Article
Biochemistry & Molecular Biology
Kenta H. T. Cho, Mhoyra Fraser, Bing Xu, Justin M. Dean, Alistair J. Gunn, Laura Bennet
Summary: The TLR7 agonist GDQ shows transient neuroprotective effects post-asphyxia by modulating blood pressure and suppressing early seizures, while inducing prolonged epileptiform activity later.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Su Woong Jung, Jung-Woo Seo, Seon Hwa Park, Yang Gyun Kim, Ju-Young Moon, Sangdun Choi, Sang-Ho Lee
Summary: TIP1 demonstrated significant protective effects in a mouse model of renal IRI, reducing plasma creatinine levels, alleviating tubular injury, inhibiting inflammatory cytokine expression, decreasing apoptosis and oxidative stress levels, and reducing cell infiltration, suggesting potential benefits in attenuating kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lei Zhang, Guangshuai Liu, Tian Xia, Xiufeng Yang, Guolei Sun, Chao Zhao, Chunzhu Xu, Honghai Zhang
Summary: The study analyzed TLR genes from the genomes and transcriptomes of 102 amphibian species to understand their evolutionary patterns. Results showed that TLR genes can be divided into seven subfamilies, with TLR4 subfamily found only in Anura. Purification selection played a leading role in amphibian TLR evolution, and different domains had different evolution rates. Positive selection patterns and single-nucleotide polymorphisms were observed in TLR genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Xin Zhi, Peipei Yang, Yunxue Xu, Zhifei Dai, Xiuli Yue, Linxue Qian
Summary: This review discusses the functions of Toll-like receptors (TLRs) in the tumor microenvironment and the pathways that activate immune responses. It also summarizes recent developments in nanotechnology for immunomodulation with TLR agonists. Nanotechnology can improve the efficacy of TLR agonist-based immunotherapy and address its limitations.
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Review
Immunology
Niloofar Deravi, Mohadeseh Poudineh, Marzieh Pirzadeh, Hanie Yavarpour-Bali, Hoda Mehrabi, Gisou Erabi, Amene Saghazadeh, Nima Rezaei
Summary: Endothelial cells play a critical role in innate immune and inflammatory responses, and Toll-like receptors (TLRs) are key in activating innate mechanisms in ECs. Endothelial dysfunction may lead to tissue damage in various diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoqin Tang, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, Chunling Zhao, Jianming Wu
Summary: Platelets, as the second most abundant blood component, play a crucial role in various physiological and pathological functions. In addition to its traditional role in hemostasis and thrombosis, platelets also have an indispensable role in inflammatory diseases. Thrombocytopenia, a common hematologic problem, is closely related to the fatality of many diseases, highlighting the significance of its prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Stavros Garantziotis, Rashmin C. Savani
Summary: The extracellular matrix (ECM) is not only a structure but also plays key roles in cellular responses. Proteoglycans (PGs), a component of ECM, have been found to be crucial in both health maintenance and disease development by activating the innate immune system and influencing cell fate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Wicherska-Pawlowska, Tomasz Wrobel, Justyna Rybka
Summary: The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) through pattern recognition receptors (PRRs), activating immune cells and initiating inflammatory and immune responses. This system also plays a role in cancer immunosurveillance, with potential for natural and synthetic agonists of PRRs to be used as adjuvants in cancer immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yang Xun, Hua Yang, Bozena Kaminska, Hua You
Summary: Glioma is a fast proliferating and highly invasive brain tumor that is difficult to treat and often recurs. Toll-like receptors play dual roles in the glioma microenvironment, eliciting both anti-tumoral and pro-tumoral responses. Targeting TLRs in glioma treatment may provide new strategies for immunotherapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Immunology
Yingchi Zhang, Jia Liu, Changlun Wang, Junxian Liu, Wei Lu
Summary: Toll-like receptor gene polymorphisms can increase the risk of autoimmune diseases, and studying these variations can expand our understanding of the pathogenesis of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Urology & Nephrology
Minghui Liu, Ke Zen
Summary: Toll-like receptors (TLRs) play a crucial role in the development and progression of renal diseases, with TLR2 and TLR4 promoting disease progression in renal ischemia-reperfusion injury, diabetic nephropathy, CKD, and infection-associated renal diseases. Stimulation of TLR7/8 and TLR9 by host-derived nucleic acids also plays a key role in systemic lupus erythematosus.
Review
Oncology
Eileena F. Giurini, Mary Beth Madonna, Andrew Zloza, Kajal H. Gupta
Summary: In this review, we discuss the role of Toll-like receptors (TLRs) in cancer and their potential as a target for immunotherapy. TLRs are transmembrane receptors involved in innate immunity and can recognize molecules derived from microbes and damaged cells. Activation of TLRs can lead to either pro-tumoral effects or anti-tumoral effects, depending on the TLR and tumor type. Understanding the effects of TLR stimulation in cancer is crucial for developing effective immunotherapeutic strategies against cancer.
Article
Physiology
Jay H. Lipinski, Nicole R. Falkowski, Gary B. Huffnagle, John R. Erb-Downward, Robert P. Dickson, Beth B. Moore, David N. O'Dwyer
Summary: The absence of toll-like receptors results in altered lung microbiota with changes in community composition, reduced diversity, and bacterial burden. Co-housing wild-type mice with toll-like receptor-deficient mice for 3 weeks did not significantly affect the composition of the lung microbiome. Toll-like receptor signaling plays a role in shaping lung microbiota.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cristina Vazquez-Carballo, Melania Guerrero-Hue, Cristina Garcia-Caballero, Sandra Rayego-Mateos, Lucas Opazo-Rios, Jose Luis Morgado-Pascual, Carmen Herencia-Bellido, Mercedes Vallejo-Mudarra, Isabel Cortegano, Maria Luisa Gaspar, Belen de Andres, Jesus Egido, Juan Antonio Moreno
Summary: Acute kidney injury (AKI) is a significant health issue, particularly in low- and middle-income countries. Studies suggest that inflammation plays a crucial role in the development of AKI, and anti-inflammatory agents targeting Toll-like receptors may help reduce kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Yi Zhang, Michael Chopp, Xian Shuang Liu, Haifa Kassis, Xinli Wang, Chao Li, Guangning An, Zheng Gang Zhang
DEVELOPMENTAL NEUROBIOLOGY
(2015)
Article
Clinical Neurology
Haifa Kassis, Amjad Shehadah, Michael Chopp, Cynthia Roberts, Zheng Gang Zhang
Article
Neurosciences
Michael E. Authement, Ludovic D. Langlois, Haifa Kassis, Shawn Gouty, Matthieu Dacher, Ryan D. Shepard, Brian M. Cox, Fereshteh S. Nugent
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Neurosciences
Xian Shuang Liu, Michael Chopp, Wan Long Pan, Xin Li Wang, Bao Yan Fan, Yi Zhang, Haifa Kassis, Rui Lan Zhang, Xiao Ming Zhang, Zheng Gang Zhang
MOLECULAR NEUROBIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Haifa Kassis, Amjad Shehadah, Chao Li, Yi Zhang, Yisheng Cui, Cynthia Roberts, Neema Sadry, Xianshuang Liu, Michael Chopp, Zheng Gang Zhang
NEUROCHEMISTRY INTERNATIONAL
(2016)
Review
Genetics & Heredity
Haifa Kassis, Amjad Shehadah, Michael Chopp, Zheng Gang Zhang
Article
Biochemistry & Molecular Biology
Michael E. Authement, Ludovic D. Langlois, Ryan D. Shepard, Caroline A. Browne, Irwin Lucki, Haifa Kassis, Fereshteh S. Nugent
Article
Biochemistry & Molecular Biology
Michael E. Authement, Ludovic D. Langlois, Ryan D. Shepard, Caroline A. Browne, Irwin Lucki, Haifa Kassis, Fereshteh S. Nugent
Article
Neurosciences
Ryan D. Shepard, Shawn Gouty, Haifa Kassis, Aylar Berenji, William Zhu, Brian M. Cox, Fereshteh S. Nugent
EXPERIMENTAL NEUROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Xian Shuang Liu, Michael Chopp, Xin Li Wang, Li Zhang, Ann Hozeska-Solgot, Tao Tang, Haifa Kassis, Rui Lan Zhang, Charles Chen, Jennifer Xu, Zheng Gang Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Haifa Kassis, Michael Chopp, Xian Shuang Liu, Amjad Shehadah, Cynthia Roberts, Zheng Gang Zhang
NEUROCHEMISTRY INTERNATIONAL
(2014)
Article
Neurosciences
X. S. Liu, M. Chopp, H. Kassis, L. F. Jia, A. Hozeska-Solgot, R. L. Zhang, C. Chen, Y. S. Cui, Z. G. Zhang
Article
Endocrinology & Metabolism
Raanan Shamir, Haifa Kassis, Marielle Kaplan, Tova Naveh, Naim Shehadeh
PEDIATRIC DIABETES
(2008)
Article
Multidisciplinary Sciences
Xian Shuang Liu, Michael Chopp, Rui Lan Zhang, Tang Tao, Xin Li Wang, Haifa Kassis, Ann Hozeska-Solgot, Li Zhang, Charles Chen, Zheng Gang Zhang