Article
Surgery
Benjamin T. Harris, Phuong T. Le, Janaina Da Silva Martins, Lama Alabdulaaly, Roland Baron, Mary L. Bouxsein, Clifford J. Rosen, Alison N. Pletch
Summary: This study found that Igfbp2-/- mice were protected against trabecular bone loss and had attenuated cortical bone loss 4 weeks after vertical sleeve gastrectomy (VSG).
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Endocrinology & Metabolism
Chiara Mele, Marina Caputo, Alice Ferrero, Tommaso Daffara, Beatrice Cavigiolo, Daniele Spadaccini, Antonio Nardone, Flavia Prodam, Gianluca Aimaretti, Paolo Marzullo
Summary: Obesity is a global health challenge and effective treatments are needed to prevent its associated comorbidities. Bariatric surgery, while effective for weight control in obese individuals, can lead to accelerated bone loss and skeletal weakness. The response of bone to bariatric surgery includes decreased bone density and altered bone structure, increasing the risk of falls and fractures. Factors such as malabsorption, mechanical unloading, and changes in molecular interactions between adipose tissue, bone, and muscle may contribute to these effects. Evaluating and monitoring bone health, as well as implementing specific interventions such as nutrient supplementation, physical activity, and rehabilitation programs, are important for individuals undergoing bariatric surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jason Stencel, Hamid R. Alai, Aneesh Dhore-patil, Daniela Urina-Jassir, Thierry H. Le Jemtel
Summary: Preserved ejection fraction heart failure in obese individuals has become common in clinical practice due to the obesity epidemic. It is challenging to determine if obesity enables the development of preserved ejection fraction heart failure or if it is a convergence of two prevalent conditions. However, the obese phenotype of preserved ejection fraction heart failure provides an opportunity to study the effects of bariatric surgery on reversing left ventricular remodeling.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Wei Leng Chin, Po-Jui Chi, Wei-Chieh Hung, Chi-Wei Lin, Chung-Yen Chen, Jian-Han Chen
Summary: This study found that bariatric surgery may decrease the risk of non-traffic accident-related fractures in patients with obesity, but the risk remains higher in this group compared to the general population.
Review
Nutrition & Dietetics
Giuseppe Massimo Sangiorgi, Alberto Cereda, Nicola Porchetta, Daniela Benedetto, Andrea Matteucci, Michela Bonanni, Gaetano Chiricolo, Antonino De Lorenzo
Summary: Obesity is a major global health issue, with the prevalence increasing worldwide, making novel strategies to combat it crucial. Endovascular bariatric surgery (EBS) is seen as a promising innovation for weight and hormonal imbalance reduction in obese individuals, offering less invasiveness and faster recovery compared to traditional surgical methods.
Article
Endocrinology & Metabolism
Alexandra Krez, Sanchita Agarwal, Mariana Bucovsky, Donald J. McMahon, Yizhong Hu, Marc Bessler, Beth Schrope, Angela Carrelli, Shannon Clare, Xiang-Dong Edward Guo, Shonni J. Silverberg, Emily M. Stein
Summary: The study revealed that African American and Latina women experienced substantial and progressive bone loss, deterioration of microarchitecture, and trabecular morphology following Roux-en-Y gastric bypass (RYGB) surgery. This study emphasizes the importance of further research to understand the long-term skeletal consequences of bariatric surgery in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Materials Science, Biomaterials
Ernesto Carlos Sanchez, Francisco Barajas-Olmos, Paulina Baca, Carlos Zerrweck, Lizbeth Guilbert, Angelica Martinez-Hernandez, Federico Centeno, Lorena Orozco
Summary: The altered functions of adipose tissue in obesity can be improved by bariatric surgery, which leads to changes in DNA methylation in adipose tissue. After six months postoperative, 1155 CpG sites show changes in DNA methylation, with 66 of them correlating with body mass index. Some of these sites also correlate with lipid profiles. These findings suggest that epigenetic regulation may play a role in the alteration of adipose tissue functions in obesity.
Editorial Material
Medicine, General & Internal
Mary Elizabeth Patti
Summary: This article introduces various new nutrient-stimulated, hormone-based therapies for obesity and type 2 diabetes, which have caused a buzz at the 2023 American Diabetes Association Scientific Sessions. Among them, a phase 2 trial showed that the triple-hormone-receptor agonist retatrutide has unprecedented efficacy in treating obesity.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Engineering, Biomedical
Hatice B. Bingol, Johan C. M. E. Bender, Joost A. Opsteen, Sander C. G. Leeuwenburgh
Summary: Biodegradable bone adhesives are highly sought-after biomaterials that can replace traditional metallic devices for bone fixation. However, these biomaterials must meet numerous requirements, and commercially available bone-adhesive biomaterials that fulfill all of these requirements are currently not available. This comprehensive review provides an extensive overview of the development of bone adhesives from a translational perspective, highlighting the definition, classification, and chemistry of various types of bone adhesives. The review also focuses on materials capable of gluing two pieces of bone together within a time frame of minutes to days and critically reflects on commonly employed adhesion tests and the current state-of-the-art in their preclinical and clinical applicability.
MATERIALS TODAY BIO
(2023)
Article
Multidisciplinary Sciences
Sangsoo Han, Jiwon Park, Sangun Nah, Hae-Dong Jang, Kyungdo Han, Jae-Young Hong
Summary: Underweight is an important modifiable risk factor for fractures. A large population cohort study found a significant association between the severity of underweight and fracture risk.
SCIENTIFIC REPORTS
(2022)
Review
Nutrition & Dietetics
Neda Haghighat, Asma Kazemi, Omid Asbaghi, Fateme Jafarian, Nader Moeinvaziri, Babak Hosseini, Masoud Amini
Summary: This meta-analysis found that bariatric surgery, especially Roux en-Y gastric bypass, may be more effective in reducing fat mass and maintaining fat-free mass in patients with morbid obesity over 1 year.
CLINICAL NUTRITION
(2021)
Review
Medicine, Research & Experimental
Xiaodan Ou, Mingguang Chen, Lizhen Xu, Wei Lin, Huibin Huang, Gang Chen, Junping Wen
Summary: Bariatric surgery has a certain impact on bone density, especially in patients over 40 years of age and individuals with a postsurgical time of greater than 12 months. It is important for these patients to pay attention to bone density screening and osteoporosis prevention. Further research is needed to analyze longer-term changes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Narriane Chaves Pereira de Holanda, Ingrid de Lima Carlos, Caio Chaves de Holanda Limeira, David Cesarino de Sousa, Fabio Antonio Serra de Lima Junior, Telis de Vilela Araujo, Ana Carla Peres Montenegro, Francisco Bandeira
Summary: This study reviewed the current data and found that bariatric surgery is associated with an increased risk of fractures, especially with malabsorptive techniques. It is important to note that the included interventional trials had a low rating on the risk of bias assessment.
ENDOCRINE PRACTICE
(2022)
Article
Agriculture, Dairy & Animal Science
Haidong Wei, Yanju Bi, Yulai Wang, Qian Zhao, Runxiang Zhang, Jianhong Li, Jun Bao
Summary: Keel bone fractures in laying hens can affect the welfare, health, and production performance of the hens. Through a study of 120 Hy-line Brown laying hens, it was found that abnormal bone metabolism is associated with keel bone fractures, highlighting the importance of bone health in laying hens.
Review
Biology
Roberta Bottino, Andreina Carbone, Tiziana Formisano, Saverio D'Elia, Massimiliano Orlandi, Simona Sperlongano, Daniele Molinari, Pasquale Castaldo, Alberto Palladino, Consiglia Barbareschi, Salvatore Tolone, Ludovico Docimo, Giovanni Cimmino
Summary: Obesity is a global epidemic due to lifestyle changes, and it is associated with an increased risk of cardiovascular disease, particularly type 2 diabetes. Bariatric surgery has been proven to reduce the occurrence of obesity-related cardiovascular diseases and overall mortality by inducing hormonal and metabolic changes. These surgical techniques not only result in weight loss but also provide metabolic improvement and cardiovascular benefits for patients.
