Article
Hematology
Dario Bongiovanni, Jiaying Han, Melissa Klug, Kilian Kirmes, Giacomo Viggiani, Moritz von Scheidt, Nina Schreiner, Gianluigi Condorelli, Karl-Ludwig Laugwitz, Isabell Bernlochner
Summary: Reticulated platelets (RPs) are young, hyper-reactive platelets that are larger and contain more RNA compared to older platelets. They have higher thrombogenicity and are associated with insufficient antiplatelet response to aspirin and specific P2Y(12) receptor inhibitors. RPs are promising biomarkers for the prediction of adverse cardiovascular events in cardiovascular disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
David J. Schneider, Heidi S. Taatjes-Sommer, Jayne Prats, Efthymios N. Deliargyris
Summary: The study showed that the pharmaceutical lipid excipients used in a novel oral formulation with aspirin do not impair the pharmacodynamic effects of aspirin or alter platelet function. Additionally, when the inhibition of platelet aggregation by aspirin was limited, the excipients tended to enhance its pharmacodynamic effects.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Cell Biology
Wandi Zhu, Shihui Guo, Max Homilius, Cissy Nsubuga, Shane H. Wright, Dajun Quan, Ashmita Kc, Samuel S. Eddy, Rachelle A. Victorio, Manu Beerens, Robert Flaumenhaft, Rahul C. Deo, Calum A. MacRae
Summary: This study identified dysregulation of the mechanosensory ion channel Piezo1 in platelets, red blood cells, and neutrophils of patients with type 2 diabetes mellitus (T2DM), leading to prothrombotic cellular responses. Inhibition of Piezo1 protected against thrombosis, providing a new target for modulating T2DM-related thrombosis.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Hematology
Melina Del Bianco-Rondeau, Maxime Robert-Halabi, Samara Bloom, Remi Rabasa-Lhoret, Jean-Claude Tardif, Marie Lordkipanidze, Guillaume Marquis-Gravel
Summary: The use of aspirin for the primary prevention of cardiovascular events in patients with diabetes is still controversial. Patients with diabetes have increased platelet reactivity and are often obese, which may require different dosing schedules and formulations for effective treatment.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Endocrinology & Metabolism
Ying-Chen Chen, Bing-Ze Lu, Yu-Chen Shu, Yuan-Ting Sun
Summary: This study found that cerebral microangiopathy with increased blood-brain barrier leakage occurs early in patients with type 2 diabetes mellitus (T2DM), before the appearance of cerebral small vessel disease (CSVD) on MRI. The involvement of white matter and gray matter is different in T2DM-related CSVD, and there are distinct features and mechanisms compared to other CSVDs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Frances C. Taylor, David W. Dunstan, Ashleigh R. Homer, Paddy C. Dempsey, Bronwyn A. Kingwell, Rachel E. Climie, Neville Owen, Neale D. Cohen, Robyn N. Larsen, Megan Grace, Nina Eikelis, Michael J. Wheeler, Melanie K. Townsend, Nirav Maniar, Daniel J. Green
Summary: This study showed that interrupting prolonged sitting with activity breaks every 30 minutes significantly improved femoral artery flow-mediated dilation in T2D patients compared to uninterrupted sitting. More frequent and shorter breaks were found to be more beneficial for vascular health in T2D individuals.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Hematology
Hamzah Khan, Abdelrahman Zamzam, Reid C. Gallant, Muzammil H. Syed, Margaret L. Rand, Heyu Ni, Thomas L. Forbes, Mohammed Al-Omran, Mohammad Qadura
Summary: The study investigated aspirin non-sensitivity in patients with vascular disease and found that 24% of patients were non-sensitive to 81 mg of aspirin. Non-sensitive patients had significantly higher rates of major adverse cardiovascular events and major adverse limb events compared to sensitive patients, highlighting the need for improved medical management options for this patient population.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Karolina Siewiera, Magdalena Labieniec-Watala, Hassan Kassassir, Nina Wolska, Dawid Polak, Cezary Watala
Summary: The study found that prolonged exposure of blood platelets to high concentrations of glucose in diabetes can lead to increased mitochondrial respiration, but this is not the main reason for abnormal platelet functioning. Additionally, metformin was not able to inhibit platelet activation under in vitro conditions, indicating that its beneficial effect on the coagulation system in vivo may be related to other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Alessandro Aliotta, Debora Bertaggia Calderara, Maxime G. Zermatten, Lorenzo Alberio
Summary: The study demonstrated contrasting patterns in the intracellular ion concentrations of COAT-activated platelets compared to non-COAT platelets, with the former showing high and prolonged calcium concentration, transient sodium increase, and fast potassium efflux. Inhibition of the sodium-calcium exchanger (NCX) reduced calcium mobilization and prevented the formation of procoagulant platelets, highlighting the critical and dichotomous role of NCX during platelet activation induced by convulxin-plus-thrombin.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cell Biology
Tong Wu, Lizhi Chen, Lingqi Zhou, Jie Xu, Kaihua Guo
Summary: Platelets may play an important role in the pathogenesis of Alzheimer's disease, as their Aβ content increases with age and aged platelets can accelerate Aβ deposition in the brain, leading to learning and memory deficits in recipient mice. Administering aspirin as a platelet activation inhibitor effectively alleviated these toxic processes. In vitro blood-brain barrier models were used to explore the possible cytotoxicity of these platelets.
Article
Cardiac & Cardiovascular Systems
William A. E. Parker, Rebecca Sagar, Zeyad Kurdee, Fladia Hawkins, Khalid M. Naseem, Peter J. Grant, Robert F. Storey, Ramzi A. Ajjan
Summary: The study found that patients with diabetes respond differently to the antiplatelet and profibrinolytic effects of aspirin compared to healthy controls, especially those with elevated HbA1c. Higher HbA1c levels were associated with poor response to aspirin in diabetes, indicating that reducing glucose levels can improve the anti-thrombotic action of aspirin in diabetes.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhenyan Han, Yuan Zhang, Xuelan Li, Wei-Hsiu Chiu, Yuzhu Yin, Hongying Hou
Summary: This study compared placental volume (PV) and vascular indices between pregnant women with and without gestational diabetes mellitus (GDM) using three-dimensional (3D) Power Doppler ultrasound. Results showed significant differences in PV, vascularization index (VI), flow index (FI), and vascularization flow index (VFI) between the two groups. Combining maternal age, gravida, PV, and VFI may be a more accurate marker for detecting GDM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Lina Badimon, Gemma Vilahur, Bianca Rocca, Carlo Patrono
Summary: Arachidonic acid is a common omega-6 polyunsaturated fatty acid that can produce various biologically active substances. It exists in esterified form in cell membrane phospholipids and is released through the actions of phospholipases, affecting important physiological processes such as blood coagulation and vascular functions.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Lawrence A. Leiter, Deepak L. Bhatt, Darren K. McGuire, Hwee Teoh, Kim Fox, Tabassome Simon, Shamir R. Mehta, Eli I. Lev, Robert G. Kiss, Anthony J. Dalby, Hector Bueno, Wilhelm Ridderstrale, Anders Himmelmann, Jayne Prats, Yuyin Liu, Jane J. Lee, John Amerena, Mikhail N. Kosiborod, Philippe Gabriel Steg
Summary: The THEMIS study and its subanalysis THEMIS-PCI showed that ticagrelor plus aspirin had a favorable net clinical benefit in individuals with type 2 diabetes and stable coronary artery disease, particularly among those who had previous percutaneous coronary intervention. The efficacy of ticagrelor plus aspirin on reducing major adverse cardiovascular events was generally consistent across subgroups, while the major bleeding event rate was increased by ticagrelor across all subgroups. Additionally, in THEMIS-PCI but not in the overall THEMIS population, ticagrelor generally produced a favorable net clinical benefit across different diabetes-related factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jeffrey J. Rade, Bruce A. Barton, Ramachandran S. Vasan, Shari S. Kronsberg, Vanessa Xanthakis, John F. Keaney, Naomi M. Hamburg, Nikolaos Kakouros, Thomas A. Kickler
Summary: This study found that systemic thromboxane generation is significantly associated with all-cause and cardiovascular mortality regardless of aspirin use. In participants without cardiovascular disease, TXB2-M is associated with cardiovascular mortality, while aspirin use is associated with all-cause mortality in those with low TXB2-M levels.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Editorial Material
Urology & Nephrology
Y. K. Onno Teng, Ton J. J. Rabelink
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Surgery
Cyril P. Landstra, Michiel F. Nijhoff, Dave L. Roelen, Aiko P. J. de Vries, Eelco J. P. de Koning
Summary: Islet transplantation stabilizes glycemic control in patients with complicated diabetes mellitus, but rapid functional decline could be due to islet allograft rejection. Currently, there is no reliable method for assessing rejection and treatment protocols are lacking. This study aimed to identify diagnostic features of islet allograft rejection and evaluate the effectiveness of high-dose methylprednisolone treatment.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Lushun Yuan, Ruifang Li-Gao, Aswin Verhoeven, Huub J. van Eyk, Maurice B. Bizino, Patrick C. N. Rensen, Martin Giera, Ingrid M. Jazet, Hildo J. Lamb, Ton J. Rabelink, Bernard M. van den Berg
Summary: This study aimed to investigate the association between changes in HDL composition and increased microvascular risk in individuals with type 2 diabetes mellitus. Differences in HDL composition were found between Dutch South Asian and Dutch white Caucasian individuals with diabetes, and these differences were associated with the incidence of microvascular complications. These HDL compositional differences could serve as ethnicity-specific biomarkers for type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Rene van Tienhoven, Maria J. L. Kracht, Arno R. van der Slik, Sofia Thomaidou, Anouk H. G. Wolters, Ben N. G. Giepmans, Juan Pablo Romero Riojas, Michael S. Nelson, Francoise Carlotti, Eelco J. P. de Koning, Rob C. Hoeben, Arnaud Zaldumbide, Bart O. Roep
Summary: Transcriptome analysis identified insulin-gene-derived transcripts in non-beta endocrine islet cells. Researchers studied alternative splicing of human INS mRNA in pancreatic islets and found an alternatively spliced INS product that is expressed in delta cells but not in beta cells. This variant encodes the complete insulin signal peptide and B chain, and its presence in delta cells may play a role in islet autoimmunity and pathology.
Article
Endocrinology & Metabolism
Juliette A. de Klerk, Joline W. J. Beulens, Hailiang Mei, Roel Bijkerk, Anton Jan van Zonneveld, Robert W. Koivula, Petra J. M. Elders, Leen M. 't Hart, Roderick C. Slieker
Summary: The aim of this study was to identify differentially expressed lncRNAs and mRNAs in whole blood of people with type 2 diabetes across five different clusters. The results showed that multiple lncRNAs and mRNAs were found to be differentially expressed among clusters, with particular significance in the MOD cluster. These findings contribute to our understanding of the molecular mechanisms underlying different clusters of type 2 diabetes.
Article
Multidisciplinary Sciences
Rosalie G. J. Rietjens, Gangqi Wang, Anouk I. M. van der Velden, Angela Koudijs, M. Cristina Avramut, Sander Kooijman, Patrick C. N. Rensen, Johan van der Vlag, Ton J. Rabelink, Bram Heijs, Bernard M. van den Berg
Summary: Diabetes is a major risk factor for kidney disease, with diabetic nephropathy occurring in almost half of all diabetic patients. Metabolism has been found to play a crucial role in determining cell fate and repair. Mass spectrometry imaging was used to identify specific metabolic dysregulation in different tissues in order to understand the early metabolic changes in renal cell types caused by diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Marije Koning, Ellen Lievers, Thierry Jaffredo, Cathelijne W. van den Berg, Ton J. Rabelink
Summary: Kidney organoids derived from human induced pluripotent stem cells resemble adult kidneys to a certain extent, but lack functional vasculature and limited maturation in vitro. Transplanting kidney organoids into the celomic cavity of chicken embryos induces vascularization and enhances maturation. This technique is efficient and enables transplantation and analysis of a large number of organoids.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Medicine, General & Internal
Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H. van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A. A. M. Kamps, Daniel H. van Raalte, Rutger W. van der Meer, Hildo J. Lamb, Jan-Luuk Hillebrands, Ton J. Rabelink, Marissa L. Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
Summary: PPAR y agonists can ameliorate proteinuria by inhibiting the expression of glomerular HPSE, providing a potential mechanism for the renoprotective effects of these drugs.
Article
Biochemistry & Molecular Biology
Marissa L. L. Maciej-Hulme, Jasper J. J. Van Gemst, Patience Sanderson, Angelique L. W. M. M. Rops, Jo H. H. Berden, Bart Smeets, I. Jonathan Amster, Ton J. J. Rabelink, Johan van der Vlag
Summary: Proliferative forms of glomerulonephritis are characterized by leukocyte influx, albuminuria, and loss of kidney function. The glycocalyx, comprised of heparan sulfate, plays a crucial role in glomerular inflammation. Exogenous glomerular glycocalyx and low-molecular-weight heparin reduce proteinuria and granulocyte/macrophage influx in experimental glomerulonephritis, as well as prohibit granulocyte adhesion to glomerular endothelial cells. The development of HS-based therapeutics for inflammatory glomerular diseases is justified by these findings.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Endocrinology & Metabolism
Eelco J. P. de Koning, Francoise Carlotti
Summary: Pancreatic islet cell replacement therapy is a promising strategy for treating type 1 diabetes, but the limited availability of organ donors and the need for immunosuppression hinder its widespread use. Huang and colleagues have developed an efficient method to convert primary human gastric stem cells derived from stomach tissue into insulin-producing β-cells.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Letter
Urology & Nephrology
Jolijn R. van Leeuwen, Ton J. Rabelink, Y. K. Onno Teng
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Medicine, Research & Experimental
Jolijn R. van Leeuwen, Tamara Popov, Achim Obergfell, Ton J. Rabelink, Y. K. Onno Teng
BIOLOGICS-TARGETS & THERAPY
(2023)
Article
Rheumatology
Ebru Dirikgil, Sander W. Tas, Cornelis A. Verburgh, Darius Soonawala, A. Elisabeth Hak, Hilde H. F. Remmelts, Daphne IJpelaar, Gozewijn D. Laverman, Abraham Rutgers, Jaap M. van Laar, Hein J. Bernelot Moens, Peter M. J. Verhoeven, Ton J. Rabelink, Willem Jan W. Bos, Y. K. Onno Teng
Summary: Diagnosing ANCA-associated vasculitis (AAV) can be challenging due to its rarity and complexity. Diagnostic delay is associated with non-generalized disease and ENT involvement.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2022)
Article
Respiratory System
Lushun Yuan, Shuzhen Cheng, Wendy M. P. J. Sol, Anouk I. M. van der Velden, Hans Vink, Ton J. Rabelink, Bernard M. van den Berg
Summary: Accumulating evidence suggests that endothelial dysfunction is involved in the progression of COVID-19. This study found that serum factors of severe COVID-19 patients may affect the glycocalyx and lead to endothelial dysfunction. The study also demonstrated that certain substances circulating in the plasma of COVID-19 patients in intensive care units are associated with endothelial glycocalyx degradation, barrier disruption, inflammation, and increased coagulation.
Article
Biochemistry & Molecular Biology
Qiao Zhao, Sabine J. L. Nooren, Laurien E. Zijlstra, Jos J. M. Westenberg, Lucia J. M. Kroft, J. Wouter Jukema, Noeleen C. Berkhout-Byrne, Ton J. Rabelink, Anton Jan van Zonneveld, Marjolijn van Buren, Simon P. Mooijaart, Roel Bijkerk
Summary: The prevalence of end-stage kidney disease (ESKD) is increasing in older patients, with cardiovascular disease (CVD) being the main cause of death. Circulating angiogenic miRNAs, angiopoietin-2 (Ang-2), and asymmetric dimethylarginine (ADMA) levels are associated with cardiovascular structure and function in ESKD patients. ADMA and miR-27a levels are higher in ESKD patients with coronary heart disease, while miR-27a levels are higher in patients with atrial fibrillation. These markers are strongly correlated with measures of cardiovascular structure and function.