Article
Biochemistry & Molecular Biology
Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin, Chia-Yu Chang, Ching- Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Chin-San Liu, Yan-Ting Chen, Hong-Lin Su
Summary: Research found that mitochondrial transplantation can moderately attenuate the degeneration of retinal layers in RCS rats. This result was confirmed through histological examination and OCT measurement of retina thickness. VEP analysis showed that the transmission time of electrical signals after mitochondrial transplantation was similar to the normal value. The results suggest that mitochondrial transplantation can improve the degeneration of photoreceptors in RCS rats and have potential for clinical application.
Review
Neurosciences
Fangyuan Zhen, Tongdan Zou, Ting Wang, Yongwei Zhou, Shuqian Dong, Houbin Zhang
Summary: Rhodopsin is a light-sensitive receptor that initiates the phototransduction cascade. Mutations in the rhodopsin-encoding gene are the leading cause of retinitis pigmentosa. The high allelic heterogeneity suggests complex pathogenic mechanisms related to protein misfolding and dysfunction.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Ophthalmology
Johnny Di Pierdomenico, Alejandro Gallego-Ortega, Ana Martinez-Vacas, David Garcia-Bernal, Manuel Vidal-Sanz, Maria P. Villegas-Perez, Diego Garcia-Ayuso
Summary: Syngeneic bone marrow mononuclear stem cell transplantation can reduce photoreceptor degeneration and have anti-gliotic effects on Muller cells, but does not improve retinal function.
ACTA OPHTHALMOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Yogita Kanan, Sean F. Hackett, Henry T. Hsueh, Mahmood Khan, Laura M. Ensign, Peter A. Campochiaro
Summary: Retinitis pigmentosa (RP) is a genetic disorder that causes rod photoreceptor degeneration and subsequent cone photoreceptor degeneration. Reduced oxygen consumption from the loss of rods leads to retinal hyperoxia and oxidative stress, resulting in cone cell death and degeneration. However, reducing inspired oxygen levels can reduce retinal hyperoxia, preserve cone structure and function, and decrease oxidative damage in animal models of RP.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Cell Biology
Diego Garcia-Ayuso, Johnny Di Pierdomenico, David Garcia-Bernal, Manuel Vidal-Sanz, Maria P. Villegas-Perez
Summary: Retinal degenerative diseases causing photoreceptor loss are a leading cause of irreversible vision loss. Currently, there are limited treatments available. Transplantation of bone marrow derived-mononuclear stem cells has shown promise in protecting photoreceptors and may have a wide range of clinical applications. Future research may combine this therapy with other treatments to achieve better therapeutic effects.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yang Liu, Yafang Wang, Yushu Xiao, Xiaomeng Li, Shang Ruan, Xueting Luo, Xiaoling Wan, Fenghua Wang, Xiaodong Sun
Summary: By establishing a CNGA1 knockout mouse model, researchers observed progressive retinal thinning and functional deficits as typical phenotypes for RP, along with degeneration in rods and cones, microglial activation, and oxidative stress damage. RNA-sequencing analysis indicated down-regulated synaptic transmission and phototransduction as early triggers for photoreceptor degeneration. The study contributes to understanding the mechanisms of photoreceptor death during RP progression and provides a novel model for potential therapeutic development.
Article
Neurosciences
Hyeonhee Roh, Yanjinsuren Otgondemberel, Jeonghyeon Eom, Daniel Kim, Maesoon Im
Summary: This study investigates the electric response features of retinal ganglion cells (RGCs) in rd8 mice with retinal degeneration caused by Crb1 mutation. The results show that different types of RGCs have different electric response features in the early stage of RP, suggesting the importance of genotype- and RGC type-dependent analyses for retinal prosthetic research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Natalia Martinez-Gil, Oksana Kutsyr, Agustina Noailles, Laura Fernandez-Sanchez, Lorena Vidal, Xavier Sanchez-Saez, Carla Sanchez-Castillo, Pedro Lax, Nicolas Cuenca, Antonio G. Garcia, Victoria Maneu
Summary: P2X7R and P2X4R play important roles in retinal diseases and their expression increases during disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Sohair A. Eltony, Heba S. Mohaseb, Amel A. Ahmed, Manal M. Sayed
Summary: This study aimed to investigate the effect of metformin on the retina of the ENU-induced rat model of RP. The results showed that metformin could reduce retinal degeneration and improve the morphology of glia and blood capillaries. This suggests that metformin has a neuroprotective effect on the retina.
Article
Cell & Tissue Engineering
Yeh Chwan Leong, Valentina Di Foggia, Hema Pramod, Maria Bitner-Glindzicz, Aara Patel, Jane C. Sowden
Summary: This study investigated the pathomechanism of Usher syndrome type 1B (RP) using 3D retinal organoids generated from induced pluripotent stem cells derived from USH1B patients. The results revealed differential gene expression related to mitochondrial functions, proteasomal protein degradation, and RNA splicing. Single-cell RNA sequencing showed MYO7A expression in rod photoreceptor and Mu center dot ller glial cells, suggesting involvement in stress responses and apoptotic signaling pathways. This human model provides important insights for the development of therapeutic strategies.
Article
Cell & Tissue Engineering
Harshini Surendran, Swapna Nandakumar, Vijay Bhaskar K. Reddy, Jonathan Stoddard, Varsha K. Mohan, Pramod K. Upadhyay, Trevor J. McGill, Rajarshi Pal
Summary: This study demonstrated the in vivo functionality of RPE and PRP cells derived from a clinical-grade hiPSC line, showing promise for potential regenerative cell therapies in patients. The extensively characterized RPE and PRP cells expressed specific markers and demonstrated functional activity after transplantation, indicating strong efficacy and safety data for future clinical trials.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Davide Allegrini, Raffaele Raimondi, Alfredo Borgia, Tania Sorrentino, Giovanni Montesano, Panos Tsoutsanis, Giuseppe Cancian, Yash Verma, Francesco Paolo De Rosa, Mario R. Romano
Summary: Recent evidence suggests that curcumin may be effective in treating retinal diseases by modulating gene transcription, reducing cell apoptosis, and improving vascular function. However, its limited bioavailability has hindered its use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Ronja Jung, Carina Kelbsch, Helmut Wilhelm, Barbara Wilhelm, Torsten Strasser, Tobias Peters, Melanie Kempf, Friederike Kortuem, Lisa Pohl, Krunoslav Stingl, Katarina Stingl
Summary: This study explored the frequency preferences of human rods using transcorneal electrostimulation (TES) and found that healthy individuals had a clear peak response around 6-8Hz, while patients with retinitis pigmentosa had reduced responses in the lower frequency range. These findings suggest that different retinal cell types can be selectively activated via TES in vivo.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yafei Lyu, Randy Zauhar, Nicholas Dana, Christianne E. Strang, Jian Hu, Kui Wang, Shanrun Liu, Naifei Pan, Paul Gamlin, James A. Kimble, Jeffrey D. Messinger, Christine A. Curcio, Dwight Stambolian, Mingyao Li
Summary: The study utilized single-cell RNA sequencing to analyze gene expression in retinal cells of AMD patients, revealing changes in cell types and gene expression in AMD eyes compared to normal eyes, particularly in certain specific cell types in the macula region. KEGG pathway analysis showed enrichment in pathways related to complement, coagulation, antigen presentation, and signaling in AMD eyes, highlighting part of the pathogenesis of AMD.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Geetika Kaur, Nikhlesh K. Singh
Summary: Vision depends on the precise structure and functioning of the retina, and any stress or injury can disrupt it, leading to vision impairment, loss, and blindness. Inflammation plays a crucial role in the development of retinal disorders, such as glaucoma, macular degeneration, diabetic retinopathy, and retinitis pigmentosa. This review provides evidence on the role of inflammation in these disorders and suggests potential therapeutic targets.
NEURAL REGENERATION RESEARCH
(2023)
Article
Ophthalmology
Karlos Italo S. Viana, Camila T. Gordilho, Felipe P. P. Almeida, Marcelo M. Esperandio, David R. Lucena, Denny M. Garcia, Ingrid U. Scott, Andre M. Messias, Rodrigo Jorge
Summary: The study compared functional and anatomic outcomes of combined pars plana vitrectomy (PPV) and phacoemulsification (phaco) versus PPV and deferred phaco in patients with full-thickness macular hole (FTMH) and no significant cataract. Results showed similar outcomes in terms of visual acuity, macular sensitivity, and FTMH closure rate at 1-year follow-up between the two treatment approaches.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Carolina Assis P. Vilela, Andre Messias, Rodrigo T. Calado, Rubens C. Siqueira, Marcelo Jordao L. Silva, Dimas T. Covas, Jayter S. Paula
Summary: The study reported on the use of bone marrow-derived mesenchymal stem cells (MSCs) in treating advanced glaucoma, with no improvement seen in visual acuity or visual field post-treatment. Although one patient experienced retinal detachment and proliferative vitreoretinopathy after 15 days, the other patient showed stable ERG responses throughout the study period. Further research involving modified MSCs is needed to address the lack of visual function improvement observed in the study.
DOCUMENTA OPHTHALMOLOGICA
(2021)
Article
Cell & Tissue Engineering
Carina Costa Cotrim, Andre M. Vieira Messias, Rodrigo Jorge, Rubens Camargo Siqueira
STEM CELLS INTERNATIONAL
(2020)
Article
Ophthalmology
Leandro Chaves, Andre Messias, Zelia Correa, Rodrigo Jorge
Summary: This study examined the safety and early outcomes of intravitreal metoprolol injections in patients with CCH. The results showed no acute ocular toxicity in patients followed for 30 days, with some patients showing improvement in symptoms.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Luiza Toscano, Andre Messias, Katharina Messias, Rafaella de Cenco Lopes, Jefferson A. Santana Ribeiro, Ingrid U. Scott, Rodrigo Jorge
Summary: PIR + IVR or PRP + IVR are comparable strategies in controlling FLA in PDR patients and resulted in similar retinal function impairment up to one-year follow-up.
DOCUMENTA OPHTHALMOLOGICA
(2021)
Article
Genetics & Heredity
Maria Solaki, Britta Baumann, Peggy Reuter, Sten Andreasson, Isabelle Audo, Carmen Ayuso, Ghassan Balousha, Francesco Benedicenti, David Birch, Pierre Bitoun, Delphine Blain, Beatrice Bocquet, Kari Branham, Jaume Catala-Mora, Elfride De Baere, Helene Dollfus, Mohammed Falana, Roberto Giorda, Irina Golovleva, Irene Gottlob, John R. Heckenlively, Samuel G. Jacobson, Kaylie Jones, Herbert Jaegle, Andreas R. Janecke, Ulrich Kellner, Petra Liskova, Birgit Lorenz, Loreto Martorell-Sampol, Andre Messias, Isabelle Meunier, Fernanda Belga Ottoni Porto, Eleni Papageorgiou, Astrid S. Plomp, Thomy J. L. de Ravel, Charlotte M. Reiff, Agnes B. Renner, Thomas Rosenberg, Guenther Rudolph, Roberto Salati, E. Cumhur Sener, Paul A. Sieving, Franco Stanzial, Elias Traboulsi, Stephen H. Tsang, Balazs Varsanyi, Richard G. Weleber, Ditta Zobor, Katarina Stingl, Bernd Wissinger, Susanne Kohl
Summary: This study provides a comprehensive overview of the CNGA3 variant spectrum in 1060 genetically confirmed ACHM patients, with 385 of them carrying likely disease-causing variants in CNGA3. By combining their own genetic data with literature and public database records, the researchers extended the CNGA3 variant spectrum to a total of 316 variants, with 244 of them interpreted as likely disease-causing. They also reported 48 novel likely disease-causing variants, with 24 of them being missense substitutions. Extensive in silico analyses and functional data were provided to advance the pathogenicity assessment of the identified variants.
Article
Ophthalmology
Jose Edisio da Silva Tavares Neto, Francyne Veiga Reis Cyrino, Moises Moura Lucena, Ingrid U. U. Scott, Andre Marcio Vieira Messias, Rodrigo Jorge
Summary: This study aims to investigate the safety of a combination of intravitreal bevacizumab and propranolol for the treatment of neovascular age-related macular degeneration (nARMD). The results showed that there were no adverse events or signals of ocular toxicity observed during the 12-week trial. Further studies using this combination therapy are warranted.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Article
Ophthalmology
Francyne Veiga Reis, Pedro Dalgalarrondo, Jose Edisio da Silva Tavares Neto, Murilo Wendeborn Rodrigues, Ingrid U. Scott, Rodrigo Jorge
Summary: This study aimed to investigate the safety and effects of combined intravitreal injection of dexamethasone and bevacizumab in patients with refractory diabetic macular edema (DME). The results indicated that the combined therapy led to increased intraocular pressure and the need for anti-glaucomatous eye drops, as well as reduced central sub-foveal thickness. However, there was no significant improvement in best-corrected visual acuity.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Article
Ophthalmology
Rodrigo Jorge, Igor Coelho, Gustavo Viani, Amanda Alexia R. Vieira, Fernando Chahud, Daniel G. Abud, Zelia M. Correa
Summary: This case illustrates the feasibility of combining induction intra-arterial chemotherapy (IAC) prior to ruthenium brachytherapy for large choroidal melanoma.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2022)
Article
Ophthalmology
Annelise Nicotti Goncalves, Ingrid U. Scott, Rodrigo Jorge
Summary: The study found that using intravitreal metoprolol to treat patients with chronic central serous chorioretinopathy can achieve good outcomes without significant side effects.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2022)
Article
Ophthalmology
Jessica Deponti Gobbi, Joao Pedro Romero Braga, Moises M. Lucena, Victor C. F. Bellanda, Miguel V. S. Frasson, Daniel Ferraz, Victor Koh, Rodrigo Jorge
Summary: This study evaluated the effectiveness of retinal photography obtained by undergraduate students using a smartphone-based device in screening and early diagnosing diabetic retinopathy (DR). The results showed a high agreement rate between the images obtained from the smartphone-based device and the regular fundus camera, indicating the potential of the smartphone-based device in detecting DR.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2022)
Article
Ophthalmology
Danilo Moyses Jorge, Jose Edisio da Silva Tavares Neto, Omero Benedicto Poli-Neto, Ingrid U. Scott, Rodrigo Jorge
Summary: PPV with preoperative IVB is associated with more rapid clearance of VH and improvement in BCVA than IVB injections alone. However, after 24 weeks of follow-up, the reduction in VH score and BCVA were similar between both treatment strategies.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2021)
Article
Infectious Diseases
Ana Iara Costa Ferreira, Cinara Cassia Brandao de Mattos, Fabio Batista Frederico, Cassia Rubia Bernardo, Gildasio Castelo de Almeida Junior, Rubens Camargo Siqueira, Cristina Silva Meira-Strejevitch, Vera Lucia Pereira-Chioccola, Luiz Carlos de Mattos
INFECTION GENETICS AND EVOLUTION
(2020)
Review
Ophthalmology
Carina Costa Cotrim, Rodrigo Jorge, Maria Carolina de Oliveira, Fabiano Pieroni, Andre M. Vieira Messias, Rubens Camargo Siqueira
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
(2020)
