Recent Studies of the Human Chromosome 9p21 Locus, Which Is Associated With Atherosclerosis in Human Populations

Cardiovascular Disease Risk Prediction With and Without Knowledge of Genetic Variation at Chromosome 9p21.3

(2013) Nina P. Paynter   ANNALS OF INTERNAL MEDICINE

Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population

(2012) Francesca Gori et al.   BMC Medical Genetics

Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation

(2011) Chao-Ling Kuo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

(2011) Dov Shiffman et al.   BMC Cardiovascular Disorders

The Coronary Artery Disease–Associated 9p21 Variant and Later Life 20-Year Survival to Cohort Extinction

(2011) Ambarish Dutta et al.   Circulation-Cardiovascular Genetics

Association of Genetic Variants and Incident Coronary Heart Disease in Multiethnic Cohorts

(2011) Nora Franceschini et al.   Circulation-Cardiovascular Genetics

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

(2011) Diego Ardissino et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

(2011) Olivier Harismendy et al.   NATURE

Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction

(2011) Jessica Shea et al.   NATURE GENETICS

Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

(2011) Kathryn P Burdon et al.   NATURE GENETICS

Long noncoding RNA in genome regulation

(2011) Tiffany Hung et al.   RNA Biology

ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21

(2010) Lesca M. Holdt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis

(2010) Danish Saleheen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of Chr9p21 genes CDKN2B (p15INK4b), CDKN2A (p16INK4a, p14ARF) and MTAP in human atherosclerotic plaque

(2010) Lesca Miriam Holdt et al.   ATHEROSCLEROSIS

Replication of the association of chromosomal region 9p21.3with generalized aggressive periodontitis (gAgP) using an independent case-control cohort

(2010) Florian D Ernst et al.   BMC Medical Genetics

Site Specificity of Aneurysmal Disease

(2010) P.E. Norman et al.   CIRCULATION

Chromosome 9p21 Variant Predicts Mortality After Coronary Artery Bypass Graft Surgery

(2010) J. D. Muehlschlegel et al.   CIRCULATION

The 9p21.3 Locus

(2010) Paul F. Bray et al.   Circulation-Cardiovascular Genetics

Association of Single Nucleotide Polymorphisms on Chromosome 9p21.3 With Platelet Reactivity

(2010) Kiran Musunuru et al.   Circulation-Cardiovascular Genetics

Epigenetic regulation of theINK4b-ARF-INK4alocus

(2010) Nikolay Popov et al.   Epigenetics

The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease

(2010) R. S. Patel et al.   EUROPEAN HEART JOURNAL

Forearm vasodilator reactivity in homozygous carriers of the 9p21·3 rs1333049 G>C polymorphism

(2010) Stefan Aschauer et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Association Between 9p21 Genomic Markers and Heart Disease

(2010) Glenn E. Palomaki et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection

(2010) A. S. Schaefer et al.   JOURNAL OF MEDICAL GENETICS

p19ARFDeficiency Reduces Macrophage and Vascular Smooth Muscle Cell Apoptosis and Aggravates Atherosclerosis

(2010) Herminia González-Navarro et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The 9p21 Locus and Coronary Heart Disease

(2010) Jeffrey L. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gene Dosage of the Common Variant 9p21 Predicts Severity of Coronary Artery Disease

(2010) Sonny Dandona et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

(2010) Samuli Ripatti et al.   LANCET

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

(2010) Axel Visel et al.   NATURE

A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese

(2010) Satoko Uno et al.   NATURE GENETICS

A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci

(2010) Jin-Xin Bei et al.   NATURE GENETICS

Genome-wide association study identifies five new breast cancer susceptibility loci

(2010) Clare Turnbull et al.   NATURE GENETICS

Chromosome 9p21 and Coronary Artery Disease

(2010) Ruth McPherson   NEW ENGLAND JOURNAL OF MEDICINE

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 INK4B tumor suppressor gene

(2010) Y Kotake et al.   ONCOGENE

Differential Effects of Chromosome 9p21 Variation on Subphenotypes of Intracranial Aneurysm

(2010) Hirofumi Nakaoka et al.   STROKE

Chromosome 9p21 in Ischemic Stroke

(2010) Christopher D. Anderson et al.   STROKE

A Genome-Wide Association Study of Optic Disc Parameters

(2010) Wishal D. Ramdas et al.   PLoS Genetics

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression

(2010) Michael S. Cunnington et al.   PLoS Genetics

Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

(2010) Christin E. Burd et al.   PLoS Genetics

Value of genetic profiling for the prediction of coronary heart disease

(2009) Jeroen B. van der Net et al.   AMERICAN HEART JOURNAL

Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke

(2009) Andreas Gschwendtner et al.   ANNALS OF NEUROLOGY

Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus

(2009) Olga Jarinova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Single nucleotide polymorphism on chromosome 9p21 and endothelial progenitor cells in a general population cohort

(2009) Shu Ye et al.   ATHEROSCLEROSIS

A Common Variant at 9p21 Is Associated With Sudden and Arrhythmic Cardiac Death

(2009) Christopher Newton-Cheh et al.   CIRCULATION

Impact of Adding a Single Allele in the 9p21 Locus to Traditional Risk Factors on Reclassification of Coronary Heart Disease Risk and Implications for Lipid-Modifying Therapy in the Atherosclerosis Risk in Communities Study

(2009) Ariel Brautbar et al.   Circulation-Cardiovascular Genetics

Common Genetic Variants on Chromosome 9p21 Confers Risk of Ischemic Stroke

(2009) J. Gustav Smith et al.   Circulation-Cardiovascular Genetics

9p21 is a Shared Susceptibility Locus Strongly for Coronary Artery Disease and Weakly for Ischemic Stroke in Chinese Han Population

(2009) Hu Ding et al.   Circulation-Cardiovascular Genetics

The 9p21 Myocardial Infarction Risk Allele Increases Risk of Peripheral Artery Disease in Older People

(2009) Christie Cluett et al.   Circulation-Cardiovascular Genetics

A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study

(2009) K. Yamagishi et al.   EUROPEAN HEART JOURNAL

Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke

(2009) Robin Lemmens et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension

(2009) Björn Wahlstrand et al.   JOURNAL OF HYPERTENSION

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

(2009) Michael A van Es et al.   NATURE GENETICS

New common variants affecting susceptibility to basal cell carcinoma

(2009) Simon N Stacey et al.   NATURE GENETICS

Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility

(2009) Margaret Wrensch et al.   NATURE GENETICS

Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi

(2009) Mario Falchi et al.   NATURE GENETICS

Genome-wide association study identifies three loci associated with melanoma risk

(2009) D Timothy Bishop et al.   NATURE GENETICS

Genome-wide association study identifies five susceptibility loci for glioma

(2009) Sanjay Shete et al.   NATURE GENETICS

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

Genomewide Association Studies of Stroke

(2009) M. Arfan Ikram et al.   NEW ENGLAND JOURNAL OF MEDICINE

INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis

(2009) Yan Liu et al.   PLoS One

Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants

(2009) Lasse Folkersen et al.   PLoS One

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis

(2009) Arne S. Schaefer et al.   PLoS Genetics

Coronary Artery Disease–Associated Locus on Chromosome 9p21 and Early Markers of Atherosclerosis

(2008) Nilesh J. Samani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease

(2008) Heribert Schunkert et al.   CIRCULATION

Validation of the Association of Genetic Variants on Chromosome 9p21 and 1q41 With Myocardial Infarction in a Japanese Population

(2008) Yumiko Hiura et al.   CIRCULATION JOURNAL

Association of Variation in the Chromosome 9p21 Locus With Myocardial Infarction Versus Chronic Coronary Artery Disease

(2008) Benjamin D. Horne et al.   Circulation-Cardiovascular Genetics

Chromosome 9p21.3 Coronary Heart Disease Locus Genotype and Prospective Risk of CHD in Healthy Middle-Aged Men

(2008) P. J. Talmud et al.   CLINICAL CHEMISTRY

Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion

(2008) Andrew R Thompson et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts

(2008) Juha Karvanen et al.   GENETIC EPIDEMIOLOGY

Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study

(2008) Themistocles L. Assimes et al.   HUMAN MOLECULAR GENETICS

Interaction Between Poor Glycemic Control and 9p21 Locus on Risk of Coronary Artery Disease in Type 2 Diabetes

(2008) Alessandro Doria   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A HapMap harvest of insights into the genetics of common disease

(2008) Teri A. Manolio et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiovascular disease and periodontitis: an update on the associations and risk

(2008) Gösta Rutger Persson et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Association of Genetic Variation on Chromosome 9p21 With Susceptibility and Progression of Atherosclerosis

(2008) Shu Ye et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Use of Carotid Ultrasound to Identify Subclinical Vascular Disease and Evaluate Cardiovascular Disease Risk: A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the Society for Vascular Medicine

(2008) James H. Stein et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

(2008) Anna Helgadottir et al.   NATURE GENETICS

Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21

(2008) Mar Matarin et al.   STROKE

Four SNPs on Chromosome 9p21 in a South Korean Population Implicate a Genetic Locus That Confers High Cross-Race Risk for Development of Coronary Artery Disease

(2007) Gong-Qing Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY