Article
Food Science & Technology
Wei Luo, Jinqiu Wang, Ling Sun, Rui Li, Di Wu, Jie Tang, Jiamin Zhang, Fang Geng
Summary: The study found that ultrasound disrupted the cellular structure and permeability of Salmonella bacteria, leading to accumulation of reactive oxygen species and a reduction in ATP and ATPase activity. These adverse effects disrupted the metabolic process in Salmonella cells and enhanced the lethality of chlorine dioxide.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou
Summary: Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming, which provides potential targets for therapeutic interventions. This review summarizes recent discoveries of metabolic alterations in ccRCC, including changes in glucose, lipid, and amino acid metabolism. It also discusses the development of metabolic drugs targeting these pathways and proposes future trends in drug development. Overall, this review highlights the potential for developing new treatments for ccRCC based on metabolic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Oliver J. Perkin, Yung-Chih Chen, Drusus A. Johnson, Joel E. Thomas, Greg Atkinson, James A. Betts, Javier T. Gonzalez
Summary: Ingesting polymerized polyphenols (PP) alone at doses <150 mg does not significantly alter early-phase postprandial triacylglycerol concentrations in healthy adults. However, the addition of caffeine and catechins to PP lowers postprandial glucose and insulin concentrations. Therefore, the effects of PP on postprandial lipemia are limited, but the addition of caffeine and catechins may have a regulatory effect on postprandial blood glucose and insulin.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Guankui Wang, Markella Zannikou, Laren Lofchy, Yue Li, Hanmant Gaikwad, Irina Balyasnikova, Dmitri Simberg
Summary: The type of fluorescent label on liposomes significantly impacts their extravasation and accumulation in tumors. In animal experiments, indocarbocyanine lipids (ICLs) were found to spread and accumulate in tumor tissue more easily compared to fluorescent phospholipids (FPLs).
Review
Food Science & Technology
Jingwen Liu, Jiaoxian Cao, Yiming Li, Fujiang Guo
Summary: Obesity is a global health problem associated with various diseases. Beneficial flavonoids in foods combat obesity through multiple mechanisms. This review summarizes the biological targets, mechanisms, therapeutic interventions, and clinical evidence related to flavonoids' effects on obesity.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Fisheries
Xing Zhang, Yunshan Zhang, Xiu Shi, Kun Dai, Zi Liang, Min Zhu, Ziyao Zhang, Zeen Shen, Jun Pan, Chonglong Wang, Xiaolong Hu, Chengliang Gong
Summary: The study found that lipid metabolism in BmN cells was disrupted upon BmCPV infection, leading to significant induction of major lipid constituents in the cellular membrane. Glycerophospholipid metabolism was identified as one of the most enriched pathways affected by the altered lipids.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Michihito Kyo, Zhaozhong Zhu, Ryohei Shibata, Michimasa Fujiogi, Jonathan M. Mansbach, Carlos A. Camargo, Kohei Hasegawa
Summary: This study identified specific nasopharyngeal lipids that can differentiate between respiratory syncytial virus (RSV) and rhinovirus (RV) bronchiolitis in infants. These lipids, including phosphatidylcholine (18:2/18:2), dihydroceramide (16:0), and eicosapentaenoic acid, are also associated with the severity of bronchiolitis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Plant Sciences
Yan Du, Ding-xiang Li, Dong-yu Lu, Ran Zhang, Qiao-qiao Zhong, Yan-lin Zhao, Xiao-xiao Zheng, Shuai Ji, Liang Wang, Dao-Quan Tang
Summary: This study confirms that mulberry leaf water extract can effectively alleviate lipid accumulation and inflammation by regulating ADPN/AMPK-mediated signaling pathways and relevant metabolic disturbances.
Article
Biochemistry & Molecular Biology
Ruizhi Li, Chen Cao, Zhaojun Zheng, Xiaoyan Yang, Chin Ping Tan, Yongjiang Xu, Yuanfa Liu
Summary: Intake of saturated lipids alters the levels of specific fatty acids in the liver and visceral fats, impacting the expression of lipid metabolism-related genes and leading to changes in lipid metabolism.
Review
Nutrition & Dietetics
Carmen Rodriguez-Garcia, Cristina Sanchez-Quesada, Maria Jose Martinez-Ramirez, Jose J. Gaforio
Summary: Lipodystrophy syndromes are rare diseases that result in dysfunction of adipose tissue and abnormal accumulation of triglycerides. Both genetic and acquired factors may contribute to the development of lipodystrophy, and dietary fats can modulate gene activity. This article summarizes the main genes involved in lipodystrophy and reviews the effects of dietary fats on its development.
Article
Biochemistry & Molecular Biology
Ewelina Bik, Lukasz Mateuszuk, Jagoda Orleanska, Malgorzata Baranska, Stefan Chlopicki, Katarzyna Majzner
Summary: The antimalarial drug Chloroquine (CQ) was found to not be toxic to endothelial cells at concentrations of 1-30 μM and did not induce inflammation. However, it did lead to increased staining intensity of neutral lipids, lysosomotropism, and autophagy inhibition. This indicates alterations in lipid composition of endothelial cells upon exposure to CQ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marija Brankovic, Igor Jovanovic, Marija Dukic, Tijana Radonjic, Svetlana Opric, Slobodan Klasnja, Marija Zdravkovic
Summary: The emerging issues of concern are non-alcoholic fatty liver disease (NAFLD) and its advanced stage non-alcoholic steatohepatitis (NASH), which may lead to chronic liver complications. Oxidative stress and metabolic disorders play important roles in the progression of NASH. Currently, NASH treatment is primarily focused on lifestyle changes due to the lack of approved therapeutic options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Peter Libby
Summary: Inflammation plays a key role in each stage of the life cycle of atherosclerotic plaques, with inflammatory mediators involved in various processes. Clinical complications of atherosclerotic plaques often involve thrombosis triggered by plaque disruption, and inflammatory processes regulate both plaque rupture and healing.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Judita Klimova, Milos Mraz, Helena Kratochvilova, Zdenka Lacinova, Kvetoslav Novak, David Michalsky, Jan Kvasnicka, Robert Holaj, Denisa Haluzikova, Radka Petrakova Dolezalova, Matej Zitek, Zuzana Kratka, Veronika Todorovova, Jiri Widimsky, Martin Haluzik, Tomas Zelinka, Ondrej Petrak
Summary: Evaluation of BAT activity in PPGL patients revealed a connection with catecholamine levels, but no direct relationship with increased energy metabolism was found.
Article
Immunology
Xiu-Ping Cheng, Xiao-Wan Wang, Han-Fei Sun, Liang Xu, Opeyemi Joshua Olatunji, Yan Li, Jia-Ting Lin, Jian Zuo
Summary: This study retrospectively analyzed serological indicators of rheumatoid arthritis (RA) patients and compared the disease severity and metabolic status of different RA patient groups. The results showed that NAMPT overexpression is a risk factor for joint injuries and nutrient depletion in RA, while up-regulation of SIRT1 can restrain inflammation and lipid depletion.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Letter
Nutrition & Dietetics
David S. Ludwig, Louis J. Aronne, Arne Astrup, Rafael de Cabo, Lewis C. Cantley, Mark Friedman, Steven B. Heymsfield, James D. Johnson, Janet C. King, Ronald M. Krauss, Daniel E. Lieberman, Gary Taubes, Jeff S. Volek, Eric C. Westman, Walter C. Willett, William S. Yancy, Cara B. Ebbeling
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Ying Wang, Hua Gao, Fudi Wang, Zhongde Ye, Michal Mokry, Adam W. Turner, Jianqin Ye, Simon Koplev, Lingfeng Luo, Tom Alsaigh, Shaunak S. Adkar, Maria Elishaev, Xiangyu Gao, Lars Maegdefessel, Johan L. M. Bjorkegren, Gerard Pasterkamp, Clint L. Miller, Elsie G. Ross, Nicholas J. Leeper
Summary: This study reveals that vascular smooth muscle cells (SMCs) undergo dedifferentiation and activation of pro-inflammatory pathways during the development of atherosclerosis. ATF3, a transcription factor, is identified as an upstream regulator of this transition. ATF3 represses the transition of SMCs towards a subset of cells that promote vascular inflammation by activating the complement cascade. The expression of ATF3 is negatively correlated with complement component C3, and genetic variations that reduce ATF3 expression are associated with an increased risk for atherosclerosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Haoning Howard Cen, Bahira Hussein, Jose Diego Botezelli, Su Wang, Jiashuo Aaron Zhang, Nilou Noursadeghi, Niels Jessen, Brian Rodrigues, James A. Timmons, James D. Johnson
Summary: Hyperinsulinemia, often considered as a compensatory response to insulin resistance, may actually contribute to insulin resistance. The molecular mechanisms underlying this cyclic process are poorly understood. This study found a reliable negative correlation between fasting insulin and INSR mRNA in skeletal muscle. Through cell culture experiments, it was demonstrated that elevated insulin levels attenuated AKT and ERK signaling in muscle cells. RNA-sequencing analysis revealed changes in gene expression related to insulin receptor signaling, FOXO signaling, and glucose metabolism pathways. Hyperinsulinemia led to reduced Insr gene expression and decreased surface INSR protein. SIN3A was identified as a negative regulator of Insr mRNA. These findings provide insights into the mechanisms of hyperinsulinemia-induced insulin resistance in muscle.
Article
Multidisciplinary Sciences
Sos Skovso, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Meneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Summary: Insulin receptor protein is present in pancreatic beta-cells, but the consequences of beta-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell insulin receptor affects male and female mice differently and can contribute to hyperinsulinemia in the context of glucose stimulation.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Anni M. Y. Zhang, Ken H. Chu, Brian F. Daly, Titine Ruiter, Yan Dou, Jenny C. C. Yang, Twan J. J. de Winter, Justin Chhuor, Su Wang, Stephane Flibotte, Yiwei Bernie Zhao, Xiaoke Hu, Hong Li, Elizabeth J. Rideout, David F. Schaeffer, James D. Johnson, Janel L. Kopp
Summary: Reducing Ins2 gene dosage may help suppress pancreatic cancer precancerous lesions induced by hyperinsulinemia, with high-fat diet affecting mice of different genders. Single-cell transcriptomics revealed that hyperinsulinemia affected multiple cell types in the pancreas.
CANCER & METABOLISM
(2022)
Correction
Multidisciplinary Sciences
Cody Durrer, Sean McKelvey, Joel Singer, Alan M. Batterham, James D. Johnson, Kelsey Gudmundson, Jay Wortman, Jonathan P. Little
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
David S. Ludwig, Caroline M. Apovian, Louis J. Aronne, Arne Astrup, Lewis C. Cantley, Cara B. Ebbeling, Steven B. Heymsfield, James D. Johnson, Janet C. King, Ronald M. Krauss, Gary Taubes, Jeff S. Volek, Eric C. Westman, Walter C. Willett, William S. Yancy, Mark Friedman
Summary: The obesity pandemic continues to spread despite efforts to decrease energy intake and increase energy expenditure. There are two possible explanations for this failure: the public has not fully embraced the current approach, or the approach itself is based on an erroneous paradigm. The energy balance model attributes obesity to overeating, while the carbohydrate-insulin model suggests that hormonal responses to processed carbohydrates lead to energy deposition in adipose tissue. Resolving the deficiencies in the energy balance model is crucial to inform prevention and treatment strategies, but both models agree on targeting processed carbohydrates as major drivers of obesity.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Chieh Min Jamie Chu, Honey Modi, Cara Ellis, Nicole A. J. Krentz, Sos Skovso, Yiwei Bernie Zhao, Haoning Cen, Nilou Noursadeghi, Evgeniy Panzhinskiy, Xiaoke Hu, Derek A. Dionne, Yi Han Xia, Shouhong Xuan, Mark O. Huising, Timothy J. Kieffer, Francis C. Lynn, James D. Johnson
Summary: This study investigates the dynamic states of insulin gene activity in beta cells and shows that the heterogeneity of insulin production can be explained by these dynamic states. Using live cell imaging, FACS, and single-cell RNA sequencing, the researchers found that approximately 25% of beta cells exhibited higher insulin gene activity at any given moment. They also found that insulin gene activity in these cells changed over time.
Article
Endocrinology & Metabolism
Sandra Postic, Srdjan Sarikas, Johannes Pfabe, Viljem Pohorec, Lidija Krizancic Bombek, Nastja Sluga, Masa Skelin Klemen, Jurij Dolensek, Dean Koro, Andraz Stonzer, Carmella Evans-Molina, James D. Johnson, Marjan Slak Rupnik
Summary: Physiological glucose or ryanodine stimulation of 13 cell collectives generates a large number of [Ca2+]c events, which can be rapidly assessed with our newly developed automatic image segmentation and [Ca2+]c event identification pipeline. The event durations segregate into three reproducible modes produced by a progressive temporal summation. Using pharmacological tools, we show that activation of ryanodine intracellular Ca2+ receptors is both sufficient and necessary for glucose-dependent [Ca2+]c oscillations in 13 cell collectives.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Cell Biology
Connie L. K. Leung, Subashini Karunakaran, Michael G. Atser, Leyla Innala, Xiaoke Hu, Victor Viau, James D. Johnson, Susanne M. Clee
Summary: Genetic factors play a role in obesity, but their effects are generally small. Studying animal models can provide insights into the genetic regulation of obesity. This study identified novel genes, Pdk1 and Itga6, that may modulate obesity, lipid metabolism, insulin secretion, and glucose homeostasis.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Cardiac & Cardiovascular Systems
Chae Syng Lee, Yajie Zhai, Rui Shang, Trevor Wong, Aurora J. Mattison, Haoning Howard Cen, James D. Johnson, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
Summary: The study found that flow-induced mechanical forces can increase the release of heparanase from endothelial cells, affecting cardiac metabolism. The release of heparanase is mediated by activation of purinergic receptors and protein kinase D, and is augmented in diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
George P. Brownrigg, Yi Han Xia, Chieh Min Jamie Chu, Su Wang, Charlotte Chao, Jiashuo Aaron Zhang, Sos Skovso, Evgeniy Panzhinskiy, Xiaoke Hu, James D. Johnson, Elizabeth J. Rideout
Summary: This study aims to investigate the crucial role of pancreatic beta cells in maintaining glucose homeostasis and the impact of sex differences on this process. By comparing the gene expression and function of beta cells in males and females, we found that female patients have more reliable insulin secretion and higher resilience to endoplasmic reticulum stress.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere
Summary: Loss of IAPP signaling may not increase the risk of pancreatic cancer in individuals with diabetes.
MOLECULAR METABOLISM
(2022)
Review
Physiology
Liam G. Hall, John P. Thyfault, James D. Johnson
Summary: Exercise and regular physical activity are beneficial for preventing and managing metabolic diseases, while exercise cessation can lead to metabolic derangements. This article reviews the impact of exercise and exercise cessation on β-cell function, with a focus on glucose-stimulated insulin secretion (GSIS). It also explores potential mechanisms by which β-cells adapt to exercise and highlights areas for future research.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Sos Skovso, Peter Overby, Jasmine Memar-Zadeh, Jason T. C. Lee, Jenny C. C. Yang, Iryna Shanina, Vaibhav Sidarala, Elena Levi-D'Ancona, Jie Zhu, Scott A. Soleimanpour, Marc S. Horwitz, James D. Johnson
Summary: The study confirmed the protective effects of Cre in preventing diabetes development in NOD mice, and suggested the possibility that Cre itself may have additional protective effects.