Article
Cardiac & Cardiovascular Systems
Sifan Qian, Shoujiang You, Yaming Sun, Qiuyi Wu, Xianhui Wang, Weiting Tang, Xiaofeng Dong, Chun-feng Liu, Tan Xu, Yongjun Cao, Chongke Zhong
Summary: This study found a significant positive association between elevated fasting remnant cholesterol levels and abnormal cIMT in patients with ischemic stroke, even in patients with optimal LDL cholesterol levels. Future prospective studies are needed to validate these findings and assess the impact of remnant cholesterol-lowering interventions in patients with ischemic stroke.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Kyung-Hyun Cho
Summary: This article summarizes the changes in the quantity, quality, and functionality of high-density lipoproteins (HDL) in the context of health and disease, and discusses their potential role in the diagnosis and treatment of diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Genki Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study investigated the association between LDL cholesterol, HDL cholesterol, and LDL/HDL ratio and the incidence of diabetes, and identified the cut-off values for incident diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jakub Ratajczak, Aldona Kubica, Piotr Michalski, Lukasz Pietrzykowski, Aleksandra Bialczyk, Agata Kosobucka-Ozdoba, Katarzyna Bergmann, Krzysztof Buczkowski, Magdalena Krintus, Piotr Jankowski, Jacek Kubica
Summary: In this cross-sectional study of 200 primary care patients without diagnosed cardiovascular disease, age, diabetes, material status, BMI, gender, and hypertension were found to be related to abnormal lipid parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Guido Rossi-Herring, Thalia Belmonte, Andrea Rivas-Urbina, Sonia Benitez, Noemi Rotllan, Javier Crespo, Vicenta Llorente-Cortes, Jose Luis Sanchez-Quesada, David de Gonzalo-Calvo
Summary: This study examined the expression profiles of miRNAs in lipoprotein fractions (VLDL, LDL, and HDL) isolated from the serum through various methods. The results showed stable detection of different miRNAs in each fraction, with VLDL-specific miRNAs detected for the first time. Functional enrichment analysis indicated the potential roles of lipoprotein-carried miRNAs in cardiovascular disease-related mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Petri Kresanov, Juha Mykkanen, Markku Ahotupa, Mika Ala-Korpela, Markus Juonala, Jari Kaikkonen, Mika Kahonen, Terho Lehtimaki, Tommi Vasankari, Jorma Viikari, Olli T. Raitakari
Summary: The study found that oxidized HDL lipids were not significantly associated with lipoprotein subclass lipid concentrations and composition after adjusting for certain factors, while oxidized LDL lipids were associated with multiple markers of lipoprotein subclass lipid concentrations and composition. Additionally, HDL and LDL subclass measures, such as phospholipid and triglyceride composition, were directly associated with oxidized LDL lipids, while cholesterol ester and free cholesterol composition in HDL and LDL were inversely associated. These results suggest that LDL oxidation may play a role in atherogenesis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Dmitry A. Kashirskikh, Vasily N. Sukhorukov, Vladislav Kalmykov, Andrey V. Omelchenko, Alexander N. Orekhov
Summary: Atherosclerosis is a major cause of serious cardiovascular disorders, and its pathogenesis involves multiple processes. Reverse transport of cholesterol is a mechanism that plays a protective role against atherosclerosis. Disordered cholesterol metabolism can result in dyslipidemia and early atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Markus Axmann, Birgit Plochberger, Mario Mikula, Florian Weber, Witta Monika Strobl, Herbert Stangl
Summary: Cholesterol transfer between lipoprotein particles and the plasma membrane is crucial for lipid supply in the human body. Different density lipoprotein particles deliver cholesterol to cells through redundant pathways, which can compensate for defects in one pathway but may lead to systemic diseases later on. Intracellular membrane-membrane contact sites and the plasma membrane itself play roles in cholesterol transfer.
Article
Biochemistry & Molecular Biology
Alberto Cordero, Natalia Munoz-Garcia, Teresa Padro, Gemma Vilahur, Vicente Bertomeu-Gonzalez, David Escribano, Emilio Flores, Pilar Zuazola, Lina Badimon
Summary: This study investigated the role of lipoprotein functionality as well as particle number and size in patients with acute coronary syndrome (ACS) and on-target LDL-C levels. It was found that ACS patients had higher susceptibility to LDL oxidation and lower HDL-antioxidant capacity. They also had lower HDL-C and Apolipoprotein A-I levels compared to non-ACS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Nurjannatul Naim Kamaruddin, Lukman Hakim Mohd Din, Allicia Jack, Aina Farahiyah Abdul Manan, Habsah Mohamad, Tengku Sifzizul Tengku Muhammad
Summary: This study investigated the effects of a selected fraction of A. planci on PCSK9 gene expression, LDLR protein level, and LDL-C uptake. The results showed that the selected fraction reduced PCSK9 gene expression, increased LDLR protein level, and promoted LDL-C uptake. These findings suggest that the selected fraction has the potential to lower circulating LDL-C levels and may be a promising therapeutic intervention for preventing the progression of atherosclerosis.
Review
Geriatrics & Gerontology
Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang, Yanyan Xu, Zhen Qin, Gangqiong Liu, Qiguang Wang, Kang Tian, Khoon S. Lim, Chris J. Charles, Jinying Zhang, Junnan Tang
Summary: Dyslipidemia increases the risk of atherosclerosis, and lipoproteins play a significant role in its development. Understanding lipoprotein function can help predict risk and provide novel treatment approaches for atherosclerosis.
Article
Physiology
Mark T. Fuller, Omid Dadoo, Ting Xiong, Pardh Chivukula, Melissa E. MacDonald, Samuel K. K. Lee, Richard C. Austin, Suleiman A. Igdoura, Bernardo L. Trigatti
Summary: High levels of LDL cholesterol and low levels of HDL cholesterol increase the risk of cardiovascular disease. Mice that lack certain genes involved in LDL clearance or HDL functionality are used as models for studying atherosclerosis. This study compared the development of atherosclerosis in different knockout mouse models and found that mice lacking the HDL receptor had similar plaque sizes and compositions in their aortic sinuses but more extensive atherosclerosis in their descending aortas and coronary arteries. These findings suggest that factors other than hypercholesterolemia, such as inflammation and immune system dysregulation, contribute to atherosclerosis in these mice.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Mone't B. Thompson, Daniel Muldoon, Kelvin C. de Andrade, Neelam Giri, Blanche P. Alter, Sharon A. Savage, Robert D. Shamburek, Payal P. Khincha
Summary: The study found that oral androgen therapy in DC patients altered lipid and lipoprotein levels, potentially increasing the risk of atherogenic cardiovascular disease. Individuals on androgens for DC-related BMF should undergo cardiovascular disease monitoring.
Article
Oncology
Giovanna Revilla, Lidia Cedo, Mireia Tondo, Antonio Moral, Jose Ignacio Perez, Rosa Corcoy, Enrique Lerma, Victoria Fuste, T. Srivinasa Reddy, Francisco Blanco-Vaca, Eugenia Mato, Joan Carles Escola
Summary: Cholesterol is crucial for various functions in endocrine-related cells, including hormone and steroid production. While LDL-cholesterol and HDL-cholesterol were not consistently associated with endocrine-related cancer risk, LDL receptor plays a critical role in endocrine-related tumor cells by enhancing circulating LDL-C uptake.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Environmental Sciences
Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Hus, Calin Deleanu, Hubert Dirven, Birgitte Lindeman
Summary: This study explores the association between serum PFAS concentrations and lipoprotein subclasses. After adjusting for confounders, the adjusted models found positive associations between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. Significant associations were observed between certain PFASs and cholesterol in large to medium LDL particle sizes among women. The study also found that most PFASs tended to be associated with a reduction in VLDL particle number and VLDL triglyceride.
ENVIRONMENTAL POLLUTION
(2022)
