Article
Multidisciplinary Sciences
Zarifeh Heidary, Shaghayegh Haghjooy Javanmard, Iman Izadi, Nasrin Zare, Jafar Ghaisari
Summary: This paper presents a multiscale model for studying the metastasis process of cancer cells in a three-dimensional space. The model combines the interactions between cancer cells and their microenvironment components, molecular dynamics, cellular and tissue levels, providing a comprehensive framework for research. The study reveals the significant role of cancer associated fibroblasts in metastasis and uncovers their mechanisms through spatial-temporal modeling of circulating signals. The model's capability is validated by comparing its outputs with experimental results. The research suggests that the proposed multiscale model can contribute to improving the efficiency of therapeutic methods in metastasis prevention.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, Research & Experimental
Kwang Ho Yoo, Nikita Thapa, Yong Joon Chwae, Seung Hyun Yoon, Beom Joon Kim, Jung Ok Lee, You Na Jang, Jaeyoung Kim
Summary: Osteoarthritis (OA) still lacks an effective and safe treatment. Targeting transforming growth factor (TGF)-beta and using stem cell-derived exosomes have emerged as potential therapeutic approaches for OA.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
Article
Cell Biology
Caroline Gelabert, Panagiotis Papoutsoglou, Irene Golan, Eric Ahlstrom, Adam Ameur, Carl-Henrik Heldin, Laia Caja, Aristidis Moustakas
Summary: This study demonstrates that LINC00707 interacts with Smad proteins, limiting the output of TGF beta signaling and suppressing cancer cell invasion.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Sijia Liu, Maarten van Dinther, Sophie C. Hagenaars, Yuanzhuo Gu, Thomas B. Kuipers, Hailiang Mei, Maria Catalina Gomez-Puerto, Wilma E. Mesker, Peter ten Dijke
Summary: Triple-negative breast cancer (TNBC) is a challenging subtype due to its aggressive nature and low response to current therapies. Understanding TNBC metastasis may lead to better diagnosis and treatment options. In this study, OPTN was found to play a surprising role in inhibiting TNBC metastasis by suppressing the TGF beta signaling pathway. These findings suggest that OPTN may be a potential target for suppressing TNBC metastasis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Review
Biochemistry & Molecular Biology
Miguel Alcoceba, Maria Garcia-Alvarez, Alejandro Medina, Rebeca Maldonado, Veronica Gonzalez-Calle, Maria Carmen Chillon, Maria Eugenia Sarasquete, Marcos Gonzalez, Ramon Garcia-Sanz, Cristina Jimenez
Summary: The MYD88 gene plays a role in the innate immune system and mutations in this gene, particularly the L265P mutation, have been linked to lymphoma development, especially in patients with Waldenstrom's macroglobulinemia. The absence of MYD88 mutations in WM patients may lead to aggressive lymphoma transformation and resistance to certain treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Review
Medicine, Research & Experimental
Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K. Mainigi
Summary: Atrial fibrillation is a common clinically significant arrhythmia with four fundamental pathophysiological mechanisms, with TGF-beta playing a key role. Studies have shown that TGF-beta 1 is involved in the development and propagation of atrial fibrillation.
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Meng-Yan Wang, Wen-Juan Liu, Le-Yi Wu, Gang Wang, Cheng-Lin Zhang, Jie Liu
Summary: This article provides a comprehensive review of the research progress in TGF-beta 2, highlighting its role in various biological processes and its association with diseases related to dysregulation of its signaling.
Review
Biochemistry & Molecular Biology
Jinwook Chung, Md Nazmul Huda, Yoonhwa Shin, Sunhee Han, Salima Akter, Insug Kang, Joohun Ha, Wonchae Choe, Tae Gyu Choi, Sung Soo Kim
Summary: The interaction between reactive oxygen species (ROS) and transforming growth factor-beta (TGF-beta) signaling pathway plays a critical role in tumor development and progression. While ROS can influence TGF-beta signaling, the TGF-beta pathway can regulate ROS production, leading to a complex relationship between the two in cancer cells. Understanding this crosstalk may provide new insights and potential approaches in cancer biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Gabriel Bandeira, Katia Rocha, Monize Lazar, Suzana Ezquina, Guilherme Yamamoto, Monica Varela, Vanessa Takahashi, Meire Aguena, Thomaz Gollop, Mayana Zatz, Maria Rita Passos-Bueno, Ana Krepischi, Oswaldo Keith Okamoto
Summary: This study evaluated the frequency of pathogenic/likely pathogenic germline variants in 105 Brazilian women with breast and/or ovarian cancer, identifying P/LP variants in 21% of patients and VUS variants in 14.3% of patients. A novel pathogenic ATM intragenic deletion was also discovered, along with a higher frequency of a BRCA1 pathogenic variant compared to other studies. These findings help characterize the genetic background of breast cancer predisposition in the Brazilian population.
Review
Cell & Tissue Engineering
Gabriella Shih Ping Hsia, Joyce Esposito, Leticia Alves da Rocha, Sofia Ligia Guimaraes Ramos, Oswaldo Keith Okamoto
Summary: Transplantation is crucial for individuals with end-stage organ failure diseases, but faces challenges such as organ rejection, donor shortage, and long waiting lines. With investments in laboratory-grown organs and advancements in organoid technology, regenerative medicine approaches hold promise for growing organs in vitro in the future.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Lucila N. Kerbauy, Nancy D. Marin, Mecit Kaplan, Pinaki P. Banerjee, Melissa M. Berrien-Elliott, Michelle Becker-Hapak, Rafet Basar, Mark Foster, Luciana Garcia Melo, Carly C. Neal, Ethan McClain, May Daher, Ana Karen Nunez Cortes, Sweta Desai, Francesca Wei Inng Lim, Mayela Carolina Mendt, Timothy Schappe, Li Li, Hila Shaim, Mayra Shanley, Emily L. Ensley, Nadima Uprety, Pamela Wong, Enli Liu, Sonny O. Ang, Rong Cai, Vandana Nandivada, Vakul Mohanty, Qi Miao, Yifei Shen, Natalia Baran, Natalie W. Fowlkes, Ken Chen, Luis Muniz-Feliciano, Richard E. Champlin, Yago L. Nieto, Joachim Koch, Martin Treder, Wolfgang Fischer, Oswaldo Keith Okamoto, Elizabeth J. Shpall, Todd A. Fehniger, Katayoun Rezvani
Summary: The study suggests that using bispecific engagers and cytokine pre-activation can enhance NK-cell cytotoxicity against NK-resistant cancers. Additionally, there are differences in treatment response based on the source of NK cells.
CLINICAL CANCER RESEARCH
(2021)
Meeting Abstract
Hematology
Heitor Duarte Andrade, Andrea Tiemi Kondo, Lucila Kerbauy, Raquel de Melo Alves Paiva, Denise Cristine Oliveira, Larissa Leggieri Coa, Kelen Cristina Arcuri Alvarez, Mariana Lorenzi Savioli, Bruna Melo Coelho Loureiro, Oswaldo Keith Okamoto, Nelson Hamerschlak, Jose Mauro Kutner, Juliana Aparecida Preto Godoy
Article
Virology
Raiane Oliveira Ferreira, Isabela Granha, Rodolfo Sanches Ferreira, Heloisa de Siqueira Bueno, Oswaldo Keith Okamoto, Carolini Kaid, Mayana Zatz
Summary: Research indicates that the Zika virus has potential oncolytic effects against embryonal CNS tumors, with different administration routes and virus load playing crucial roles in treatment safety and effectiveness. Systemic injections of ZIKV(BR) showed tropism to the brain in mice with subcutaneous tumors, and serial injections at the site of brain tumor effectively destroyed the tumor without causing neurological or organ damage, leading to increased survival rates in mice.
Article
Cell Biology
Raquel M. Alves-Paiva, Sabrina do Nascimento, Denise De Oliveira, Larissa Coa, Kelen Alvarez, Nelson Hamerschlak, Oswaldo Keith Okamoto, Luciana C. Marti, Andrea T. Kondo, Jose Mauro Kutner, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Juliana A. Preto de Godoy
Summary: This study reports a case where MSCs derived from an elderly donor entered a senescence state after three passages. MSCs cultured with AS displayed an early senescence state, and there were more senescence cells and altered gene expression compared to cells cultured with FBS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Maria Susana Joya Marodin, Juliana A. Godoy, Raquel M. Alves-Paiva, Kelen Alvarez, Thiago Giove Mitsugi, Ana Cristina Victorino Krepischi, Nelson Hamerschlak, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Andrea T. Kondo, Jose Mauro Kutner, Oswaldo Keith Okamoto
Summary: Cytogenetic aberrations, such as trisomy 5, may occur in human mesenchymal stromal cells (MSC) during ex vivo expansion. It is still unclear how these aberrations affect the neoplastic transformation threshold or medicinal properties of MSC products. In this study, MSC cultures with clonal trisomy 5 showed reduced cell proliferation, increased senescence-associated beta-galactosidase activity, and poor tumor initiating capability. However, subcutaneous injection of these MSC populations did not generate tumors in immunodeficient mice within a six-month follow-up period. Importantly, MSC populations with clonal trisomy 5 maintained their immunomodulatory properties similar to euploid MSC upon interferon gamma (IFN gamma) licensing. These findings suggest that bone marrow MSC products with clonal trisomy 5 may still retain their therapeutic potential and support the definition of release criteria for autologous MSC products in critical clinical scenarios.
STEM CELLS INTERNATIONAL
(2022)
Meeting Abstract
Hematology
Lucila Kerbauy, Larissa Leggieri Coa, Micheli Severo Sielski, Juliana Aparecida Preto Godoy, Andrea Tiemi Kondo, Julia Teixeira Cottas Azevedo, Augusto Barbosa, Oswaldo Keith Okamoto, Jose Mauro Kutner, Nelson Hamerschlak, Raquel de Melo Alves Paiva
Meeting Abstract
Oncology
G. Bandeira, K. Rocha, M. Lazar, S. Ezquina, G. Yamamoto, T. Gollop, M. Zatz, M. Passos-Bueno, A. Krepischi, O. Keith Okamoto
EUROPEAN JOURNAL OF CANCER
(2022)
Meeting Abstract
Oncology
Matthew Sherwood, Carolini Kaid, Thiago Mitsugi, Yilu Zhou, Yihua Wang, Paul Skipp, Juliet Gray, Oswaldo Okamoto, Rob Ewing
Meeting Abstract
Oncology
Rodolfo Sanches Ferreira, Bruno H. S. Araujo, Oswaldo Okamoto
Article
Medicine, General & Internal
Alessandro Rozim Zorzi, Eliane Antonioli, Juliana Aparecida Preto de Godoy, Oswaldo Keith Okamoto, Andrea Tiemi Kondo, Jose Mauro Kutner, Camila Cohen Kaleka, Moises Cohen, Mario Ferretti
Summary: This article describes a case of autologous chondrocyte implantation that was contaminated by Mycoplasma pneumoniae during cell culture, and discusses the measures taken to successfully complete cell therapy.
EINSTEIN-SAO PAULO
(2022)
Meeting Abstract
Cell & Tissue Engineering
L. N. Kerbauy, L. Coa, A. T. Kondo, J. A. Godoy, I. Bello, O. K. Okamoto, J. M. Kutner, N. Hamerschlak, R. D. Alves Paiva
Meeting Abstract
Cell & Tissue Engineering
T. R. Santos, C. Kaid, D. D. Araujo, I. S. Neville, M. Uno, M. Zatz, O. K. Okamoto
Meeting Abstract
Cell & Tissue Engineering
J. A. Godoy, R. D. Alves Paiva, A. T. Kondo, L. N. Kerbauy, M. Rodrigues, O. K. Okamoto, J. M. Kutner