Review
Biochemistry & Molecular Biology
Manuel Yepes, Yena Woo, Cynthia Martin-Jimenez
Summary: The neurovascular unit is a complex structure involving various cells and components that are essential for maintaining normal neuronal function. Plasminogen activators play a crucial role in regulating the function of the neurovascular unit, with dysfunction leading to neurodegenerative disorders. Research on the expression and function of tissue-type plasminogen activator and urokinase-type plasminogen activator in the neurovascular unit has provided valuable insights into neurovascular and neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Victor M. Schuettfort, Benjamin Pradere, David D'Andrea, Nico C. Grossmann, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Pierre I. Karakiewicz, Reza Sari Motlagh, Satoshi Katayama, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Harun Fajkovica, Eva Comperat, Dmitry Enikeev, Shahrokh F. Shariat
Summary: Elevated preoperative plasma levels of uPA, SuPAR, and PAI-one were confirmed to be associated with aggressive disease features and worse survival outcomes in patients treated with RC for UCB. These biomarkers have the potential to identify patients who may benefit from intensified/multimodal therapy and improve the discriminatory power of predictive/prognostic models.
JOURNAL OF UROLOGY
(2021)
Article
Immunology
Yu-Wen Cheng, Ze-Bei Zhang, Bei-Di Lan, Jing-Rong Lin, Xiao-Hui Chen, Ling-Ran Kong, Lian Xu, Cheng -Chao Ruan, Ping-Jin Gao
Summary: Obesity-induced adipose tissue-derived factors play a key role in cardiac damage, with the newly identified adipokine PDGF-D potentially regulating cardiac remodeling in obese mice. The study demonstrates that uPA activates PDGF-D and accelerates AngII-induced cardiac remodeling in obese mice by a new interaction pattern between macrophage and adipocyte.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Maria Makuszewska, Magdalena Cieslinska, Maria M. Winnicka, Bozena Skotnicka, Kazimierz Niemczyk, Tomasz Bonda
Summary: This study evaluated the protein products and tissue distribution of plasminogen activation and inhibition genes during the healing process of tympanic membrane (TM) perforation. The results showed that plasminogen activation (uPA, uPAR, tPA) and inhibitory (PAI-1) molecules form a well-structured regulatory system of epithelial migration, which is critical for TM healing after perforation.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ashna A. Kumar, Benjamin J. Buckley, Marie Ranson
Summary: This review provides an overview of the role of the urokinase plasminogen activation system (uPAS) in pancreatic cancer, with a focus on pancreatic ductal adenocarcinoma (PDAC), and summarizes the substantial evidence supporting the role of uPAS components in this disease. The review further outlines the potential clinical utility of uPAS components as diagnostic and prognostic biomarkers for PDAC, as well as the rationale for developing novel uPAS-targeted therapeutics.
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Sheraz Butt, Jorgen L. Jeppesen, Line Vinderslev Iversen, Mogens Fenger, Jesper Eugen-Olsen, Charlotte Andersson, Soren Jacobsen
Summary: Our study found a strong correlation between suPAR plasma levels and pulmonary involvement in patients with systemic sclerosis, particularly with interstitial lung disease and pulmonary fibrosis. Future studies may validate whether suPAR estimation can be used for monitoring severe pulmonary involvement in SSc.
Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Filomena Napolitano, Nunzia Montuori
Summary: This study discusses the role of platelets in fibrinolysis, highlighting their profibrinolytic properties through the involvement of components in the Plasminogen Activation System (PAS). The findings suggest that while antifibrinolytic effects prevail in the initial phase of hemostasis, platelets may enhance fibrinolysis at later stages through engagement with PAS components. Understanding the spatial and temporal characteristics of platelet-mediated fibrinolysis could lead to improved therapeutic options for bleeding and thrombotic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lindsey A. Miles, Lina Ny, Malgorzata Wilczynska, Yue Shen, Tor Ny, Robert J. Parmer
Summary: The role of plasminogen receptors on cell surfaces in promoting fibrinolysis is well recognized, with these receptors shown to regulate fibrin surveillance in addition to plasminogen directly bound to fibrin. Data from murine models predominantly demonstrate the ability of specific plasminogen receptors on eukaryotic cells to promote fibrinolysis in vivo. The roles of distinct plasminogen receptors in intravascular fibrinolysis, immune cell recruitment in the inflammatory response, wound healing, and lactational development are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Sarah Thomas Broome, Giuseppe Musumeci, Alessandro Castorina
Summary: This study reveals that doxycycline and minocycline can act as positive allosteric modulators of the PAC1 receptor to promote proteolytic activity in Schwann cells, potentially aiding in neuroregeneration.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Xiaowei Nie, Chenyou Shen, Jianxin Tan, Xusheng Yang, Wei Wang, Youai Dai, Haijian Sun, Zhiyuan Wu, Jingyu Chen
Summary: The study demonstrated that Andrographolide (ANDRO) may reverse pulmonary vascular remodeling through modulation of NOX/Nrf2-mediated oxidative stress and NF-kappa B-mediated inflammation, suggesting therapeutic potential in the treatment of pulmonary hypertension.
Article
Cell Biology
Koji Sugioka, Teruo Nishida, Aya Kodama-Takahashi, Junko Murakami, Fukutaro Mano, Kiyotaka Okada, Masahiko Fukuda, Shunji Kusaka
Summary: Corneal fibroblasts are regulated by collagen, and the targeting of Endo180 and uPA receptor may play a role in the regulation of alpha-SMA expression in a manner dependent on TGF-beta signaling. uPA deficiency may promote the interaction between collagen and Endo180 and increase alpha-SMA expression.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Julia Elrod, Annika Heuer, Jasmin Knopf, Janina Schoen, Lavinia Schoenfeld, Magdalena Trochimiuk, Carolin Stiel, Birgit Appl, Laia Pagerols Raluy, Ceren Saygi, Leticija Zlatar, Sami Hosari, Dmytro Royzman, Thomas H. Winkler, Guenter Lochnit, Moritz Leppkes, Robert Gruetzmann, Georg Schett, Christian Tomuschat, Konrad Reinshagen, Martin Herrmann, Tobias A. Fuchs, Michael Boettcher
Summary: Peritoneal adhesions, commonly occurring conditions causing intestinal obstruction and pelvic pain, are poorly understood. However, DNases have been found to significantly reduce the formation of adhesions in experimental models.
Article
Polymer Science
Markus Lunzer, Boris Maryasin, Tommaso Zandrini, Stefan Baudis, Aleksandr Ovsianikov, Robert Liska
Summary: Photolabile groups are important components in photo-responsive polymers. Disulfides can be used for facile crosslinking and localized cleavage by two-photon irradiation, but their formation is challenging. The study identifies a reactive lead compound and investigates the effects of the molecular linker structure on hydrogel stability.
Article
Engineering, Biomedical
Olivier Guillaume, Oliver Kopinski-Gruenwald, Gregor Weisgrab, Theresia Baumgartner, Aysu Arslan, Karin Whitmore, Sandra Van Vlierberghe, Aleksandr Ovsianikov
Summary: Tissue engineering and regenerative medicine (TERM) has previously relied on scaffold-based or scaffold-free strategies, but a new approach called the third TERM strategy, involving highly porous microscaffolds and single spheroids, has the potential to overcome limitations of previous options. A systematic study comparing microscaffold-based tissue units with conventional spheroids demonstrated that the microscaffold did not impede spheroid formation or impact viability. Additionally, the fusion and differentiation potential necessary for TERM applications were preserved. Microscaffold-based tissue units offer benefits such as enhanced cell retention, decreased compaction, and better size control for tissue constructs formed through self-assembly.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Beatrice Richter, Tamar Kapanadze, Nina Weingaertner, Stefanie Walter, Isabel Vogt, Andrea Grund, Jessica Schmitz, Jan Hinrich Braesen, Florian P. Limbourg, Dieter Haffner, Maren Leifheit-Nestler
Summary: High phosphate intake may lead to progressive kidney injury and represents an underestimated health problem for kidney health.
Article
Materials Science, Multidisciplinary
Boris Chichkov
Summary: This paper presents a personal view on the potential development and applications of laser printing technologies based on laser-induced forward transfer of inorganic and biological materials, including micro- and nanoparticles, living cells, and microorganisms.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Peripheral Vascular Disease
Christian Beger, Astrid Mayerboeck, Konrad Klein, Theresa Karg, Kai M. Schmidt-Ott, Olaf Randerath, Florian P. Limbourg
Summary: This study assessed the current practice of blood pressure measurement and associated values in German medical practices. The findings suggest that blood pressure control is insufficient and measurements are often not performed according to guideline recommendations.
Article
Hematology
Nadia Meyer, Katja Richter, Lars Brodowski, Constantin von Kaisenberg, Anette Melk, Bernhard Schmidt, Florian P. Limbourg, Bianca Schroeder-Heurich, Frauke Von Versen-Hoeynck
Summary: Kidney transplantation affects endothelial progenitor cells in women, leading to increased cardiovascular risk.
Review
Biotechnology & Applied Microbiology
Tommaso Zandrini, Sammy Florczak, Riccardo Levato, Aleksandr Ovsianikov
Summary: Bioprinting aims to create 3D structures with embedded cells that mimic the native extracellular matrix, but limited spatial resolution has been a hindrance. This opinion article reviews the emergence and discusses the most promising high-definition (HD) bioprinting techniques to overcome this limitation and enable the fabrication of more complex tissue and organ models in tissue engineering.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Vadim Veiko, Yuliya Karlagina, Ekaterina Zernitckaia, Elena Egorova, Maxim Radaev, Andrey Yaremenko, Gennadiy Chernenko, Valery Romanov, Nadezhda Shchedrina, Elena Ivanova, Boris Chichkov, Galina Odintsova
Summary: Laser processing of dental implant surfaces allows for control of surface structure and the creation of biomimetic topographies. The study shows that implants with continuous topography have the best secondary stability and osseointegration.
Article
Peripheral Vascular Disease
Christian Beger, Theresa Karg, Jan B. Hinrichs, Bastian Ringe, Hermann Haller, Bernhard C. Meyer, Florian P. Limbourg
Summary: This study analyzed patients with treatment-resistant hypertension and inadequate low renin in the presence of renin-angiotensin system inhibition (RASi), indicating a risk for primary aldosteronism (PA). The study found that low renin in the presence of RASi is a strong indicator of autonomous aldosterone secretion in patients with resistant hypertension, suggesting it as an on-medication screening test for PA.
Article
Materials Science, Multidisciplinary
Mariia Matiushechkina, Andrey B. Evlyukhin, Vladimir A. Zenin, Michele Heurs, Boris N. Chichkov
Summary: To implement high-efficiency Si-nanosphere metasurface mirrors in gravitational wave detectors, the exact dimensional and configuration parameters of the total system need to be determined beforehand. The reflective properties and limitations of multi-layer metasurfaces with embedded Si nanoparticles should be investigated. This study demonstrates how the substrate and protective layer influence optical properties, as well as how dimensional and material characteristics affect light reflectivity. Manufacturing imperfections, such as variations in Si nanoparticle sizes and placement, are also considered, along with methods to maintain high reflectivity under different conditions.
Review
Crystallography
Volodymyr Vasylkovskyi, Iryna Bespalova, Mykola Slipchenko, Olena Slipchenko, Yuriy Zholudov, Boris Chichkov
Summary: This review discusses the potential application of perovskite nanostructures in electrochemiluminescent (ECL) analytical systems. Perovskite nanostructures possess unique optical, electronic, and chemical properties, making them promising materials for ECL. The review focuses on recent advances in the use of perovskite and perovskite-related nanostructures with different compositions and modifications in ECL with various media, coreactants, and reaction types. The optimal methods for perovskite nanoparticle synthesis and electrode modification are also reviewed, along with the possibilities and perspectives of using perovskite-related nanostructures for ECL generation.
Article
Cardiac & Cardiovascular Systems
Christian Beger, Dominik Rueegger, Anna Lenz, Steffen Wagner, Herrmann Haller, Kai Martin Schmidt-Ott, Dirk Volland, Florian P. Limbourg
Summary: Self-monitoring of blood pressure at home is recommended in hypertension guidelines. This study found that the initial blood pressure category and measurement schedule influenced blood pressure values during home blood pressure monitoring (HBPM). BP classification tracking revealed that the time to reach the final BP category depended on the baseline category, with users in higher categories requiring more time to reach their definitive BP class. Overall, >90% of users maintained their category by day 5. Completing at least two HBPM periods resulted in a decrease in average blood pressure and improved hypertension control.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Physics, Multidisciplinary
Vladimir R. Tuz, Alexei V. Prokhorov, Alexander V. Shesterikov, Valentyn S. Volkov, Boris N. Chichkov, Andrey B. Evlyukhin
Summary: The emergence of new materials and fabrication techniques has contributed to the development of advanced photonic and communication devices. This paper proposes and numerically studies a metasurface made of bulk MoS2, a novel material with unique properties suitable for optical applications. By utilizing the natural anisotropy of MoS2, the metasurface is able to split electric and magnetic dipole modes and bring them into overlap by optimizing geometric parameters. At resonant frequencies, the metasurface acts as either an electric or a magnetic mirror depending on the polarization of incident light. It can be considered an alternative to traditional mirrors and optical splitters for designing compact and highly efficient metadevices that manipulate electromagnetic waves on a subwavelength scale.
ANNALEN DER PHYSIK
(2023)
Article
Chemistry, Multidisciplinary
Volodymyr Vasylkovskyi, Iryna Bespalova, Andrey Evlyukhin, Yuriy Zholudov, Iaroslav Gerasymov, Daniil Kurtsev, Denys Kofanov, Olena Slipchenko, Mykola Slipchenko, Boris Chichkov
Summary: The application of pulsed laser ablation technique for generating cerium-doped garnet nanoparticles in liquids is investigated. The morphological and optical properties of the obtained nanoparticles are demonstrated. The influence of single crystals of Gd3Al2.4Ga2.6O12:Ce3+, Lu3Al5O12:Ce3+, and Y3Al1.25Ga3.75O12:Ce3+ as well as the parameters of liquid media on the generation of garnet nanoparticles are experimentally studied using TEM and UV-Vis spectroscopy methods. The study reveals the relationship between the size, shape, and internal structure of the nanoparticles and the external laser ablation conditions and laser melting processes of NPs in the colloidal solutions. This work provides important information for the utilization of the generated nanoparticles as building blocks for structures with predetermined optical properties.
Proceedings Paper
Engineering, Electrical & Electronic
Andrei Buzykin, Yulia Karlagina, Maxim Radaev, Elena Egorova, Ekaterina Zernitskaya, Boris Chichkov, Nils Heine, Meike Stiesch, Katharina Doll, Galina Odintsova, Vadim Veiko
Summary: The study demonstrates a novel approach using laser technology to obtain TiO2 coating on a titanium mesh for controlled bone augmentation in oral implantology. This has significant implications for the antibacterial properties required in the medical application of titanium materials.
LASER-BASED MICRO- AND NANOPROCESSING XVI
(2022)