Review
Biochemistry & Molecular Biology
Sakshi Taneja, Stefan W. Vetter, Estelle Leclerc
Summary: Hypoxia, characterized by inadequate oxygen supply to tissues, is common in solid tumors. Cellular response to hypoxic conditions is mediated by activating HIFs, which control the expression of many target genes. Recent studies suggest that RAGE signaling plays a crucial role in tumor biology under hypoxic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shengqi Huo, Qian Wang, Wei Shi, Lulu Peng, Yue Jiang, Mengying Zhu, Junyi Guo, Dewei Peng, Moran Wang, Lintong Men, Bingyu Huang, Jiagao Lv, Li Lin
Summary: This study investigated the effects of advanced glycosylation end products (AGEs) and copper in diabetic cardiomyopathy (DCM). The results showed that both AGEs and copper induced cardiomyocyte death and exacerbated the process. These findings suggest that excessive AGEs and copper can disrupt copper homeostasis and promote cardiomyocyte death, potentially serving as a therapeutic target for DCM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Harbinder Singh, Devendra K. Agrawal
Summary: This article summarizes the structural features and pathological effects of RAGE, as well as its potential in the treatment of chronic inflammatory diseases. The importance of antagonizing the interactions between RAGE and its ligands is emphasized, and future research directions are discussed.
DRUG DEVELOPMENT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ljuba Bacharova, Marta Kollarova, Branislav Bezak, Allan Bohm
Summary: Left ventricular hypertrophy (LVH) refers to the complex rebuilding of the left ventricle, which can lead to heart failure and life-threatening ventricular arrhythmias. Imaging methods such as echocardiography and cardiac magnetic resonance can diagnose the increase in left ventricle size, while other methods can evaluate the functional status and underlying processes of LVH. Molecular and genetic biomarkers offer insights and potential for targeted therapy. This review summarizes the main biomarkers used in LVH evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Abeer M. Mahmoud, Mohamed M. Ali
Summary: The study found that high glucose and glycation end products increase CD147 expression and glycosylation in human adipocytes, possibly mediated by NF kappa B and RAGE. This leads to increased activity of MMP2 and MMP9, contributing to cardiovascular complications in diabetes.
Review
Food Science & Technology
Yeliz Serin, Gamze Akbulut, Halime Ugur, Mustafa Yaman
Summary: Recent changes in dietary habits have increased intake of AGEs, highlighting the need for more in vitro research to provide better nutritional recommendations.
CURRENT OPINION IN FOOD SCIENCE
(2021)
Article
Biology
Yan Yang, Guoyu Liu, Feng Li, Lucas B. Carey, Changjin Sun, Kaiping Ling, Hiroyuki Tachikawa, Morihisa Fujita, Xiao-Dong Gao, Hideki Nakanishi
Summary: The multiligand receptor RAGE plays a crucial role in mediating phagocytosis by non-professional phagocytes (NPPs) through the use of RNA fragments as ligands for internalization. This study reveals a new mechanism of phagocytosis by NPPs, showing that spores of Saccharomyces cerevisiae are efficiently internalized by NPPs due to the attachment of RNA fragments derived from cytosolic RNA species to the spore wall. Furthermore, the researchers demonstrate that RAGE is involved in phagocytosis by NPPs, not only in response to spores but also to other macromolecules containing RAGE ligands.
COMMUNICATIONS BIOLOGY
(2022)
Editorial Material
Urology & Nephrology
Raad Chowdhury, Manisha Jhamb
Summary: The study found that a 6-month intradialytic cycling program led to a significant reduction in left ventricular mass in hemodialysis patients, but did not have a significant effect on physical function, physical activity, or health-related quality of life.
KIDNEY INTERNATIONAL
(2021)
Article
Food Science & Technology
Pei Zhu, Ying Zhang, Chenchen Xie, Huilin Liu, Baoguo Sun
Summary: This study demonstrated that carbon dots derived from highland barley bran can effectively inhibit the formation of advanced glycation end products (AGEs) by reducing the glycosylation sites in glycosylated beta-casein.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Medicine, General & Internal
Lize Evens, Ellen Heeren, Jean-Luc Rummens, Annelies Bronckaers, Marc Hendrikx, Dorien Deluyker, Virginie Bito
Summary: In vitro studies showed that AGEs have a time- and concentration-dependent negative effect on CASCs survival, proliferation, migration, and apoptosis, partially mediated through RAGE activation. The potential of anti-AGEs therapies in the context of stem cell therapy after MI requires further investigation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lida Fan, Wenzhe Yu, Beiang Zhang, Bin Cao, Mingfu Wang, Xiaoqian Hu
Summary: This study revealed the distinctive effects of various AGEs on glucose metabolism, with MGO-BSA being the most active in promoting insulin resistance and impacting glucose tolerance when consumed in the diet.
Review
Endocrinology & Metabolism
Yimin Dai, Shuang Zhou, Lin Qiao, Zhao Peng, Jiuliang Zhao, Dong Xu, Chanyuan Wu, Mengtao Li, Xiaofeng Zeng, Qian Wang
Summary: Diabetes mellitus affects pulmonary function and can lead to related complications. Non-apoptotic programmed cell deaths have been found to be associated with diabetic pulmonary dysfunction. The AGE-RAGE axis plays an important role in the traditional pathogenesis of diabetes lung disease as well as non-apoptotic cell death.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Jonathan Grinstein, Mark N. Belkin, Sara Kalantari, Kevin Bourque, Christopher Salerno, Sean Pinney
Summary: Left ventricular assist devices (LVADs) are a lifesaving therapy for advanced heart failure, but can lead to hemodynamic-related events (HDREs) such as right-sided heart failure (RHF) and aortic insufficiency (AI). HDREs manifest later than hemocompatibility-related adverse events (HRAEs) and require different strategies for mitigation. Differentiating HDREs from HRAEs is crucial for advancing LVAD technology and improving pump-patient durability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Yuan Yuan, Ling Yan, Qing-Qing Wu, Heng Zhou, Ya-Ge Jin, Zhou-Yan Bian, Wei Deng, Zheng Yang, Di-Fei Shen, Xiao-Feng Zeng, Sha-Sha Wang, Hongliang Li, Qi-Zhu Tang
Article
Genetics & Heredity
Kay-Marie Lamar, Sasha Bogdanovich, Brandon B. Gardner, Quan Q. Gao, Tamari Miller, Judy U. Earley, Michele Hadhazy, Andy H. Vo, Lisa Wren, Jeffery D. Molkentin, Elizabeth M. McNally
Article
Biochemistry & Molecular Biology
Jeffery A. Goldstein, Sasha Bogdanovich, Anastasia Beiriger, Lisa M. Wren, Ann E. Rossi, Quan Q. Gao, Brandon B. Gardner, Judy U. Earley, Jeffery D. Molkentin, Elizabeth M. McNally
HUMAN MOLECULAR GENETICS
(2014)
Article
Biochemistry & Molecular Biology
Bijoy Chellan, Ling Yan, Timothy J. Sontag, Catherine A. Reardon, Marion A. Hofmann Bowman
JOURNAL OF LIPID RESEARCH
(2014)
Article
Cell Biology
Ermelinda Ceco, Sasha Bogdanovich, Brandon Gardner, Tamari Miller, Adam DeJesus, Judy U. Earley, Michele Hadhazy, Lucas R. Smith, Elisabeth R. Barton, Jeffery D. Molkentin, Elizabeth M. McNally
SCIENCE TRANSLATIONAL MEDICINE
(2014)
Article
Orthopedics
Shane Rayos Del Sol, Alvarho Guzman, Sophia Sarang Shin Yin, Brandon Gardner, Stewart Bryant, Moyukh O. Chakrabarti, Patrick J. McGahan, James L. Chen
Summary: This article introduces a unique arthroscopic repair method for superior one-third subscapularis tears, using a self-punching knotless soft suture anchor through a single anterior working portal, which is time-saving, efficient, reproducible, and minimizes iatrogenic damage and postoperative complications.
ARTHROSCOPY TECHNIQUES
(2021)
Article
Orthopedics
Dong Hyeon Kim, Joo Yeon Kim, Juho Park, Mika Talwar, Sarah Jenkins, Brandon Gardner, Patrick McGahan, James L. Chen
Summary: The use of arthroscopic Bankart repair for anterior shoulder instability has become increasingly popular. However, the high recurrence rate in the presence of glenohumeral bony defects, especially Hill-Sachs lesions, has raised concerns. Our technique combines remplissage with Bankart repair to fill the Hill-Sachs defect, preventing loss of shoulder stiffness and stability. This minimally invasive procedure offers a low failure rate.
ARTHROSCOPY TECHNIQUES
(2022)
Article
Orthopedics
Joo Yeon Kim, Hee-Yon Park, Shane Rayos Del Sol, Stewart Bryant, Brandon Gardner, Moyukh O. Chakrabarti, Steven Perinovic, Patrick J. McGahan, James L. Chen
Summary: Anterior shoulder pathology involving the subscapularis often requires simultaneous repairs of the biceps tendon, but single anterior portal subscapularis repairs have become popular in recent years. Biceps tenodesis, commonly performed through open or arthroscopic procedures, restores the functional length-tension relation and preserves joint function.
ARTHROSCOPY TECHNIQUES
(2021)
Article
Orthopedics
Hee-Yon Park, Brandon Gardner, Joo Yeon Kim, Stewart Bryant, Moyukh Chakrabarti, Patrick McGahan, James L. Chen
Summary: The success of an anterior cruciate ligament reconstruction is influenced by several factors, including the origin, type, and morphology of the graft. This technical note describes a 4-strand hamstring autograft technique that uses a simple diamond-type braid to increase the cross-sectional area and produce a more oval shape, potentially leading to higher success rates and positive long-term outcomes. Increasing the graft diameter has been associated with better outcomes, and this braiding construct may offer additional tensile strength and resistance to failure compared to undersized grafts prepared with conventional techniques.
ARTHROSCOPY TECHNIQUES
(2021)
Article
Orthopedics
Stewart A. Bryant, Garrett Trang, Hannah M. Nash, Brandon B. Gardner, Joo Yeon Kim, Hee-Yon Park, Moyukh Chakrabarti, Patrick McGahan, James L. Chen
Summary: Achilles tendon repair has evolved over the past 30 years, with percutaneous repair offering comparable failure rates but fewer complications and faster recovery than open procedures. However, percutaneous repairs carry the risk of sural nerve injury. Mini-open repair bridges the gap between percutaneous and open procedures, potentially reducing nerve injury risk while maintaining efficiency in procedure time and patient recovery.
ARTHROSCOPY TECHNIQUES
(2021)
Article
Orthopedics
Joo Yeon Kim, Stewart Bryant, Brandon Gardner, Hee-Yon Park, Whitney Tse, Moyukh Chakrabarti, Patrick McGahan, James L. Chen
Summary: Pathology of the acromioclavicular joint is often treated with distal clavicle excision, with both open and arthroscopic techniques available. Recent studies show no significant difference in patient satisfaction or complication rates between the two techniques, though arthroscopic methods may be more challenging due to limited depth perception. It is noted that open excisions are still widely performed due to technical difficulties with arthroscopic methods.
ARTHROSCOPY TECHNIQUES
(2021)
Article
Orthopedics
Joo Yeon Kim, Hee-Yon Park, Stewart Bryant, Brandon Gardner, Moyukh Chakrabarti, Patrick McGahan, James L. Chen
Summary: Shoulder injuries such as acromioclavicular joint separations are common, with varying treatment practices including reconstruction and repair. This technical note describes a surgical technique involving allograft reconstruction and a Suture Cerclage System for precise reduction and restoration of anatomical alignment in the AC joint.
ARTHROSCOPY TECHNIQUES
(2021)
Article
Orthopedics
Hannah M. Nash, Garrett Trang, Stewart A. Bryant, Asher B. Mirvish, Brandon B. Gardner, Moyukh O. Chakrabarti, Patrick J. McGahan, James L. Chen
Summary: Total shoulder arthroplasty (TSA) has evolved over the years and is commonly used for arthritis. Stemless TSA is a unique bone-preserving design that eliminates rotational malalignment. The use of biological mesh and platelet-rich plasma injection has been found to improve healing in recent literature.
ARTHROSCOPY TECHNIQUES
(2021)