Article
Cardiac & Cardiovascular Systems
Anand Rohatgi, Marit Westerterp, Arnold von Eckardstein, Alan Remaley, Kerry-Anne Rye
Summary: Low high-density lipoprotein cholesterol (HDL-C) is associated with adverse lifestyle choices, cardiovascular diseases, inflammatory disorders, and other conditions. Therapeutic strategies targeting HDL-C levels have not been successful, and future focus should be on optimizing HDL function for better outcomes.
Review
Geriatrics & Gerontology
Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang, Yanyan Xu, Zhen Qin, Gangqiong Liu, Qiguang Wang, Kang Tian, Khoon S. Lim, Chris J. Charles, Jinying Zhang, Junnan Tang
Summary: Dyslipidemia increases the risk of atherosclerosis, and lipoproteins play a significant role in its development. Understanding lipoprotein function can help predict risk and provide novel treatment approaches for atherosclerosis.
Article
Hematology
Lilli Arndt, Ileana Hernandez-Resendiz, Doreen Moos, Janine Dokas, Silvana Mueller, Franziska Jeromin, Richard Wagner, Uta Ceglarek, Iris M. Heid, Marcus Hoering, Gerhard Liebisch, Sonja C. Stadler, Ralph Burkhardt
Summary: This study demonstrates that deficiency of Trib1 promotes the formation of atherosclerotic lesions and increases plasma cholesterol and triglyceride levels in Ldlr(-/-) mice. It also suggests that Trib1 deficiency alters hepatic lipid metabolism and induces inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Hematology
Karin E. Bornfeldt
Summary: Both type 1 and type 2 diabetes are associated with an increased risk of atherosclerotic cardiovascular disease. Recent findings suggest that increased levels of circulating remnant lipoproteins in people with diabetes could be the missing link between diabetes and CVD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Zhan Hu, Wendao Liu, Xiumeng Hua, Xiao Chen, Yuan Chang, Yiqing Hu, Zhenyu Xu, Jiangping Song
Summary: In this study, researchers used single-cell sequencing to investigate the cellular composition of human nondiseased cardiac arteries, identifying 25 subpopulations representing 10 main arterial cell types. They found specific vascular smooth muscle cell and fibroblast subpopulations in different arteries and predicted increased intercellular communication in atherosclerosis. The results provide a cell atlas for potential identification of vascular disease-associated cell populations and development of new therapeutic strategies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Prakriti Gaba, Michelle L. O'Donoghue, Jeong-Gun Park, Stephen D. Wiviott, Dan Atar, Julia F. Kuder, KyungAh Im, Sabina A. Murphy, Gaetano M. De Ferrari, Zbigniew A. Gaciong, Kalman Toth, Ioanna Gouni-Berthold, Jose Lopez-Miranda, Francois Schiele, Francois Mach, Jose H. Flores-Arredondo, J. Antonio G. Lopez, Mary Elliott-Davey, Bei Wang, Maria Laura Monsalvo, Siddique Abbasi, Robert P. Giugliano, Marc S. Sabatine
Summary: This study found that long-term achievement of lower LDL-C levels (below 20 mg/dL) in patients with atherosclerotic cardiovascular disease was associated with a lower risk of cardiovascular events without significant safety concerns.
Article
Nutrition & Dietetics
Buket Akcan, Asim oerem, Yahya Altinkaynak, Birguel Kural, Cihan oerem, Mehmet Soenmez, Mauro Serafini
Summary: This study investigated the association between circulating endothelial progenitor cells (EPCs) levels and post-prandial lipemia in healthy subjects. It found significant differences in lipid parameters between men and women, with men showing higher levels of total cholesterol, LDL-C, and triglycerides. Circulating EPCs levels were significantly higher in men with post-prandial hyperlipidemia, suggesting a response to endothelial injury related to atherogenic remnant particles.
FRONTIERS IN NUTRITION
(2022)
Review
Cardiac & Cardiovascular Systems
MacRae F. Linton, Patricia G. Yancey, Huan Tao, Sean S. Davies
Summary: Epidemiologic studies have shown that HDL-C levels are inversely related to ASCVD, suggesting that HDL-C is a major risk factor for ASCVD. However, clinical trials have questioned the role of HDL-C in mediating ASCVD risk. Progress in understanding the composition of HDL particles has revealed that HDL-C levels do not necessarily reflect HDL function. HDL has been found to have antiatherogenic functions, such as reverse cholesterol transport and suppression of inflammation, but its oxidative modifications can lead to dysfunction and inflammation.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Paul Wolkowicz, C. Roger White, G. M. Anantharamaiah
Summary: Obesity in the United States has led to a rise in type 2 diabetes mellitus, dyslipidemia, and cardiovascular disease. Inflammation plays a key role in insulin resistance and diabetic complications. Increasing functional HDL levels is crucial in reducing inflammation and diabetic complications.
Article
Hematology
Jing Liu, Baiba K. Gillard, Dedipya Yelamanchili, Antonio M. Gotto, Corina Rosales, Henry J. Pownall
Summary: Mice lacking the HDL receptor Scarb1 exhibit increased bioavailability of FC in HDL, leading to elevated FC content in multiple tissue sites associated with female infertility, impaired cell maturation, cardiac dysfunction, and atherosclerosis. Sex-dependent differences in tissue-lipid composition and plasma FC clearance rates were also observed. Higher HDL-FC bioavailability may serve as a potential biomarker mechanistically linked to various pathologies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Jiahuan Chen, Huanyu Zhang, Linquan Li, Xinwei Zhang, Dazhong Zhao, Lingyu Wang, Jiaqi Wang, Ping Yang, Huan Sun, Kun Liu, Weiwei Chen, Lin Li, Feng Lin, Zhanjun Li, Y. Eugene Chen, Jifeng Zhang, Daxin Pang, Hongsheng Ouyang, Yuquan He, Jianglin Fan, Xiaochun Tang
Summary: In this study, Lp-PLA(2) knockout rabbits were generated using the CRISPR/Cas9 system to investigate the role of Lp-PLA(2) in blood lipid regulation and atherosclerosis. The results showed that Lp-PLA(2) deficiency reduced plasma lipid levels and protected against cholesterol-induced atherosclerosis in rabbits. Furthermore, Lp-PLA(2) deficiency impaired cholesterol biosynthesis and inhibited the adhesion between monocytes and endothelial cells.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Hematology
Christian M. Madsen, Anette Varbo, Borge G. Nordestgaard
Summary: Recent studies have suggested that extremely high levels of HDL cholesterol are associated with increased mortality, indicating that HDL may have harmful effects in some instances. Furthermore, observational and genetic studies have shown that HDL might be linked to the development of major noncardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Environmental Sciences
Chiara Macchi, Cesare R. Sirtori, Alberto Corsini, Pier Mannuccio Mannucci, Massimiliano Ruscica
Summary: According to the WHO, the entire global population is exposed to air pollution levels higher than recommended for health preservation. Air pollution, a complex mixture of particles and gases, poses a major global threat to public health. Particulate matter PM2.5 has been identified as a causal factor for cardiovascular diseases such as hypertension, coronary artery disease, stroke, heart failure, arrhythmias, and cardiovascular mortality. This review explores the proatherogenic effects of PM2.5, including endothelial dysfunction, chronic inflammation, reactive oxygen species, mitochondrial dysfunction, and arterial plaque instability.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Kunimaro Furuta, Qianqian Guo, Kevin D. Pavelko, Jeong-Heon Lee, Keith D. Robertson, Yasuhiko Nakao, Jan Melek, Vijay H. Shah, Petra Hirsova, Samar H. Ibrahim
Summary: The study revealed that VCAM-1 plays a significant role in the pathogenesis of NASH, with increased expression observed in NASH mouse models and human NASH. Inhibition of VCAM-1 could attenuate diet-induced NASH in mice and may serve as a potential therapeutic strategy for human NASH.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Clinical Neurology
Takao Hoshino, Kentaro Ishizuka, Sono Toi, Takafumi Mizuno, Ayako Nishimura, Shuntaro Takahashi, Sho Wako, Kazuo Kitagawa
Summary: This study found a close association between atherogenic dyslipidemia (AD) and residual vascular risk in stroke patients. Patients with AD were more likely to have intracranial artery stenosis and had a higher risk of major adverse cardiovascular events and ischemic stroke within 1 year. AD was predictive of major adverse cardiovascular events regardless of baseline low-density lipoprotein cholesterol (LDL-C) levels.
