Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cardiac & Cardiovascular Systems
Guanxin Zhang, Qing Qin, Chen Zhang, Xiaobo Sun, Kyosuke Kazama, Bing Yi, Fang Cheng, Zhi-Fu Guo, Jianxin Sun
Summary: The study finds that NDRG1 plays an essential role in cell differentiation, proliferation, and stress responses. The expression of NDRG1 significantly increases in cytokine-stimulated endothelial cells and atherosclerotic lesions. Inhibition of NDRG1 not only suppresses the expression of procoagulant molecules but also exerts antithrombotic effects in endothelial cells, highlighting its potential as a therapeutic target for vascular diseases.
CIRCULATION RESEARCH
(2023)
Review
Hematology
Prisca K. Lin, George E. Davis
Summary: Large and medium-sized vessels react differently from capillaries to stimuli inducing vascular disease, undergoing extracellular matrix (ECM) remodeling. While arteries persist and undergo modifications in response to injurious stimuli, capillaries may undergo regression responses.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Immunology
Yanhao He, Guangde Yang, Lijing Sun, Hongqian Gao, Feng Yao, Zhen Jin, Zihan Zheng, Lifang Chen, Weirong Wang, Nanbo Zheng, Rong Lin
Summary: SIRT6 protects against vascular inflammation through its deacetylase activity and the NRF2-dependent signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Tianying Hong, Xianmei Pan, Han Xu, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia
Summary: Vascular inflammation is a common pathological basis for many cardiovascular diseases. Jatrorrhizine, a component of Rhizoma Coptidis, has been found to reduce carotid intimal hyperplasia and vascular inflammation in mice, and inhibit endothelial cell inflammation induced by H2O2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Carmen Gutierrez-Munoz, Luis Miguel Blanco-Colio
Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud
Summary: This review summarizes the importance of cellular processes and dysfunction in the development of pulmonary arterial hypertension, as well as the roles of circulating and resident vascular cells in pulmonary vascular remodeling.
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Ophthalmology
Jin-Sang Yu, Jad Daw, Jose-Andres C. Portillo, Carlos S. Subauste
Summary: The study found that CD40 in endothelial cells can promote the upregulation of ICAC-1 and leukostasis in diabetic mice, suggesting a pro-inflammatory role. However, it does not lead to the upregulation of pro-inflammatory cytokines and NOS2.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Holly Ryan, Laurence Morel, Erika Moore
Summary: Vascular inflammation caused by overly activated immune cells is a significant factor contributing to morbidity and mortality in systemic lupus erythematosus (SLE). There are several mouse models currently used to study the pathogenesis of SLE, each with different mechanisms. The diversity of these models allows for the investigation of different aspects of the disease. To better understand the mechanisms of vascular inflammation in SLE and assist future researchers in selecting appropriate mouse models to study cardiovascular complications, it is suggested to directly compare vascular inflammation among different mouse models of SLE. Additionally, the use of in vitro vascular assays is proposed to further investigate prevalent vascular inflammation processes in different mouse models of SLE.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jakob R. Kaeppler, Jianzhou Chen, Mario Buono, Jenny Vermeer, Pavitra Kannan, Wei-Chen Cheng, Dimitrios Voukantsis, James M. Thompson, Mark A. Hill, Danny Allen, Ana Gomes, Veerle Kersemans, Paul Kinchesh, Sean Smart, Francesca Buffa, Claus Nerlov, Ruth J. Muschel, Bostjan Markelc
Summary: This study used multiphoton microscopy to investigate the effect of radiation therapy on tumor vasculature. The results showed that there was minimal structural change in the perfused vasculature after radiation therapy, but non-perfused vessels and blind ends were significantly impaired, accompanied by apoptosis and reduced proliferation of endothelial cells.
Article
Pharmacology & Pharmacy
Jin Liu, Jessica Kwan Wun Tsang, Frederic Khe Cheong Fung, Sookja Kim Chung, Zhongjie Fu, Amy Cheuk Yin Lo
Summary: This study comprehensively analyzed the role of retinal microglia in retinopathy of prematurity (ROP), and found that the activation of retinal microglia was closely associated with increased retinal microglia and vessels in the process of vascular abnormalities. Additionally, the pharmacological inhibition of retinal microglia exacerbated the retinal vascular consequences in ROP.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu
Summary: The glycocalyx plays a crucial role in inflammation and the development of vascular diseases, with endothelial dysfunction potentially leading to tissue swelling, chronic inflammation, and thrombosis. Eliminating endothelial inflammation may be a key target for treating vascular diseases. Research indicates that by disrupting the cycle of endothelial dysfunction and inflammation, the glycocalyx can help alleviate the progression of inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Claudia Rodriguez, Ana Sanchez, Javier Saenz-Medina, Mercedes Munoz, Medardo Hernandez, Miguel Lopez, Luis Rivera, Cristina Contreras, Dolores Prieto
Summary: Obesity-induced dysregulation of AMPK activity is the underlying cause of kidney vascular dysfunction, and activation of AMPK improves metabolic state, protects renal endothelial function, and exerts potent vascular antioxidant and anti-inflammatory effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Hematology
Jonathan A. Stiber, Jiao-Hui Wu, Lisheng Zhang, Igor Nepliouev, Zhu-Shan Zhang, Victoria G. Bryson, Leigh Brian, Rex C. Bentley, Phillip R. Gordon-Weeks, Paul B. Rosenberg, Neil J. Freedman
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Article
Hematology
Melissa A. Brown, Lisheng Zhang, Vrad W. Levering, Jiao-Hui Wu, Lisa L. Satterwhite, Leigh Brian, Neil J. Freedman, George A. Truskey
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2010)
Article
Hematology
Jiao-Hui Wu, Lisheng Zhang, Alexander C. Fanaroff, Xinjiang Cai, Krishn C. Sharma, Leigh Brian, Sabrina T. Exum, Sudha K. Shenoy, Karsten Peppel, Neil J. Freedman
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2012)
Article
Hematology
Jiao-Hui Wu, Alexander C. Fanaroff, Krishn C. Sharma, Liisa S. Smith, Leigh Brian, Betty A. Eipper, Richard E. Mains, Neil J. Freedman, Lisheng Zhang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Shoukang Zhu, Anuj Malhotra, Lisheng Zhang, Shanming Deng, Taifang Zhang, Neil J. Freedman, Robert Storms, Karsten Peppel, Pascal J. Goldschmidt-Clermont, Chunming Dong
Article
Cardiac & Cardiovascular Systems
Jihee Kim, Lisheng Zhang, Karsten Peppel, Jiao-Hui Wu, David A. Zidar, Leigh Brian, Scott M. DeWire, Sabrina T. Exum, Robert J. Lefkowitz, Neil J. Freedman
CIRCULATION RESEARCH
(2008)
Article
Biochemistry & Molecular Biology
Lisheng Zhang, Jessica J. Connelly, Karsten Peppel, Leigh Brian, Svati H. Shah, Sarah Nelson, David R. Crosslin, Tianyuan Wang, Andrew Allen, William E. Kraus, Simon G. Gregory, Elizabeth R. Hauser, Neil J. Freedman
HUMAN MOLECULAR GENETICS
(2010)
Article
Medicine, Research & Experimental
Yuan Lu, Lisheng Zhang, Xudong Liao, Panjamaporn Sangwung, Domenick A. Prosdocimo, Guangjin Zhou, Alexander R. Votruba, Leigh Brian, Yuh Jung Han, Huiyun Gao, Yunmei Wang, Koichi Shimizu, Kaitlyn Weinert-Stein, Maria Khrestian, Daniel I. Simon, Neil J. Freedman, Mukesh K. Jain
JOURNAL OF CLINICAL INVESTIGATION
(2013)
Article
Surgery
Lisheng Zhang, Leigh Brian, Neil J. Freedman
JOURNAL OF VASCULAR SURGERY
(2012)
Article
Genetics & Heredity
Svati H. Shah, Neil J. Freedman, Lisheng Zhang, David R. Crosslin, David H. Stone, Carol Haynes, Jessica Johnson, Sarah Nelson, Liyong Wang, Jessica J. Connelly, Michael Muehlbauer, Geoffrey S. Ginsburg, David C. Crossman, Christopher J. H. Jones, Jeffery Vance, Michael H. Sketch, Christopher B. Granger, Christopher B. Newgard, Simon G. Gregory, Pascal J. Goldschmidt-Clermont, William E. Kraus, Elizabeth R. Hauser
Article
Hematology
Lisheng Zhang, Karsten Peppel, Perumal Sivashanmugam, Eric S. Orman, Leigh Brian, Sabrina T. Exum, Neil J. Freedman
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2007)
Article
Biochemistry & Molecular Biology
Jiao-Hui Wu, Robi Goswami, Xinjiang Cai, Sabrina T. Exum, Xuewei Huang, Lisheng Zhang, Leigh Brian, Richard T. Premont, Karsten Peppel, Neil J. Freedman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2006)
Article
Cardiac & Cardiovascular Systems
K Peppel, LS Zhang, ES Orman, PO Hagen, A Amalfitano, L Brian, NJ Freedman
CARDIOVASCULAR RESEARCH
(2005)
Article
Hematology
LS Zhang, K Peppel, L Brian, L Chien, NJ Freedman
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2004)