Article
Cardiac & Cardiovascular Systems
Prakriti Gaba, Michelle L. O'Donoghue, Jeong-Gun Park, Stephen D. Wiviott, Dan Atar, Julia F. Kuder, KyungAh Im, Sabina A. Murphy, Gaetano M. De Ferrari, Zbigniew A. Gaciong, Kalman Toth, Ioanna Gouni-Berthold, Jose Lopez-Miranda, Francois Schiele, Francois Mach, Jose H. Flores-Arredondo, J. Antonio G. Lopez, Mary Elliott-Davey, Bei Wang, Maria Laura Monsalvo, Siddique Abbasi, Robert P. Giugliano, Marc S. Sabatine
Summary: This study found that long-term achievement of lower LDL-C levels (below 20 mg/dL) in patients with atherosclerotic cardiovascular disease was associated with a lower risk of cardiovascular events without significant safety concerns.
Article
Hematology
Wynn G. Hunter, Alexander G. Smith, Rui C. Pinto, Suzanne Saldanha, Anamika Gangwar, Mandana Pahlavani, Sneha Deodhar, John Wilkins, Ambarish Pandey, David Herrington, Philip Greenland, Ioanna Tzoulaki, Anand Rohatgi
Summary: This study investigated the associations between metabolites and cholesterol efflux capacity (CEC) and found independent associations between CEC and the largest-sized particle subclasses of VLDL and HDL, as well as their constituent apolipoproteins and lipids. However, metabolite profiles had poor accuracy in predicting CEC, and race was found to be the most important factor influencing CEC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Hematology
Christian M. Madsen, Anette Varbo, Borge G. Nordestgaard
Summary: Recent studies have suggested that extremely high levels of HDL cholesterol are associated with increased mortality, indicating that HDL may have harmful effects in some instances. Furthermore, observational and genetic studies have shown that HDL might be linked to the development of major noncardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Canclini, Amir Mohammad Malvandi, Patrizia Uboldi, Najoua Jabnati, Liliana Grigore, Alberto Zambon, Andrea Baragetti, Alberico Luigi Catapano
Summary: This study aimed to investigate the interaction between PCSK9 and LDL, and found that PCSK9 interacts with a subfraction of LDL, with a binding percentage ranging from 2% to 30%, which is not correlated with plasma or LDL cholesterol levels. The association of PCSK9 with LDL appears to be sensitive to high salt concentrations. FPLC and iodixanol gradient ultracentrifugation are identified as the most suitable methods for studying this association.
Article
Cardiac & Cardiovascular Systems
Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela Cheng, Marcus Seldin, Pauline Morand, Richard Lee, Mary Chen, Angel Baldan, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling
Summary: This study reveals a novel role of RNF130 in regulating LDL-C levels by modulating the availability of LDLR.
CIRCULATION RESEARCH
(2023)
Article
Hematology
Jiahuan Chen, Huanyu Zhang, Linquan Li, Xinwei Zhang, Dazhong Zhao, Lingyu Wang, Jiaqi Wang, Ping Yang, Huan Sun, Kun Liu, Weiwei Chen, Lin Li, Feng Lin, Zhanjun Li, Y. Eugene Chen, Jifeng Zhang, Daxin Pang, Hongsheng Ouyang, Yuquan He, Jianglin Fan, Xiaochun Tang
Summary: In this study, Lp-PLA(2) knockout rabbits were generated using the CRISPR/Cas9 system to investigate the role of Lp-PLA(2) in blood lipid regulation and atherosclerosis. The results showed that Lp-PLA(2) deficiency reduced plasma lipid levels and protected against cholesterol-induced atherosclerosis in rabbits. Furthermore, Lp-PLA(2) deficiency impaired cholesterol biosynthesis and inhibited the adhesion between monocytes and endothelial cells.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anna E. Engell, Henrik L. Jorgensen, Bent S. Lind, Anton Pottegard, Christen L. Andersen, John S. Andersen, Margit Kriegbaum, Mia K. Grand, Lise Bathum
Summary: Lipid levels in blood have decreased significantly in the general population due to the use of statins. This trend was observed in primary health care patients who were not using statins from 2001 to 2018, with substantial decreases in total cholesterol and low-density lipoprotein cholesterol levels, especially in the elderly population.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Maureen Sampson, Rami A. Ballout, Daniel Soffer, Anna Wolska, Sierra Wilson, Jeff Meeusen, Leslie J. Donato, Erica Fatica, James D. Otvos, Eliot A. Brinton, Robert S. Rosenson, Peter Wilson, Marcelo Amar, Robert Shamburek, Sotirios K. Karathanasis, Alan T. Remaley
Summary: This study developed a new algorithm for classifying lipoprotein disorders based on the standard lipid panel, categorizing patients into classical Fredrickson-like phenotypes and introducing a new hypolipidemic phenotype (Type VI) due to genetic mutations in apoB-metabolism. The validity of the new algorithm was confirmed through lipid analysis by NMR and by concordance with classification by agarose gel electrophoresis/beta-quantification, demonstrating its potential for improving the care of patients at risk for ASCVD.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Bradley Tucker, Sonia Sawant, Hannah McDonald, Kerry-Anne Rye, Sanjay Patel, Kwok Leung Ong, Blake J. Cochran
Summary: This study investigates the relationship of blood lipid and lipoprotein levels with leukocyte counts in the UK Biobank cohort, finding that triglyceride levels are positively associated with total and differential leukocyte counts. Other relationships between lipid/lipoprotein levels and leukocyte counts were also explored, providing insight into potential direct involvement in leukogenesis.
Review
Cell Biology
Anna Wolska, Mart Reimund, Denis O. Sviridov, Marcelo J. Amar, Alan T. Remaley
Summary: Since the breakthrough of using insulin to treat diabetic patients in the 1920s, there has been a growing interest in developing various proteins and their peptide mimetics for treating medical disorders. Currently, there are over 60 approved peptides for human use and more than 150 peptides in clinical development. This review mainly focuses on peptide mimetics related to cardiovascular diseases, discussing the biochemistry, design, and clinical trials of peptides based on apoA-I, apoE, and apoC-II, while also addressing the limitations and challenges in developing apolipoprotein mimetic peptides into new drugs.
Article
Hematology
Ayea El-Ghazali, Sneha Deodhar, Suzanne Saldanha, Brooke Smyth, Mark Izbrand, Anamika Gangwar, Mandana Pahlavani, Anand Rohatgi
Summary: Cholesterol efflux capacity (CEC) is a clinically relevant cardiovascular biomarker inversely associated with atherosclerotic cardiovascular disease events. Extreme high and low CEC are persistent and robust phenotypes, showing significant differences in CEC patterns across the size distribution of molecules. Further studies are needed to determine specific molecular species linked to CEC in a size-specific manner.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Clare MacLeod, Patrick W. F. Hadoke, Mark Nixon
Summary: Glucocorticoids play important roles in atherosclerosis, with potential athero-protective and pro-atherogenic responses. The mechanisms underlying their effects are complex and require further investigation. Understanding the regulation of glucocorticoid bioavailability in the vasculature may provide insights into their potential benefit in the treatment of cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Sport Sciences
Gina Wood, Emily Taylor, Vanessa Ng, Anna Murrell, Aditya Patil, Tom van der Touw, Ronald Sigal, Mitch Wolden, Neil Smart
Summary: This study analyzed data from nearly 3000 participants undergoing aerobic exercise training, and found that aerobic exercise training had a significant positive impact on improving lipid profiles, particularly on triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Meta-regression indicated that intensity may explain changes in triglycerides, while volume may explain changes in HDL-C and LDL-C. Adjusting aerobic exercise training intervention variables could enhance the effects on triglycerides and cholesterol levels.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Congzhuo Jia, Josephine L. C. Anderson, Eke G. Gruppen, Yu Lei, Stephan J. L. Bakker, Robin P. F. Dullaart, Uwe J. F. Tietge
Summary: The study found that in the general population, high-density lipoprotein anti-inflammatory capacity is inversely associated with first cardiovascular events, independent of HDL cholesterol and cholesterol efflux capacity.
Article
Chemistry, Multidisciplinary
Shifa Jebari-Benslaiman, Kepa B. Uribe, Asier Benito-Vicente, Unai Galicia-Garcia, Asier Larrea-Sebal, Izortze Santin, Iraide Alloza, Koen Vandenbroeck, Helena Ostolaza, Cesar Martin
Summary: A therapeutic strategy based on apoA-I nanoparticles has been developed to improve the treatment of atherosclerosis. The strategy involves a two-step administration to induce gene overexpression and promote cholesterol efflux. Experimental results indicate that this approach can efficiently target atherosclerotic lesions and improve prognosis.
Article
Cardiac & Cardiovascular Systems
Julio A. Chirinos, Lei Zhao, Yi Jia, Cecilia Frej, Luigi Adamo, Douglas Mann, Swapnil V. Shewale, John S. Millar, Daniel J. Rader, Benjamin French, Jeff Brandimarto, Kenneth B. Margulies, John S. Parks, Zhaoqing Wang, Dietmar A. Seiffert, James Fang, Nancy Sweitzer, Christina Chistoffersen, Bjoern Dahlbaeck, Bruce D. Car, David A. Gordon, Thomas P. Cappola, Ali Javaheri
Article
Biochemistry & Molecular Biology
Ya Pei, Dammah Otieno, Inah Gu, Sun-Ok Lee, John S. Parks, Keith Schimmel, Hye Won Kang
Summary: The study found that quercetin supplementation in high-fat diet-fed mice attenuated obesity by promoting browning of white adipose tissue and increasing nonshivering thermogenesis in brown adipose tissue.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biology
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S. Parks, Cristina Furdui, Peter W. Stacpoole, Jennifer Martinez, Charles E. McCall, Matthew A. Quinn
Summary: Metabolic reprogramming occurs in the immune system during sepsis, particularly in the liver, with changes in lipid metabolism, mitochondrial energy, and redox balance. Targeting mitochondrial energy metabolism can rebalance the transcriptional and metabolic manifestations of sepsis in the liver.
Article
Hematology
Srividya Velagapudi, Lucia Rohrer, Francesco Poti, Renate Feuerborn, Damir Perisa, Dongdong Wang, Grigorios Panteloglou, Anton Potapenko, Mustafa Yalcinkaya, Andreas J. Hulsmeier, Bettina Hesse, Alexander Lukasz, Mingxia Liu, John S. Parks, Christina Christoffersen, Markus Stoffel, Manuela Simoni, Jerzy-Roch Nofer, Arnold von Eckardstein
Summary: The study revealed that ApoM and S1P(1) play a role in promoting the endothelial barrier function and facilitating the transport of HDL. The findings suggest that HDL crosses the endothelial barrier through specific mechanisms rather than passive filtration.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Parag Anilkumar Chevli, Barry I. Freedman, Fang-Chi Hsu, Jianzhao Xu, Megan E. Rudock, Lijun Ma, John S. Parks, Nicholette D. Palmer, Michael D. Shapiro
Summary: Distinct metabolic signatures associated with subclinical coronary atherosclerosis were identified in African American and European American participants of the Diabetes Heart Study.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniel C. Parker, Ma Wan, Kurt Lohman, Li Hou, Anh Tram Nguyen, Jingzhong Ding, Alain Bertoni, Steve Shea, Gregory L. Burke, David R. Jacobs, Wendy Post, David Corcoran, Ina Hoeschele, John S. Parks, Yongmei Liu
Summary: miRNAs play a role in the occurrence and development of type 2 diabetes (T2D) and are also associated with lipid levels.
Article
Multidisciplinary Sciences
L. Madison Kirk, Charlotte Mae K. Waits, Alexander C. Bashore, Beverly Dosso, Allison K. Meyers, Antonio C. Renaldo, Thomas J. DePalma, Kelli N. Simms, Nathaniel Hauser, Chia-Chi Chuang Key, Charles E. McCall, John S. Parks, Susan Sergeant, Carl D. Langefeld, Aleksander Skardal, Elaheh Rahbar
Summary: The Modern Western Diet is associated with the increase in metabolic and inflammatory diseases. Dietary omega-6 polyunsaturated fatty acids (PUFAs), specifically linoleic acid (LA) and arachidonic acid (ARA), are believed to contribute to these diseases by being metabolized into pro-inflammatory compounds. Genetic variants near the fatty acid desaturase (FADS) haplotype block, particularly single nucleotide polymorphism rs174537, regulate the conversion of LA to ARA. This study used a three-dimensional human hepatic culture to investigate PUFA metabolism and gene-diet interactions.
Article
Food Science & Technology
Ya Pei, John S. Parks, Hye Won Kang
Summary: Quercetin improves obesity-induced inflammation in BAT by suppressing the NF kappa B pathway through activation of SIRT1.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Cardiac & Cardiovascular Systems
Qingxia Zhao, Zhan Wang, Allison K. Meyers, Jennifer Madenspacher, Manal Zabalawi, Qianyi Zhang, Elena Boudyguina, Fang-Chi Hsu, Charles E. McCall, Cristina M. Furdui, John S. Parks, Michael B. Fessler, Xuewei Zhu
Summary: Macrophages play a central role in atherosclerosis pathogenesis, and SLC37A2 deficiency can accelerate atherosclerosis development by affecting macrophage inflammatory responses rather than blood lipid levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Meeting Abstract
Endocrinology & Metabolism
Jingzhong Ding, Kurt Lohman, Stephen B. Kritchevsky, John S. Parks, Ina Hoeschele, Barb J. Nicklas, Jamehl Demons, Yongmei Liu
Article
Biochemistry & Molecular Biology
Ya Pei, Olugbenga Balogun, Dammah Otieno, John S. Parks, Hye Won Kang
Summary: This study found that supplementation of 30% BSG in a high-fat diet can alleviate obesity-induced NAFLD in mice by regulating liver metabolism and bile acid synthesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Kylie Kavanagh, Alexander C. Bashore, Matthew A. Davis, Matthew J. Jorgensen, Christopher J. McClouth, Daniel A. Beavers, John S. Parks
Summary: This study demonstrates the efficacy of early time-restricted feeding (eTRF) in increasing high-density lipoprotein (HDL) cholesterol efflux capacity (CEC) in nonhuman primates (NHPs). eTRF induces larger-sized HDL particles, increases HDL apolipoprotein A-1 content, lowers triglyceride concentrations, and increases plasma CEC primarily to HDL particles.
Article
Oncology
Zhiwei Ji, Jade Moore, Nelmi O. Devarie-Baez, Joshua Lewis, Hanzhi Wu, Kirtikar Shukla, Elsa I. Silva Lopez, Victor Vitvitsky, Chia-Chi Chuang Key, Mercedes Porosnicu, Melissa L. Kemp, Ruma Banerjee, John S. Parks, Allen W. Tsang, Xiaobo Zhou, Cristina M. Furdui
Summary: Redox metabolism is an important regulator in cancer, affecting tumor progression, response to therapies, and patients' quality of life. However, the ability to integrate redox information across signaling and metabolic networks is currently limited, hindering the advancement of new cancer therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R. Rawnsley, Mualla Ozcan, Julio A. Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S. Parks, Lei Zhao, David Gordon, Francisco Ramirez-Valle, Kenneth B. Margulies, Thomas P. Cappola, Ankit A. Desai, Lauren N. Pedersen, Carmen Bergom, Nathan O. Stitziel, Michael P. Rettig, John F. DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri
Summary: This study reveals that Apolipoprotein M (ApoM) is inversely associated with mortality in heart failure patients and is reduced by anthracyclines like doxorubicin. In the presence of Dox stress, ApoM can sustain myocardial autophagic flux through post-transcriptional regulation, attenuate Dox cardiotoxicity, and prevent lysosomal injury.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Parag Anilkumar Chevli, Nicholette Allred, Fang-Chi Hsu, John Parks, Barry Freedman, Michael Shapiro
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)