Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation

Coordinating Tissue Interactions: Notch Signaling in Cardiac Development and Disease

(2012) José Luis de la Pompa et al.   DEVELOPMENTAL CELL

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms

(2011) Dennis Bruemmer et al.   Annals of the New York Academy of Sciences

Urokinase-Type Plasminogen Activator Deficiency in Bone Marrow–Derived Cells Augments Rupture of Angiotensin II–Induced Abdominal Aortic Aneurysms

(2011) Haruhito A. Uchida et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Diet-Induced Aortic Valve Disease in Mice Haploinsufficient for the Notch Pathway Effector RBPJK/CSL

(2011) Meritxell Nus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice

(2011) H. H. Outtz et al.   BLOOD

Direct regulation of interleukin-6 expression by Notch signaling in macrophages

(2011) Wipawee Wongchana et al.   Cellular & Molecular Immunology

Blocking the NOTCH Pathway Inhibits Vascular Inflammation in Large-Vessel Vasculitis

(2011) Kisha Piggott et al.   CIRCULATION

Diagnostic and therapeutic strategies for small abdominal aortic aneurysms

(2011) Ahmed Klink et al.   Nature Reviews Cardiology

Inhibitory Role of Notch1 in Calcific Aortic Valve Disease

(2011) Asha Acharya et al.   PLoS One

Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice

(2010) Haruhito A. Uchida et al.   ATHEROSCLEROSIS

Different Effects of Commonly Prescribed Statins on Abdominal Aortic Aneurysm Wall Biology

(2010) R. Hurks et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Notch1 Deficiency Results in Decreased Inflammation during Wound Healing and Regulates Vascular Endothelial Growth Factor Receptor-1 and Inflammatory Cytokine Expression in Macrophages

(2010) H. Hamilton Outtz et al.   JOURNAL OF IMMUNOLOGY

ABSENCE OF ABDOMINAL ANEURYSM IN ADULTS WITH COARCTATION AND/OR BICUSPID AORTIC VALVE - IS THIS REALLY AN “AORTOPATHY”?

(2010) Anurag Sahu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aortic Adventitial Fibroblasts Participate in Angiotensin-Induced Vascular Wall Inflammation and Remodeling

(2010) Brian C. Tieu et al.   JOURNAL OF VASCULAR RESEARCH

Markers of inflammation in men with small abdominal aortic aneurysm

(2010) Duncan J. Parry et al.   JOURNAL OF VASCULAR SURGERY

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Pathophysiology and epidemiology of abdominal aortic aneurysms

(2010) Ian M. Nordon et al.   Nature Reviews Cardiology

γ-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice

(2009) Toru Aoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

(2009) Catherine Rush et al.   BMC GENOMICS

Chlamydial lipopolysaccharide (cLPS) is present in atherosclerotic and aneurysmal arterial wall—cLPS levels depend on disease manifestation

(2009) Pirkka Vikatmaa et al.   CARDIOVASCULAR PATHOLOGY

Interferon-γ and the Interferon-Inducible Chemokine CXCL10 Protect Against Aneurysm Formation and Rupture

(2009) Victoria L. King et al.   CIRCULATION

Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator

(2009) B. Bin Hafeez et al.   CLINICAL CANCER RESEARCH

An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice

(2009) Brian C. Tieu et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

(2009) David J Loane et al.   NATURE MEDICINE

Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability

(2008) C. P. Hans et al.   CARDIOVASCULAR RESEARCH

Medical Management of Small Abdominal Aortic Aneurysms

(2008) B. Timothy Baxter et al.   CIRCULATION

Circulating Markers of Abdominal Aortic Aneurysm Presence and Progression

(2008) Jonathan Golledge et al.   CIRCULATION