Article
Cardiac & Cardiovascular Systems
Joseph M. Miano, Edward A. Fisher, Mark W. Majesky
Summary: Studying the phenotypic modulation of vascular smooth muscle cells is crucial for understanding the pathogenesis of atherosclerosis and developing new therapies. Recent technological and conceptual advances shed light on the multifunctionality and plasticity of VSMCs.
Article
Cardiac & Cardiovascular Systems
Kim A. Dora, Lyudmyla Borysova, Xi Ye, Chloe Powell, Timea Z. Beleznai, Christopher P. Stanley, Vito D. Bruno, Tobias Starborg, Errin Johnson, Anna Pielach, Michael Taggart, Nicola Smart, Raimondo Ascione
Summary: This study investigated the myogenic reactivity of coronary microvascular smooth muscle cells in patients with heart valve disease and identified a correlation between poor myogenic tone and expression of cellular markers.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
J. Colgren, S. A. Nichols
Summary: The study finds molecular and functional similarities between a contractile module in sponge tissues and muscle tissues in other animals, suggesting a common evolutionary origin.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Lei Wang, Megan Rice, Sandra Swist, Thomas Kubin, Fan Wu, Shengpeng Wang, Simone Kraut, Norbert Weissmann, Thomas Boettger, Matthew Wheeler, Andre Schneider, Thomas Braun
Summary: The study revealed that BMP9 and BMP10 act directly on VSMCs for induction and maintenance of their contractile state. The effects of BMP9/10 in VSMCs are mediated by different combinations of BMP type 1 receptors in a vessel bed-specific manner, offering new opportunities to manipulate blood pressure in the pulmonary circulation.
Article
Cardiac & Cardiovascular Systems
Melissa A. Luse, Nenja Kruger, Miranda E. Good, Lauren A. Biwer, Vlad Serbulea, Anita Salamon, Rebecca A. Deaton, Norbert Leitinger, Axel Godecke, Brant E. Isakson
Summary: This study reveals the important role of the fat mass obesity (FTO) gene in regulating smooth muscle contractility, possibly through methylation of serum response factor (Srf).
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Developmental Biology
Michael Donadon, Massimo M. Santoro
Summary: The article primarily describes the developmental origin of smooth muscle cells in different organs, as well as their specification and differentiation in the cardiovascular, respiratory, and intestinal systems. It discusses the important roles of smooth muscle in organ development and how they instruct the development of other organs through signaling and mechanical feedback mechanisms. By understanding smooth muscle cell development, the aim is to advance therapeutic approaches related to tissue regeneration and other smooth muscle-related diseases.
Review
Biology
Qunhui Yang, Masatoshi Hori
Summary: Hypertension is a key risk factor for cardiovascular disease and is linked to the contractile machinery in vascular smooth muscle. Different signaling pathways regulate blood pressure by controlling myosin phosphorylation, with implications for physiological and pathophysiological conditions of hypertension.
Article
Cardiac & Cardiovascular Systems
Kunzhe Dong, Jian Shen, Xiangqin He, Guoqing Hu, Liang Wang, Islam Osman, Kristopher M. Bunting, Rachael Dixon-Melvin, Zeqi Zheng, Hongbo Xin, Meixiang Xiang, Almira Vazdarjanova, David J. R. Fulton, Jiliang Zhou
Summary: CARMN is a highly conserved SMC-specific long noncoding RNA that plays a crucial role in maintaining the contractile phenotype of VSMCs, and it is the first noncoding RNA discovered to interact with myocardin.
Article
Anatomy & Morphology
Benedicta Mensah
Summary: Contrary to its previous understanding as a fibrosed remnant, the ligamentum arteriosum (LA) is found to be mainly composed of muscular elements that have contractile abilities and can affect the distensibility of the attached great vessels.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yiting Jia, Chenfeng Mao, Zihan Ma, Jiaqi Huang, Wenqiang Li, Xiaolong Ma, Siting Zhang, Meihong Li, Fang Yu, Yingying Sun, Jingzhou Chen, Juan Feng, Yuan Zhou, Qingbo Xu, Ling Zhao, Yi Fu, Wei Kong
Summary: This study reveals that Prohibitin 2 interacts with hnRNPA1 to maintain the contractile phenotype of VSMCs and counteracts metabolic reprogramming, indicating its crucial role in preventing vascular diseases.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anne Virsolvy, Aurelie Fort, Lucie Erceau, Azzouz Charrabi, Maurice Hayot, Franck Aimond, Sylvain Richard
Summary: The study revealed the important role of Na-v channels in vasomotion of human arteries, with activation of these channels leading to rhythmic oscillatory contractile activity in the vasculature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Matthew Stephens, Simon Roizes, Pierre-Yves von der Weid
Summary: The study found that Lovastatin and Simvastatin have concentration-dependent effects on the contractility of intestinal lymphatic vascular smooth muscle, which are related to their structural characteristics. Lovastatin acts by increasing the function of RhoKinase, while Simvastatin results in mitochondrial depolymerization in lymphatic smooth muscle cells, affecting their function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Fang Cheng, Tao Lu, Yicheng Wang, Didi Yuan, Zehong Wei, Yongguo Li, Jianbo Li, Renkuan Tang
Summary: The present study investigated the expression of alpha-SMA and SM22 alpha in the airway smooth muscle of children with acute interstitial pneumonia (AIP). The findings suggest that enhanced ASM contractile function is involved in the death mechanism of children with AIP.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2022)
Article
Biophysics
Gijs Ijpma, Anne-Marie Lauzon
Summary: Muscle tissue mechanics and contractility measurements are closer to in vivo tissue properties compared to cultured cell level experiments. However, tissue level experiments lack the same time resolution and consistency as cell culture studies. This study presents a system that allows contractile tissues to be incubated while intermittently tested for their mechanical and contractile properties, improving time resolution, repeatability, and robustness while reducing contamination risk and tissue damage from repeated handling.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cell Biology
Nadim E. Hachem, Luisa Humpfle, Peter Simon, Miriam Kaese, Birgit Weinhold, Juliane Guenther, Sebastian P. Galuska, Ralf Middendorff
Summary: The absence of polySia in postnatal testis resulted in impaired differentiation of peritubular smooth muscle cells (SMCs), but not vascular SMCs, suggesting that polySia may play a role in maintaining the differentiated phenotype of non-vascular SMCs.
Correction
Cell Biology
I. P. Hayward, K. R. Bridle, G. R. Campbell, P. A. Underwood, J. H. Campbell
CELL BIOLOGY INTERNATIONAL
(2016)
Article
Pathology
Jane E. Mooney, Barbara E. Rolfe, Geoffrey W. Osborne, David P. Sester, Nico van Rooijen, Gordon R. Campbell, David A. Hume, Julie H. Campbell
AMERICAN JOURNAL OF PATHOLOGY
(2010)
Article
Cell Biology
S. J. Le, M. Gongora, B. Zhang, S. Grimmond, G. R. Campbell, J. H. Campbell, B. E. Rolfe
Article
Engineering, Biomedical
Yang Cao, Bing Zhang, Tristan Croll, Barbara E. Rolfe, Julie H. Campbell, Gordon R. Campbell, Darren Martin, Justin J. Cooper-White
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2008)
Article
Cell & Tissue Engineering
Gordon R. Campbell, Geoffrey Turnbull, Lina Xiang, Michael Haines, Shannon Armstrong, Barbara E. Rolfe, Julie H. Campbell
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2008)
Review
Biochemistry & Molecular Biology
G. R. Campbell, J. H. Campbell
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2007)
Review
Cell Biology
Michel R. Hoenig, Gordon R. Campbell, Julie H. Campbell
ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH
(2006)
Meeting Abstract
Biochemical Research Methods
BE Rolfe, B Zhang, M Wigan, K Pearson, Y Chen, N Pantarat, S Le, S Jahnke, Y Chau, GR Campbell, JH Campbell
Meeting Abstract
Biochemical Research Methods
JE Mooney, BE Rolfe, B Zhang, DP Sester, JH Campbell, GR Campbell
Meeting Abstract
Biochemical Research Methods
S Le, BE Rolfe, GR Campbell, JH Campbell
Meeting Abstract
Biochemical Research Methods
SR Armstrong, GR Campbell, JH Campbell, MH Little
Meeting Abstract
Cell & Tissue Engineering
Yang Cao, Bing Zhang, Tristan I. Croll, Barbara E. Rolfe, Julie H. Campbell, Gordon R. Campbell, Darren J. Martin, Justin J. Cooper-White
TISSUE ENGINEERING
(2006)
Review
Cardiac & Cardiovascular Systems
BE Rolfe, NF Worth, CJ World, JH Campbell, GR Campbell
Meeting Abstract
Peripheral Vascular Disease
K. Tailford, S. Jhanke, P. Stickler, S. J. Le, Z. Cong, G. R. Campbell, J. H. Campbell
ATHEROSCLEROSIS SUPPLEMENTS
(2006)
