Article
Multidisciplinary Sciences
Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Diana Cervantes, Elke Kruger, Frank L. Heppner, Deborah A. Ferrington, Hong Wei Chu
Summary: This study reveals that airway epithelial LMP7 plays an important role in resolving RV-mediated lung inflammation by reducing pro-inflammatory cytokines and viral load, as well as enhancing the expression of the negative immune regulator A20/TNFAIP3. The induction of airway epithelial LMP7 may provide a potential therapeutic intervention against RV infection.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Timothy French, Nicole Israel, Henning Peter Duesedau, Anne Tersteegen, Johannes Steffen, Clemens Cammann, Eylin Topfstedt, Daniela Dieterich, Thomas Schueler, Ulrike Seifert, Ildiko Rita Dunay
Summary: Cell survival and function depend on the balance of protein synthesis and degradation. The immunoproteasome plays a critical role in inflammation and control of parasitic infection, influencing neuroinflammation outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Karen Geoffroy, Bruna Araripe Saraiva, Melissa Viens, Delphine Beland, Marie-Claude Bourgeois-Daigneault
Summary: Proteasome dependency is a common characteristic in many cancers that can be targeted with proteasome inhibitors. A modified form of the proteasome called the immunoproteasome (ImP) has been associated with better outcomes in breast cancer, particularly triple-negative breast cancer (TNBC). However, there is a lack of studies on ImP expression at the protein level in large patient cohorts, and the cellular source of ImPs is often overlooked. The findings from our study suggest that high expression of ImP by tumor cells may serve as a prognostic marker for TNBC outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi
Summary: This study aims to investigate the mechanism of MCL-1i-induced Mcl-1 protein stability. Both in vivo and in vitro experiments demonstrate that MCL-1i-induced Mcl-1 protein stability is mainly associated with defective Mcl-1 ubiquitination and concurrent apoptosis induction. Additionally, MCL-1i also enhances Mcl-1Thr163 phosphorylation via ERK pathway, contributing to Mcl-1 stability.
CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Flore Sneyers, Martijn Kerkhofs, Femke Speelman-Rooms, Kirsten Welkenhuyzen, Rita La Rovere, Ahmed Shemy, Arnout Voet, Guy Eelen, Mieke Dewerchin, Stephen W. G. Tait, Bart Ghesquiere, Martin D. Bootman, Geert Bultynck
Summary: Intracellular Ca2+ signals play a crucial role in various cellular processes. Research has shown that BAPTAi can induce apoptosis in cancer cells by inhibiting mTORC1 activity and impairing glycolysis, independent of Ca2+ signaling. Additionally, direct inhibition of PFKFB3 emerges as a potential therapeutic target in MCL-1-dependent cancers.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Omar Al-Odat, Max von Suskil, Robert Chitren, Weam Elbezanti, Sandeep Srivastava, Tulin Budak-Alpddogan, Subash Jonnalagadda, Bharat Aggarwal, Manoj Pandey
Summary: Mcl-1 protein plays a critical role in the progression of multiple myeloma and inhibiting this protein is considered a therapeutic strategy. Remarkable advancements have been made in the development of selective Mcl-1 inhibitors, which can be used as single agents or in combination therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Haolan Wang, Ming Guo, Hudie Wei, Yongheng Chen
Summary: MCL-1, an antiapoptotic protein, is frequently overexpressed in many tumor types and closely associated with tumorigenesis, poor prognosis, and drug resistance. Its central role in regulating the mitochondrial apoptotic pathway makes it an attractive target for cancer therapy. Progress has been made towards MCL-1 inhibitors and some have entered clinical trials.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Chemistry, Organic
Patrick B. Brady, Bryan K. Sorensen, Roberto M. Risi, Michael L. Curtin, Robert A. Mantei, Alan S. Florjancic, Anthony Mastracchio, Cheng Ji, Aaron R. Kunzer, Chunqiu Lai, Gregory E. Storer, Vincent S. Chan, Rodger F. Henry, Andrew J. Souers, Michael R. Michaelides, Andrew S. Judd, T. Matthew Hansen
Summary: We describe the synthesis of ABBV-467 on a decagram scale, enabling preclinical characterization. The strategy is convergent and stereoselective.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Cell Biology
Ming Li, Feng Gao, Xiaoying Li, Yu Gan, Shuangze Han, Xinfang Yu, Haidan Liu, Wei Li
Summary: The E3 ligase TRAF4 is closely related to radioresistance in oral squamous cell carcinoma (OSCC) by stabilizing MCL-1 through Akt signaling. Targeting TRAF4 may be a promising strategy to overcome radioresistance in OSCC.
CELL DEATH & DISEASE
(2022)
Article
Hematology
Meghan E. Turnis, Ewa Kaminska, Kaitlyn H. Smith, Brittany J. Kartchner, Peter Vogel, Jonathan D. Laxton, Richard A. Ashmun, Paul A. Ney, Joseph T. Opferman
Summary: Deletion of erythroid-specific Mcl1 results in embryonic lethality due to severe anemia caused by lack of mature red blood cells. MCL-1 is required only during early definitive erythropoiesis, with developing erythrocytes becoming MCL-1 independent and upregulating BCL-xL expression during later stages.
Article
Immunology
Jin Liu, Yang Liu, Snigdha Panda, Anguo Liu, Jun Lei, Irina Burd
Summary: This study aimed to analyze the subsets of placenta CD8+ T cells, revealing that LPS injection induced changes in the properties of CD8+ T cells and Tc1/Tc2 ratio, with an expansion of Tc1 cells and a significantly higher Tc1/Tc2 ratio in the LPS group compared to the PBS group in a mouse model. The study also found an increase in TNF-alpha and IFN-gamma expression in the LPS group, indicating a Tc1-bias response following intrauterine injection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pooja Mittal, Sujata Singh, Rajesh Sinha, Anju Shrivastava, Archana Singh, Indrakant Kumar Singh
Summary: MCL-1 plays a crucial role in cancer cells and its overexpression is associated with drug resistance. Advancements in selective MCL-1 inhibitors offer new therapeutic strategies for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Kaixin Wu, Seon-Min Woo, Seung-Un Seo, Taeg-Kyu Kwon
Summary: BMI-1, a polycomb ring finger oncogene, is highly expressed in multiple cancer cells and plays a role in cancer cell proliferation, invasion, and apoptosis. Inhibition of BMI-1 leads to Mcl-1 destabilization by downregulating DUB3, ultimately inducing cancer cell death. This study demonstrates the importance of BMI-1 in cancer stemness and the potential therapeutic implications of targeting BMI-1 in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
David J. De George, Tingting Ge, Balasubramaniam Krishnamurthy, Thomas W. H. Kay, Helen E. Thomas
Summary: Type 1 diabetes is an autoimmune disease that affects children. It is challenging to study in humans due to the difficulty in biopsy and early stage activity. The NOD mouse model provides an opportunity to understand the molecular mechanisms of the disease. IFN-γ plays a role in inflammation and autoreactive T cell proliferation, but inhibiting it may not be an effective therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Hui San Chin, Nai Yang Fu
Summary: The protein Mcl-1 plays a crucial role in cell survival, with its essential functions revealed through genetically engineered mouse models. Understanding its physiological roles in different tissues and developmental stages has implications for the treatment of various diseases, including cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Zaruhi Karabekian, Hao Ding, Gulnaz Stybayeva, Irina Ivanova, Narine Muselimyan, Amranul Haque, Ian Toma, Nikki G. Posnack, Alexander Revzin, David Leitenberg, Michael A. Laflamme, Narine Sarvazyan
TISSUE ENGINEERING PART A
(2015)
Article
Genetics & Heredity
Lakhmir S. Chawla, Ian Toma, Danielle Davison, Khashayar Vaziri, Juliet Lee, Raymond Lucas, Michael G. Seneff, Aoibhinn Nyhan, Timothy A. McCaffrey
BMC MEDICAL GENOMICS
(2016)
Article
Microbiology
Sarah K. Hilton, Eduardo Castro-Nallar, Marcos Perez-Losada, Ian Toma, Timothy A. McCaffrey, Eric P. Hoffman, Marc O. Siegel, Gary L. Simon, W. Evan Johnson, Keith A. Crandall
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Biochemical Research Methods
Allyson L. Byrd, Joseph F. Perez-Rogers, Solaiappan Manimaran, Eduardo Castro-Nallar, Ian Toma, Tim McCaffrey, Marc Siegel, Gary Benson, Keith A. Crandall, William Evan Johnson
BMC BIOINFORMATICS
(2014)
Article
Biochemistry & Molecular Biology
Timothy A. McCaffrey, Constantine Tziros, Jannet Lewis, Richard Katz, Robert Siegel, William Weglicki, Jay Kramer, Tong Mak, Ian Toma, Liang Chen, Elizabeth Benas, Alexander Lowitt, Shruti Rao, Linda Witkin, Yi Lian, Yinglei Lai, Zhaoqing Yang, Sidney W. Fu
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2013)
Article
Microbiology
Ian Toma, Marc O. Siegel, John Keiser, Anna Yakovleva, Alvin Kim, Lionel Davenport, Joseph Devaney, Eric P. Hoffman, Rami Alsubail, Keith A. Crandall, Eduardo Castro-Nallar, Marcos Perez-Losada, Sarah K. Hilton, Lakhmir S. Chawla, Timothy A. McCaffrey, Gary L. Simon
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Pharmacology & Pharmacy
Shawneequa L. Callier, Ian Toma, Timothy McCaffrey, Arthur F. Harralson, Travis J. O'Brien
PERSONALIZED MEDICINE
(2014)
Meeting Abstract
Rheumatology
G. St Laurent, I. Toma, B. Seilheimer, M. Tackett, J. Zhou, M. Ri, D. Shtokalo, Y. Vyatkin, T. Jepson, K. Cesnulevicius, T. Mccaffrey
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Meeting Abstract
Rheumatology
G. St Laurent, I. Toma, M. Tackett, J. Zhou, M. Ri, D. Shtokalo, Y. Vyatkin, T. Jepson, K. Cesnulevicius, B. Seilheimer, T. Mccaffrey
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Meeting Abstract
Oncology
L. R. Martella, F. Daniel, A. Moretti, I. Toma, F. Lancia, E. Tiberi, E. Mauro, A. Schirone, A. Santini, A. Frassoldati
ANNALS OF ONCOLOGY
(2017)
Meeting Abstract
Oncology
L. Belluomini, F. Fiorica, A. Stefanelli, A. Santini, B. Urbini, F. Daniel, R. Martella, I. Toma, F. Lancia, A. Moretti, E. Banno, C. Giorgi, A. Frassoldati
ANNALS OF ONCOLOGY
(2017)
Meeting Abstract
Cell & Tissue Engineering
N. Muselimyan, Z. Karabekian, I. Toma, N. G. Posnack, N. Sarvazyan
TISSUE ENGINEERING PART A
(2015)
Meeting Abstract
Cardiac & Cardiovascular Systems
Ramesh Mazhari, Ian Toma, Nahal Konjedi, Claire Murphy, Farzad Moussavi, Maziar Sadri, Palak Shah, Timothy McCaffrey
Meeting Abstract
Rheumatology
G. St Laurent, B. Seilheimer, M. Tackett, J. Zhou, D. Shtokalo, Y. Vyatkin, P. Kapranov, I. Toma, T. Mccaffrey
ANNALS OF THE RHEUMATIC DISEASES
(2017)
Article
Biochemistry & Molecular Biology
Georges St Laurent, Bernd Seilheimer, Michael Tackett, Jianhua Zhou, Dmitry Shtokalo, Yuri Vyatkin, Maxim Ri, Ian Toma, Dan Jones, Timothy A. McCaffrey
FRONTIERS IN MOLECULAR BIOSCIENCES
(2017)