Article
Medicine, Research & Experimental
Benshuo Cai, Juan Du
Summary: This study found that BMP-4 may be involved in GDM-related hypertension through the NOX-1/COX-2 signaling pathway, while VCAM-1 may be closely associated with GDM-related hypertension. Overexpression of BMP-4 may lead to hypertension by impairing endothelial function during pregnancy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jian Liu, Yi Zhang, Dan Qu, Huina Zhang, Li Wang, Chi Wai Lau, Jing-Yan Han, Danzeng Pingcuo, Yu Huang, Limei Liu
Summary: The study revealed the existence of a BMP4-ROS cycle in diabetic mice, with Sal B disrupting this cycle to improve endothelial function. Sal B also inhibited the p38 MAPK/JNK/caspase 3 cascade and improved endothelium-dependent relaxations in diabetic mice. Furthermore, overexpression of BMP4 induced oxidative stress and impaired endothelium-dependent relaxations in non-diabetic mice, which was reversed by Sal B treatment.
Review
Biochemistry & Molecular Biology
Tatsuya Maruhashi, Yukihito Higashi
Summary: Endothelial dysfunction is crucial in the progression of atherosclerosis and is significantly associated with diabetes mellitus and oxidative stress. Selecting appropriate therapeutic interventions that improve endothelial function is important for preventing diabetic vascular complications. Various hypoglycemic drugs and agents like GLP-1 receptor agonists and SGLT2 inhibitors may improve endothelial function through multiple mechanisms independent of glucose control or insulin signaling.
Letter
Medicine, General & Internal
Juan P. Frias, Laura Fernandez Lando, Katelyn Brown
Summary: In the SURPASS-2 trial, treatment with Tirzepatide showed better glycemic control and greater weight loss compared to Semaglutide in patients with type 2 diabetes. Additionally, there were no significant differences in mean systolic blood pressure among the enrolled patients in different treatment groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Er-Fei Luo, Hong-Xia Li, Yu-Han Qin, Yong Qiao, Gao-Liang Yan, Yu-Yu Yao, Lin-Qing Li, Jian-Tong Hou, Cheng-Chun Tang, Dong Wang
Summary: Ferroptosis is involved in endothelial dysfunction caused by diabetes, with activation of the p53-xCT-GSH axis playing a crucial role in endothelial cell ferroptosis and dysfunction.
WORLD JOURNAL OF DIABETES
(2021)
Article
Multidisciplinary Sciences
Kazuya Morita, Naoyuki Matsumoto, Kengo Saito, Toshihide Hamabe-Horiike, Keishi Mizuguchi, Yohei Shinmyo, Hiroshi Kawasaki
Summary: The study revealed that AQP4 is selectively expressed in astrocytes in the mouse cerebral cortex during development, and that BMP signaling plays a role in altering AQP4 levels in the cortex.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Michal Dubsky, Jiri Veleba, Dominika Sojakova, Natalia Marhefkova, Vladimira Fejfarova, Edward B. Jude
Summary: Endothelial dysfunction (ED) is an important indicator of future atherosclerosis and cardiovascular disease, particularly in individuals with diabetes. This article provides a summary of the evidence regarding ED in people with diabetes and explores various factors that can influence the presence and severity of ED and its consequences. The article emphasizes the lack of data on ED in type 1 diabetes and discusses the relationship between ED and arterial stiffness. Interesting studies have shown that ED affects microRNA, microvesicles, lipid levels, and the endoplasmic reticulum. A better understanding of ED could offer valuable insights into the microvascular complications of diabetes, their treatment, and even their prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Raffaele Maio, Edoardo Suraci, Benedetto Caroleo, Cristina Politi, Simona Gigliotti, Angela Sciacqua, Francesco Andreozzi, Francesco Perticone, Maria Perticone
Summary: The study suggests that endothelial dysfunction plays a significant role in the pathways leading to diabetes and cardiovascular events in hypertensive patients. Analysis using an illness-event model indicates that a decrease in forearm blood flow is associated with an increased risk of cardiovascular events and diabetes in these patients.
Review
Biochemistry & Molecular Biology
Nadezhda Barvitenko, Elisaveta Skverchinskaya, Alfons Lawen, Elena Matteucci, Carlota Saldanha, Giuseppe Uras, Alessia Manca, Muhammad Aslam, Antonella Pantaleo
Summary: ROS are recognized as important signaling messengers in endothelial cells, with potential positive effects on pro-survival pathways downstream of G(i)-protein-coupled receptors. However, the role of ROS in stabilizing the endothelial barrier remains uncertain.
Review
Biochemistry & Molecular Biology
Wioletta Zielinska, Jan Zabrzynski, Maciej Gagat, Alina Grzanka
Summary: TRPM2 is a non-selective calcium-permeable cation channel expressed in various mammalian tissues, playing a role in regulating endothelial function. Inhibitors targeting TRPM2 show potential as a therapeutic approach for diseases associated with increased production of reactive oxygen species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rachel L. Washburn, Karl Mueller, Gurvinder Kaur, Tanir Moreno, Naima Moustaid-Moussa, Latha Ramalingam, Jannette M. Dufour
Summary: Diabetes mellitus is a complex metabolic disease affecting one-third of the United States population, characterized by hyperglycemia. For patients with Type 1 diabetes, C-peptide may have potential therapeutic effects on various complications.
Article
Biochemistry & Molecular Biology
Thomas Jansen, Miroslava Kvandova, Isabella Schmal, Sanela Kalinovic, Paul Stamm, Marin Kuntic, Marc Foretz, Benoit Viollet, Andreas Daiber, Matthias Oelze, John F. Keaney Jr, Thomas Muenzel, Eberhard Schulz, Swenja Kroeller-Schoen
Summary: The study demonstrates that mice with endothelial-specific deletion of alpha 1AMPK have detrimental effects during voluntary exercise training, including increased reactive oxygen species production, eNOS uncoupling, and endothelial dysfunction. These results suggest that endothelial alpha 1AMPK plays a critical role in vascular protection and determines whether the effects of exercise on the vasculature are beneficial or harmful.
Review
Immunology
Jingxue Ye, Lanfang Li, Min Wang, Qiuxiao Ma, Yu Tian, Qiong Zhang, Jiushi Liu, Bin Li, Bengang Zhang, Haitao Liu, Guibo Sun
Summary: Atherosclerosis is a common complication of diabetes mellitus, characterized by endothelial dysfunction, inflammation, and oxidative stress. NLRP3 plays a crucial role in both diabetes and atherosclerosis, with its diverse activation modes providing new insights for targeted interventions in metabolic diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaorui Wang, Wenwen Han, Yi Zhang, Yi Zong, Na Tan, Yan Zhang, Li Li, Chang Liu, Limei Liu
Summary: This study investigates the impact of an sEH inhibitor on renovascular endothelial dysfunction in hypertensive rats. The results show that the inhibitor effectively reverses the deleterious effects, such as increased blood pressure and reduced renal blood flow. Additionally, the study reveals the potential role of miR-155-5p in the development of vascular endothelial dysfunction in hypertension.
Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Yi Zhong, Li Deng, Jiafu Li, Xiaoqiu Tan, Jian Feng
Summary: Diabetes eventually leads to chronic vascular complications, with TGR5 potentially serving as a novel therapeutic target for diabetes-associated endothelial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sharen Lee, Jiandong Zhou, Keith Sai Kit Leung, Abraham Ka Chung Wai, Kamalan Jeevaratnam, Emma King, Tong Liu, Wing Tak Wong, Carlin Chang, Ian Chi Kei Wong, Bernard Man Yung Cheung, Gary Tse, Qingpeng Zhang
Summary: Based on real-world data of type 2 diabetic patients in Hong Kong, the use of SGLT2Is was associated with lower risk of incident AF, stroke/transient ischemic attack, and cardiovascular and all-cause mortality outcomes compared to DPP4Is.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Chak Kwong Cheng, Xiao Lin, Yujie Pu, Joyce Ka Yu Tse, Yu Wang, Cheng-Lin Zhang, Xiaoyun Cao, Chi Wai Lau, Juan Huang, Lei He, Jiang-Yun Luo, Yu-Tsung Shih, Song Wan, Chi Fai Ng, Li Wang, Ronald Ching Wan, Jeng-Jiann Chiu, Ting Fung Chan, Xiao Yu Tian, Yu Huang
Summary: This study utilized single-cell RNA sequencing to explore the transcriptional landscape and heterogeneity of dysfunctional endothelial cells in atherosclerotic aortae. SOX4 was identified as a novel marker for atherosclerosis and was shown to promote atherogenesis and endothelial-to-mesenchymal transition. Hyperlipidemia-associated cytokines and oscillatory blood flow were found to upregulate SOX4 expression, while the anti-diabetic drug metformin suppressed SOX4 levels in endothelial cells.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Jiandong Zhou, Sharen Lee, Yingzhi Liu, Jeffrey Shi Kai Chan, Guoliang Li, Wing Tak Wong, Kamalan Jeevaratnam, Shuk Han Cheng, Tong Liu, Gary Tse, Qingpeng Zhang
Summary: We hypothesized that an interpretable gradient boosting machine (GBM) model considering comorbidities, P-wave and echocardiographic measurements, can better predict mortality and cerebrovascular events in mitral regurgitation (MR).
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Rheumatology
Jiandong Zhou, Xuejin Liu, Oscar Hou-In Chou, Lifang Li, Sharen Lee, Wing Tak Wong, Qingpeng Zhang, Carlin Chang, Tong Liu, Gary Tse, Fengshi Jing, Bernard Man Yung Cheung
Summary: This retrospective study compared the effects of SGLT2 inhibitors and DPP4 inhibitors on the risk of gout. The results showed that patients using SGLT2 inhibitors had a significantly lower incidence of gout and a lower risk of all-cause mortality compared to those using DPP4 inhibitors.
Article
Biochemistry & Molecular Biology
Qinyu Yao, Qi Cui, Jia Liu, Xinya Xie, Tingting Jiang, Haodong Wang, Ziwei Zhao, Wenfei Zhao, Xiong Du, Baochang Lai, Lei Xiao, Nanping Wang
Summary: Hyperlipidemia plays a crucial role in the progression of inflammatory cardiovascular diseases. This study reveals that free fatty acids (FFAs) can increase the protein level of integrin beta 1 by inducing nitric oxide synthesis, leading to S-nitrosylation and stabilization of the protein. This process promotes monocyte/macrophage adhesion to endothelium.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Oncology
Jeffrey Shi Kai Chan, Sharen Lee, Dicken Kong, Ishan Lakhani, Kenrick Ng, Edward Christopher Dee, Pias Tang, Yan Hiu Athena Lee, Danish Iltaf Satti, Wing Tak Wong, Tong Liu, Gary Tse
Summary: This prospective cohort study analyzed cancer patients receiving immune checkpoint inhibitors in Hong Kong from 2013 to 2021, and found that the use of immune checkpoint inhibitors may lead to new-onset diabetes mellitus. Male patients were more likely to develop this risk, but there was no significant difference in risk between PD-1 inhibitors and PD-L1 inhibitors users.
Article
Endocrinology & Metabolism
Carlin Chang, Jiandong Zhou, Oscar Hou In Chou, Justin Chan, Keith Sai Kit Leung, Teddy Tai Loy Lee, Wing Tak Wong, Abraham Ka Chung Wai, Tong Liu, Qingpeng Zhang, Sharen Lee, Gary Tse
Summary: This study evaluated the predictive value of neutrophil-to-lymphocyte ratio (NLR) for ischemic stroke and atrial fibrillation (AF) in patients with type 2 diabetes mellitus. The results showed that NLR was significantly associated with an increased risk of new-onset ischemic stroke and AF. NLR had predictive value for ischemic stroke but lower predictive value for AF in Chinese type 2 diabetes patients.
ENDOCRINOLOGY DIABETES & METABOLISM
(2023)
Editorial Material
Cell Biology
Lin-Hua Jiang, Xiaoqiang Yao, Bilal cig
Article
Nutrition & Dietetics
Chui Yiu Bamboo Chook, Yiu Ming Cheung, Ka Ying Ma, Fung Ping Leung, Hanyue Zhu, Qingshan Jason Niu, Wing Tak Wong, Zhen-Yu Chen
Summary: Research found that cardiovascular diseases are the leading cause of death in type 2 diabetes, and current diabetic medications have limited effects on cardiovascular mortality. Experiments on mouse aortas showed that protocatechuic acid (PCA) can improve endothelial function and has antioxidant and anti-inflammatory effects. The protection on cardiovascular function is exerted through the Akt/eNOS pathway. Therefore, it is recommended for diabetic patients to consume an appropriate amount of PCA daily.
FRONTIERS IN NUTRITION
(2023)
Editorial Material
Medicine, Research & Experimental
Xiao Yu Tian, Wing Tak Wong, Zhiming Zhu
Summary: Sodium chloride cotransporter (NCC) is crucial for regulating blood pressure through Na+ reabsorption. In a recent study published in Nature, Fan et al. successfully determined the structure of human NCC and provided insights into the mechanism of action of thiazide diuretics, which will pave the way for future drug development.
Article
Cardiac & Cardiovascular Systems
Sharen Lee, Cheuk To Skylar Chung, Danny Radford, Oscar Hou In Chou, Teddy Tai Loy Lee, Zita Man Wai Ng, Leonardo Roever, Rajesh Rajan, George Bazoukis, Konstantinos P. P. Letsas, Shaoying Zeng, Fang Zhou Liu, Wing Tak Wong, Tong Liu, Gary Tse
Summary: This study found that there are differences in health care resource utilization and costs between patients with Brugada syndrome (BrS) and congenital long QT syndrome (LQTS). BrS patients have lower total costs but higher costs for Accident and Emergency (A & E) and general outpatient services, while they have lower costs for inpatient stay and specialist outpatient services compared to LQTS patients.
CLINICAL CARDIOLOGY
(2023)
Review
Food Science & Technology
Wing-Fu Lai, Dahong Zhang, Obireddy Sreekanth Reddy, Wing-Tak Wong
Summary: Turmeric contains a pigment called curcumin, which has health benefits such as neuroprotection, chemoprevention, and antioxidation. However, its poor solubility and low bioavailability limit its effectiveness.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Wing-Fu Lai, Obireddy Sreekanth Reddy, Lucy Law, Haicui Wu, Wing-Tak Wong
Summary: In this study, a crosslinked blended hydrogel was generated using gelatine and chitosan with clusteroluminogenic properties, which not only exhibited intrinsic antibacterial properties and high tunability in delivery performance but also had a self-indicating capacity for quality control during hydrogel preparation. The release profiles of the agent-loaded gels followed the Higuchi model well, with the non-Fickian mechanism being the major mechanism of the release process. Our gels have high efficiency in agent loading and have great potential in bioactive agent delivery and related biomedical applications.
Article
Pharmacology & Pharmacy
Francis M. Chen, Huixian Li, Dittman Lai-Shun Chung, Angel T. L. Mak, Fung Ping Leung, Ho Yin Edwin Chan, Wing Tak Wong
Summary: This study reveals that SCA3 patient-specific induced neural progenitor cells (iNPCs) exhibit proliferative defects and reduced autophagic expression compared to control. Furthermore, these SCA3 iNPCs undergo rapid senescence and do not survive subsequent passages. However, exposure to interleukin-4 (IL-4) can increase autophagic programs and reduce the proliferation defect in SCA3 iNPCs.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Sport Sciences
Chen Zheng, Jason M. R. Gill, Feng Hua Sun, Wendy Yajun Huang, Sinead Sheridan, Xiang-Ke Chen, Yalan Wu, Chun-Kwok Wong, Xiao Yu Tian, Stephen Heung-Sang Wong
Summary: Increasing daily physical activity is an effective way to reduce the risk of cardiometabolic diseases. This study compared the effects of increasing light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) on cardiometabolic markers in Chinese adults with obesity. The results showed that MVPA had more positive effects on body composition and cardiometabolic biomarkers compared to LPA.
JOURNAL OF SPORTS SCIENCES
(2023)