only half of the women with SLE had guideline-congruent screening, highlighting the need for increased awareness and consensus among providers regarding SLE-specific cervical cancer screening.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Xinyu Hao, Dongying Zheng, Muhanmmad Khan, Lixia Wang, Timo Hamalainen, Fengyu Cong, Hongming Xu, Kedong Song
Summary: This study aimed to develop predictive models using machine learning techniques to explore more information from medical records of pregnant women with SLE for predicting adverse outcomes. After analysis and selection, 18 variables showed statistical differences and 40 variables were identified as contributing predictors. The Random Forest algorithm demonstrated the best discrimination ability for overall predictive models and achieved the best performance in real-time predictive accuracy assessment. Machine learning models could overcome the limitations of statistical methods in the presence of small sample sizes and numerous variables, and the RF classifier performed well in such structured medical records.
Article
Rheumatology
Katarina Bremme, Sonja Honkanen, Iva Gunnarsson, Roza Chaireti
Summary: Pregnant women with systemic lupus erythematosus (SLE), especially those with renal involvement, have a higher risk of obstetric complications such as preeclampsia, which can lead to premature birth and the need for a cesarean section. More frequent antenatal check-ups and closer follow-up are recommended for these patients to improve obstetric outcomes.
Article
Medicine, General & Internal
Fanny Urbain, Maharajah Ponnaiah, Farid Ichou, Marie Lhomme, Clement Materne, Sophie Galier, Julien Haroche, Eric Frisdal, Alexis Mathian, Herve Durand, Micheline Pha, Miguel Hie, Anatol Kontush, Philippe Cluzel, Philippe Lesnik, Zahir Amoura, Maryse Guerin, Fleur Cohen Aubart, Wilfried Le Goff
Summary: This study uncovers the contribution of disturbed metabolism to the presence of coronary artery calcium and the associated risk of coronary heart disease in patients with systemic lupus erythematosus (SLE). Identification of novel lipid and metabolite biomarkers may help stratifying patients for reducing cardiovascular disease morbidity and mortality in SLE.
Article
Rheumatology
Luisa Brites, Stefanie Silva, Laura Andreoli, Luis Ines
Summary: This study aimed to analyze the effectiveness of reproductive health counseling in women with SLE and identify gaps in patient educational needs. The results showed that most women of childbearing age with SLE received effective reproductive health counseling and used contraceptive methods, although there were still some unmet needs in patient counseling.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Rheumatology
Maddalena Larosa, Veronique Le Guern, Gaelle Guettrot-Imbert, Nathalie Morel, Noemie Abisror, Chafika Morati-Hafsaoui, Pauline Orquevaux, Elisabeth Diot, Andrea Doria, Francoise Sarrot Reynauld, Nicolas Limal, Viviane Queyrel, Odile Souchaud-Debouverie, Laurent Sailler, Maelle Le Besnerais, Tiphaine Goulenok, Anna Molto, Emmanuelle Pannier-Metzger, Loic Sentilhes, Luc Mouthon, Estibaliz Lazaro, Nathalie Costedoat-Chalumeau
Summary: The specific roles of remission status, lupus low disease activity state (LLDAS), and damage accrual on the prognosis of pregnancies in women with SLE are unknown. This study found that damage at conception and lupus anticoagulant were significantly associated with adverse pregnancy outcomes, while hypocomplementemia in the first trimester was associated with maternal flares later in pregnancy.
Article
Rheumatology
E. M. J. Bos, E. C. Rijnink, M. Zandbergen, J. D. N. Diaz de Pool, M. M. Almekinders, J. H. M. Berden, M. Bijl, E. C. Hagen, C. Kolster-Bijdevaate, G. M. Steup-Beekman, R. Wolterbeek, K. W. M. Bloemenkamp, H. J. Baelde, J. A. Bruijn, I. M. Bajema, S. Wilhelmus
Summary: This study aimed to investigate the presence, amount, and origin of microchimerism in peripheral blood of pregnant and non-pregnant women with SLE. The results showed that microchimerism was more common in non-pregnant SLE patients compared to control subjects. The majority of microchimerism originated from the fetus. Pregnant SLE patients had significantly higher levels of fetal chimeric cells in their peripheral blood after delivery.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Catherine A. Sims, Amanda M. Eudy, Jayanth Doss, Jennifer L. Rogers, Rebecca E. Sadun, Lisa Criscione-Schreiber, Kai Sun, Megan E. B. Clowse
Summary: Women with active SLE or on teratogens are at a higher risk of poor pregnancy outcomes. The HOP-STEP Intervention effectively identifies pregnancy interest, allowing rheumatologists to optimize disease control and medication regimens before conception.
Article
Obstetrics & Gynecology
Jessica Lee, Melissa Papic, Erin Baldauf, Glenn Updike, E. Bimla Schwarz
Article
Obstetrics & Gynecology
Sonya Borrero, Cara Nikolajski, Julia R. Steinberg, Lori Freedman, Aletha Y. Akers, Said Ibrahim, Eleanor Bimla Schwarz
Article
Endocrinology & Metabolism
Sarah H. O'Brien, Terah Koch, Sara K. Vesely, Eleanor Bimla Schwarz
Article
Pediatrics
Tarah T. Colaizy, Melissa C. Bartick, Briana J. Jegier, Brittany D. Green, Arnold G. Reinhold, Andrew J. Schaefer, Debra L. Bogen, Eleanor Bimla Schwarz, Alison M. Stuebe
JOURNAL OF PEDIATRICS
(2016)
Editorial Material
Health Care Sciences & Services
E. Bimla Schwarz
JOURNAL OF GENERAL INTERNAL MEDICINE
(2015)
Article
Public, Environmental & Occupational Health
Angela A. Kaslow, Patrick S. Romano, Eleanor Schwarz, Ulfat Shaikh, Elisa K. Tong
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2018)
Article
Obstetrics & Gynecology
Alisse Hauspurg, Malamo E. Countouris, Arun Jeyabalan, Carl A. Hubel, James M. Roberts, Eleanor B. Schwarz, Janet M. Catov
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2019)
Article
Psychology, Developmental
Angela Barney, Felicia Rodriguez, Eleanor Bimla Schwarz, Reiley Reed, Daniel Tancredi, Claire D. Brindis, Christine Dehlendorf, Kathleen P. Tebb
Summary: After facing funding disruption, a teen pregnancy prevention project funded by the US Office of Adolescent Health shifted to online recruitment strategy, which resulted in lower costs, a diverse sample, and reaching a wider geographic region. The study showed that online recruitment can cut costs and be more efficient, but special considerations are needed when considering social media recruitment.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Obstetrics & Gynecology
Kathleen P. Tebb, Christine Dehlendorf, Felicia Rodriguez, Margaret Fix, Daniel J. Tancredi, Reiley Reed, Claire D. Brindis, Eleanor Bimla Schwarz
Summary: The SpeakOut intervention did not improve contraceptive communication, knowledge or use among participating teens or their peers. While primary participants receiving SpeakOut were less likely to discontinue contraception within 9 months, this difference did not reach statistical significance. Most secondary participants reported peer communication about contraception, and contraceptive knowledge remained incomplete in all study groups.
Article
Obstetrics & Gynecology
Daniel Grossman, Sarah Raifman, Natalie Morris, Andrea Arena, Lela Bachrach, Jessica Beaman, M. Antonia Biggs, Curtiss Hannum, Stephanie Ho, Eleanor B. Schwarz, Marji Gold
Summary: The study findings indicate that medication abortion with mail-order pharmacy dispensing of mifepristone is effective, feasible, and acceptable to patients. The majority of participants expressed satisfaction with receiving medications by mail and stated they would use the service again if needed. The rate of adverse events was low and not related to mail-order pharmacy dispensing.
Article
Health Care Sciences & Services
Eleanor Bimla Schwarz, Carrie A. Lewis, Melanie S. Dove, Eryn Murphy, Diana Zuckerman, Claudia Nunez-Eddy, Daniel J. Tancredi, Raegan McDonald-Mosley, Sarita Sonalkar, Mark Hathaway, Aileen M. Gariepy
Summary: This study compares the effectiveness and safety of intrauterine contraceptives (IUC) to laparoscopic tubal ligation for Medicaid clients. The results indicate that IUC is at least as effective as tubal ligation in preventing pregnancy at 1-year post-procedure, with lower rates of infection and pelvic pain 6 to 12 months post-procedure.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Letter
Health Care Sciences & Services
Eleanor Bimla Schwarz, Aileen Gariepy, Sarita Sonalkar
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Jennifer L. Michener, David A. Hirsh, Pelin Batur, Rachel S. Casas, Vidya Gopinath, Lydia E. Pace, Christine Prifti, Jennifer Rusiecki, Eleanor Bimla Schwarz, Megha Shankar, Mindy Sobota, Deborah Gomez Kwolek
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Heike Thiel de Bocanegra, Monica Braughton, Mary Bradsberry, Mike Howell, Julia Logan, Eleanor Bimla Schwarz
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2017)
Article
Obstetrics & Gynecology
Aileen Gariepy, Lisbet S. Lundsberg, Nicole Vilardo, Nancy Stanwood, Kimberly Yonkers, Eleanor B. Schwarz