Article
Primary Health Care
Michelle Greiver, Alys Havard, Juliana K. F. Bowles, Sumeet Kalia, Tao Chen, Babak Aliarzadeh, Rahim Moineddin, Julian Sherlock, William Hinton, Frank Sullivan, Braden O'Neill, Conrad Pow, Aashka Bhatt, Fahurrozi Rahman, Bernardo Meza-Torres, Melisa Litchfield, Simon de Lusignan
Summary: The uptake of new glucose-lowering medications among patients with type 2 diabetes in Australia, Canada, England, and Scotland was analyzed. The study found that new drugs are displacing sulfonylureas and combinations of metformin and new drug classes are increasing. Despite evidence of better outcomes, the adoption of SGLT2 inhibitors lagged behind DPP4 inhibitors.
BRITISH JOURNAL OF GENERAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Ting-Ying Huang, Carla Rodriguez-Watson, Tongtong Wang, Shawna R. Calhoun, James Marshall, Jillian Burk, Young Hee Nam, Aaron B. Mendelsohn, Aziza Jamal-Allial, Robert T. Greenlee, Mano Selvan, Pamala A. Pawloski, Cheryl N. McMahill Walraven, Ashish Rai, Sengwee Toh, Jeffery S. Brown
Summary: This study evaluated the data relevancy and quality of the IMEDS-DD for diabetes research and compared its type 2 diabetes cohort to the general population. The results showed that the IMEDS-DD contains robust information for conducting pharmacoepidemiological studies in diabetes.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Pharmacology & Pharmacy
Chin-Hsiao Tseng
Summary: Chronic therapy with metformin in patients with type 2 diabetes mellitus is associated with a lower risk of hemorrhoid, with a consistent risk reduction of approximately 40-50% observed in various analyses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Wu-Chien Chien, Earl Fu, Chi-Hsiang Chung, Chia-Mao Cheng, Hsiao-Pei Tu, Wei-Cheng Lee, Wei-Liang Chen, Kuang-Chung Shih
Summary: This study used the National Health Insurance Research Database of Taiwan to find that periodontitis patients are more likely to develop type 2 diabetes, while patients with diabetes are more likely to have severe periodontitis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Chin-Hsiao Tseng
Summary: This study did not find a significant effect of vildagliptin on dementia risk, as no significant results were observed in either the unmatched or matched cohort.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Lars Christian Lund, Patricia Hjorslev Jensen, Anton Pottegard, Morten Andersen, Nicole Pratt, Jesper Hallas
Summary: Using Danish nationwide health registries, researchers identified 70 drug-diabetes associations, of which 27 were previously unknown. These findings are important for understanding the drugs that can cause diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Anton Pottegard, Lars Christian Lund, Daniel Pilsgaard Henriksen, Lars Folkestad, Maja Hellfritzsch, Jesper Hallas, Kasper Bruun Kristensen
Summary: The study did not find an increased risk of splanchnic vein thrombosis associated with the use of DPP-4 inhibitors based on a population-based new-user cohort study.
DIABETES OBESITY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Joseph E. Blais, Yue Wei, Kevin K. W. Yap, Hassan Alwafi, Tian-Tian Ma, Ruth Brauer, Wallis C. Y. Lau, Kenneth K. C. Man, Chung Wah Siu, Kathryn C. B. Tan, Ian C. K. Wong, Li Wei, Esther W. Chan
Summary: From 2008 to 2018, global consumption of Lipid-modifying agents, particularly statins, has increased. While the relationship between LMA consumption and cholesterol concentrations remains unclear, the trends in LMA use globally align with international lipid guidelines and show an increase in consumption of low-density lipoprotein lowering therapies. Country-level patterns of LMA use and total and non-HDL cholesterol varied considerably.
Article
Public, Environmental & Occupational Health
Danila Felix Coutinho, Roberta Carvalho de Figueiredo, Bruce B. Duncan, Maria Ines Schmidt, Sandhi Maria Barreto, Maria de Fatima Haueisen Sander Diniz
Summary: The study found that in patients with diabetes, polypharmacy was not significantly associated with better diabetes control, and potential drug interactions were often related to the management of comorbidities.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2021)
Article
Pharmacology & Pharmacy
Mikkel Hojlund, Christina Blanner Wagner, Rikke Wesselhoeft, Kjeld Andersen, Anders Fink-Jensen, Jesper Hallas
Summary: This study found that low-dose chlorprothixene use is associated with increased risk of diabetes and cardiovascular adverse events compared with low-dose quetiapine use.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Cristina Leal Rodriguez, Benjamin Skov Kaas-Hansen, Robert Eriksson, Jorge Hernansanz Biel, Kirstine G. Belling, Stig Ejdrup Andersen, Soren Brunak
Summary: This study aimed to investigate potential drug-drug interactions and their associated adverse outcomes in Danish hospital prescriptions, and identify patient types that are more affected. The results showed that certain drug combinations may lead to adverse outcomes, including increased mortality rates. Therefore, caution should be exercised to avoid these unsafe drug combinations during prescribing.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Endocrinology & Metabolism
Chin-Hsiao Tseng
Summary: This study compared the risk of gingival and periodontal diseases (GPD) between patients with type 2 diabetes mellitus who were ever users and never users of metformin. The results showed that long-term use of metformin was significantly associated with a reduced risk of GPD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Eric Hu, Tong Shu Li, Nathan E. Wineinger, Andrew I. I. Su
Summary: In the study, the use of repurposed drug candidates in the treatment of Alzheimer's disease (AD) was investigated by mining electronic health record data. The analysis of claims from members with commercial health insurance coverage revealed correlations between the use of certain drugs and AD incidence and claim frequency. Medications for psychotic and mental illnesses were associated with higher disease incidence and frequency, while antibiotics and anti-inflammatory drugs were associated with lower AD incidence rates to some extent. These observations provide insights into the prescription and claim relationships between different drug types and Alzheimer's disease.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Haruka Shida, Kazuhiro Kajiyama, Sono Sawada, Chieko Ishiguro, Mikiko Kubo, Ryota Kimura, Mai Hirano, Noriyuki Komiyama, Toyotaka Iguchi, Yukio Oniyama, Yoshiaki Uyama
Summary: The PMDA has conducted pharmacoepidemiological studies using real-world data from medical information databases for postmarketing drug safety assessment. The National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) is one of these databases. The studies have supported regulatory decision-making for drug safety and contributed to the evolving use of real-world data in Japan.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Bianca Aparecida Martin, Camila Nunes Lemos, Luciana Facco Dalmolin, Caroline Arruda, iris Sperchi Camilo Brait, Maurilio de Souza Cazarim, Estael Luzia Coelho da Cruz-Cazarim, Paula Carolina Pires Bueno, Maurilio Polizello Junior, Leonardo Regis Leira Pereira, Renata Nahas Cardili, Renata Fonseca Vianna Lopez
Summary: Atopic dermatitis is a challenging chronic inflammatory skin disease. The addition of green propolis to cold cream has the potential to help alleviate AD symptoms without changing the cream's properties. Preclinical study indicated that both propolis-loaded cold cream and blank cold cream improved patients' quality of life, but propolis-loaded cream showed better effectiveness in reducing disease severity.
Article
Psychology, Clinical
Rafaela Sirtoli, Teresa Balboa-Castillo, Ruben Fernandez-Rodriguez, Renne Rodrigues, Gladys Morales, Miriam Garrido-Miguel, Yulder Valencia-Marin, Camilo Molino Guidoni, Arthur Eumann Mesas
Summary: This study analyzed the association between alcohol-related problems and sleep in first-year college students from Brazil, Chile, and Spain. The findings showed that first-year college students at risk of alcohol-related problems were more likely to report worse sleep quality, while the frequency of alcohol consumption was not associated with sleep quality or duration.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Clinical Neurology
Soraya G. Goncalves, Arthur E. Mesas, Daiane S. Bravo, Marcela M. Birolim, Camilo M. Guidoni, Selma M. Andrade, Renne Rodrigues
Summary: Poor sleep quality among correctional officers is associated with occupational factors such as higher mental demands, experiencing psychological violence at work, thinking about work-related issues in free time, job dissatisfaction, and willingness to find another job.
BEHAVIORAL SLEEP MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Alan Maicon de Oliveira, Fabiana Rossi Varallo, Joao Paulo Vilela Rodrigues, Guilherme Jose Aguilar, Nereida Kilza da Costa Lima, Leonardo Regis Leira Pereira
Summary: This study aimed to evaluate whether Pharmaceutical Care (PC) in a geriatric ward in Brazil improves the safety of pharmacotherapy in older individuals. The results showed that polypharmacy and multiple diseases were associated with increased adverse drug events and medication errors. However, implementing PC can reduce unnecessary polypharmacy and contribute to the deprescribing of medications at hospital discharge.
CURRENT DRUG SAFETY
(2023)
Article
Psychology, Biological
Marcela Z. Campanini, Alberto D. Gonzalez, Selma M. Andrade, Edmarlon Girotto, Marcos A. S. Cabrera, Camilo M. Guidoni, Paula C. A. Araujo, Arthur E. Mesas
Summary: This study found a bidirectional association between poor sleep quality and chronic low back pain (cLBP). Changes in sleep quality over time were associated with an increased likelihood of cLBP, and baseline cLBP was associated with worsened sleep quality. Mental health conditions played a significant confounding role in the relationship between sleep and cLBP.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Pharmacology & Pharmacy
Mauricio Fabio Gomes, Camilo Molino Guidoni
Summary: This study analyzed the pharmacotherapeutic problems identified by clinical pharmacists in an ICU and the acceptance of pharmaceutical interventions for solving these problems. The results showed that the majority of the problems were classified as unnecessary drug treatment, with excessive drug administration as the main cause, particularly related to antimicrobials. 350 pharmaceutical interventions were performed, mostly consisting of informing the prescribers and having a high acceptability rate. In conclusion, clinical pharmacy activities in the ICU can identify, prevent, and correct pharmacotherapeutic problems, contributing to the optimization of pharmacotherapy in terms of need, efficacy, and safety.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Gladys Morales, Teresa Balboa-Castillo, Ruben Fernandez-Rodriguez, Miriam Garrido-Miguel, Camilo Molino Guidoni, Rafaela Sirtoli, Arthur Eumann Mesas, Renne Rodrigues
Summary: This study aimed to determine the association between adherence to the Mediterranean diet and depressive symptoms in Chilean university students. The study found that students with moderate and high adherence to the Mediterranean diet had a lower likelihood of depression. In addition, the consumption of fruits, vegetables, nuts, avocado, fish, and seafood was also associated with lower odds of depressive symptoms.
CADERNOS DE SAUDE PUBLICA
(2023)
Article
Parasitology
Fabio Henrique Kwasniewski, Emanuel Marques da Silva, Edmarlon Girotto, Denise Maria Candido, Miriam de Cassia Toffolo, Daniel Emilio Dalledone Siqueira, Luiz Roberto Costa Gomes, Camilo Molino Guidoni
Summary: We report the first pediatric case of a Jaguajir agamemnon scorpion sting in southern Brazil. The patient was admitted within 15 min and experienced pain, local edema, erythema, whole-body pruritus, and tongue paresthesia, which disappeared later. The patient's condition was considered mild, with a positive outcome, and she recovered completely.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2023)
Article
Pharmacology & Pharmacy
Ricardo Augusto dos Santos Silva, Andre Oliveira Baldoni, Camila Pereira Alvim, Paulo Roque Obreli Neto, Camilo Molino Guidoni, Isabella Ribeiro Silva, Roberta Carvalho Figueiredo
Summary: This study proposes and evaluates the test-retest reliability of indicators of the correct use of sodium alendronate in elderly patients. Data collection was performed through questionnaires in face-to-face in-home interviews. The reliability of the questions was evaluated using agreement percentage and Kappa coefficient. The results suggest that the proposed questions have adequate reliability and can be used as a simple and quick way to evaluate the quality of sodium alendronate use among the elderly.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fernanda Vicioni-Marques, Francisco Wanderley Garcia de Paula-Silva, Milena Rodrigues Carvalho, Alexandra Mussolino de Queiroz, Osvaldo de Freitas, Maira Peres Ferreira Duarte, David John Manton, Fabricio Kitazono de Carvalho
Summary: Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia. This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity. The results showed that preemptive analgesia improved the effectiveness of infiltrative anesthesia and patient comfort during restorative procedures.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Larisse Eduardo Adami, Osvaldo de Freitas, Fellipe Augusto Tocchini de Figueiredo, Maira Peres Ferreira, Ana Paula Macedo, Rene Oliveira do Couto, Vinicius Pedrazzi
Summary: This study demonstrates the clinical efficacy of mucoadhesive patches designed for needle-free pre-operative local anesthesia in dentistry. The patches were shown to initiate anesthesia within a short time frame, reaching maximum effect within 15 to 25 minutes, and lasting at least 50 minutes without any reported side effects.
BRAZILIAN ORAL RESEARCH
(2021)
Review
Parasitology
Lucas Borges Pereira, Maria Olivia Barboza Zanetti, Larissa Pombeiro Sponchiado, Joao Paulo Vilela Rodrigues, Marilia Silveira de Almeida Campos, Fabiana Rossi Varallo, Leonardo Regis Leira Pereira
Summary: This systematic review found a high use of broad-spectrum antibiotics in Brazilian hospitals in the 21st century. However, the lack of standardized antibiotic utilization metrics impairs the mapping of drug consumption at the national level.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2021)
Article
Pediatrics
Rafaele Maria Tirolla, Edmarlon Girotto, Camilo Molino Guidoni
Summary: The study found that suicide attempts mainly occurred in female children, most of whom used only one product, mainly medications. The main reason for suicide attempts was conflicts with family and/or friends. Suicide attempts were more frequent in 2001-2003 and 2016-2018.
REVISTA PAULISTA DE PEDIATRIA
(2021)
Article
Chemistry, Medicinal
Frederico Severino Martins, Sherwin K. B. Sy, Edemilson Cardoso da Conceicao, Maria Jose Vieira Fonseca, Osvaldo de Freitas
Summary: The study optimized a topical gel formulation for the treatment of vitiligo, demonstrating good pharmacokinetic and pharmacodynamic properties in a mouse model.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2021)
Article
Biotechnology & Applied Microbiology
Guilherme Rodrigues Fernandes Campos, Joseph Ward, Shucheng Chen, Cintia Bittar, Joao Paulo Vilela Rodrigues, Ana de Lourdes Candolo Martinelli, Fernanda Fernandes Souza, Leonardo Regis Leira Pereira, Paula Rahal, Mark Harris
Summary: Hepatitis C virus genotype 3 shows a high level of baseline and acquired resistance to direct-acting antivirals, particularly those targeting the NS5A protein. A study on Brazilian patients treated with NS5A DAA daclatasvir and nucleoside analogue sofosbuvir revealed a novel substitution at NS5A amino acid residue 98, indicating a potential mechanism for high DAA resistance.
JOURNAL OF GENERAL VIROLOGY
(2021)
