Review
Oncology
Mohamed Labib Salem, Samar Salman, Ibrahim O. Barnawi
Summary: This study summarizes the potential of IL-12 as a cytokine for conditioning T cells in ACT, showing that short-term (3 days) IL-12 conditioning can enhance the function of tumor-reactive CD8(+) T cells and induce tumor eradication associated with tumor-specific memory response.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Gastroenterology & Hepatology
Bram Verstockt, Azucena Salas, Bruce E. Sands, Clara Abraham, Haim Leibovitzh, Markus Neurath, Niels Vande Casteele
Summary: IL-12 and IL-23 play a crucial role in intestinal homeostasis and inflammation, and are implicated in the pathogenesis of inflammatory bowel disease. Monoclonal antibodies targeting IL-12 and/or IL-23 have been developed for the treatment of Crohn's disease and ulcerative colitis. This Review summarizes the biological characteristics of IL-12 and IL-23, discusses their role in intestinal homeostasis and inflammation, and highlights the development of drugs targeting IL-12 and/or IL-23.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Engineering, Biomedical
In Seon Jeon, Jae Do Yoo, Smriti Gurung, Minseong Kim, Chanju Lee, Eun Jung Park, Rang-Woon Park, Byungheon Lee, Soyoun Kim
Summary: The use of ferritin nanocages displaying PD-L1pep1 shows potential as an effective immunotherapy by specifically targeting PD-L1 expressed on cancer cells and restoring T cell activities. In a mouse model, these nanocages demonstrated antitumor activity and were more potent when encapsulating the chemotherapeutic drug doxorubicin compared to a monoclonal antibody against PD-L1. This suggests that ferritin nanocages could be a promising immunotherapeutic nanomedicine for solid tumors.
Review
Pharmacology & Pharmacy
Seong-Bin Yang, Nipa Banik, Bomin Han, Dong-Nyeong Lee, Jooho Park
Summary: With advancements in bioinformatics, amino acid-based drug-design strategies have become increasingly important in pharmaceutics. Despite previous limitations of low selectivity and rapid degradation, peptide-based therapeutics combined with drug-delivery systems have emerged, particularly in anticancer therapy.
Article
Engineering, Biomedical
Yingmei Luo, Ze Chen, Mingjian Sun, Baohong Li, Fan Pan, Aiqing Ma, Jianhong Liao, Ting Yin, Xiaofan Tang, Guojun Huang, Baozhen Zhang, Hong Pan, Mingbin Zheng, Lintao Cai
Summary: This study developed IL-12 nanostimulant-engineered CAR T cell (INS-CAR T) biohybrids for boosting antitumor immunity, which showed promising effects in eliminating solid tumors and minimizing side effects.
Review
Biotechnology & Applied Microbiology
Ala Orafaie, Ahmad Reza Bahrami, Maryam M. Matin
Summary: This article provides an overview of anti-breast cancer peptides, including their sources, biological activities, and the pros and cons of using them. The emphasis is placed on improving the effectiveness of these peptides in cancer therapy.
Article
Pharmacology & Pharmacy
So-Hyeon Park, Jun-Hyuck Lee, Seong-Bin Yang, Dong-Nyeong Lee, Tae-Bong Kang, Jooho Park
Summary: A novel peptide and drug conjugate (PDC) called RR-BA was developed using a cathepsin-B-specific peptide (RR) and bile acid (BA), which could self-assemble in an aqueous solution to form stable nanoparticles. The nano-sized RR-BA conjugate exhibited significant inhibitory effects on cathepsin B and showed anticancer effects against mouse colorectal cancer cells (CT26). In vivo experiments in CT26 tumor-bearing mice also confirmed its therapeutic effect and low toxicity. Therefore, the RR-BA conjugate holds promise as an effective anticancer drug candidate for targeting cathepsin B in cancer therapy.
Article
Chemistry, Multidisciplinary
Pengwen Chen, Wenqian Yang, Koji Nagaoka, George Lo Huang, Takuya Miyazaki, Taehun Hong, Shangwei Li, Kazunori Igarashi, Kazuyoshi Takeda, Kazuhiro Kakimi, Kazunori Kataoka, Horacio Cabral
Summary: Researchers have developed a nanocytokine that can release active interleukin 12 (IL-12) specifically in tumor tissues, leading to localized antitumoral inflammation without causing systemic immune responses and toxicities. This strategy shows promising potential for safer and more effective immunotherapies.
Article
Nanoscience & Nanotechnology
Changhuan Zhang, Qinghua Li, Chenghu Wu, Jilong Wang, Ming Su, Junjie Deng
Summary: The development of a PEGylated hyaluronic acid nanogel with hypoxia and enzymatic responsiveness allows selective release of interleukin-12 in the tumor microenvironment, showing anti-tumor effects on melanoma. This novel strategy provides efficient delivery, on-demand release, and enhanced access of proteins to hypoxic tumor regions, potentially benefiting the treatment of various cancers.
Article
Medicine, Research & Experimental
Yanan Zhang, Xingang Yang, Shengnan Xu, Wenjia Jiang, Zhongwei Gu, Miao Guo, Jifu Wei
Summary: This study constructed dendritic peptide-based multifunctional nanoparticles (Au@SPP@DOX) for enhanced cancer therapy. The nanoparticles showed good biocompatibility and could accumulate at tumor sites to release the loaded DOX. Under low-dose radiation, Au@SPP@DOX induced reactive oxygen species production, mitochondrial dysfunction, and tumor cell apoptosis.
MOLECULAR PHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Youji Hong, Yvette Robbins, Xinping Yang, Wojciech K. Mydlarz, Anastasia Sowers, James B. Mitchell, James L. Gulley, Jeffrey Schlom, Sofia R. Gameiro, Cem Sievers, Clint T. Allen
Summary: This study demonstrates that local administration of a tumor-targeted IL-12 antibody fusion protein can achieve potent immune control of established tumors with low doses to avoid systemic toxicity. The treatment leads to reinvigoration and proliferation of exhausted T lymphocytes, induction of Th1 immunity, and a decrease in regulatory T cells and suppressive myeloid cells. Single-cell analysis also reveals similar IL-12 receptor expression patterns in human head and neck carcinomas.
Article
Nanoscience & Nanotechnology
Anjali Barnwal, Surajit Ganguly, Jayanta Bhattacharyya
Summary: In this study, Interleukin-12 (IL-12) was encapsulated in extracellular vesicles derived from activated dendritic cells (DEVs) with tumor antigens. The DEV-IL delayed the growth of murine glioblastoma by recruiting immune cells, depleting immunosuppressive cells, and inhibiting angiogenesis. It also enhanced systemic immunity by increasing CTL activity and proinflammatory cytokines levels in the spleen.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Daniel Octavian Costache, Oana Feroiu, Adelina Ghilencea, Mihaela Georgescu, Ana Caruntu, Constantin Caruntu, Sorin George Tiplica, Mariana Jinga, Raluca Simona Costache
Summary: The concept of systemic inflammatory syndrome is crucial for modern and future therapies, as it helps understand the collaboration and balance between various systems and organs in the human body. The concept of environment-inadequacy status is related to this, encompassing the disorders in the organism's response to undefined environmental situations. Psoriasis is a clear example of an inadequate body response with excessive systemic inflammation. Modern biological therapies, which aim to reshape cytokine configuration, have been successful in controlling diseases like psoriasis. Concerns have been raised about the potential alteration of immune surveillance and promotion of cancer progression due to the important roles of cytokines in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna Piotrowska, Renata Zaucha, Oliwia Krol, Michal Aleksander Zmijewski
Summary: Preconditioning of patient-derived melanoma cells with 1,25(OH)(2)D-3 enhances the inhibitory effect of cediranib and vemurafenib and reduces mitochondrial respiration parameters. Moreover, cancer-associated fibroblasts play a crucial role in melanoma growth. Thus, 1,25(OH)(2)D-3 could be considered as an adjuvant agent in the treatment of malignant melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Yanjing Li, Ronghui Zhou, Dexuan Xiao, Sirong Shi, Shuanglin Peng, Shihong Wu, Peng Wu, Yunfeng Lin
Summary: The study introduces a high-performance nanosystem based on N,S-codoped graphene quantum dots (GQDs) to overcome PDT resistance in cancer by generating high levels of reactive oxygen species in tumor cells through specific binding. This system inhibits survival pathways of cancer cells and has potential for future PDT therapies.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Justyna Czapla, Tomasz Cichon, Ewelina Pilny, Magdalena Jarosz-Biej, Sybilla Matuszczak, Alina Drzyzga, Lukasz Krakowczyk, Ryszard Smolarczyk
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Ryszard Smolarczyk, Justyna Czapla, Magdalena Jarosz-Biej, Kyle Czerwinski, Tomasz Cichon
Summary: Tumor blood vessel formation is crucial for tumor expansion, and targeting tumor vessels specifically can be an effective anti-cancer treatment method.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Benjamin Motais, Sandra Charvatova, Zuzana Walek, Matous Hrdinka, Ryszard Smolarczyk, Tomasz Cichon, Justyna Czapla, Sebastian Giebel, Michal Simicek, Tomas Jelinek, Tereza Sevcikova, Jiri Sobotka, Zdenek Koristek, Roman Hajek, Juli R. Bago
Summary: Cellular immunotherapy has shown promising results in cancer treatment, but faces challenges such as off-tumor toxicity and tumor recurrence. A study aimed to utilize NK cells' anti-tumor characteristics to target a wide range of cancers, combining them with the anti-CD-38 antibody Daratumumab for a synergistic effect against multiple myeloma, showing a significant reduction in tumor volume in mouse models.
Article
Pharmacology & Pharmacy
Joanna Jaworska, Ryszard Smolarczyk, Monika Musial-Kulik, Tomasz Cichon, Paulina Karpeta-Jarzabek, Jakub Wlodarczyk, Mateusz Stojko, Henryk Janeczek, Aleksandra Kordyka, Bozena Kaczmarczyk, Malgorzata Pastusiak, Janusz Kasperczyk
Summary: Local delivery of chemotherapy drugs from nonwoven-structured polyesters can reduce systemic side effects and provide high local concentration, enhancing the efficacy of anticancer therapy. Electrospun drug-eluting systems using PGCL and PLGA showed promising tumor inhibition in a mouse model of breast cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Natalia Kulach, Ewelina Pilny, Tomasz Cichon, Justyna Czapla, Magdalena Jarosz-Biej, Marek Rusin, Alina Drzyzga, Sybilla Matuszczak, Stanislaw Szala, Ryszard Smolarczyk
Summary: The study demonstrated that MSC are effective carriers of IL-12 cytokine, showing anti-tumor effects in primary and metastatic melanoma models. The use of MSC as carriers allowed for intravenous administration of IL-12 without toxic side effects, resulting in reduced tumor growth and metastases, decreased vascular density, and increased immune response in treated mice. Therapeutic properties of IL-12 cytokine were successfully exerted by modified MSC without inducing toxicity.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Alina Drzyzga, Tomasz Cichon, Justyna Czapla, Magdalena Jarosz-Biej, Ewelina Pilny, Sybilla Matuszczak, Piotr Wojcieszek, Zbigniew Urbas, Ryszard Smolarczyk
Summary: Tumor growth relies on abnormal vasculature, making targeting tumor blood vessels an effective approach to cancer therapy. This study aimed to determine the optimal sequencing of vascular disrupting agents and radiotherapy to enhance therapeutic efficacy, highlighting the importance of immune cell activation and sequential therapeutic agent administration. Combining vascular disrupting agents with radiotherapy effectively inhibits tumor growth but requires careful planning of administration sequence for maximum synergistic therapeutic effect.
Article
Oncology
Justyna Czapla, Alina Drzyzga, Sybilla Matuszczak, Ewelina Pilny, Tomasz Cichon, Krzysztof Stojecki, Ryszard Smolarczyk
Summary: This study investigated the anti-cancer properties of a standardized composition of compounds (trans-resveratrol, quercetin, vitamin E, and selenium) in a mouse model of CT26 colorectal carcinoma. The results showed that the administration of this composition inhibited the growth of colorectal carcinoma in mice without causing overall toxicity.
ANTICANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Beata Biesaga, Ryszard Smolarczyk, Anna Mucha-Malecka, Justyna Czapla, Janusz Rys, Krzysztof Malecki
Summary: Infection with HPV16 in cancers of the oral cavity and oropharynx is an important factor for prognosis, with some studies suggesting the possibility of differentiating prognosis of HPV16-positive patients by STING immunoexpression. The study aimed to analyze the influence of STING immunoexpression on overall and disease-free survival of patients with HPV16-positive and -negative OCSCC and OPSCC. Results showed that tumor STING immunoexpression has prognostic potential in patients with active HPV16 infection in cancers of oral cavity and oropharynx.
Article
Cell Biology
Sandra Charvatova, Benjamin Motais, Justyna Czapla, Tomasz Cichon, Ryszard Smolarczyk, Zuzana Walek, Sebastian Giebel, Roman Hajek, Juli R. Bago
Summary: We propose a novel approach for the local treatment of multiple myeloma bone disease (MBD) using a combination of natural killer cells (NKs) and mesenchymal stem cells (MSCs) within a fibrin scaffold, known as FINM. In vitro studies demonstrated that NKs within FINM exerted a robust anti-tumor activity against MM cells and suppressed osteoclast activity in a 3D model of MBD. The combination of FINM with other therapeutic agents showed a clear therapeutic synergistic effect.
Article
Biochemistry & Molecular Biology
Sybilla Matuszczak, Krzysztof Szczepanik, Aleksandra Grzadziel, Alina Drzyzga, Tomasz Cichon, Justyna Czapla, Ewelina Pilny, Ryszard Smolarczyk
Summary: Radiotherapy is an effective treatment for head and neck squamous cell carcinomas (HNSCCs), but resistance to radiation therapy is common. In this study, the researchers examined the effects of radiation therapy on cell survival and secretion in a co-culture model of HNSCCs in vitro. They found that the presence of fibroblasts and endothelial cells inhibited cell cycle checkpoints and promoted cell cycle progression. Additionally, they observed an anti-apoptotic effect in the co-cultures, which may be due to increased secretion of IL-6 and MCP-1.
Article
Oncology
Justyna Czapla, Alina Drzyzga, Sybilla Matuszczak, Tomasz Cichon, Marek Rusin, Magdalena Jarosz-Biej, Ewelina Pilny, Ryszard Smolarczyk
Summary: The study demonstrates that combining immunotherapy with anti-vascular treatment can effectively inhibit the growth of poorly immunogenic melanoma and triple-negative breast tumors. This approach alters the tumor microenvironment and stimulates the immune response. However, it does not significantly affect the production of the cytokine PD-1.
FRONTIERS IN ONCOLOGY
(2023)
