Review
Cell Biology
Fan-E Mo
Summary: Mechanical forces from blood flow shear stress play a direct role in regulating endothelial gene expression and phenotype. Blood flow patterns intricately control the production of extracellular matrix proteins and integrin receptors in arterial endothelial cells. Disturbed flow can lead to dysfunctional endothelial responses, while laminar flow promotes atheroresistant phenotype. Targeting the interaction between matrix proteins and integrins is a potential therapeutic approach for atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Immunology
Yuna Du, Huiqing Zhang, Yujie Guo, Kuangyu Song, Lifeng Zeng, Yiguo Chen, Zhengyu Xie, Rong Li
Summary: The study found that CD38(-/-) mice injected with Escherichia coli resulted in more severe pulmonary injuries and higher levels of cytokine mRNA expressions. CD38 deficiency increased the expressions of IL-1 beta and MCP-1 and aggravated pulmonary injury through the TLR4/ERK/NF-kB signaling pathway in sepsis.
MICROBES AND INFECTION
(2021)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Psychology, Developmental
Craig A. Erickson, Charles R. Tessier, Christina Gross, Ernest Pedapati, Logan K. Wink, Kelli C. Dominick, Rebecca C. Shaffer, Hilary Rosselot, Michael P. Hong, Andrew P. Bantel, Elizabeth Berry-Kravis, Paul S. Horn, Ryan Adams, John A. Sweeney
Summary: This study investigated the activity of ERK1/2 in autism spectrum disorder (ASD). The results showed that lymphocytic ERK1/2 activation was faster in individuals with ASD, and this was correlated with greater social impairment. The differences in ERK1/2 activation were more pronounced in younger individuals.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Fernando S. Santiago, Yue Li, Levon M. Khachigian
Summary: The mutation in Ser26 or deletion of Egr-1 disrupts endothelial cell proliferation, migration, and network formation, leading to apoptosis and increased expression of VE-cadherin. This highlights the importance of Ser26 in Egr-1 for various proangiogenic processes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Hidenori Kanno, Sei Naito, Yutaro Obara, Hiromi Ito, Osamu Ichiyanagi, Takafumi Narisawa, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya
Summary: ERK5 has been found to be highly expressed in clear cell renal cell carcinoma (ccRCC) and is associated with high grade, high recurrence rate, and high cancer-specific survival. The expression of ERK5 is regulated by miR-143. Inhibition of ERK5 holds promise as a potential target for ccRCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Toxicology
Yujia Xie, Jixuan Ma, Meng Yang, Lieyang Fan, Weihong Chen
Summary: Silicosis is a scarring lung disease caused by inhaling fine particles of crystalline silica in the workplace. The underlying molecular mechanisms of silicosis are not fully understood, but recent studies have highlighted the role of the activated ERK signaling pathway in regulating oxidative stress, inflammatory response, fibroblast activation, and other processes involved in the formation and development of silicosis.
TOXICOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kanako Miyano, Seiya Hasegawa, Noriho Asai, Miaki Uzu, Wakako Yatsuoka, Takao Ueno, Miki Nonaka, Hideaki Fujii, Yasuhito Uezono
Summary: The Japanese herbal medicine Hangeshashinto (HST) has been shown to improve chemotherapy-induced oral ulcerative mucositis (OUM) through enhancing the migration of human oral keratinocytes (HOK) by upregulating CXCL12 via ERK.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ruoqi Yang, Guiping Zhao, Lili Zhang, Yu Xia, Huijuan Yu, Bin Yan, Bin Cheng
Summary: This study constructed an efficient and reliable multi-stage virtual screening-in vitro biological validation system to identify potential inhibitors targeting ERK2. By using machine learning models, ADME/T prediction, and molecular docking, several candidate inhibitors were identified from natural products, and one of them exhibited acceptable inhibitory activity in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Virology
Jie Ni, Shunlin Hu, Xiaoquan Wang, Xiaowen Liu, Zenglei Hu, Xiufan Liu
Summary: This study investigates the relationship between the ERK pathway and Newcastle disease virus (NDV) replication. It was found that activation of the ERK pathway is required for NDV replication, as specific blockage of this pathway significantly decreased viral gene expression, replication, and cytopathogenic effects caused by NDV.
ARCHIVES OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryan W. Barrs, Jia Jia, Michael Ward, Dylan J. Richards, Hai Yao, Michael J. Yost, Ying Mei
Summary: This study develops a peptide-functionalized alginate hydrogel bioink with defined mechanical, rheological, and biochemical properties for direct bioprinting of microvascularized tissues. The bioink synergistically promotes vascular morphogenesis and capillary-scale endothelial tube formation by conjugating an integrin-binding peptide and a vascular endothelial growth factor-mimetic peptide with a protease-sensitive linker onto a biodegradable alginate. The resulting vascularized tissue construct exhibits pericyte-endothelial cell colocalization, angiogenic sprouting, and deposition of fibronectin and collagen in vascular and tissue components.
Article
Cardiac & Cardiovascular Systems
Michael Warkala, Dongying Chen, AnnJosette Ramirez, Ali Jubran, Michael Schonning, Xia Wang, Huaning Zhao, Sophie Astrof
Summary: The development of the fourth pharyngeal arch arteries involves a multistep process with contributions from SHF-derived ECs, remodeling of endothelial plexus into PAAs, and remodeling of PAAs into the aortic arch artery and its major branches. Cell-ECM interactions regulated by integrin alpha 5 beta 1 and Fn1 are essential at each developmental stage.
CIRCULATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Jinfeng Liu, Liang Ning
Summary: Emodin can significantly reduce the apoptosis rate of myocardial tissues and improve cardiac function in rats with post-MI HF, indicating its potential therapeutic effect in alleviating post-MI HF. The changes in cardiac parameters and protein expressions were dose-dependent on emodin administration.