Article
Geriatrics & Gerontology
Takafumi Mizuno, Tohru Hosoyama, Makiko Tomida, Yoko Yamamoto, Yuko Nakamichi, Shigeaki Kato, Minako Kawai-Takaishi, Shinya Ishizuka, Yukiko Nishita, Chikako Tange, Hiroshi Shimokata, Shiro Imagama, Rei Otsuka
Summary: Vitamin D deficiency may affect muscle strength and contribute to the onset of sarcopenia. However, the relationship between vitamin D and muscle mass is unclear.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Nutrition & Dietetics
Dominique Ulrike Glatt, Emeir McSorley, L. Kirsty Pourshahidi, Raquel Revuelta Iniesta, Jane McCluskey, Laura Beggan, Mary Slevin, Nigel Gleeson, Diego F. Cobice, Sara Dobbin, Pamela J. Magee
Summary: This study investigated the vitamin D status and related factors in children in Northern Ireland. The results showed that over half of the children were deficient or insufficient in vitamin D. Additionally, vitamin D intake, outdoor activity time, and muscle strength were positively correlated with vitamin D levels. Therefore, it is recommended to supplement vitamin D, consume foods rich in vitamin D, and increase outdoor activities in winter to prevent vitamin D inadequacy.
Article
Cell Biology
Shelby E. Bollen, Joseph J. Bass, Satoshi Fujita, Daniel Wilkinson, Martin Hewison, Philip J. Atherton
Summary: Muscle atrophy and sarcopenia can impact an individual's health, and vitamin D deficiency may worsen this effect. The mechanisms linking vitamin D and sarcopenia are not fully understood, but research has shown the importance of vitamin D in skeletal muscle functioning.
CELLULAR SIGNALLING
(2022)
Article
Nutrition & Dietetics
Joshua P. Sutherland, Ang Zhou, Elina Hypponen
Summary: This study used genetic methods to explore the causal relationship between vitamin D and skeletal muscle-related traits, as well as to investigate the potential pathophysiology of probable sarcopenia and sarcopenic obesity. The results suggested a causal relationship between vitamin D and skeletal muscle health, but a weaker association with the risk of sarcopenic obesity.
Article
Biochemistry & Molecular Biology
Philip R. Fischer, Neamat Almasri
Summary: Nutritional rickets can be caused by either vitamin D deficiency or insufficient dietary intake of calcium, and the combined deficiencies of calcium and vitamin D interact. Other factors also play a role in the pathogenesis of nutritional rickets.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Jia-Li Zhang, Christina Chui-Wa Poon, Man-Sau Wong, Wen-Xiong Li, Yi-Xun Guo, Yan Zhang
Summary: This systematic review and meta-analysis examines the effects of vitamin D supplementation on muscle strength and mobility in postmenopausal women. The results suggest that vitamin D supplementation improves muscle strength, but has no significant effect on mobility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Sport Sciences
Alexander T. Carswell, Sarah Jackson, Paul Swinton, Thomas J. O'Leary, Jonathan C. Y. Tang, Samuel J. Oliver, Craig Sale, Rachel M. Izard, Neil P. Walsh, William D. Fraser, Julie P. Greeves
Summary: This study found that there are associations between serum vitamin D metabolites and physical performance. 25-hydroxyvitamin D (25(OH)D) is negatively correlated with 2.4-km run time and positively correlated with muscle power, while 1,25-dihydroxyvitamin D (1,25(OH)(2)D) is positively correlated with run time and negatively correlated with strength and muscle power. 24,25-dihydroxyvitamin D (24,25(OH)(2)D) is negatively correlated with run time. The vitamin D metabolites together explain a small portion of variance in physical performance. VDR SNPs are not associated with physical performance.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Nutrition & Dietetics
Marni E. Shoemaker, Owen F. Salmon, Cory M. Smith, Maria O. Duarte-Gardea, Joel T. Cramer
Summary: There is conflicting evidence regarding the roles of vitamin D and iron in muscle health, with vitamin D having a positive effect on muscle mass and iron having a positive effect on aerobic and anaerobic performance. However, studies have reported mixed results for both vitamin D and iron on muscle strength and function. While deficiency in both vitamin D and iron commonly occur together, there is limited research on their effects on muscle health and inflammation. Nutrients within food sources may be more effective in improving skeletal muscle health compared to isolated nutrients such as iron and vitamin D.
Review
Geriatrics & Gerontology
Nifon K. Gkekas, Panagiotis Anagnostis, Vasileios Paraschou, Dimitrios Stamiris, Spilios Dellis, Eustathios Kenanidis, Michael Potoupnis, Eleftherios Tsiridis, Dimitrios G. Goulis
Summary: The study showed that in patients with sarcopenia, vitamin D supplementation combined with protein can improve muscle strength, but has no effect on muscle mass or performance. Additionally, there were no specific effects on other muscle indicators.
Article
Nutrition & Dietetics
Agnieszka Radom, Andrzej Wedrychowicz, Stanislaw Pieczarkowski, Szymon Skoczen, Przemyslaw Tomasik
Summary: Maintaining optimal vitamin D levels after breast cancer treatment is important for reducing recurrence risk and extending survival time. A study in Polish women after mastectomy found that vitamin D deficiency was more common in this group compared to the general population, highlighting the importance of vitamin D supplementation and monitoring. By providing recommendations and increasing awareness about vitamin D supplementation, there was a significant increase in the number of patients who started supplementing and the average dose of supplements.
Article
Nutrition & Dietetics
Addolorata Corrado, Cinzia Rotondo, Daniela Cici, Stefano Berardi, Francesco Paolo Cantatore
Summary: This study demonstrated that supplementation with calcifediol is more effective and faster than cholecalciferol in increasing 25(OH)D serum levels and improving muscular function in post-menopausal women. Weekly administration of cholecalciferol showed the best results in this regard.
Review
Biochemistry & Molecular Biology
Giuseppe Schepisi, Caterina Gianni, Sara Bleve, Silvia De Padova, Cecilia Menna, Cristian Lolli, Alessia Filograna, Vincenza Conteduca, Milena Urbini, Valentina Galla, Chiara Casadei, Giovanni Rosti, Ugo De Giorgi
Summary: Testicular cancer is the most frequent tumor in young males, often curable. The relationship between vitamin D deficiency and orchiectomy has become a debated topic in recent decades, as vitamin D deficiency may lead to metabolic disorders in long-term TC survivors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Joseph J. Bass, Abid A. Kazi, Colleen S. Deane, Asif Nakhuda, Stephen P. Ashcroft, Matthew S. Brook, Daniel J. Wilkinson, Bethan E. Phillips, Andrew Philp, Janelle Tarum, Fawzi Kadi, Ditte Andersen, Amadeo Munoz Garcia, Ken Smith, Iain J. Gallagher, Nathaniel J. Szewczyk, Mark E. Cleasby, Philip J. Atherton
Summary: Reduced vitamin D receptor (VDR) expression leads to skeletal muscle atrophy through the induction of autophagy, without affecting muscle protein synthesis or anabolic signaling. VDR knockdown impairs mitochondrial function and myogenic regulation, highlighting its crucial role in maintaining muscle mass and limiting autophagy. These findings suggest a fundamental regulatory role of VDR in myogenesis and muscle mass regulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Nutrition & Dietetics
Zhaojun Chen, Yunxia Zhu, Ting Wu, Xia Qian, Ye Hu, Wensheng Hu
Summary: This study evaluated the effects of maternal vitamin D deficiency during pregnancy on glycolipid metabolism in offspring at different stages of life, and explored the effectiveness of different dosages of vitamin D supplementation.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Luciano Mendoza-Garces, Maria Consuelo Velazquez-Alva, Maria Fernanda Cabrer-Rosales, Isabel Arrieta-Cruz, Roger Gutierrez-Juarez, Maria Esther Irigoyen-Camacho
Summary: The study revealed a high prevalence of low plasma 25(OH)D concentrations among Mexican community-dwelling older women, and Vitamin D deficiency was associated with low handgrip strength, being at risk of malnutrition/malnourished, and diagnosed with type 2 diabetes mellitus.
Biographical-Item
Endocrinology & Metabolism
C. Zerbini, A. Orcesi Pedro, R. M. Pereira, M. Lazaretti-Castro, P. Halbout, C. Cooper
OSTEOPOROSIS INTERNATIONAL
(2022)
Correction
Endocrinology & Metabolism
C. Zerbini, A. Orcesi Pedro, R. M. Pereira, M. Lazaretti-Castro, P. Halbout, C. Cooper
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Leonardo Bandeira, Marise Lazaretti-Castro, Neil Binkley
Summary: The potential role of vitamin D deficiency in the severity of Covid-19 infection has been suggested based on existing evidence of its effects on the immune system. While most observational and cohort studies indicate a relationship between low vitamin D levels and greater Covid severity, results from interventional studies are inconsistent. Prospective randomized controlled studies are underway to further evaluate the effects of vitamin D on the outcomes of Covid-19.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Endocrinology & Metabolism
Livia Marcela Santos, Monique Ohe, Sthefanie Pallone, Isabela Nacaguma, Ilda Kunii, Renata Silva, Cynthia Maria Brandao, Jose Gilberto Vieira, Marise Lazaretti-Castro
Summary: This study aimed to investigate the association between 25OHD and bone mass and microarchitecture in PHPT patients and controls. The results showed that PHPT patients had lower bone density and microarchitecture values compared to controls, but there were no significant differences in 25OHD concentrations between the two groups.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Review
Endocrinology & Metabolism
Fernanda Salles Reis, Marise Lazaretti-Castro
Summary: Hypophosphatasia (HPP) is an inherited disease characterized by low alkaline phosphatase activity, leading to the accumulation of metabolites and various clinical manifestations. Enzyme replacement therapy is the main treatment for HPP.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Correction
Endocrinology & Metabolism
Livia Marcela dos Santos, Monique Nakayama Ohe, Sthefanie Giovanna Pallone, Isabela Ohki Nacaguma, Ilda Sizue Kunii, Renata Elen Costa da Silva, Sergio Setsuo Maeda, Jose Gilberto Henriques Vieira, Marise Lazaretti-Castro
Article
Endocrinology & Metabolism
Livia Marcela dos Santos, Monique Nakayama Ohe, Sthefanie Giovanna Pallone, Isabela Ohki Nacaguma, Ilda Sizue Kunii, Renata Elen Costa da Silva, Sergio Setsuo Maeda, Jose Gilberto Henriques Vieira, Marise Lazaretti-Castro, Szu-Wen Chang, Hung-Chang Lee
Summary: This study evaluated the changes in different forms of 25(OH)D after supplementation with vitamin D3 in individuals with primary hyperparathyroidism and controls. The results showed that after supplementation, total 25(OH)D levels increased in both groups, but the increase was lower in the primary hyperparathyroidism group. Furthermore, total 25(OH)D had a better correlation with parathyroid hormone (PTH) in this situation.
Article
Endocrinology & Metabolism
Mariana Zuccolotto Foroni, Maysa Seabra Cendoroglo, Eliane Naomi Sakane, Rosangela Villa Marin-Mio, Patricia Ferreira do Prado Moreira, Sergio Setsuo Maeda, Marise Lazaretti-Castro
Summary: The study aimed to assess the serum concentrations of 25 hydroxyvitamin D in elderly individuals in Sao Paulo, Brazil and investigate its associations with musculoskeletal system, physical performance, and health markers. The findings revealed a high prevalence of vitamin D deficiency and showed positive correlations between serum 25 hydroxyvitamin D concentrations with bone mass and dynamic balance, and negative correlations with PTH levels and osteoporosis diagnosis.
Article
Endocrinology & Metabolism
Debora Meira Ramos Amorim, Gustavo Kendy Camargo Koga, Rodrigo Nolasco dos Santos, Paulo Fernando Carvalho Secundo, Eloy de Avila Fernandes, Leonardo Cardili, Sergio Setsuo Maeda, Artur da Rocha Correa Fernandes, Marise Lazaretti-Castro
Summary: This study reports a case of OI type VI in which a deletion in exon 8 of the SERPINF1 gene was identified, and discusses the relationship between this genetic abnormality and tumor formation.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
Andrea Giustina, Roger Bouillon, Bess Dawson-Hughes, Peter R. Ebeling, Marise Lazaretti-Castro, Paul Lips, Claudio Marcocci, John P. Bilezikian
Summary: This paper presents the findings of the 5th International Conference Controversies in Vitamin D held in Italy. The conference aimed to discuss the relationship between Vitamin D and aging. The results indicate that vitamin D deficiency can lead to various skeletal and extra-skeletal outcomes, and older adults are at a higher risk due to factors such as reduced sun exposure. Strategies to prevent negative outcomes include sun exposure, food fortification, and supplementation. The most effective and practical strategy for the aging population is vitamin D supplementation.
Article
Geriatrics & Gerontology
Osvaldo Daniel Messina, Maritza Vidal, Jorge A. Morales Torres, Luis Fernando Vidal, Constanza Arguissain, Rosa Maria Pereira, Patricia Clark, Sonia Cerdas Perez, Claudia Campusano, Marise Lazaretti-Castro, Cristiano Zerbini, Juan J. Scali, Lucia Mendez Sanchez, Maria L. Peralta-Pedrero, Andrea Cavallo, Francisco J. Valdivia Ibarra, Talina Hernandez Perez
Summary: This study compiled guidelines and recommendations for the diagnosis and management of glucocorticoid-induced osteoporosis (GIO) in Latin America. Through systematic literature review and expert voting, 50 consistent recommendations were formed, providing guidance for general practitioners and primary care physicians in their clinical practice.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Isabela Cristina Januario Silva, Marise Lazaretti-Castro
Summary: Vitamin D deficiency is a common health problem worldwide, affecting the musculoskeletal system as well as various other physiological functions. Further clinical analysis and long-term follow-up studies are needed to determine the impact of vitamin D on extraskeletal health and to establish standardized assessment methods.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Meeting Abstract
Geriatrics & Gerontology
M. Lazaretti-Castro
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Livia Marcela Santos, Monique Nakayama Ohe, Sthefanie Giovanna Pallone, Isabela Ohki Nacaguma, Ilda Sizue Kunii, Renata Elen Costa da Silva, Jose Gilberto Henriques Vieira, Marise Lazaretti-Castro
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Sthefanie Giovanna Pallone, Ilda Sizue Kunii, Renata Elen Costa da Silva, Marise Lazaretti-Castro
Summary: Hyperphosphatemic familial tumor calcinosis (HFTC) is a rare disease characterized by high levels of phosphate in the blood and deposition of calcium and phosphorus crystals. This case report describes a 50-year-old woman diagnosed with HFTC, who had a homozygous variant in the GALNT3 gene. Despite treatment with acetazolamide, sevelamer, and a phosphorus-restricted diet, her phosphatemia remained high and calcifications continued to progress. The use of teriparatide (TPTD) showed some effectiveness in reducing phosphatemia, but also led to increased calciuria.
CALCIFIED TISSUE INTERNATIONAL
(2022)
